Here's what MassChallenge companies won big this year. Photo courtesy of MassChallenge

Nine startups that went through the 2021 Houston cohort for MassChallenge Texas have received cash prizes from the global accelerator.

Now in its 12th year, Boston-based MassChallenge awarded 39 equity-free cash and investment prizes to 36 early-stage companies from the 2021 virtual programs across Austin, Boston, Houston, and Rhode Island. The startups were recognized at a virtual showcase. Of the 229 companies to go through the program this year, about 70 of those were a part of the Houston cohort, which was announced in June, however none of the nine Houston cohort companies are based in Houston.

Here's which companies from the Houston program received awards:

  • AEROSENS, based in Miami, is a platform able to maximize aircraft cabin security and increase efficiency while reducing costs, using Bluetooth Low Energy sensors and the everyday smartphone or tablet. The company received a $25,000 Gold Award.
  • Analatom, based in Santa Clara, California, received the $10,000 FM Global Resilience Prize. The company has created an AI Deep Learning inspection technology automatically flag surface defects in images reducing maintenance costs improving inspection quality.
  • Astrileux Corporation, based in La Jolla, California, is accelerating manufacturing of next-gen ICs at 7 nm and smaller increasing power and performance in the era of zettabyte computing. The company scored one of the three top awards — a $100,000 Diamond Award.
  • Card Medic, based in the United Kingdom, received a $50,000 Platinum Award for its innovative digital technology designed to improve communication between healthcare staff and patients, across any barrier.
  • Exum Instruments, based in Denver, is combining high-performance tech with intuitive, seamless operations, Exum is solving materials characterization for a variety of industries. The company received a $25,000 Gold Award.
  • Grain4Grain, based in San Antonio, is using proprietary upcycling technology to turn byproducts from alcohol producers into low carb, high fiber flour alternatives at low cost. The company received a $25,000 Gold Award.
  • KNWN Technologies, based in DelRay Beach, received the Houston Angel Network Investment Prize as well as a $25,000 Gold Award. The technology provides a new level of identity validation for businesses to know and protect customer identity from enrollment through the life of the relationship.
  • Krtkl, based in San Francisco, is a new high-reliability edge-computing and artificial-intelligence solutions for robotics, sensing, and communications applications. The company received the ISSNL + CASIS Technology in Space Prize.
  • LucyDX, based in Middletown, Delaware, is preventing blindness in diabetics through early detection. The company received a $25,000 Gold Award.

Texas-based Ecliptic Capital will also give out its Investment Prize, but did not announce their winner at the showcase. The organization announced its full list of winners online and at the showcase.

"We designed our process to work with all founders especially those who may be overlooked or underestimated by traditional equity accelerators and investment models. These founders still benefit from and deserve access to accountability, expertise, and a network traditionally often made available only to venture-backed companies," says Siobhan Dullea, CEO of MassChallenge, in the press release. "The 229 startups from this year's cohort demonstrate just how much opportunity exists beyond the closed process of venture when we widen the lens. Congratulations to the winners."

MassChallenge Texas has named its 2021 cohorts — including 71 companies to accelerate in Houston. Photo courtesy of MassChallenge

MassChallenge Texas names the 71 startups that make up its latest Houston cohort

ready to grow

Five Houston-based startups have been accepted into MassChallenge's 50th startup accelerator.

Three of the local startups are part of the program's Houston cohort, and two are part of the Austin cohort. In all, 71 startups from around the world are participating in the new Houston cohort.

Aside from Houston and Austin, there are cohorts in Boston and Rhode Island. This year's MassChallenge class, announced June 28, comprises 229 startups from 20 countries.

The five Houston-based startups in MassChallenge's latest accelerator program are:

  • Church Space, an "Airbnb for churches" that enables churches to rent out space for worship, events, meetings, and ghost kitchens. It's part of the Houston cohort.
  • Every Shelter, which localizes response and relief efforts for global refugee crises. It's part of the Houston cohort.
  • Milkify, which freeze-dries breast milk, enabling mothers to carry it in a powdered form. It's part of the Houston cohort.
  • Javari, a music prediction and discovery platform. It's part of the Austin cohort.
  • Netnoids Rx Laboratories, which provides a platform called Spanio that lets individuals and companies test therapeutics. It's part of the Austin cohort.

"At the core of these early stage businesses is the entrepreneurial spirit of their founders. Entrepreneurial spirit is the unique blend of optimism, passion, and drive that gets founders and their businesses through the daunting early days," Jon Nordby, managing director of MassChallenge Texas, says in a news release.

Church Space, Every Shelter, and Milkify are among the 71 startups in the new Houston cohort. MassChallenge released the names of 69 of those companies. The two others are in stealth mode. Below are the names of the 69 publicly identified startups.

Energy / clean tech

  • Ener.com
  • SeebeckCell Technologies

General

  • Algdeha
  • Analatom
  • Astrileux
  • DeepCharge
  • Freshspire
  • Grain4Grain
  • Intelligent NanoFiber
  • Lepidext
  • Lodgeur
  • Milkify
  • NanoFlowX
  • Nature Knows
  • NjordFrey
  • ProFish Ghana
  • Solo
  • Stagetime

Health care / life sciences

  • AMF Medical
  • Arcascope
  • CardMedic
  • CaringWire
  • Exposphere Fitness
  • Galileo Innovations
  • Insu Health Design
  • Kismet Technologies
  • LucyDx
  • Newton Tech
  • Nightingale Caring Solutions
  • Nurlabs
  • Refined Imaging
  • Ronawk
  • SafetySit
  • SONOflammation
  • Tender Light Scientific
  • Uniphage
  • WestFace Medical

Social impact

  • Carta Digital
  • Every Shelter
  • Nile Agro Value Chain

Tech

  • Aerosens
  • Areanna AI
  • Church Space
  • CodeLn
  • Cybrik
  • Debtle
  • Edusko Africa
  • Exum Instruments
  • Fanorama Social Media
  • Glo3D.com
  • HintEd
  • Invento Robotics
  • KNWN Technologies
  • Krtki
  • Magos
  • Makeena
  • Manus Robotics
  • ModoScript
  • Notewardy
  • Nuw
  • Otomo
  • Owiwi
  • Patturn
  • Privoce
  • Third Ray
  • Tru-Spot Technologies
  • Yada.ai
  • Xena Intelligence
  • Xiggit

To be selected for the MassChallenge program, startups went through a two-round process that included more than 1,000 judges. During the program, participants will receive tools and advice to grow their businesses.

At the end of this year's program, startups will compete for equity-free cash prizes and grants adding up to $100,000. The prizes and grants will be awarded in October.

Attention Houston female founders — there are two new accelerator programs to have on your radars. Photo via Getty Images

Houston organizations announce two new female founder-focused programs

who runs the world?

A couple of Houston startup development organizations have recently announced programing and opportunities for female founders looking to advance their businesses.

Impact Hub Houston has announced that it has partnered up with Frost Bank to sponsor eight female founders to participate in Impact Hub's new Accelerate Membership Program. Applications are now open online and once the inaugural cohort is selected, they will receive the program for three months at no cost.

"At Impact Hub we believe the time to act is now. It's why we are excited to launch our new Accelerate Membership," says Maria Trindade, global network development director at Impact Hub Global, in a news release. "Its unique approach combines all the benefits of an enterprise support program with the flexibility that entrepreneurs need; plus its tailored nature makes this intervention highly accessible for entrepreneurs from diverse backgrounds who may not be able to dedicate full-time to their business idea."

Impact Hub Houston has also teamed up with MassChallenge for their own initiative supporting female founders in the Houston-Galveston region in partnership with Houston-based Workforce Solutions. The three organizations are collaborating to launch launch a bootcamp to support female founders in the greater Houston region.

"There is unprecedented growth in startup creation as a result of the pandemic and founders from all corners of the world are connecting in this virtual environment to build and scale amazing ideas," says Jon Nordby, managing director of MassChallenge Texas, in a news release. "With these new collaborations, we are also witnessing a massive gap in access to startup development resources. Our partnership with Workforce Solutions and Impact Hub Houston will help female founders build on their existing knowledge to become life-long innovators."

Applications for the bootcamp opened April 1 and will close at 5 pm on April 7 and are available online in both English and Spanish. The industry agnostic program will leverage MassChallenge's acceleration model and Impact Hub Houston's inclusive incubation expertise to accelerate female founders by connecting them with the resources they need to launch and scale high-impact businesses, according to the release.

"As a female founder myself, I'm incredibly excited about this opportunity to support and uplift more women entrepreneurs and women-led businesses in our region," says Grace Rodriguez, CEO and executive director of Impact Hub Houston, in the release. "By now, it's no secret that women, and especially women of color, are under-invested in; and this is our chance to change that by helping more women strengthen their businesses and prepare to seek funding."

Houston Exponential has announced the 38 finalists for the inaugural Listies Awards. Photo via Getty Images

Exclusive: HX names finalists for inaugural Houston innovation awards

the listies go to...

Ever wonder what Houston startups and innovators are the best of the best? Here's your chance to figure it out. The inaugural Listies awards program has named its finalists.

The Listies, brought to you by Houston Exponential in partnership with InnovationMap, will name the winning companies and people across 12 awards on November 20 at 3 pm at a virtual event as a part of Impact Hub's annual The Houston Innovation Summit (THIS). Click here to register for the free event.

Nominations were open until Friday, November 6, and then a group of judges made up of members of the Houston innovation ecosystem reviewed the submissions to settle on the finalists. Below, in alphabetical order, the 38 finalists are listed for each category.

DEI champion

  • Heath Butler
  • Maria Maso
  • Grace Rodriguez

Individual contributor

  • Michael Matthews
  • Slawek Omylski
  • Brad True

Mentor of the year

  • Keith Kreuer
  • Wade Pinder
  • Landi Spearman

Outstanding leadership

  • Stephanie Campbell
  • Grace Rodriguez
  • Roberta Schwartz

Corporate innovation

  • Chevron Technology Ventures
  • Houston Methodist
  • Shell Ventures

Investor of the year

  • CSL Capital Management
  • Golden Section VC (GSTVC)
  • Integr8d Capital

SDO superstar

  • MassChallenge Houston
  • Rice Alliance
  • TMCx

Welcome to Houston

  • Greentown Labs
  • TestCard
  • Win-Win

Civic engagement

  • Annapurna
  • Luminare
  • McMac Cx

COVID pivot/phoenix

  • Luminare
  • re:3D
  • sEATz

People choice

  • INK
  • Liongard
  • Luminare
  • re:3D
  • Topl

Soonicorn

  • GoExpedi
  • Liongard
  • Medical Informatics Corp.
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CultureMap Emails are Awesome

Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 23 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.

Elon Musk's SpaceX is about to make its debut on Wall Street

Money Moves

Elon Musk's rocket company SpaceX will make its debut on Wall Street Friday, June 12, and both institutional and retail investors are expected to gobble up the 555.6 million shares going up for sale at $135 apiece. Musk, already the world's richest man, could become its first trillionaire.

SpaceX is likely to become the biggest IPO ever, with proceeds of around $75 billion. SpaceX hopes to become the first company to send people to Mars. In fact, part of Musk’s future compensation depends on SpaceX eventually establishing a colony of at least 1 million people on the red planet.

Why SpaceX is going public now

In a video conference on Musk's social media platform X, he told JPMorgan CEO Jamie Dimon that people have suggested for the last 10 years that he take SpaceX public. He's doing it now because the company plans to put 100,000 next-generation Starlink satellites into orbit. Deploying AI data centers in space is a “massive new growth base and you need capital for that,” he said.

Going public provides access to the capital that SpaceX needs. But it also exposes it to more scrutiny from shareholders and more regulatory oversight. That includes filing quarterly financial reports, which critics say incentivizes short-term thinking over longer-term planning and creates unnecessary costs for a company. Securities regulators are currently soliciting public comment on a proposal to require public companies to file the financial reports only twice every year.

How the IPO impacts the company

Musk will hold the majority of a special class of shares, giving him control over decisions related to company strategy, finances and personnel. On the latter, because of his ownership of most of these Class B shares, the only person who can fire Musk as CEO is Musk.

The company credits Musk with being the “driving force” behind its growth, innovation and success. But what happens if Musk is no longer in the picture? SpaceX warns that the loss of Musk could disrupt its ability to execute its strategy as well as hurt its “reputation and relationships with customers, partners and other stakeholders.”

The company also warns that finding a replacement with the same skills and experience as Musk would be time-consuming, if not nearly impossible. As Wedbush Securities analyst Dan Ives wrote Wednesday, “At the end of the day Musk is SpaceX and SpaceX is Musk.”

What could make or break SpaceX

Currently in the test phase, the gigantic reusable Starship rocket is key to SpaceX realizing Musk's ambitions. Much of the commercial space business hinges on SpaceX developing Starship’s capability to be fully reusable and hearty enough for a quick turnaround between flights. If that doesn't happen, SpaceX warns that putting data centers and satellites in space will take longer and cost more money, meaning it risks customers bailing on the company.

Analysts say that by pioneering reusable rockets, SpaceX has established a clear lead on competitors such as Blue Origin, led by Amazon founder Jeff Bezos. The Starlink satellite business competes with, among others, AST SpaceMobile – which is relying on a SpaceX rocket to send its latest generation of satellites into orbit next week.

The prospectus filed last week says SpaceX’s biggest potential market is the sale of business-oriented artificial intelligence products designed to transform how people get work done. It’s an opportunity SpaceX predicts would be worth $22.7 trillion if it could somehow dominate rivals like Anthropic, OpenAI and Microsoft in a highly competitive industry. But the prospectus shows no clear path to profitability for the xAI business, which merged with SpaceX earlier this year.

Why Wall Street is paying attention

If the SpaceX IPO is as successful, the stock could quickly join the Nasdaq 100, a widely followed index that tracks the 100 largest non-financial companies in the composite. That's important because some popular funds, such as the $460 billion QQQ exchange-traded fund, mimic the index and will automatically buy whatever is listed in the index.

Nasdaq recently changed its rules to allow select companies to enter the Nasdaq 100 after just 15 trading days.

S&P Dow Jones Indices, on the other hand, is sticking to established and more traditional thresholds that will not allow SpaceX or other companies with gargantuan IPOs faster entry into its S&P 500 index. That means even high-profile companies will still need to wait for their stocks to trade a full 12 months before they can enter the index.

Companies want to be in the S&P 500 in particular because it's arguably the most important index on Wall Street, with trillions of dollars either mimicking it exactly or benchmarked against it. Vanguard's VOO fund that tracks the S&P 500 has roughly $950 billion invested in it, for example.