U.S. News names 5 Houston suburbs as the best places to retire in 2026

Retirement Report

The Woodlands is the No. 4 best place to retire. Photo courtesy of Visit The Woodlands

Houston-area suburbs should be on the lookout for an influx of retirees in 2026. A new study by U.S. News and World Report has declared The Woodlands and Spring as the fourth and fifth best cities to retire in America, with three other local cities making the top 25.

The annual report, called "250 Best Places to Retire in the U.S. in 2026" initially compared 850 U.S. cities, and narrowed the list down to a final 250 cities (up from 150 previously). Each locale was analyzed across six indexes: quality of life for individuals reaching retirement age, value (housing affordability and cost of living), health care quality, tax-friendliness for retirees, senior population and migration rates, and the strength of each city's job market.

Midland, Michigan was crowned the No. 1 best place to retire in 2026. The remaining cities that round out the top five are Weirton, West Virginia (No. 2) and Homosassa Springs, Florida (No. 3).

According to U.S. News, about 15 percent of The Woodlands' population is over the age of 65. The median household income in this suburb is $139,696, far above the national average median household income of $79,466.

Though The Woodlands has a higher cost of living than many other places in the country, the report maintains that the city "offers a higher value of living compared to similarly sized cities."

"If you want to buy a house in The Woodlands, the median home value is $474,279," the city's profile on U.S. News says. "And if you're a renter, you can expect the median rent here to be $1,449." For comparison, the report says the national average home value is $370,489.

Spring ranked as the fifth best place to retire in 2026, boasting a population of more than 68,000 residents, 11 percent of whom are seniors. This suburb is located less than 10 miles south of The Woodlands, while still being far enough away from Houston (about 25 miles) for seniors to escape big city life for the comfort of a smaller community.

"Retirees are prioritizing quality of life over affordability for the first time since the beginning of the COVID-19 pandemic," said U.S. News contributing editor Tim Smart in a press release.

The median home value in Spring is lower than the national average, at $251,247, making it one of the more affordable places to buy a home in the Houston area. Renters can expect to pay a median $1,326 in monthly rent, the report added.

Elsewhere in Houston, Pearland ranked as the 17th best place to retire for 2026, followed by Conroe (No. 20) and League City (No. 25).

Other Texas cities that ranked among the top 50 best places to retire nationwide include Victoria (No. 12), San Angelo (No. 28), and Flower Mound (No. 37).

The top 10 best U.S. cities to retire in 2026 are:

  • No. 1 – Midland, Michigan
  • No. 2 – Weirton, West Virginia
  • No. 3 – Homosassa Springs, Florida
  • No. 4 – The Woodlands, Texas
  • No. 5 – Spring, Texas
  • No. 6 – Rancho Rio, New Mexico
  • No. 7 – Spring Hill, Florida
  • No. 8 – Altoona, Pennsylvania
  • No. 9 – Palm Coast, Florida
  • No. 10 – Lynchburg, Virginia
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This article originally appeared on CultureMap.com.

Pearland is the No. 2 best place to live in the U.S. Photo via pearlandedc.com

2 Houston suburbs named among 10 best places to live by U.S. News & World Report

Where to Live

The Houston suburbs of Pearland and League City have landed among the top 10 best places to live in 2025, according to U.S. News & World Report.

New for the 2025-2026 "Best Places to Live in the U.S." rankings, U.S. News expanded its coverage from 150 to 250 U.S. cities, and updated its methodology to examine each city based on five livability indexes: Quality of life, value, desirability, job market, and net migration.

Pearland ranked No. 3 nationwide, earning a 7.0 score alongside No. 1-winning Johns Creek, Georgia and No. 2 winner Carmel, Indiana.

Pearland also landed on top of U.S. News separate rankings of the best places to live in Texas for 2025-2026.

Some facts about Pearland that put it at the top of the list include its median household income ($115,504), its median home values ($319,753), and its bustling population of nearly 124,000 residents.

Housing costs in Pearland are extremely attractive compared to other places in the country, as the national average home is worth over $370,000. It's no wonder this Houston neighbor has been adding more high-income households than many other places in Texas.

Pearland's population is a healthy mix of young individuals and families, with 29 percent of residents under 20 years old and 36 percent of the population between the ages of 20-44. Nearly a quarter of Pearland's population is between 45-64-years-old, while only 12 percent of residents are over 65, the report says.

Pearland's reputation as one of the safest cities in America is also boosting its community appeal.

Pearland Pear Trail Pearland's Pear-Scape Trail is a popular public art trail that residents, families, and visitors can enjoy. The sculptures are scattered all over the city.City of Pearland - Government/Facebook

"Finding a community to be part of can play a major role in making a place feel like home," U.S. News said. "If you’re a parent with young children, you may want to live in a neighborhood with other people in that phase of life. If you’re a professional moving to a hot job market for your field, you may want to live in an apartment close to the office or within walking distance of friends and colleagues."

Pearland also enjoys a better job market than other cities, the report added. Pearland's unemployment rate as of 2023 was only 3.6 percent, lower than the national average unemployment rate of 4.5 percent.

However, if people are looking for a public transportation-friendly city, they may need to look elsewhere. Almost all commuters in Pearland drive to their workplaces, making access to a vehicle absolutely necessary for living in the suburb. Pearland's 31.2-minute average commute time is also 9.2 minutes higher than the national average, U.S. News said.

Other Houston-area suburbs

League City ranked three spots behind Pearland as the 6th best place to live in the U.S., and No. 2 in Texas. The city boasts a median household income of $120,670, and affordable median home values at $327,511.

Workers in League City also predominantly rely on vehicles for their daily commutes, and only 3.7 percent of the population use public transport to get to work. Commuters spend an average time of 27.5 minutes driving to work, U.S. News determined.

More than half (63.5 percent) of all League City residents are married, and 54 percent of the population are between the ages of 25 and 64-years-old.

Here's how other Houston-area cities faired among the top 100:

  • No. 16 – Sugar Land
  • No. 44 – The Woodlands
  • No. 45 – Katy
  • No. 67 – Missouri City
  • No. 73 – Spring

Houston drops out of the top 100

Though Houston proper made substantial improvements to land among the top 100 best places to live in U.S. News' 2024-2025 report, the city has once again plummeted toward the bottom of the list for 2025-2026.

Houston slumped to No. 381 this year, and only ranked No. 63 in the statewide comparison, showing that the city has lost its charm in favor of its appealing suburban neighbors.

The top 10 best places to live in the U.S. are:

  • No. 1 – Johns Creek, Georgia
  • No. 2 – Carmel, Indiana
  • No. 3 – Pearland, Texas
  • No. 4 – Fishers, Indiana
  • No. 5 – Cary, North Carolina
  • No. 6 – League City, Texas
  • No. 7 – Apex, North Carolina
  • No. 8 – Leander, Texas
  • No. 9 – Rochester Hills, Michigan
  • No. 10 – Troy, Michigan
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This story originally appeared on CultureMap.com.

League City, Sugar Land, and Pearland were just crowned among the top 10 safest and most affordable cities to live in the U.S. Photo via Getty Images

3 affordable Houston neighbors rank among America's 10 safest cities

HIGH PRAISE FOR THE 'BURBS

Crime may be a concern for some Houstonians, but life is a little more relaxed just beyond the city limits.

Three Houston-area suburbs – League City, Sugar Land, and Pearland – were just crowned among the top 10 safest and most affordable cities to live in the U.S., as declared in a new report by GoBankingRates.

The study, "50 Safest and Most Affordable US Cities To Live In," ranked the largest U.S. cities by population based on their cost of living and crime rate averages. Crime rates were determined based on the number of crimes per 1,000 city residents from the FBI’s Crime Data Explorer in 2022, the year with the most recent available data.

League City proudly landed in the No. 4 spot nationally, thanks to its low property and violent crime rates as well as a high median household income. Sugar Land and Pearland weren't too far behind in the top 10, ranking No. 6 and No. 7, respectively. The report emphasized these suburbs all offer "vibrant cultural scenes" and strong job markets for adults, along with great schools and abundant recreational activities for families to enjoy.

A League City household makes a median income of $117,316 annually, with an average mortgage cost of $2,216 per month, the report found. The total monthly cost of living in the family friendly city adds up to $4,157.

There were a total of 1,497 property crimes reported in the city in 2022, and 126 total violent crimes. For context, the U.S. Census Bureau estimated the population in League City spans more than 116,000 residents in 2023. That means the city's rate for violent crimes is 1.08 per 1,000 residents, and the property crime rate is 12.85 per 1,000 residents, according to the findings.

Sugar Land's median household income is much higher than League City's, at $132,247 per year. However, so were the average mortgage costs ($2,715 per month) and total monthly cost of living ($4,852).

There were 1,745 property crimes and 97 violent crimes reported in Sugar Land in 2022. That would place Sugar Land's property crime rate at 16.16 per 1,000 city residents, and 0.90 violent crimes per 1,000 residents.

Here's how the report breaks down Pearland's cost of living and crime rate statistics:

  • Median household income: $111,123
  • Household average mortgage cost: $2,257
  • Total monthly cost of living: $4,352
  • Property crimes (reported in 2022): 2,152
  • Property crime per 1,000 residents: 17.09
  • Violent crimes (reported in 2022): 117
  • Violent crime per 1,000 residents: .93

Large Texas cities, such as Houston proper, Dallas, Fort Worth, Austin, and San Antonio, were all noticeably absent in the ranking. This is likely because – as most Texans are aware – bigger cities often have higher crime rates and higher costs of living than their outlying suburbs.

"Choosing a family-friendly place to live is a significant decision that involves a balancing act between safety and affordability in any big city," the report said. "Whether you’re a young professional, a growing family or a retiree, finding real estate where you feel comfortable — both physically and financially — is crucial for a high quality of life."

Other Texas cities that were ranked in the top 25 safest and most affordable places to live include El Paso (No. 11), McKinney (No. 15), Frisco (No. 16), Laredo (No. 18), Grand Prairie (No. 21), Plano (No. 22), Carrollton (No. 23), and McAllen (No. 24).

The top 10 safest and most affordable U.S. cities to live in are:

  • No. 1 – Elgin, Illinois
  • No. 2 – Cary, North Carolina
  • No. 3 – Gilbert, Arizona
  • No. 4 – League City, Texas
  • No. 5 – Rochester, Minnesota
  • No. 6 – Sugar Land, Texas
  • No. 7 – Pearland, Texas
  • No. 8 – Meridian, Idaho
  • No. 9 – Broken Arrow, Oklahoma
  • No. 10 – Olathe, Kansas
The full report and its methodology can be found on gobankingrates.com

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The Woodlands ranked No. 24 out of 343 U.S. cities. Photo via thewoodlands.com

Houston suburb clocks in among best job markets in America

by the numbers

In a surprising turn of events, it's not Houston proper that's earning recognition for its job market, but The Woodlands. The north Houston suburb boasts the No. 24 best job market in the nation, according to a new report by SmartAsset.

The study examined 343 U.S. cities across six main data points from 2021 and 2022, for which the most recent data is available: A city's unemployment rates; median income to housing payment ratio, commute times, the percentage of remote workers, the percentage of employed residents with health insurance, and income growth between 2019-2022.

The report discovered that The Woodlands has a 4.8 percent unemployment rate, and its residents' median earnings landed at $73,079 annually. The average housing costs in The Woodlands make up 28.7 percent of an individual's yearly income, which can be estimated at about $1,750 per month.

Remote-work flexibility was another major consideration in the study. Working from home means no real commute time, as long as you don't count the time it takes to get out of bed and walk into the home office. Unfortunately for The Woodlands, a majority of workers are commuting to their jobs, and only 24.5 percent of employees work remotely.

For those who do need to drive to-and-from work, a separate SmartAsset study on remote workforces discovered the average commute time in The Woodlands is about 27 minutes long.

Houston fell far behind in the report, landing at No. 272 out of 343 total U.S. cities. The city's unemployment rate is only 5.9 percent, but its residents' median earnings barely tip over $38,000 a year. Only 11.5 percent of Houstonians work from home, and their housing costs account for 39.4 percent of their total income.

Houston ranked outside the top 20 best cities for tech workers earlier in 2024, further highlighting a significant downward shift in the employment atmosphere for the region.

"With costs of living skyrocketing in recent years and the demand for different skill sets changing, job seekers must be resourceful to find opportunities that best suit them," the report said. "This could mean relocating for higher income, an improved work-life balance, growth potential or benefits."

Other Houston-area cities that made it in the top 200 in the report are:

  • No. 99 – Sugar Land
  • No. 113 – Pearland
  • No. 172 – League City
The full report and its methodology can be found on smartasset.com.

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The study's findings are shedding light on further growing financial stress and affordability struggles throughout the U.S., likely heightened by inflation and cost of living increases. Photo via Getty Images

Here's what it takes to be a middle class earner in Houston in 2024

by the numbers

No one wants to hear that they aren't making enough money to be considered "middle class," but those income ceilings are getting more difficult to maintain year after year across the Houston area. And a new report has revealed The Woodlands has the No. 10 highest income ceiling for American middle class earners in 2024.

According to the 2024 edition of SmartAsset's annual "What It Takes to Be Middle Class in America" report, middle class households in The Woodlands would need to make between $91,548 and $274,670 a year to be labeled "middle class." Additionally, the suburb's median middle class household income comes out to $137,335 a year.

The report used a variation of Pew Research's definition of a middle class household, stating the salary range is "two-thirds to double the median U.S. salary." To determine income limits, the report analyzed data from the Census Bureau's 2022 one-year American Community Survey. New to the 2024 report, SmartAsset widened its analysis of income data from 100 to 345 of the largest American cities.

The Woodlands' middle class income thresholds are egregiously higher than the national average, the study found.

"In a large U.S. city, a middle-class income averages between $52,000 and $155,000," the report says. "The median household income across all 345 cities is $77,345, making middle-class income limits fall between $51,558 and $154,590."

Sugar Land was right behind The Woodlands, ranking No. 13 out of all 345 U.S. cities, with households needing to make between $88,502 and $265,532 a year to maintain their "middle class" status.

In a shocking turn of events, Houston plummeted into No. 254 this year after ranking among the top 100 in SmartAsset's 2023 report. At the time, a Houston household needed to make between $37,184 and $110,998 a year to be considered middle class. But the latest findings from the 2024 report show the necessary salary range to maintain a middle class designation in Houston is now between $40,280 and $120,852 a year.

The study's findings are shedding light on further growing financial stress and affordability struggles throughout the U.S., likely heightened by inflation and cost of living increases.

"As a middle-class American, there is some expectation for living a lifestyle of relative comfort," the report said. "But as costs have increased significantly over the last few years, the middle class is now feeling a squeeze in their finances."

Here’s what it takes to be middle class in other Houston-area cities:

  • No. 34 – Atascocita: between $71,748 and $215,266 a year
  • No. 39 – League City: between $69,904 and $209,734 a year
  • No. 45 – Pearland: between $69,990 and $206,992 a year
  • No. 211 – Conroe: between $43,814 and $131,456 a year
  • No. 273 – Pasadena: between $38,048 and $114,156 a year

Middle class income thresholds within the top 10 U.S. cities
The Woodlands wasn't the only Texas city to earn a spot in the top 10. Frisco, a suburb outside of Dallas, ranked two spots higher to claim No. 8 in the national comparison of U.S. cities with the highest income thresholds to be labeled middle class.

Middle class households in Frisco need to make between $97,266 and $291,828 a year, with the median household income at $145,914, according to the report.

Unsurprisingly, half of the top 10 cities with the highest middle class income ceilings are in California. The report found households in four of the five cities could be bringing in over $300,000 a year in income and still be classified as middle class.

California’s overall high cost-of-living means residents in the No. 1 city of Sunnyvale would need to make between $113,176 and $339,562 a year to be labeled middle class. Sunnyvale overtook Fremont for the top spot in the report in 2024.

The top 10 cities with the highest middle class ceilings are:

  • No. 1 – Sunnyvale, California
  • No. 2 – Fremont, California
  • No. 3 – San Mateo, California
  • No. 4 – Santa Clara, California
  • No. 5 – Bellevue, Washington
  • No. 6 – Highlands Ranch, Colorado
  • No. 7 – Carlsbad, California
  • No. 8 – Frisco, Texas
  • No. 9 – Naperville, Illinois
  • No. 10 – The Woodlands, Texas

The full report and its methodology can be found on smartasset.com.

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The Woodlands is the U.S. city with the No. 10 biggest holiday spending budget in 2023, and a few other Texas neighborhoods rank highly as well. The Woodlands Mall/Facebook

Houston suburb ranks No. 10 for holiday spending

shop 'til you drop

Santa and his elves get busier with every passing year, but sometimes even Kris Kringle has to use his black card to get the job done. And according to a new study by Wallethub, Santa's gonna be working overtime to fulfill the orders for residents of The Woodlands this holiday season.

The personal finance experts have determined The Woodlands is the U.S. city with the No. 10 biggest holiday spending budget in 2023. Shoppers in the affluent Houston suburb are expected to spend $3,316 this festive season.

According to the U.S. Census Bureau, The Woodlands' estimated population of 114,436 had a median household income of $130,011.

This is The Woodlands' first time in the holiday shopping spotlight. The Houston suburb ranked a much lower – No. 71 – in last year's report with an average spending budget of $1,733. Way to step it up.

The nearby city of Sugar Land is a returnee, and moved up one place from No. 15 last year into No. 14 this year. The average holiday budget for a Sugar Land household is $3,210.

Houston fell into No. 209 this year with an average household holiday budget of $1,296. Houston skyrocketed away from its previous rank as No. 366 in 2022 with an average spending budget of $890.

Six other East Texas cities landed in this year's report on the heftiest holiday budgets:

  • No. 31 – Pearland ($2,566)
  • No. 34 – Missouri City ($2,517)
  • No. 234 – Beaumont ($1,244)
  • No. 238 – Pasadena ($1,237)
  • No. 407 – Conroe ($935)
  • No. 438 – Baytown ($872)

Each year, WalletHub calculates the maximum holiday budget for over 550 U.S. cities "to help consumers avoid post-holiday regret," the website says. The study factors in income, age of the population, and other financial indicators such as debt-to-income ratio, monthly-income-to monthly-expenses ratio, and savings-to-monthly-expenses ratio.

Shoppers will have to keep a closer eye on their bank accounts this year while they search for the best gifts for their loved ones. Many consumers are running out of savings accumulated during the height of the COVID-19 pandemic, according to Yao Jin, an associate professor of supply chain management at Miami University.

To combat overspending, Jin suggests setting hard budgets based on personal financial circumstances and develop a list of "must haves" rather than "nice to haves."

"Holiday times are festive, and retailers know that festivities can boost mood and lead to a propensity to overspend," he said in the Wallethub report. "In fact, that is also why retailers tend to have more generous return policies to both alleviate concerns of unwanted gifts and buyer’s remorse. The key to avoiding holiday overspending is for consumers to take the emotions out of the decision, to the extent possible."

Other Texas cities that made it in the top 100 include:
  • No. 3 – Frisco ($3,546)
  • No. 5 – Flower Mound ($3,485)
  • No. 22 – Allen ($2,964)
  • No. 30 – Plano ($2,566)
  • No. 44 – Cedar Park ($2,354)
  • No. 56 – McKinney ($2,165)
  • No. 67 – Carrollton ($1,928)
  • No. 71 – Austin ($1,877)
  • No. 77 – Richardson ($1,809)
  • No. 95 – League City ($1,733)
  • No. 99 – North Richland Hills ($1,706)

The report and its methodology can be found on wallethub.com.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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