Report: Houston sees huge jump in new businesses amid the pandemic

by the numbers

A recent report finds that the rate of new Houston startups has popped up significantly. Photo by Zview/Getty Images

By one measure, Houston could be considered the startup capital of Texas.

A new study by personal finance website LendingTree shows the Houston metro area experienced a 37.4 percent jump in new-business applications from 2019 to 2020. That was the highest growth rate among Texas’ six biggest metro areas and the 20th highest growth rate among the 100 U.S. metro areas with the most new-business applications in 2020.

In 2019, the Houston area racked up 85,998 new-business applications, according to U.S. Census Bureau data cited by LendingTree. A year later, the number of applications in the region soared to 118,183. The data measures applications for nine-digit employer identification numbers (EINs), which the IRS uses to track businesses for tax purposes. An EIN is similar to a person’s Social Security number.

“The pandemic has created so much financial chaos for so many people, and that uncertainty surely spurred many Americans to take the plunge,” says Matt Schulz, chief credit analyst at LendingTree.

“Some folks did it out of necessity because of income or job losses,” he adds. “Some folks did it to feel more secure, as the idea of relying on one source of income just didn’t make sense anymore for a lot of people. Others likely did it because they’d wanted to for years but never felt the time was right.”

Across the U.S., the retail sector witnessed the heftiest increase (59.7 percent) in new-business applications from 2019 to 2020.

“So many companies have made it so easy to sell online that people feel good about taking the plunge,” Schulz says. “Setting up an online store is generally simpler, quicker and less expensive than ever, so the barriers to entry that once scared potential entrepreneurs away from opening a new store aren’t the obstacles that they once were.”

Memphis, Tennessee, topped the LendingTree list. The metro area saw a 77.9 rise in new-business applications from 2019 to 2020.

Elsewhere in Texas:

  • Dallas ranked 37th nationally and second in Texas, with a 29 percent increase in new-business applications.
  • San Antonio ranked 62nd nationally and third in Texas, with an 18 percent increase in new-business applications.
  • McAllen ranked 77th nationally and fourth in Texas, with a 13.3 percent increase in new-business applications.
  • Austin ranked 78th nationally and fifth in Texas, with a 13.2 percent increase in new-business applications.
  • El Paso ranked 79th nationally and sixth in Texas, with an 11.9 percent increase in new-business applications.
We're up to our ears in debt, Houston. Photo by Image Source/Getty Images

Surprising share of Houstonians saddled with $10,000 or more in credit card debt

fully charged

You hear that noise, Houston? It's the sound of your bank account screaming under the weight of the heavier debt load you're shouldering.

A report released by personal finance platform LendingTree shows Houston ranks tenth among the 100 largest U.S. metro areas for the share of people with credit card balances totaling at least $10,000.

In an aggressive jump, Houston climbed from No. 32 two years ago to No. 10 this year. According to LendingTree, 20 percent of cardholders in the metro have credit card debt of at least $10,000, and 1.6 percent have credit card debt of at least $50,000.

Elsewhere in Texas, Austin jumped 20 spots in the ranking to sixth in the nation, compared with its 26th-place showing in LendingTree's 2019 report. Some 20.8 percent of Austinites show credit card balances totaling at least $10,000. LendingTree says 1.7 percent of cardholders in Austin owe at least $50,000.

Meanwhile, Dallas-Fort Worth moved from No. 33 to No. 18. Today, 19.2 percent of cardholders in the metro have debt totaling at least $10,000 and 1.5 percent have credit card debt totaling at least $50,000.

San Antonio rose from No. 27 to No. 26. There, 18.4 percent of cardholders have credit card debt of $10,000 or more and 1.2 percent have credit card debt of $50,000 or more.LendingTree offers perhaps a partial explanation for the increase in five-digit credit card balances among Texas metros: "While the saying goes that 'everything is bigger in Texas,' that hasn't traditionally been the case with salaries in the Lone Star State. The big metros in Texas have generally trailed behind the big coastal metros in that measure."

Bridgeport, Connecticut, holds the No. 1 spot for the largest share of cardholders (24.3 percent) with at least $10,000 in debt.------

This article originally ran on CultureMap.

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Houston researchers develop dissolvable implant for targeted cancer drug delivery

cancer research

Researchers at Houston Methodist have developed a biodegradable implant that can be used to safely and consistently deliver drug treatments to tumors and then dissolve without the need for further surgery.

The implant is only the size of a grain of rice, but its potential is staggering. The biodegradable nanofibrous drug-eluting seed (b-NDES) works as a reservoir parked inside a soft tumor, where it can slowly release immune-stimulating drugs over time. This overcomes a consistent problem with drugs such as immune checkpoint inhibitors. Normal systemic administration sees comparatively little of the drug making its way to the tumor, with most of it circulating throughout the body. The b-NDES is like deploying a small guerrilla fighting force embedded in enemy territory, doing maximum damage to the entrenched tumor.

"To improve cancer treatment, we're trying to start a fire inside the tumor itself," Corrine Chua, associate professor in the Center for BioNanoengineering at Houston Methodist Research Institute, said in a news release. "By activating immune cells directly within the tumor microenvironment, those cells can then travel throughout the body and seek out cancer wherever it exists. The b-NDES platform was developed to help keep therapeutic drugs concentrated inside tumors while minimizing exposure to healthy tissues.”

Chua co-led the study with Alessandro Grattoni, chair and director of the Center for BioNanoengineering at Houston Methodist Research Institute.

The study included support from the Nancy Owens Breast Cancer Foundation and the National Institutes of Health/National Cancer Institute.

Chau and Grattoni used preclinical models of triple-negative breast cancer, an aggressive form of cancer that is estrogen receptor-negative, progesterone receptor-negative and HER2-negative. Because of the receptor negativity, some popular treatments like tamoxifen and trastuzumab are ineffective. Chemotherapy has been shown to be the best course of action.

The b-NDES implant is deployed alongside radiation drugs. It keeps the drugs focused on the tumor, reducing the amount of harmful side effects typically seen when drugs are circulated more widely in the body. In 60 percent of the models, tumors were eliminated and did not cause side effects beyond the tumor site. Once the drugs have been deployed, the implant breaks down naturally.

While promising, more research will have to be done to expand use to other tumor types.

"Although the study focused on triple-negative breast cancer models, the approach could have broader applications for solid tumors," Grattoni added in the release. "It could potentially be used in cancers where there is a tumor lesion accessible for placement, including pancreatic or lung cancers."

New Houston platform Same Day Reels launches for on-demand content creation

In The Moment

If an event doesn't happen on Instagram, did it even really happen? In today's social media-driven age of branding and audience engagement, the answer increasingly is no.

Houston entrepreneur Karen De Amat is looking to fill the online content creation needs of companies with her new venture, Same Day Reels, which launched in early August. It will serve as a platform to connect companies and brands with talent that can help turn an event into a viral moment as it is happening.

"Events move quickly, and social media moves even faster,” said De Amat. “Same Day Reels was built to help brands capture the moment while it still matters. We are creating a more efficient way for businesses and creators to work together. Brands need content faster, and creators need more opportunities to turn their talent into real work. Same Day Reels brings those needs together.”

The company is focused on adding livestreams and concurrent short video content to "activations, launches, fundraisers, grand openings, conferences, hospitality experiences, and private celebrations." Such content can significantly increase the visibility of a product or brand according to digital marketing brands like Wyzowl, whose data found 63 percent of people in 2026 prefer to learn about new products via short video.

Packages offered by Same Day Reels will include filming, editing, and publishing content within hours of the targeted event.

De Amat says that her content creation platform will be a way to preserve the excitement of events and launches by enshrining them with immediate social media-driven memories.

“Event content is no longer just something you post after the fact,” De Amat said. “It is part of how people experience, remember and share the moment.”

Previously, De Amat is also the founder and CEO of Social Behavior, an influencer marketing company she launched from her home in 2014. It quickly garnered an array of clients and thrust De Amat into the spotlight, including numerous appearances on Fox 26's The Isiah Factor. Influencer Marketing Hub named her one of the top CEOs of influencer marketing companies in Houston in 2025.

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This article originally appeared on CultureMap.com.

Bristol Myers Squibb to build $2.3B Houston pharma manufacturing campus

coming soon

New Jersey-based pharmaceutical giant Bristol Myers Squibb Co. has officially named Houston as the home of its new state-of-the-art manufacturing site.

The 60,000-square-foot facility represents a $2.3 billion investment, according to a news release. It is expected to create 500 skilled jobs and will be located in Houston's Generation Park.

BMS first announced that it was considering Houston among 16 other cities for the facility in May. The new hub will manufacture small molecule, biologic and antibody-drug conjugates and is part of a $40 billion commitment to invest in the United States over five years. Construction is slated to begin next year, with the facility coming online in 2030.

"We're building the domestic manufacturing capabilities needed to deliver the next generation of medicines and support future scientific breakthroughs. Houston and the state of Texas offer the talent, infrastructure, and partnership needed to help bring that vision to life," Christopher Boerner, CEO and board chair of BMS, said in the release.

The new facility will feature a modular, multi-modal design, which will allow the company to reconfigure and add to its manufacturing capabilities over time. BMS says it expects the facility to "(grow) in scale and capability well beyond its opening configuration."

"Our decision to build this state-of-the-art manufacturing campus in Houston, Texas, reflects our confidence in the region’s ability to support a world-class, digitally advanced supply operation,” Karin Shanahan, EVP and chief supply chain and operations officer of BMS, added in the release. “This facility is designed to deliver the speed, quality, and reliability that patients depend on, combining flexible, modular manufacturing with advanced digital capabilities to ensure consistent supply across multiple modalities. It strengthens our ability to operate with resilience and positions us to reliably deliver medicines to patients today while adapting future demands.”

Texas Gov. Greg Abbott shared that the state has granted BMS a $4.89 million Texas Enterprise Fund (TEF) grant for the project. TEF grants, administered by the Texas Economic Development & Tourism Office, support business relocation or expansion projects that create "new, good-paying jobs in the community and attract significant new capital investment to the state." The development is also a qualified project under the Texas Jobs, Energy, Technology, and Innovation (JETI) program.

“Texas is a global hub for life sciences, where today’s innovations shape the future of healthcare,” Abbott said in a news release. “This $2.3 billion investment by Bristol Myers Squibb in the dynamic biotech ecosystem in Houston is a testament to the depth of our skilled workforce and the pipeline of talent coming through our nation-leading technical colleges and research universities. With lower operating costs and easy access to markets across the U.S. and the world, Texas drives affordability for consumers.”

"Bristol Myers Squibb’s announcement is a tremendous win for Texas and the Houston region, further reinforcing our position as a premier destination for life sciences and advanced manufacturing,” added Greater Houston Partnership President and CEO Steve Kean.

Last fall, Eli Lilly and Co. selected Generation Park, a 4,300-acre, master-planned commercial district near Lake Houston, for its $6.5 billion manufacturing plant. More than 300 locations in the U.S. competed for the factory. Read more here.

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