Houston researchers advance unique nasal vaccine that prevents COVID transmission

cutting spread at the source

The University of Houston's Navin Varadarajan explains that while COVID vaccines prevent advanced disease, they don’t prevent transmission. But he has a solution. Photo via Getty Images

Since the force of COVID-19 hit globally in 2020, scientists have made efficient progress in the fight against it. As Dr. Navin Varadarajan puts it, vaccines have “allowed us to become a society again.”

And he should know, the M.D. Anderson Professor of William A. Brookshire Chemical and Biomolecular Engineering at University of Houston just published back-to-back studies for nasal sprays that combat viruses. One, the NanoSTING therapeutic, has proven effective in treating strains of SARS-CoV-2 and the flu virus. The other, NanoSTING-NS Pan-coronavirus Vaccine is targeted at preventing the transmission of multiple COVID variants altogether.

Why a nasal vaccine? Varadarajan explains that while COVID vaccines prevent advanced disease, they don’t prevent transmission.

“Intramuscular vaccines do not facilitate a component of peer immunity called mucosal immunity, which takes care of these points of entries, these wet surfaces, which can be of the nose and the wet surfaces of the nose, and so they don't prevent transmission,” he tells InnovationMap. “So I can be vaccinated, I pick up a small infection that's confined largely to my nostrils, and I can still pass it on to vulnerable people, the aged, the immunocompromised people who have all the drugs they're taking to fight other things, like cancer patients. And so for them, the vaccines tend to be less efficacious, and if I transfer it to them, unfortunately they can end up in a hospital, right? And so preventing transmission is the way to end this cycle.”

Dr. Navin Varadarajan is the M.D. Anderson Professor of William A. Brookshire Chemical and Biomolecular Engineering at University of Houston. Photo via UH.edu

The NanoSTING-NS is also notable for its potential ability to end what Varadarajan calls “the endless cycle of boosting.” The way to do that, he explains, is to prevent the infection at its root. And theoretically, his lab’s invention could do that. But he cautions readers not to get too excited just yet.

The vaccine is currently in the phase of animal testing, though Varadarajan is hopeful that it could move to human samples in about a year.

The therapeutic can treat multiple respiratory viruses by using fat droplets to deliver the immune booster cGAMP.

“The ability to activate the innate immune system presents an attractive route to armoring humans against multiple respiratory viruses, viral variants and also minimizing transmission to vulnerable people,” says postdoctoral associate Ankita Leekha, first author on the paper that shares NanoSTING’s findings. “The advantage of NanoSTING is that only one dose is required, unlike the antivirals like Tamiflu that require 10 doses.”

Ankita Leekha is the first author on the paper that shares NanoSTING’s findings. Photo via UH.edu

Varadarajan puts it even more simply: “Just like we have Tylenol, just like you take aspirin, you feel like you have some symptoms, and you take it afterwards.”

Currently, he says that the partners with whom the lab is working towards commercialization are prioritizing the therapeutic over the vaccine. The reasons are clear. Varadarajan explains that, while we’ve now long had antibiotics to broadly combat infections, there hasn’t been anything like that to battle viruses. With its ability to target multiple viruses, NanoSTING could be that innovation.

“We activate the innate immune system. So our drug is not virus-specific. Our drug works by activating your own immune system, and that will then fight off different kinds of viruses,” he says.

A single product that treats everything from the common cold to COVID-19 by capitalizing on the patient’s own immune system could be closer than we realize.

The researchers hope to get the vaccine into human trials soon. Photo via UH.edu

From Your Site Articles
Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

New AI program powered by Mark Cuban opens applications for Houston students

eyes on ai

The Mark Cuban Foundation is partnering with digital consultant company Perficient’s Houston office to bring a one-of-its-kind, free artificial intelligence camp to high school students in Houston.

Applications, which are open now online, will close September 30.

“With the proliferation of AI, it’s more important than ever to increase AI education – especially among today’s youth,” Bill Davis, senior vice president at Perficient, says in a news release.

The curriculum will focus on the latest developments in the world of AI and Generative AI. The camp — held at Perficient’s Houston office on November 2, 9 and 16 — will provide students with necessary tools and technologies to help inspire a new generation of AI users and professionals. The camp aims to help underserved high school students with a focus on recruiting students of color, first generation college students, girls, and those from lower to moderate income households.

“As AI continues to become an undeniable force in all of our lives, it’s crucial that we open the door to this knowledge, especially to young people who want to explore it,” Cuban says in the release. “While technology expands and becomes more advanced, it becomes more critical that we ensure our students are prepared when they apply for schools or jobs in the future. Thanks to our work with Perficient, the bootcamp will offer an avenue to explore this fascinating field of technology to any student, no matter their means.”

Students can select from six tracks in the course that include healthcare, arts and entertainment, business and entrepreneurship, computer science, sports science, or education and career readiness. The AI Bootcamps are introductory and accessible to students in ninth through 12th grade with an interest in technology without any prior computer science experience. Transportation, resources and food will be provided.

As classes like STEM increase in popularity more programs have been created to help increase interest. More than 233,000 high school students in Texas took Career and Technical Education courses focused on STEM from 2020-2021.

“We’re proud to partner with the Mark Cuban Foundation to educate the next generation of technology leaders, mentoring students in AI, and ensuring the future of STEM,” Davis said in a news release.

UTSI's advisory board digs into cybersecurity's challenges, trends + tech

From The Board

In today's digital landscape, the convergence of Information Technology (IT) and Operational Technology (OT) presents both opportunities and challenges for critical infrastructure asset owners and operators.

UTSI, a leading systems integrator of OT technology, has assembled an OT Cybersecurity Advisory Board to address these challenges and highlight standard processes and best practices to evaluate and secure these environments.

“We are excited about the strength of our esteemed Advisory Board and are confident that these strategic alliances will enhance our competitiveness,” says Shaun Six, president of UTSI International.

A few of the drivers of OT and IT convergence include increased efficiency, enhanced data, and improved remote monitoring and control capabilities. It exists to promote the promise of connectivity, data visualization, and to enable AI and better decision-making.

Key challenges
However, there are challenges. Increased attack surface, legacy systems, and infrastructure, as well as differing security requirements and regulatory and compliance challenges are all present.

“As we witnessed our global infrastructure recover from the largest outage on July 19, this is a clear and present example of how the application of technology between IT/OT can have an impact on the underlying interdependencies in critical systems and infrastructure," says Cherise Esperaza, co-founder and president of Security Gate. "Therefore, there is an ever-increasing need for resources to be expended for this endeavor, and understanding the areas of risk alongside business outcomes as it relates to the convergence will be a critical to ensuring optimal availability of these systems.”

Increased monitoring

When it comes to security monitoring and incident response, it's vital to incorporate new tools to monitor, meeting the same standards as legacy assets and reporting vulnerabilities.

"Continuous monitoring is one of the most critical aspects of securing your IT/OT infrastructure," offers Eric Rippetoe, former CISO of Federal Energy Regulatory Commission and UTSI cybersecurity consultant. "Automated tools coupled with mature processes allow organizations to rapidly detect security threats and enable teams to quickly respond to address issues. Having a security incident and not knowing about it could result in huge remediation costs and major long-term reputational damage."

Emerging technology and trends
With the rise of AI, it makes sense now more than ever to follow the principle of "never trust, always verify." A Zero Trust architecture is a strategic approach to cybersecurity that secures an organization by eliminating implicit trust and continuously validating every stage of a digital interaction.

In line with this approach, UTSI International Corporation, as a Gold Partner of ThreatGEN, has been intensively utilizing ThreatGEN's AutoTableTop™ incident response tabletop exercise simulation tool. This advanced technology is helping UTSI provide meaningful tabletop exercises to their client base, particularly in high-risk SCADA and OT environments.

Clint Bodungen, president of ThreatGEN, emphasizes the tool's significance: "This tool is designed to sharpen incident response capabilities for teams operating in critical SCADA and OT environments. In these high-stakes settings, where system availability is paramount and the consequences of failure can be catastrophic, AutoTableTop™ provides an unparalleled platform for realistic, AI-driven tabletop exercises. It allows teams to practice and refine their responses to a wide range of scenarios, with practically zero planning time required, ensuring they're prepared for the unique challenges posed by industrial control systems where even a minor slip-up could have deadly consequences. This application of advanced simulation technology aligns with the industry's move towards more robust and realistic cybersecurity training, especially in sectors where the stakes are exceptionally high."

In conclusion
The convergence of IT and OT presents significant cybersecurity challenges for critical infrastructure. However, by understanding these challenges and implementing effective strategies, organizations can protect their essential systems from cyber threats.

“Maintaining an accurate inventory of assets poses a significant challenge for companies with control system networks," says Derek Harp, chairman, Control System Cyber Security Association International. "As outlined in our 2024 OT Cybersecurity Technology Report, not only is it difficult to identify these assets, but understanding their communication adds an additional layer of complexity. Typically, companies only gain a snapshot of their OT network status and assets' interactions during periodic assessments. Not surprisingly, our research also indicates that the frequency of these critical evaluations is increasing.”

The role of UTSI's OT Cybersecurity Advisory Board, along with the use of advanced tools like Security Gate and ThreatGEN, is pivotal in navigating this complex landscape. As the threat landscape continues to evolve, proactive measures and ongoing investment in cybersecurity will be crucial to safeguarding our most critical assets.

Play it back: Houston therapeutics co. sees momentum with expanded treatment opportunities

houston innovators podcast Episode 253

It's been a busy summer for Houston-based Coya Therapeutics, a clinical-stage biotech company that's creating revolutionary treatments for neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS.

In July, Coya announced that has expanded its collaboration with Houston Methodist Research Institute, or HMRI. The publicly traded company also announced fresh funding from the Johnson Center for Cellular Therapeutics.

Last month, Coya reported that it has expanded its treatment research to see how GLP-1 drugs — a trending drug for weight loss — can enhance the effects of its proprietary therapeutics. By combining the medicines, Howard Berman, co-founder and CEO of Coya Therapeutics, says he thinks Coya can better treat these complex immune-based diseases.

Berman joined the Houston Innovators Podcast in April of 2023 to discuss taking Coya public and his passion for the company's mission.

"I was interested in what I could do for my dad," Berman says on the Houston Innovators Podcast, explaining how he took the meeting with Dr. Stanley Appel, who then presented him with some of his research. "By slide five my jaw had hit the ground.

"He had shown that he could stop the progression in one of his early trials of ALS," Berman says.

Berman shares more of the Coya Therapeutics story on the podcast, as well as how he sees Houston's potential as an emerging hub for biotech.

"The next number of years as we develop this therapeutic regimen for ALS, we have the potential to transform Houston into something more than it is currently," he says. "Our success will be the city's success."

View All Listings