James Yockey is a co-founder of Landdox, which recently integrated with ThoughtTrace. Courtesy of Landdox

The biggest asset of most oil and gas companies is their leasehold: the contracts or deeds that give the company the right to either drill wells and produce oil and gas on someone else's land, or give them title to that land outright. A typical oil and gas company is involved in thousands of these uniquely negotiated leases, and the software to keep these documents organized hasn't been updated in more than a decade, says James Yockey, founder of Houston-based Landdox.

Landdox does just that: provides an organizational framework for companies' contracts and leaseholds. The company recently entered into an integration with Houston-based ThoughtTrace, an artificial intelligence program that can scan and pull out key words and provisions from cumbersome, complicated contracts and leaseholds.

With this integration, companies can use ThoughtTrace to easily identify key provisions of their contracts, and then sync up those provisions with their Landdox account. From there, Landdox will organize those provisions into easy-to-use tools like calendars, reminders and more.

The framework behind the integration
The concept behind Landdox isn't entirely new — there are other software platforms built to organize oil and gas company's assets — but it's the first company in this space that's completely cloud-based, Yockey says.

"Within these oil and gas leases and other contracts are really sticky provisions … if you don't understand them, and you're not managing them, it can cause you to forfeit a huge part of your asset base," Yockey says. "It can be a seven-, eight-, or nine-digit loss."

These contracts and leases can be as long as 70 or 80 pages, Yockey says, and have tricky provisions buried in them. Before the integration with ThoughtTrace, oil and gas companies would still have to manually pour over these contracts and identify key provisions that could then be sent over to Landdox, which would organize the data and documents in an easy-to-use platform. The ThoughtTrace integration removes a time-consuming aspect of the process for oil and gas companies.

"[ThoughtTrace] identifies the most needle moving provisions and obligations and terms that get embedded in these contracts by mineral owners," Yockey says. "It's a real source of leverage for the oil and gas companies. You can feed ThoughtTrace the PDF of the lease and their software will show you were these provisions are buried."

The origin story
Landdox was founded in 2015, and is backed by a small group of angel investors. Yockey says the investors provided a "little backing," and added that Landdox is a "very capital-efficient" software company.

Landdox and ThoughtTrace connected in 2017, when the companies were working with a large, private oil and gas company in Austin. The Austin-based oil and gas company opted to use Landdox and ThoughtTrace in parallel, which inspired the two companies to develop an integrated prototype.

"We built a prototype, but it was clear that there was a bigger opportunity to make this even easier," Yockey says. "To quote the CEO of ThoughtTrace, he called [the integration] an 'easy button.'"

The future of ERP software
Landdox's average customer is a private equity-backed E&P or mineral fund, Yockey says, thought the company also works with closely held, family-owned companies. Recently, though, Landdox has been adding a new kind of company to its client base.

"What's interesting is we're starting to add a new customer persona," Yockey says. "The bigger companies – the publicly traded oil and gas companies –have all kinds of different ERP (Enterprise Resource Planning) software running their business, but leave a lot to be desired in terms of what their team really needs."

At a recent North American Prospect Expo summit, Yockey says that half a dozen large capitalization oil and gas producers invited Landdox to their offices, to discuss potentially supplementing the company's ERP software.

"Instead of trying to be all things to all people, we stay in our lane, but find cool ways to connect with other software (companies)," Yockey says.

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.