Energy innovation expert, Barbara Burger, shares how she sees the future of energy playing out as a dance between mice — the startups — and elephants — the incumbent corporations. Photo via Getty Images

There is so much good to say about the state of innovation toward a lower carbon future. All the necessary ingredients seem to be here – passionate, committed and incredibly sharp innovators, capital support from seed to growth, incumbent corporations that are looking to decarbonize their base businesses and build new ones, and government agencies that have developed the incentives and programs that are needed to help navigate over the traditional valleys of death.

Why then is this so hard?

I spend a lot of my time now listening and learning from the startups (the mice) and the incumbent corporations (the elephant) and then looking for ways to help them better collaborate.

The questions I frequently get asked from both sides reflect the different worlds they live in. Many mice don’t know who to engage within the elephants — or, more importantly, how to engage with them. Nor is it often clear what the elephant might want to get out of a collaboration. Many elephants envision collaboration with startups at the conceptual level but don’t know how best to find the most promising ones nor what to do once they locate a promising one. There could likely be an entire book on the dance but for this article, let’s focus on the very early part of the dance.

Let’s assume that some early diligence has been done on one or both sides. Of course, we all know that most relationships start by one party pursuing the other (rather than some magical meeting at the center of the dance floor). Knowing the why for both parties is one of the best starts. Here’s some questions that might help with this.

For the startup, are you looking for validation of your technology solution, investment, pilots, customers, a development partner, a commercial or operating partner, an ultimate exit, or maybe all of the above? What stage of development are you at? This collaboration is key to your success; how important is it to the elephant’s success? Would your tech live outside of their fence line or within? The answers to these questions can help pinpoint where in the elephant you want to target for your initial discussions as well as start to figure out the elephant’s why.

For the incumbant corporation, are you looking for potential solutions to problems in your base business? Possible new businesses? Understanding of the landscape with a view on both threats and opportunities? How important is this problem to solve in the priorities of your company? How does the startup’s problem definition align with one that your company wants to address? What is your experience with trialing new technology? Are you okay with a startup that is backed by one of your competitors? How easily will it be to make the argument internally to get resources to deepen a relationship? If, given the go ahead internally, do you have team members that have the time and capability to collaborate with the startup? Are you willing to have it known that you are collaborating with the startup?

There are lots of questions here and the why is often an iterative journey for both sides. It is as much mindset, influence, strategy, champions, and risk tolerance at individual levels as it about technology and economics.

Let’s hope these questions get you out on the dance floor with a promising partner.

------

Barbara J. Burger is a startup adviser and mentor and serves on the board of directors for Greentown Labs. She previously led corporate innovation for two decades at Chevron.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

German biotech co. to relocate to Houston thanks to $4.75M CPRIT grant

money moves

Armed with a $4.75 million grant from the Cancer Prevention and Research Institute of Texas, a German biotech company will relocate to Houston to work on developing a cancer medicine that fights solid tumors.

Eisbach Bio is conducting a clinical trial of its EIS-12656 therapy at Houston’s MD Anderson Cancer Center. In September, the company announced its first patient had undergone EIS-12656 treatment. EIS-12656 works by suppressing cancer-related genome reorganization generated by DNA.

The funding from the cancer institute will support the second phase of the EIS-12656 trial, focusing on homologous recombination deficiency (HRD) tumors.

“HRD occurs when a cell loses its ability to repair double-strand DNA breaks, leading to genomic alterations and instability that can contribute to cancerous tumor growth,” says the institute.

HRD is a biomarker found in most advanced stages of ovarian cancer, according to Medical News Today. DNA constantly undergoes damage and repairs. One of the repair routes is the

homologous recombination repair (HRR) system.

Genetic mutations, specifically those in the BCRA1 and BCRA1 genes, cause an estimated 10 percent of cases of ovarian cancer, says Medical News Today.

The Cancer Prevention and Research Institute of Texas (CPRIT) says the Eisbach Bio funding will bolster the company’s “transformative approach to HRD tumor therapy, positioning Texas as a hub for innovative cancer treatments while expanding clinical options for HRD patients.”

The cancer institute also handed out grants to recruit several researchers to Houston:

  • $2 million to recruit Norihiro Goto from the Massachusetts Institute of Technology to MD Anderson.
  • $2 million to recruit Xufeng Chen from New York University to MD Anderson.
  • $2 million to recruit Xiangdong Lv from MD Anderson to the University of Texas Health Science Center at Houston.

In addition, the institute awarded:

  • $9,513,569 to Houston-based Marker Therapeutics for a first-phase study to develop T cell-based immunotherapy for treatment of metastatic pancreatic cancer.
  • $2,499,990 to Lewis Foxhall of MD Anderson for a colorectal cancer screening program.
  • $1,499,997 to Abigail Zamorano of the University of Texas Health Science Center at Houston for a cervical cancer screening program.
  • $1,497,342 to Jennifer Minnix of MD Anderson for a lung cancer screening program in Northeast Texas.
  • $449,929 to Roger Zoorob of the Baylor College of Medicine for early prevention of lung cancer.

On November 20, the Cancer Prevention and Research Institute granted funding of $89 million to an array of people and organizations involved in cancer prevention and research.

West Coast innovation organization unveils new location in Houston suburb to boost Texas tech ecosystem

plugging in

Leading innovation platform Plug and Play announced the opening of its new flagship Houston-area location in Sugar Land, which is its fourth location in Texas.

Plug and Play has accelerated over 2,700 startups globally last year with corporate partners that include Dell Technologies, Daikin, Microsoft, LG Chem, Shell, and Mercedes. The company’s portfolio includes PayPal, Dropbox, LendingClub, and Course Hero, with 8 percent of the portfolio valued at over $100 million.

The deal, which facilitated by the Sugar Land Office of Economic Development and Tourism, will bring a new office for the organization to Sugar Land Town Square with leasing and hiring between December and January. The official launch is slated for the first quarter of 2025, and will feature 15 startups announced on Selection Day.

"By expanding to Sugar Land, we’re creating a space where startups can access resources, build partnerships, and scale rapidly,” VP Growth Strategy at Plug and Play Sherif Saadawi says in a news release. “This location will help fuel Texas' innovation ecosystem, providing entrepreneurs with the tools and networks they need to drive real-world impact and contribute to the state’s technological and economic growth."

Plug and Play plans to hire four full-time equivalent employees and accelerate two startup batches per year. The focus will be on “smart cities,” which include energy, health, transportation, and mobility sectors. One Sugar Land City representative will serve as a board member.

“We are excited to welcome Plug and Play to Sugar Land,” Mayor of Sugar Land Joe Zimmerma adds. “This investment will help us connect with corporate contacts and experts in startups and businesses that would take us many years to reach on our own. It allows us to create a presence, attract investments and jobs to the city, and hopefully become a base of operations for some of these high-growth companies.”

The organization originally entered the Houston market in 2019 and now has locations in Bryan/College Station, Frisco, and Cedar Park in Texas.