The local community has raised some concerns about Rice Management Company's Ion project's effect on the Third Ward. Courtesy of Rice University

The city of Houston has been buzzing about Rice Management Company's Ion Innovation Hub — a 270,000-square-foot coworking and innovation hub project expected to deliver in 2021 — but there's one group isn't so thrilled with the plans: The Third Ward community.

In a public community meeting on November 12, community members gathered at the Wesley AME Church to plan a Community Benefits Agreement that would legally bind The Innovation District's development team and the Rice Management Company to move forward with the local residents' indicated best interests. According to the Houston Coalition for Equitable Development without Displacement, a newly formed group to work on the CBA, it would be the first of its kind in Houston.

The coalition is supported by Third Ward is Home Civic Club, the Emancipation Economic Development Council, the Texas Coalition of Black Democrats - Harris County, and the Houston Society for Change.

Gabriella Rowe, executive director of The Ion, presented the project's plans to the crowd, recognizing that innovation ecosystems across the country have issues with diversity.

"When you look around the tech ecosystems in the United States today, there are a couple things that stand out," Rowe says. "First and foremost is that they are extremely white and extremely male."

But since Houston is still developing its innovation infrastructure, Rowe says, the city has more opportunities to take the lessons learned from these other ecosystems and be more proactive about including diverse efforts.

One of the things The Ion is planning to incorporate to engage the community is a free coworking space — the only free coworking space in Houston, Rowe says. The Ion plans also include two public parks and community events, and both will be free and open to the public.

The Ion promises to bring free coworking, park space, and events to the area. Courtesy of Rice University

After the presentation, the estimated 150 community members in the crowd had the opportunity to address Rowe. While one local resident expressed concern with the non-inclusive verbiage The Ion is using — describing the area as "Midtown" over the pre-gentrification descriptor of Third Ward — other concerns surrounded the lack of diversity of the decision makers on the project.

"For me, that's where we need to start, which is in diversity," says Rowe, who mentions she has diversity among her programming team. "I look to all of you to come to get included in our team as we're growing."

Another concern that was raised was the job opportunities on the construction site itself. While Rowe didn't mention any specific job opportunities in construction, she did say she had been asked by the Rice Management Company to tap local artists to design the fences surrounding the site.

The meeting pivoted toward a discussion about the CBA and the importance the agreement would have moving forward. Assata Richards, founder of Sankofa Research Institute and local activist, and Mary Claire Neal, a Rice University student and leader of the Students for a Just and Equitable Innovation Corridor, and Carl Davis, chair of the Houston Society for Change and a representative of the church, have teamed up to move forward with the agreement.

Texas Appleseed, a group of volunteer lawyers, has agreed to help create and enforce the agreement, and Jeffrey Lowe, associate professor in the department of urban planning and environmental policy at Texas Southern University, has also advised the organizations.

"We've been told what's going to happen, but there's no binding agreement to make sure that it's going to happen," Richards says. "Those are just nice wishlists."

Moreover, the initiatives that have been suggested, enforceable or not, aren't enough, Richards adds, again stressing the importance of the CBA.

"We're going to be smarter this time. We're going to work with the people who have the power and make the decisions," Richards says. "You're doing all this development and come and tell me that you want art outside the building? We're talking millions of dollars of construction."

While the terms of the CBA are still in the works, some of the requests mentioned in the meeting include jobs, preservation of communities of color, affordable housing initiatives, access to affordable groceries, and opportunities for minority and African American-owned businesses.

The Ion Innovation Hub Proposed Site PlanThe Ion Innovation Hub Proposed Site Plan was included in notes pre-released ahead of the Houston Planning Commission's November 14 meeting. Photo via HPC

Neal proceeded with a presentation of actionable ways students and community members can get involved and make their voices heard. Her presentation included new concerns following the release of the master plan of The Innovation District, which the Houston Chronicle released earlier this week. The plans included a parking area that will be the next construction project following The Ion. The variance request is headed to the planning commission on Thursday.

"That's a two-day turnaround and it's the first opportunity for us to do something," Neal says. The group is intending to at least acquire a delay in the variance request moving forward.

The meeting wrapped up with a call to action for local residents as well as students. Since The Ion will include local academic institutions, student and alumni input is crucial.

"We want you to hold up and pause and think carefully on how this development is going to benefit and affect the community," Richards says.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."