Here's what MassChallenge companies won big this year. Photo courtesy of MassChallenge

Nine startups that went through the 2021 Houston cohort for MassChallenge Texas have received cash prizes from the global accelerator.

Now in its 12th year, Boston-based MassChallenge awarded 39 equity-free cash and investment prizes to 36 early-stage companies from the 2021 virtual programs across Austin, Boston, Houston, and Rhode Island. The startups were recognized at a virtual showcase. Of the 229 companies to go through the program this year, about 70 of those were a part of the Houston cohort, which was announced in June, however none of the nine Houston cohort companies are based in Houston.

Here's which companies from the Houston program received awards:

  • AEROSENS, based in Miami, is a platform able to maximize aircraft cabin security and increase efficiency while reducing costs, using Bluetooth Low Energy sensors and the everyday smartphone or tablet. The company received a $25,000 Gold Award.
  • Analatom, based in Santa Clara, California, received the $10,000 FM Global Resilience Prize. The company has created an AI Deep Learning inspection technology automatically flag surface defects in images reducing maintenance costs improving inspection quality.
  • Astrileux Corporation, based in La Jolla, California, is accelerating manufacturing of next-gen ICs at 7 nm and smaller increasing power and performance in the era of zettabyte computing. The company scored one of the three top awards — a $100,000 Diamond Award.
  • Card Medic, based in the United Kingdom, received a $50,000 Platinum Award for its innovative digital technology designed to improve communication between healthcare staff and patients, across any barrier.
  • Exum Instruments, based in Denver, is combining high-performance tech with intuitive, seamless operations, Exum is solving materials characterization for a variety of industries. The company received a $25,000 Gold Award.
  • Grain4Grain, based in San Antonio, is using proprietary upcycling technology to turn byproducts from alcohol producers into low carb, high fiber flour alternatives at low cost. The company received a $25,000 Gold Award.
  • KNWN Technologies, based in DelRay Beach, received the Houston Angel Network Investment Prize as well as a $25,000 Gold Award. The technology provides a new level of identity validation for businesses to know and protect customer identity from enrollment through the life of the relationship.
  • Krtkl, based in San Francisco, is a new high-reliability edge-computing and artificial-intelligence solutions for robotics, sensing, and communications applications. The company received the ISSNL + CASIS Technology in Space Prize.
  • LucyDX, based in Middletown, Delaware, is preventing blindness in diabetics through early detection. The company received a $25,000 Gold Award.

Texas-based Ecliptic Capital will also give out its Investment Prize, but did not announce their winner at the showcase. The organization announced its full list of winners online and at the showcase.

"We designed our process to work with all founders especially those who may be overlooked or underestimated by traditional equity accelerators and investment models. These founders still benefit from and deserve access to accountability, expertise, and a network traditionally often made available only to venture-backed companies," says Siobhan Dullea, CEO of MassChallenge, in the press release. "The 229 startups from this year's cohort demonstrate just how much opportunity exists beyond the closed process of venture when we widen the lens. Congratulations to the winners."

MassChallenge Texas has named its 2021 cohorts — including 71 companies to accelerate in Houston. Photo courtesy of MassChallenge

MassChallenge Texas names the 71 startups that make up its latest Houston cohort

ready to grow

Five Houston-based startups have been accepted into MassChallenge's 50th startup accelerator.

Three of the local startups are part of the program's Houston cohort, and two are part of the Austin cohort. In all, 71 startups from around the world are participating in the new Houston cohort.

Aside from Houston and Austin, there are cohorts in Boston and Rhode Island. This year's MassChallenge class, announced June 28, comprises 229 startups from 20 countries.

The five Houston-based startups in MassChallenge's latest accelerator program are:

  • Church Space, an "Airbnb for churches" that enables churches to rent out space for worship, events, meetings, and ghost kitchens. It's part of the Houston cohort.
  • Every Shelter, which localizes response and relief efforts for global refugee crises. It's part of the Houston cohort.
  • Milkify, which freeze-dries breast milk, enabling mothers to carry it in a powdered form. It's part of the Houston cohort.
  • Javari, a music prediction and discovery platform. It's part of the Austin cohort.
  • Netnoids Rx Laboratories, which provides a platform called Spanio that lets individuals and companies test therapeutics. It's part of the Austin cohort.

"At the core of these early stage businesses is the entrepreneurial spirit of their founders. Entrepreneurial spirit is the unique blend of optimism, passion, and drive that gets founders and their businesses through the daunting early days," Jon Nordby, managing director of MassChallenge Texas, says in a news release.

Church Space, Every Shelter, and Milkify are among the 71 startups in the new Houston cohort. MassChallenge released the names of 69 of those companies. The two others are in stealth mode. Below are the names of the 69 publicly identified startups.

Energy / clean tech

  • Ener.com
  • SeebeckCell Technologies

General

  • Algdeha
  • Analatom
  • Astrileux
  • DeepCharge
  • Freshspire
  • Grain4Grain
  • Intelligent NanoFiber
  • Lepidext
  • Lodgeur
  • Milkify
  • NanoFlowX
  • Nature Knows
  • NjordFrey
  • ProFish Ghana
  • Solo
  • Stagetime

Health care / life sciences

  • AMF Medical
  • Arcascope
  • CardMedic
  • CaringWire
  • Exposphere Fitness
  • Galileo Innovations
  • Insu Health Design
  • Kismet Technologies
  • LucyDx
  • Newton Tech
  • Nightingale Caring Solutions
  • Nurlabs
  • Refined Imaging
  • Ronawk
  • SafetySit
  • SONOflammation
  • Tender Light Scientific
  • Uniphage
  • WestFace Medical

Social impact

  • Carta Digital
  • Every Shelter
  • Nile Agro Value Chain

Tech

  • Aerosens
  • Areanna AI
  • Church Space
  • CodeLn
  • Cybrik
  • Debtle
  • Edusko Africa
  • Exum Instruments
  • Fanorama Social Media
  • Glo3D.com
  • HintEd
  • Invento Robotics
  • KNWN Technologies
  • Krtki
  • Magos
  • Makeena
  • Manus Robotics
  • ModoScript
  • Notewardy
  • Nuw
  • Otomo
  • Owiwi
  • Patturn
  • Privoce
  • Third Ray
  • Tru-Spot Technologies
  • Yada.ai
  • Xena Intelligence
  • Xiggit

To be selected for the MassChallenge program, startups went through a two-round process that included more than 1,000 judges. During the program, participants will receive tools and advice to grow their businesses.

At the end of this year's program, startups will compete for equity-free cash prizes and grants adding up to $100,000. The prizes and grants will be awarded in October.

Attention Houston female founders — there are two new accelerator programs to have on your radars. Photo via Getty Images

Houston organizations announce two new female founder-focused programs

who runs the world?

A couple of Houston startup development organizations have recently announced programing and opportunities for female founders looking to advance their businesses.

Impact Hub Houston has announced that it has partnered up with Frost Bank to sponsor eight female founders to participate in Impact Hub's new Accelerate Membership Program. Applications are now open online and once the inaugural cohort is selected, they will receive the program for three months at no cost.

"At Impact Hub we believe the time to act is now. It's why we are excited to launch our new Accelerate Membership," says Maria Trindade, global network development director at Impact Hub Global, in a news release. "Its unique approach combines all the benefits of an enterprise support program with the flexibility that entrepreneurs need; plus its tailored nature makes this intervention highly accessible for entrepreneurs from diverse backgrounds who may not be able to dedicate full-time to their business idea."

Impact Hub Houston has also teamed up with MassChallenge for their own initiative supporting female founders in the Houston-Galveston region in partnership with Houston-based Workforce Solutions. The three organizations are collaborating to launch launch a bootcamp to support female founders in the greater Houston region.

"There is unprecedented growth in startup creation as a result of the pandemic and founders from all corners of the world are connecting in this virtual environment to build and scale amazing ideas," says Jon Nordby, managing director of MassChallenge Texas, in a news release. "With these new collaborations, we are also witnessing a massive gap in access to startup development resources. Our partnership with Workforce Solutions and Impact Hub Houston will help female founders build on their existing knowledge to become life-long innovators."

Applications for the bootcamp opened April 1 and will close at 5 pm on April 7 and are available online in both English and Spanish. The industry agnostic program will leverage MassChallenge's acceleration model and Impact Hub Houston's inclusive incubation expertise to accelerate female founders by connecting them with the resources they need to launch and scale high-impact businesses, according to the release.

"As a female founder myself, I'm incredibly excited about this opportunity to support and uplift more women entrepreneurs and women-led businesses in our region," says Grace Rodriguez, CEO and executive director of Impact Hub Houston, in the release. "By now, it's no secret that women, and especially women of color, are under-invested in; and this is our chance to change that by helping more women strengthen their businesses and prepare to seek funding."

Houston Exponential has announced the 38 finalists for the inaugural Listies Awards. Photo via Getty Images

Exclusive: HX names finalists for inaugural Houston innovation awards

the listies go to...

Ever wonder what Houston startups and innovators are the best of the best? Here's your chance to figure it out. The inaugural Listies awards program has named its finalists.

The Listies, brought to you by Houston Exponential in partnership with InnovationMap, will name the winning companies and people across 12 awards on November 20 at 3 pm at a virtual event as a part of Impact Hub's annual The Houston Innovation Summit (THIS). Click here to register for the free event.

Nominations were open until Friday, November 6, and then a group of judges made up of members of the Houston innovation ecosystem reviewed the submissions to settle on the finalists. Below, in alphabetical order, the 38 finalists are listed for each category.

DEI champion

  • Heath Butler
  • Maria Maso
  • Grace Rodriguez

Individual contributor

  • Michael Matthews
  • Slawek Omylski
  • Brad True

Mentor of the year

  • Keith Kreuer
  • Wade Pinder
  • Landi Spearman

Outstanding leadership

  • Stephanie Campbell
  • Grace Rodriguez
  • Roberta Schwartz

Corporate innovation

  • Chevron Technology Ventures
  • Houston Methodist
  • Shell Ventures

Investor of the year

  • CSL Capital Management
  • Golden Section VC (GSTVC)
  • Integr8d Capital

SDO superstar

  • MassChallenge Houston
  • Rice Alliance
  • TMCx

Welcome to Houston

  • Greentown Labs
  • TestCard
  • Win-Win

Civic engagement

  • Annapurna
  • Luminare
  • McMac Cx

COVID pivot/phoenix

  • Luminare
  • re:3D
  • sEATz

People choice

  • INK
  • Liongard
  • Luminare
  • re:3D
  • Topl

Soonicorn

  • GoExpedi
  • Liongard
  • Medical Informatics Corp.
Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

Elon Musk's SpaceX site officially becomes the city of Starbase, Texas

Starbase, Texas

The South Texas home of Elon Musk’s SpaceX rocket company is now an official city with a galactic name: Starbase.

A vote Saturday, May 3, to formally organize Starbase as a city was approved by a lopsided margin among the small group of voters who live there and are mostly Musk’s employees at SpaceX. With all the votes in, the tally was 212 in favor to 6 against, according to results published online by the Cameron County Elections Department.

Musk celebrated in a post on his social platform, X, saying it is “now a real city!”

Starbase is the facility and launch site for the SpaceX rocket program that is under contract with the Department of Defense and NASA that hopes to send astronauts back to the moon and someday to Mars.

Musk first floated the idea of Starbase in 2021 and approval of the new city was all but certain. Of the 283 eligible voters in the area, most are believed to be Starbase workers.

The election victory was personal for Musk. The billionaire’s popularity has diminished since he became the chain-saw-wielding public face of President Donald Trump’s federal job and spending cuts, and profits at his Tesla car company have plummeted.

SpaceX has generally drawn widespread support from local officials for its jobs and investment in the area.

But the creation of an official company town has also drawn critics who worry it will expand Musk’s personal control over the area, with potential authority to close a popular beach and state park for launches.

Companion efforts to the city vote include bills in the state Legislature to shift that authority from the county to the new town’s mayor and city council.

All these measures come as SpaceX is asking federal authorities for permission to increase the number of South Texas launches from five to 25 a year.

The city at the southern tip of Texas near the Mexico border is only about 1.5 square miles (3.9 square kilometers), crisscrossed by a few roads and dappled with airstream trailers and modest midcentury homes.

SpaceX officials have said little about exactly why they want a company town and did not respond to emailed requests for comment.

“We need the ability to grow Starbase as a community,” Starbase General Manager Kathryn Lueders wrote to local officials in 2024 with the request to get the city issue on the ballot.

The letter said the company already manages roads and utilities, as well as “the provisions of schooling and medical care” for those living on the property.

SpaceX officials have told lawmakers that granting the city authority to close the beach would streamline launch operations. SpaceX rocket launches and engine tests, and even just moving certain equipment around the launch base, requires the closure of a local highway and access to Boca Chica State Park and Boca Chica Beach.

Critics say beach closure authority should stay with the county government, which represents a broader population that uses the beach and park. Cameron County Judge Eddie Trevino, Jr. has said the county has worked well with SpaceX and there is no need for change.

Another proposed bill would make it a Class B misdemeanor with up to 180 days in jail if someone doesn’t comply with an order to evacuate the beach.

The South Texas Environmental Justice Network, which has organized protests against the city vote and the beach access issue, held another demonstration Saturday that attracted dozens of people.

Josette Hinojosa, whose young daughter was building a sandcastle nearby, said she was taking part to try to ensure continued access to a beach her family has enjoyed for generations.

With SpaceX, Hinojosa said, “Some days it’s closed, and some days you get turned away."

Organizer Christopher Basaldú, a member of the Carrizo/Comecrudo Nation of Texas tribe, said his ancestors have long been in the area, where the Rio Grande meets the Gulf.

“It’s not just important,” he said, “it’s sacred.”