Angela Wilkins joins the Houston Innovators Podcast to discuss the intersection of data and health care. Photo courtesy

When most people hear about Houston startup Starling Medical, they might think about how much potential the medical device company has in the field of urinalysis diagnostics. But that's not quite where Angela Wilkins's head went.

Wilkins explains on the Houston Innovators Podcast that when she met the company's co-founders, Hannah McKenney and Drew Hendricks, she recognized them as very promising startup leaders taking action on a real health care problem. Starling's device can collect urine and run diagnostics right from a patient's toilet.

"It was one of those things where I just thought, 'They're going to get a bunch of data soon,'" Wilkins says. "The opportunity is just there, and I was really excited to come on and build their AI platform and the way they are going to look at data."

For about a year, Wilkins supported the startup as an adviser. Now, she's working more hands on as chief data officer as the company grows.



Wilkins, who serves as a mentor and adviser for several startups, has a 20-year career in Houston across all sides of the innovation equation, working first at Baylor College of Medicine before co-founding Mercury Data Science — now OmniScience. Most recently she served as executive director of the Ken Kennedy Institute at Rice University.

This variety in her resume makes her super connective — a benefit to all the startups she works with, she explains. The decision to transition to a startup team means she gets to work hands on in building a technology — while bringing in her experience from other institutions.

"I think I've really learned how to partner with those institutions," she says on the show. "I've really learned how to make those bridges, and that's a big challenge that startups face."

"When we talk about the Houston innovation ecosystem, it's something we should be doing better at because we have so many startups and so many places that would like to use better technology to solve problems," she continues.

Wilkins has data and artificial intelligence on the mind in everything she does, and she even serves on a committee at the state level to learn and provide feedback on how Texas should be regulating AI.

"At the end of the day, the mission is to put together a report and strategy on how we think Texas should think about AI," she explains. "It's beyond just using an algorithm, they need infrastructure."

Colorado is the first state to pass legislation surrounding AI, and Wilkins says all eyes are on how execution of that new law will go.

"We should have technology that can be double checked to make sure we're applying it in a way that's fair across all demographics. It's obvious that we should do that — it's just very hard," she says.

Procyrion has announced the closing of its series E round of funding. Photo via Getty Images

Houston medical device company secures $57.7M to fund journey to FDA approval, commercialization

fresh funding

Houston-born and bred medical device company, Procyrion, has completed its series E with a raise of $57.7 million, including the conversion of $10 million of interim financing.

Procyrion is the company behind Aortix, a pump designed to be placed in the descending thoracic aorta of heart failure patients, which has been shown to improve cardiac performance in seriously ill subjects. The money raised will allow the company to proceed with a the DRAIN-HF Study, a pivotal trial that will be used for eventual FDA approval and commercialization.

The Aortix is the brainchild of Houston cardiologist Reynolds Delgado. According to Procyrion’s CSO, Jace Heuring, Delgado, gained some of his experience with devices for the heart working with legendary Texas Heart Institute surgeon O.H. “Bud” Frazier. He filed his first patents related to the Aortix in 2005.

Heuring says that the first prototypes were built in 2011, followed by the final design in 2018. CEO Eric Fain, a California-based MD and with more than 30 years in the medical device industry, joined the company in 2018 ahead of the final design, primed to bring Aortix to the public. He visits the company’s Houston headquarters, across the street from Central Market, on a regular basis.

The device’s pilot study of 18 patients was completed in 2022. Those encouraging results paved the way for the current study, which will include an enrollment of 134 patients. The randomized study will seek to treat patients with acute decompensated heart failure. Half will be treated with standard-of-care therapy, the other half will be catheterized with an Aortix pump. A separate arm of the study will seek to treat end-stage heart failure patients who would otherwise be deemed too sick for either a transplant or an LVAD permanent pump. Fort-five healthcare centers in the United States will participate, including Texas Heart Institute.

“One of the key characteristics is [the patients] are retaining a lot of fluid,” explains Heuring in a video interview. “And when I say a lot, I mean it could be 25 or 30 or 40 pounds of fluid or more. When we put our pump in, one of the main goals is to reduce that fluid load.”

On average, about 11 liters of fluid came off of each patient. Many of those end-stage patients had previously been considered for both a heart and kidney transplant, but after using the Aortix, their kidneys responded so well that they were able to get only the heart transplant.

“These patients really are in dire straits and come into the hospital and today the only proven therapy to help these patients is to administer high doses of intravenous diuretic and some other cardiac drugs and in about 25 percent of patients those therapies are ineffective,” says Fain.

If Aortix gains approval, these sickest of the sick, usually consigned to hospice care, will have hope.

Thanks to the Series E, led by Houston’s Fannin Partners, returning investors, including Bluebird Ventures, the Aortix is inching closer to commercialization. Besides funding the DRAIN-HR study, Procyrion will also use the funds for internal programs to improve product manufacturability. One more step towards meaning advanced heart failure may not always be a death sentence.

Last month, Atul Varadhachary, managing director of Fannin, joined the Houston Innovators Podcast and alluded to Procyrion's raise. The company was born out of Fannin and still resides in the same building as Fannin.

Aortix is a pump designed to be placed in the descending thoracic aorta of heart failure patients. Photo via Procyrion

Houston-based EndoQuest has closed a $42 million round. Photo via Getty Images

Houston medical robotics startup announces $42M series C

cha-ching

A Houston medical device company that's tapping into robotics technology for the operating room has just announced a major chunk of fresh funding.

EndoQuest Robotics Inc. announced that it has closed a $42 million series C to advance its robot technology that's targeting endoluminal and gastrointestinal minimally invasive procedures. Returning investors, CE Ventures Limited and McNair Interests, and new investor, Puma Venture Capital, led the round of funding.

"Our investors share our vision of leveraging robotics to redefine the possibilities in minimally invasive procedures," Kurt Azarbarzin, CEO of EndoQuest Robotics, says in a press release. "This financing enables us to continue innovating and refining our technology, ultimately improving patient care and transforming the future of endoluminal interventions."

The funding will go toward continued research and development, regulatory initiatives, commercialization, and other key initiatives. Dr. Vipul Patel, the co-founder and senior venture partner of Puma Venture Capital, is a robotic urologic surgeon and sees potential in EndoQuest's technology.

"I've had the privilege of seeing just about every robotic surgical system either in development or on the market today and can honestly say that EndoQuest's system is a true game changer for both physicians and patients," Patel says in the release.

Founded in 2017, EndoQuest's robotics technology has not yet been cleared by the FDA and is not for commercial sale in the United States.

"The EndoQuest team is trailblazing novel solutions in minimally invasive surgery," Neeraj Agrawal, executive director of Crescent Enterprises, the parent organization to CE Ventures Limited. "We welcome our new partners, and remain fully supportive of the Company and the prospects to transform healthcare with our innovative endoluminal surgical platform."

EndoQuest Robotics is targeting endoluminal and gastrointestinal minimally invasive procedures. Image via endoquestrobotics.com

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CultureMap Emails are Awesome

10+ can't-miss Houston business and innovation events for November

WHERE TO BE

From networking meetups to pitch competitions, November is filled with opportunities for Houston innovators. Here's a roundup of events you won't want to miss out on so mark your calendars and register accordingly.

Note: This post might be updated to add more events.

Featured event: November 14 — Houston Innovation Awards

Celebrate Houston innovation at InnovationMap's 2024 Houston Innovation Awards on November 14 at TMC Helix Park. Click here to read about the finalists. Secure your tickets below.


November 4 - 5 — In-Space Physical AI Workshop

The Rice University Office of Innovation, in partnership with NASA, Purdue University and the Ion District, will host the In-Space Physical AI Workshop. The event will bring together industry leaders, startups, government agencies and researchers to explore the cutting edge of AI in space exploration. Workshop sessions will cover a range of topics in physical AI ⎯ robots or systems that apply AI to autonomously sense, interact with and adapt to their environment using complex computational, sensory and motor abilities to perform challenging real-world tasks.

This event begins Monday, November 4, from 8 am to 8:30 pm at the Ion. Click here to register.

November 6 — Waste to Work: Transforming Waste into Valuable Resources

This event will delve into innovative strategies and technologies that transform waste materials into valuable resources, driving sustainability and economic growth. Topics will include innovative technologies in waste conversion, policy and regulation, economic opportunities in waste management, success stories from around the world, and trends and predictions.

This event is Wednesday, November 6, from 3 to 6 pm at the Cooley University Life Center at UTHealth Houston. Click here to register.

November 7 — Bots & Brews

This event is the fall meetup for the H-town robotics, drones, geospatial, data & AI crowd, hosted by the Energy Drone & Robotics Coalition. Leaders from energy/engineering asset owner/operators, service companies, tech solution providers, startups & investors in the energy and industrial robotics/drone/data & AI community come together to catch up and talk about real-world solutions, projects and deployments.

The event is Thursday, November 7, from 5:30 to 7:45 at The Cannon West. Click here to register.

November 8 — Tech Fest Live

The UH Technology Bridge will be buzzing with students, industry leaders, innovators, and tech enthusiasts as they come together to celebrate the future of technology and innovation. There will be exciting panel discussions, interactive exhibits, and networking opportunities in the fields of digital media, energy, AI and entrepreneurship.

This event is Friday, November 8, from 8 am to 4 pm at UH Technology Bridge. Click here to register.

November 12 — The New Majority Summit

1863 Ventures, a D.C.-based accelerator and venture capital firm, is focused on advancing New Majority entrepreneurs—those historically marginalized or underrepresented—towards greater wealth and success. This immersive program centers on the essential skills and insights needed to transition into becoming an effective CEO.

Throughout the event, registrants will delve into key topics, including the entrepreneurial mindset, understanding one's customer base, establishing scalable processes, financial management strategies, and effective fundraising techniques. Prepare to be inspired and empowered after hearing from 1863 CEO Melissa Bradley, founder & CEO of LAMIK Beauty Kim Roxie, co-founder of Donna's Recipe Gina Woods and more.

This event is Tuesday, November 12, from 8:30 am to 5 pm at the Ensemble Theatre. Click here to register.

November 12 — Software Day at the Ion: Blockchain 2.0: Innovating Across Industries

Software Day is a monthly series driving the support, inspiration, and connections needed to help startups on their path to rapid, sustainable growth. Each month, software day will include office hours (by application), a keynote session, and networking. This software day is moderated by Samantha Lewis, partner at Mercury. Panelists include the former CEO of BBVA Compass, Manolo Sanchez and Ian Epstein, co-CEO ProfitR, global head of capital markets and distribution at republic.

This event is Tuesday, November 12, from 3:30 to 7 pm at the Ion. Click here to register.

November 13 — Envision 2024

Learn how companies in the ecosystem of the largest medical center in the world are addressing challenges head-on, meet some of our entrepreneurs, and network. This event is presented in partnership with Innovate UK and BioInnovation Institute.

This event is Wednesday, November 13, from 1 to 5 pm at TMC Innovation Factory. Click here to register.

November 14 — State of the Texas Medical Center

The Greater Houston Partnership's State of the Texas Medical Center returns. William F. McKeon, President and CEO of the Texas Medical Center, will deliver an annual address, discussing the tremendous progress in discovery and life sciences at the world's largest medical center. New to this year's State of the Texas Medical Center, is a dynamic pitch competition, the TMC Innovation Pitch Tank.

This event is Thursday, November 14, from 11 am to 1:30 pm at Hilton Americas. Click here to register.

November 15 — 2024 ERG Symposium

This event, hosted by Houston Methodist, will include a keynote from Shona Pinnock, VP of DEI for Peloton as well as insights from other local organizations such as HESS, Houston Methodist, TDECU, Greystone and more. These experts will share how ERGS are impacting business goals, enhancing company culture and employee engagement and will provide valuable insights and actionable takeaways to help organizations maximize the effectiveness of ERGs.

This event is Friday, November 15, from 9 am to 1 pm at The Westin Houston Medical Center. Click here to register.

November 19 — A Texas Talk: Reflecting on the Past, Envisioning the Future

Center for Houston’s Future’s signature fall event, Dinner and Conversation presented by Harvey-Cleary, will feature an exciting conversation between two important Texas voices. Stephen Harrigan, the award-winning author of 12 fiction and non-fiction books, will appear in conversation with Sonal Shah, CEO of the Texas Tribune, who has a long record of social impact work across multiple sectors.

This event is Tuesday, November 19, from 6 to 9 pm at the River Oaks Country Club. Click here to register.

November 21 — Visionary Voices: A Fireside Chat with Dan Ammann, President of ExxonMobil Low Carbon Solutions

In this fireside chat, Dan Ammann, president of ExxonMobil Low Carbon Solutions, will discuss ExxonMobil’s plans in advancing a thoughtful energy transition by delivering the critical energy and products the world needs and reducing their own and others’ greenhouse gas emissions. He’ll talk about Low Carbon Solutions’ transformative projects and investments aimed at bringing lower-emission technologies like hydrogen, lithium, and carbon capture and storage to market, making them accessible to carbon-intensive industries worldwide.

This event is Thursday, November 21, from 8 to 10 am at the Ion. Click here to register.

Overheard: Houston's top energy transition founders explain their biggest challenges

Houston Innovation Awards

From finding funding to navigating the pace of traditional oil and gas company tech adoption, energy transition companies face their fair share of challenges.

This year's Houston Innovation Awards finalists in the Energy Transition category explained what their biggest challenge has been and how they've overcome it. See what they said below, and make sure to secure your tickets to the Nov. 14 event to see which of these finalists win the award.

"The evolving nature of the energy industry presents opportunities to solve some of our industry's greatest challenges. At Amperon we help optimize grid reliability and stability with the power of AI demand forecasting."

Sean Kelly, CEO of Amperon, an AI platform powering the smart grid of the future

"The biggest challenge in leading an energy transition-focused startup has been balancing the urgency for sustainable solutions with the slow pace of change in traditional industries like oil and gas. Many companies are cautious about adopting new technologies, especially when it comes to integrating sustainability initiatives. We overcame this by positioning our solutions not just as environmentally friendly, but as tools that improve safety, efficiency, and cost savings. By aligning our value proposition with their operational goals and demonstrating real, measurable benefits, we were able to gain traction and drive adoption in industries that are traditionally resistant to change."

— Dianna Liu, CEO of ARIXTechnologies, an integrated robotics and data analytics company that delivers inspection services through its robotics platforms

"Scaling up production of hard tech is a major challenge. Thankfully, we recruited top-notch talent with experience in technology scale-up and chemical processes. In addition, we've begun building partnerships with some of the world's largest chemical manufacturers in our space who are excited to be a part of our journey and could rapidly accelerate our go to market strategy. We have significant demand for our product as early as 2025, so partnering with these companies to scale-up will bring our technology to market years ahead of doing it alone."

— Matthew Dawson, CEO of Elementium Materials, a battery technology with liquid electrolyte solutions

"Our pyrolysis reactor is a proprietary design that was developed during Covid. We ran simulations to prove that it works, but it was not easy to test it in a pilot facility, let alone scaling it up. We managed ... to run our pilot plant studies, while working with them remotely. We proved that our reactor worked and produced high quality products. Later, we built our own pilot plant R&D facility to continue running tests and optimizing the process. Then, there was the challenge of scaling it up to commercial size. ... We put together a task force of four different companies to come together to design and build this complex reactor in record time."

— Vibhu Sharma, CEO of InnoVentRenewables, a startup with proprietary continuous pyrolysis technology that converts waste tires, plastics, and biomass into valuable fuels and chemicals

"Energy storage and geothermal power generation are capital-intensive infrastructure projects, requiring investors with a deep commitment and the patience in terms of years to allow the technology to be developed and proven in the field. One challenge is finding that niche of investors with the vision to join our journey. We have succeeded in raising our $30 million series A with these types of investors, whom we’re confident will continue the journey as we scale."

— Cindy Taff, CEO of SageGeosystems, an energy company focused on developing and deploying advanced geothermal technologies to provide reliable power and sustainable energy storage solutions regardless of geography

"The biggest challenge we've faced has been to bring together massive independent power producers on one side who are investing hundreds of millions of dollars into grid infrastructure with multi- national tech giants on the other that don't have experience working much with energy storage. As a startup with only four employees, gaining credibility with these players was critical. We overcame this hurdle by becoming the preeminent thought leader on storage emissions, through publishing white papers, discussing the issues on podcasts, and (more)."

— Emma Konet, CTO of TierraClimate, a software provider that helps grid-scale batteries reduce carbon emissions

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This article originally ran on EnergyCapital.