3 Houston tech innovators to know this week

Who's who

Tech startups are popping up across industries from real estate to oil and gas, and these three founders are among the leaders in technology. Courtesy images

Often, technology and innovation are mistaken for each other. While not mutually exclusive, both tech and innovation work well together in Houston across all industries — from oil and gas to real estate and social media. These three founders engaged technology for their individual startups.

Srini Katta, founder and CEO of Social Chains

Courtesy of Social Chains

As a social media user, your data is already out there and being used for marketing purposes. But, rather than the Facebooks or Googles of the world making a profit, Srini Katta wanted to create a platform where users made a profit off their own data.

"On our platform, the user is a stakeholder. Our platform distributes 50 percent of the profits to the users," he says.

Social Chains already has 5,000 users and, Katta says, that's with little to no marketing efforts, which Katta is about to launch.

Martin Kay, founder and CEO of Entera Technology

Courtesy of Entera

Martin Kay, who splits his time between Houston and the Bay Area for his startup Entera Technologies, knew there had to be a better way for people searching for a home to buy. He drew a comparison between homebuyers and Netflix viewers to create Entera's software.

"We're a little bit like Netflix," he says. "They go out and get content from everyone, and they begin to watch your behavior. So, Netflix has 2,000 profiles and you probably fit five or six of those. We have almost 100 profiles and what we do is say, we're going to understand what you want, watch your behavior and instead of giving you 40,000 properties on a big map, we actually match you based on your preferences, to the five or six houses that are best for you."

Houston-based Entera has grown as the platform loads more and more data for its users to engage with.

Luther Birdzell, CEO and founder of OAG Analytics

Courtesy of OAG Analytics

Luther Birdzell always knew he wanted to run his own company, but the software and analytics professional worked in various industries before realizing that oil and gas had a huge opportunity for savings using analytics. He founded OAG Analytics in 2013 to help provide a solution for these companies.

"When I founded OAG Analytics, our mission then — and still is today — was to build a platform for the upstream oil and gas industry that enables them to manage their data, introduces world-class machine learning in minutes without having to write a single line of code, and allow them to run simulations on the resulting analysis," Birdzell says.

The company has grown to 25 employees and tripled its revenue last year. The team is forecasting another year of high grow for 2019.


This Houston company has the key to a more exact searching process when it comes to finding a new home to buy. Courtesy photo

Tech company uses machine learning to buy homes in Houston

game changer

For most consumers, the home buying process includes a very specific online search. People specify their neighborhood requirements, the number of bedrooms or bathrooms, backyard size, and more — yet still, the search results in a staggering amount of homes. It's way more than anyone can reasonably look at.

That's where Martin Kay and Entera Technology, the company he founded and is CEO of, come in. Kay, a 20-year veteran of the tech sector, who's bought multiple homes as rental properties, realized the way to solve the problem of that kind of search engine overload was through machine learning. He now works with some of the largest home-buying companies in the world, helping them find properties that match the specifications they have to attract the clients they want.

"All residential real estate is a consumer product," he says. "Ultimately, the people who are going to live in that home care most about, is it a nice home with a big backyard neat good schools, is it safe? The [home buying] companies are trying to figure out what do the end consumers really care about so we can give them exactly what they need?"

To do so, Entera collects data — lots and lots of it. Kay and his team have taught their software programs what a chef's kitchen is, for example. They did so by compiling tens of thousands of photos of kitchens and telling the software, "This is a kitchen." Then, they taught it to recognize what makes a chef's kitchen — a larger size, more than one sink, high-end appliances. They used the same techniques in identifying things like millennial-friendly neighborhoods or neighborhoods that were up-and-coming on the real estate scene. They draw from listings available with the Houston Association of Realtors and beyond, a vast array of tens of thousands of homes.

Officially launched in 2017, Entera blends its data collection and analysis with on-the-ground service. After Entera's proprietary software collects what it thinks home-buying companies want, members of Entera's service team go out to look at the homes.

"We're a little bit like Netflix," he says. "They go out and get content from everyone, and they begin to watch your behavior. So, Netflix has 2,000 profiles and you probably fit five or six of those. We have almost 100 profiles and what we do is say, we're going to understand what you want, watch your behavior and instead of giving you 40,000 properties on a big map, we actually match you based on your preferences, to the five or six houses that are best for you."

While Entera has been working with larger home-buying companies — like firms that buy tens of thousands of homes every year — Kay says they have begun working with smaller entities, and he figures within the next few years, Entera will be using the same data collection and machine learning to work with individual home buyers.

Based in Houston, Entera has operations in New York and San Francisco as well. The company has 17 full-time employees, along with approximately 100 contractors in its markets. And while Kay understand a human touch is needed in business, he loves that he can use a data model to present unbiased opinions to his clients.

"[Real estate] actually affects people's lives meaningfully," Kay says. "Real estate data — where you live, what your neighborhood is, how you make that choice — …this data matters to people in a way they can tangibly touch and understand and feel. We can help people make what are big, complex choices that are often highly ambiguous. I love it because it matters. You can measure how it matters immediately."

Data-driven tech

Courtesy of Entera

Entera focuses on collecting data and analysis and pairs it with on-the-ground service. After Entera's proprietary software collects what it thinks home-buying companies want, members of Entera's service team go out to look at the homes.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

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