Energy innovation expert, Barbara Burger, shares how she sees the future of energy playing out as a dance between mice — the startups — and elephants — the incumbent corporations. Photo via Getty Images

There is so much good to say about the state of innovation toward a lower carbon future. All the necessary ingredients seem to be here – passionate, committed and incredibly sharp innovators, capital support from seed to growth, incumbent corporations that are looking to decarbonize their base businesses and build new ones, and government agencies that have developed the incentives and programs that are needed to help navigate over the traditional valleys of death.

Why then is this so hard?

I spend a lot of my time now listening and learning from the startups (the mice) and the incumbent corporations (the elephant) and then looking for ways to help them better collaborate.

The questions I frequently get asked from both sides reflect the different worlds they live in. Many mice don’t know who to engage within the elephants — or, more importantly, how to engage with them. Nor is it often clear what the elephant might want to get out of a collaboration. Many elephants envision collaboration with startups at the conceptual level but don’t know how best to find the most promising ones nor what to do once they locate a promising one. There could likely be an entire book on the dance but for this article, let’s focus on the very early part of the dance.

Let’s assume that some early diligence has been done on one or both sides. Of course, we all know that most relationships start by one party pursuing the other (rather than some magical meeting at the center of the dance floor). Knowing the why for both parties is one of the best starts. Here’s some questions that might help with this.

For the startup, are you looking for validation of your technology solution, investment, pilots, customers, a development partner, a commercial or operating partner, an ultimate exit, or maybe all of the above? What stage of development are you at? This collaboration is key to your success; how important is it to the elephant’s success? Would your tech live outside of their fence line or within? The answers to these questions can help pinpoint where in the elephant you want to target for your initial discussions as well as start to figure out the elephant’s why.

For the incumbant corporation, are you looking for potential solutions to problems in your base business? Possible new businesses? Understanding of the landscape with a view on both threats and opportunities? How important is this problem to solve in the priorities of your company? How does the startup’s problem definition align with one that your company wants to address? What is your experience with trialing new technology? Are you okay with a startup that is backed by one of your competitors? How easily will it be to make the argument internally to get resources to deepen a relationship? If, given the go ahead internally, do you have team members that have the time and capability to collaborate with the startup? Are you willing to have it known that you are collaborating with the startup?

There are lots of questions here and the why is often an iterative journey for both sides. It is as much mindset, influence, strategy, champions, and risk tolerance at individual levels as it about technology and economics.

Let’s hope these questions get you out on the dance floor with a promising partner.

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Barbara J. Burger is a startup adviser and mentor and serves on the board of directors for Greentown Labs. She previously led corporate innovation for two decades at Chevron.

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Houston organizations launch collaborative center to boost cancer outcomes

new to HOU

Rice University's new Synthesis X Center officially launched last month to bring together experts in cancer care and chemistry.

The center was born out of what started about seven years ago as informal meetings between Rice chemist Han Xiao's research group and others from the Baylor College of Medicine’s Dan L Duncan Comprehensive Cancer Center at the Baylor College of Medicine. The level of collaboration between the two teams has grown significantly over the years, and monthly meetings now draw about 100 participants from across disciplines, fields and Houston-based organizations, according to a statement from Rice.

Researchers at the new SynthX Center will aim to turn fundamental research into clinical applications and make precision adjustments to drug properties and molecules. It will focus on improving cancer outcomes by looking at an array of factors, including prevention and detection, immunotherapies, the use of artificial intelligence to speed drug discovery and development, and several other topics.

"At Rice, we are strong on the fundamental side of research in organic chemistry, chemical biology, bioengineering and nanomaterials,” Xiao says in the statement. “Starting at the laboratory bench, we can synthesize therapeutic molecules and proteins with atom-level precision, offering immense potential for real-world applications at the bedside ... But the clinicians and fundamental researchers don’t have a lot of time to talk and to exchange ideas, so SynthX wants to serve as the bridge and help make these connections.”

SynthX plans to issue its first merit-based seed grants to teams with representatives from Baylor and Rice this month.

With this recognition from Rice, the teams from Xiao's lab and the TMC will also be able to expand and formalize their programs. They will build upon annual retreats, in which investigators can share unpublished findings, and also plan to host a national conference, the first slated for this fall titled "Synthetic Innovations Towards a Cure for Cancer.”

“I am confident that the SynthX Center will be a great resource for both students and faculty who seek to translate discoveries from fundamental chemical research into medical applications that improve people’s lives,” Thomas Killian, dean of the Wiess School of Natural Sciences, says in the release.

Rice announced that it had invested in four other research centers along with SynthX last month. The other centers include the Center for Coastal Futures and Adaptive Resilience, the Center for Environmental Studies, the Center for Latin American and Latinx Studies and the Rice Center for Nanoscale Imaging Sciences.

Earlier this year, Rice also announced its first-ever recipients of its One Small Step Grant program, funded by its Office of Innovation. The program will provide funding to faculty working on "promising projects with commercial potential," according to the website.

Houston physicist scores $15.5M grant for high-energy nuclear physics research

FUTURE OF PHYSICS

A team of Rice University physicists has been awarded a prestigious grant from the Department of Energy's Office of Nuclear Physics for their work in high-energy nuclear physics and research into a new state of matter.

The five-year $15.5 million grant will go towards Rice physics and astronomy professor Wei Li's discoveries focused on the Compact Muon Solenoid (CMS), a large, general-purpose particle physics detector built on the Large Hadron Collider (LHC) at CERN, a European organization for nuclear research in France and Switzerland. The work is "poised to revolutionize our understanding of fundamental physics," according to a statement from Rice.

Li's team will work to develop an ultra-fast silicon timing detector, known as the endcap timing layer (ETL), that will provide upgrades to the CMS detector. The ETl is expected to have a time resolution of 30 picoseconds per particle, which will allow for more precise time-of-flight particle identification.

The Rice team is collaborating with others from MIT, Oak Ridge National Lab, the University of Illinois Chicago and University of Kansas. Photo via Rice.edu

This will also help boost the performance of the High-Luminosity Large Hadron Collider (HL-LHC), which is scheduled to launch at CERN in 2029, allowing it to operate at about 10 times the luminosity than originally planned. The ETL also has applications for other colliders apart from the LHC, including the DOE’s electron-ion collider at the Brookhaven National Laboratory in Long Island, New York.

“The ETL will enable breakthrough science in the area of heavy ion collisions, allowing us to delve into the properties of a remarkable new state of matter called the quark-gluon plasma,” Li explained in a statement. “This, in turn, offers invaluable insights into the strong nuclear force that binds particles at the core of matter.”

The ETL is also expected to aid in other areas of physics, including the search for the Higgs particle and understanding the makeup of dark matter.

Li is joined on this work by co-principal investigator Frank Geurts and researchers Nicole Lewis and Mike Matveev from Rice. The team is collaborating with others from MIT, Oak Ridge National Lab, the University of Illinois Chicago and University of Kansas.

Last year, fellow Rice physicist Qimiao Si, a theoretical quantum physicist, earned the prestigious Vannevar Bush Faculty Fellowship grant. The five-year fellowship, with up to $3 million in funding, will go towards his work to establish an unconventional approach to create and control topological states of matter, which plays an important role in materials research and quantum computing.

Meanwhile, the DOE recently tapped three Houston universities to compete in its annual startup competition focused on "high-potential energy technologies,” including one team from Rice.

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This article originally ran on EnergyCapital.