Watch elite gamers face off in League of Legends. Photo by Jamie McInall/Pexels

Heads up, gamers. The most popular esport is coming to the Bayou City. The League Championship Series (LCS), will host its marquee championship event at NRG Stadium (8825 Kirby Dr.) on April 23 and 24, the organization announced.

Not only is this the first time the tournament will be held in Texas, it’s also the first time the prestigious League of Legends competition — the LCS Spring Finals — will be hosted in an NFL stadium. For the uninitiated, League of Legends is a wildly popular, team-based multiplayer strategy game.

Houston fans are invited to attend both the pregame Fan Fest celebration and the LCS Finals, a first since the pandemic. The Fan Fest starts at 10 am Saturday, April 23, and the first match starts at 2:30 pm.

As the league’s first seasonal championship event of the year, the competition will see North America’s top three teams vie for an LCS trophy, a banner in the LCS Studio rafters, and an invite to the international Mid-Season Invitational in Busan, South Korea next month, per a release.

Developed and run by influential and prolific developer and publisher Riot Games, this championship will be held in North America across four cities — Mexico City, New York City, Toronto and San Francisco, a first since 2016, a release notes.

As the most-watched esport in the world with 12 international leagues, the 10-year-old LCS is actually the third-most popular major professional sports league among 18- to 34-year-olds in the U.S., per industry insiders.

For some perspective, more than 465 million people watched esports in 2021. Esports generated more than $1 billion in revenue, according to a Newzoo report.

For more information on the Fan Fest and tournament, visit the official site.

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This article originally ran on CultureMap.

Houston-based Mainline has announced new partnerships with a few universities. Jamie McInall/Pexels

Houston esports company taps nearby universities for partnerships

Game on

A Houston esports platform has announced that four universities — including one in town — have made moves to optimize the company's technology.

Texas A&M University, the University of Texas - Austin, Louisiana State University, and Houston's own University of St. Thomas have made a deal with Mainline. The company, which just closed a $9.8 million series A round, is a software and management platform for esports tournaments.

The four schools will use the software to host and grow their on-campus esports communities, according to a news release.

"These are top universities seeing the value of esports on-campus and making a choice to support their students' desires to play and compete — much like in traditional sports," says Chris Buckner, CEO at Mainline, in the release. "Adoption of Mainline is validation of the opportunity to engage students and the broader community with a compelling esports platform, as well as strengthen a school's brand, provide additional partnership opportunities and market their initiatives"

While UST has is still in the process of utilizing Mainline for its esports platform to grow its program and will use the software for its first tournament in 2020, A&M first used Mainline's software this past spring, but has doubled down on its commitment to esports.

"Texas A&M recognizes the significant esports presence on campus and the importance of supporting this thriving student community. Mainline allows us to maintain the brand continuity of the university, and to drive incremental inventory and value for sponsors," says Mike Wright, director of public relations and strategic communications at Texas A&M Athletics, in the release.

The platform provides its clients with an easy way to manage, monetize, and market their tournaments.

At UT, the school's administration, along with its Longhorn Gaming Club, is currently running two tournaments on Mainline: Rocket League and League of Legends.

"Texas has had a long established esports community on campus, and our partnership with Mainline will enable us to more closely work with Longhorn Gaming to better support this audience to benefit our students and partners," says Mike Buttersworth, director of the Center for Sports Communication and Media at UT, in the release.

Meanwhile at LSU, the university is running an esports Rocket League qualifying tournament on the Houston company's platform to select a three-student team to represent the school at the inaugural "Power Five Esports Invitational" in New York in January, according to the release.

"This kind of tournament is a first for our campus, and Mainline is making it easy for us to be able to host this qualifying tournament for our students to ultimately represent our university at the Power Five Esports invitational," says Robert Munson, senior associate athletics director at LSU.

As for Mainline, these four schools are just the beginning for universities using the platform.

"Mainline is continuing this collegiate momentum with another 10 powerhouse universities expected to come aboard our platform by the end of 2019, and 50 more by the spring 2020," says Buckner.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.