Here's what you can expect at Houston's Comicpalooza this weekend from esports to Game of Thrones stars

Bend the knee

Comicpalooza takes place Friday, May 9, to Sunday, May 12. Courtesy of Comicpalooza

People from around the world will be flocking to downtown Houston by the thousands, and not just for the Astros and the Rockets. The 11th annual Comicpalooza is taking over the George R. Brown Convention Center from Friday, May 10, to Sunday, May 12.

"This major super block in downtown will be absolutely electric this weekend," Michael Heckman, Comicpalooza president, tells InnovationMap.

Last year, the convention attracted over 50,000 people from 47 states and 17 countries, and it made an economic impact of over $20 million, Heckman says. This year, with the help of Game of Thrones stars and an inaugural ESPN event, Comicpalooza should surpass last year's accomplishments.

Here's what you can expect from this weekend.

A crowd at the panel that has two Game of Thrones actresses

Emilia Clarke (left) plays Daenerys in Game of Thrones, and Nathalie Emmanuel plays her adviser and friend, Missandei. Photos courtesy of Comicpalooza

A panel on Saturday morning at 11 am will have two Game of Thrones stars — Emilia Clarke (Daenerys) and Nathalie Emmanuel (Missandei). The panel is sure to attract the masses, and the two actresses are major gets by the organization.

"To be able to get Emilia Clarke in the middle of the final season of Game of Thrones, with only two episodes to go — the hype has been unbelievable," Heckman says. "To be able to have a pop culture phenomenon like that come here to Houston — and it will be her first fan event. She's done the San Diego Comic Con, but that was more of a media event."

Both actresses also have autograph visits available for purchase. Clarke's are sold out online, but some opportunities will be made available day of.

The first ever ESPN collegiate esports competition

ESPN's inaugural esports competition for college students is premiering at Comicpalooza. Jamie McInall/Pexels

For the first time ever, ESPN is having a collegiate esports championship and chose Houston to be the place for the finals.

"We've understood the value of [esports] for Comicpalooza for a number of years. ESPN is making a big investment — it's their first ever event of this nature, but it won't be their last," Heckman says.

Students from hundreds of schools have competed to make it to the semifinals and championship in Houston, and scholarships are on the line. The weekend will have 22 teams across five video games — Hearthstone, Heroes of the Storm, Overwatch, StarCraft II, and Street Fighter V — according to ESPN. To read more about the competition, click here.

Makers on display

Anyone can check out the Comicpalooza Maker's Space — there's even a place to fix any cosplay wardrobe malfunctions. Photo via comicpalooza.com

Calling all makers — professionals or wannabes. Comicpalooza's Maker's Space is open to cosplayers, artists, engineers, scientists and everyone in between who wants to create and build using old and new technology, from small electrical parts to towering 3D printers and Lego masterpieces.

"What a lot of people don't know is there are so many interesting aspects to Comicpalooza — from literature tracks to a film festival to a makerspace," Heckman says. "There are hundreds of exhibitors on the expo showfloor, but there's an area carved out for makers."

A party on the promenade

Free concert anyone? Photo via comicpalooza.com

From 6 to 10 pm on Saturday, Avenida Houston will be transformed into an after party put on by Saint Arnold's and headlined by Icona Pop. It's free to attend, and you can get more info here.

VIPs all around

It's not just the Game of Thrones people being featured. Photos via comicpalooza.com

Comicpalooza attendees can grab photos with or autographs from over 30 different actors across major franchises — like Star Trek, Walking Dead, and so much more.

The list of actors is as follows: Emilia Clarke, Nathalie Emmanuel, Grant Gustin, Wilmer Valderrama, Dan Fogler, Gates McFadden, Michael Dorn, John Wesley Shipp, Peter Serafinowicz, Griffin Newman, Yara Martinez, Brendan Hines, Scott Speiser, Jeremy Davies, Andrew Divoff, Mira Furlan, Erick Avari and more.

Michael Heckman shares about some exciting new aspects of Houston's 11th annual Comicpalooza. Courtesy of Houston First

Comicpalooza expects another record year, says Houston First Corp. executive

Featured Innovator

Eleven years ago, Comicpalooza was a small event held out in Katy. Over the past few years, with the help of Houston First Corp., the three-day conference has grown to be so big, the 2019 programming will spill out of George R. Brown Convention Center and into Discovery Green, and attract over 50,000 attendees.

"These comic conventions used to just be for the hardcore pop culture fans. What we've attempted to do is make it so there's something for everyone," says Michael Heckman, Comicpalooza president and senior vice president at Houston First. "As a casual pop culture fan, there's a lot to see and do."

The festivities take place Friday, May 10, to Sunday, May 12, and include some big name events. Two Game of Thrones stars — Emilia Clarke (Daenerys Targaryen) and Nathalie Emmanuel (Missandei) — will be on a panel, and ESPN will host its first collegiate esports competition.

Heckman tells InnovationMap more about these big events and how Comicpalooza has transformed over the years.

InnovationMap: How the event has grown over the past decade? 

Michael Heckman: We've really worked hard to increase the impact of the event. There's a lot of out of town visitors that do come in — it has north of a $20 million economic impact every year. When you look at an event that is held during a traditionally slow period of time, it's a really big deal for the hotels and restaurants. The other part about it is when you're able to bring big stars to Houston, they're tweeting about it and posting Instagram stories about it. It does a lot to shine a spotlight on Houston's reputation and image.

IM: What are you most excited about for this year?

MH: It's a big sprawling event that takes place across all 1.2 million square feet of GRBCC. I'm excited about a few things. First, we've got the two folks from Game of Thrones. To be able to get Emilia Clarke in the middle of the final season of Game of Thrones, with only two episodes to go — the hype has been unbelievable. To be able to have a pop culture phenomenon like that come here to Houston — and it will be her first fan event. She's done the San Diego Comic Con, but that was more of a media event.

We've also got the ESPN Collegiate Esports Championship held here. We've done esports and gaming over the past few years, but it's a growth area for the event. To be able to hold that event with dozens of championships from around the country for this inaugural event is very exciting.

What a lot of people don't know is there are so many interesting aspects to Comicpalooza — from literature tracks to a film festival to a makerspace. There are hundreds of exhibitors on the expo showfloor, but there's an area carved out for makers. We have NASA, a cultural arts avenue, there's something for everyone. We're really looking forward to a blockbuster year.

IM: What did it mean for Houston to get ESPN’s collegiate esports program? 

MH: Esports is rapidly growing. That marketplace is developing very quickly. A lot of people and a lot of cities are figuring out what that means. We've understood the value of it for Comicpalooza for a number of years. ESPN is making a big investment — it's their first ever event of this nature, but it won't be their last.

IM: How did it come about?

MH: We've been talking to a number of folks across the landscape about how to best utilize the space that we have at GRBCC and find an opportunity that was a good fit for us. A couple people we were talking to out on the West Coast who connected us to the ESPN people, who happen to be the same division of ESPN that partners with the Houston Texans on a couple things. There's some synergies there, and they're familiar with Houston.

IM: How would you describe Comicpalooza's economic impact on Houston?

MH: Around 20 to 30 percent for the audience of Comicpalooza comes from outside of Houston. Last year, we had attendees from 47 states and 17 countries. It gives great exposure to the city, and the money they leave behind is valuable from an economic impact perspective. We think our numbers will be somewhat similar to last year.

If you look at the long term vision of what this could be, we have a beautiful campus for this event. We've moved some of our programming outside GRBCC onto the Avenida Plaza that connects to Discovery Green. If we have a full campus-wide event, that's something that's highly attractive. You grow that attendance, get up to 70 or 80 thousand people — that's a mega event. It's a snowball — once you get it started and then it just takes off. We're not there yet, but we've had really smart growth.

IM: How is the city as a whole preparing for the event?

MH: Houston's really good about handling events. It takes everything from the fire department to the police department and traffic control and 700 event volunteers — over 2,000 shifts. It's such a big footprint — it's kind of all hands on deck. It also looks like we'll have Astros at home and the Rockets playing game six of the playoffs at home. This major super block in downtown will be absolutely electric this weekend.

IM: What other events are you looking to bring to Houston?

MH: We'll always be chasing our conventions we have here. Our convention sales team looks to break another record this year. We have a lot of major events upcoming — from the college football playoff to the men's basketball Final Four, and we'll eventually pursue another Super Bowl. As we look to develop our portfolio of events that we manage here, there's a lot of opportunities here for events centered around innovation. There's a lot of talk around how Houston needs to have a better reputation for innovation. We've got aerospace, medical, oil and gas — what's an event we can create or partner on that could highlight Houston's innovation.

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Portions of this interview have been edited.

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Houston space company lands latest NASA deal to advance lunar logistics

To The Moon

Houston-based space exploration, infrastructure, and services company Intuitive Machines has secured about $2.5 million from NASA to study challenges related to carrying cargo on the company’s lunar lander and hauling cargo on the moon. The lander will be used for NASA’s Artemis missions to the moon and eventually to Mars.

“Intuitive Machines has been methodically working on executing lunar delivery, data transmission, and infrastructure service missions, making us uniquely positioned to provide strategies and concepts that may shape lunar logistics and mobility solutions for the Artemis generation,” Intuitive Machines CEO Steve Altemus says in a news release.

“We look forward to bringing our proven expertise together to deliver innovative solutions that establish capabilities on the [moon] and place deeper exploration within reach.”

Intuitive Machines will soon launch its lunar lander on a SpaceX Falcon 9 rocket to deliver NASA technology and science projects, along with commercial payloads, to the moon’s Mons Mouton plateau. Lift-off will happen at NASA’s Kennedy Space Center in Florida within a launch window that starts in late February. It’ll be the lander’s second trip to the moon.

In September, Intuitive Machines landed a deal with NASA that could be worth more than $4.8 billion.

Under the contract, Intuitive Machines will supply communication and navigation services for missions in the “near space” region, which extends from the earth’s surface to beyond the moon.

The five-year deal includes an option to add five years to the contract. The initial round of NASA funding runs through September 2029.

Play it back: Houston home tech startup begins 2025 with fresh funding

HOUSTON INNOVATORS PODCAST EPISODE 272

One of the dozen or so Houston startups kicking of the new year with fresh funding is SmartAC.com, a company that's designed a platform that enables contractors in the HVAC and plumbing industries to monitor, manage, and optimize their maintenance memberships through advanced sensors, AI-driven diagnostics, and proactive alerts.

Last month, the SmartAC.com raised a follow-on round with support from local investor Mercury to continue growth and expansion of the product, which has evolved on many ways since the company launched in 2020, emerging from stealth with $10 million raised in a series A. In a May 2023 interview for the Houston Innovators Podcast, Founder and CEO Josh Teekell explained how he embraced the power of a pivot.

The company's sensors can monitor all aspects of air conditioning units and report back any issues, meaning homeowners have quicker and less costly repairs. While SmartAC.com started with providing the service and tech to homeowners directly, Teekell says he's had a greater interest in working with plumbers and HVAC companies who then deploy the technology to their customers.

"It became quite evident that homeowners don't care about air conditioning really at all until their system breaks," Teekell says on the show. "The technology is really built around giving those contractors as another way to gain a customer relationship and keep it."

Revisit the podcast episode below where Teekell talks about SmartAC.com's last raise.

SmartAC.com's previous round in 2023 — a $22 million series B — was used grow its team that goes out to deploy the technology and train the contractors on the platform.

"We've been very fortunate to get some of the biggest names in Houston on our cap table," Teekell says in the May 2023 conversation. "Since we're raising a bunch of money locally, everyone understands what a pain air conditioning can be."

Houston biotech company tests hard-to-fight cancer therapeutics

fighting cancer

A Houston-based, female-founded biotech company has developed a treatment that could prove to be an effective therapy for a rare blood cancer.

Cellenkos Therapeutics has completed promising Phase 1b testing of its Treg cell therapy, CK0804, in the fight against myelofibrosis. According to a news release from the Cellenkos team, the use of its cord-blood-derived therapeutics could signal a paradigm shift for the treatment of this hard-to-fight cancer.

Cellenkos was founded by MD Anderson Cancer Center physician and professor Simrit Parmar. Her research at the hospital displayed the ability of a unique subset of T cells’ capability to home in on a patient’s bone marrow, restoring immune balance, and potentially halting disease progression.

Myelofibrosis has long been treated primarily with JAK (Janus Kinase) inhibitors, medications that help to block inflammatory enzymes. They work by suppressing the immune response to the blood cancer, but don’t slow the progression of the malady. And they’re not effective for every patient.

“There is a significant need for new therapeutic options for patients living with myelofibrosis who have suboptimal responses to approved JAK inhibitors,” Parmar says. “We are greatly encouraged by the safety profile and early signs of efficacy observed in this patient cohort and look forward to continuing our evaluation of the clinical potential of CK0804 in our planned expansion cohort.”

The expansion cohort is currently enrolling patients with myelofibrosis. What exactly are sufferers dealing with? Myelofibrosis is a chronic disease that causes bone marrow to form scar tissue. This makes it difficult for the body to produce normal blood cells, leaving patients with fatigue, spleen enlargement and night sweats.

Myelofibrosis is rare, with just 16,000 to 18,500 people affected in the United States. But for patients who don’t respond well to JAKs, the prognosis could mean a shorter span than the six-year median survival rate outlined for the disease by Cleveland Clinic.

Helping myelofibrosis patients to thrive isn’t the only goal for Cellenkos right now.

The company seeks to aid people with rare conditions, particularly inflammatory and autoimmune disorders, with the use of CK0804, but also other candidates including one known as CK0801. The latter drug has shown promising efficacy in aplastic anemia, including transfusion independence in treated patients.

The company closed its $15 million series A round led by BVCF Management, based in Shanghai, in 2021. Read more here.

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