James Yockey is a co-founder of Landdox, which recently integrated with ThoughtTrace. Courtesy of Landdox

The biggest asset of most oil and gas companies is their leasehold: the contracts or deeds that give the company the right to either drill wells and produce oil and gas on someone else's land, or give them title to that land outright. A typical oil and gas company is involved in thousands of these uniquely negotiated leases, and the software to keep these documents organized hasn't been updated in more than a decade, says James Yockey, founder of Houston-based Landdox.

Landdox does just that: provides an organizational framework for companies' contracts and leaseholds. The company recently entered into an integration with Houston-based ThoughtTrace, an artificial intelligence program that can scan and pull out key words and provisions from cumbersome, complicated contracts and leaseholds.

With this integration, companies can use ThoughtTrace to easily identify key provisions of their contracts, and then sync up those provisions with their Landdox account. From there, Landdox will organize those provisions into easy-to-use tools like calendars, reminders and more.

The framework behind the integration
The concept behind Landdox isn't entirely new — there are other software platforms built to organize oil and gas company's assets — but it's the first company in this space that's completely cloud-based, Yockey says.

"Within these oil and gas leases and other contracts are really sticky provisions … if you don't understand them, and you're not managing them, it can cause you to forfeit a huge part of your asset base," Yockey says. "It can be a seven-, eight-, or nine-digit loss."

These contracts and leases can be as long as 70 or 80 pages, Yockey says, and have tricky provisions buried in them. Before the integration with ThoughtTrace, oil and gas companies would still have to manually pour over these contracts and identify key provisions that could then be sent over to Landdox, which would organize the data and documents in an easy-to-use platform. The ThoughtTrace integration removes a time-consuming aspect of the process for oil and gas companies.

"[ThoughtTrace] identifies the most needle moving provisions and obligations and terms that get embedded in these contracts by mineral owners," Yockey says. "It's a real source of leverage for the oil and gas companies. You can feed ThoughtTrace the PDF of the lease and their software will show you were these provisions are buried."

The origin story
Landdox was founded in 2015, and is backed by a small group of angel investors. Yockey says the investors provided a "little backing," and added that Landdox is a "very capital-efficient" software company.

Landdox and ThoughtTrace connected in 2017, when the companies were working with a large, private oil and gas company in Austin. The Austin-based oil and gas company opted to use Landdox and ThoughtTrace in parallel, which inspired the two companies to develop an integrated prototype.

"We built a prototype, but it was clear that there was a bigger opportunity to make this even easier," Yockey says. "To quote the CEO of ThoughtTrace, he called [the integration] an 'easy button.'"

The future of ERP software
Landdox's average customer is a private equity-backed E&P or mineral fund, Yockey says, thought the company also works with closely held, family-owned companies. Recently, though, Landdox has been adding a new kind of company to its client base.

"What's interesting is we're starting to add a new customer persona," Yockey says. "The bigger companies – the publicly traded oil and gas companies –have all kinds of different ERP (Enterprise Resource Planning) software running their business, but leave a lot to be desired in terms of what their team really needs."

At a recent North American Prospect Expo summit, Yockey says that half a dozen large capitalization oil and gas producers invited Landdox to their offices, to discuss potentially supplementing the company's ERP software.

"Instead of trying to be all things to all people, we stay in our lane, but find cool ways to connect with other software (companies)," Yockey says.

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German biotech co. to relocate to Houston thanks to $4.75M CPRIT grant

money moves

Armed with a $4.75 million grant from the Cancer Prevention and Research Institute of Texas, a German biotech company will relocate to Houston to work on developing a cancer medicine that fights solid tumors.

Eisbach Bio is conducting a clinical trial of its EIS-12656 therapy at Houston’s MD Anderson Cancer Center. In September, the company announced its first patient had undergone EIS-12656 treatment. EIS-12656 works by suppressing cancer-related genome reorganization generated by DNA.

The funding from the cancer institute will support the second phase of the EIS-12656 trial, focusing on homologous recombination deficiency (HRD) tumors.

“HRD occurs when a cell loses its ability to repair double-strand DNA breaks, leading to genomic alterations and instability that can contribute to cancerous tumor growth,” says the institute.

HRD is a biomarker found in most advanced stages of ovarian cancer, according to Medical News Today. DNA constantly undergoes damage and repairs. One of the repair routes is the

homologous recombination repair (HRR) system.

Genetic mutations, specifically those in the BCRA1 and BCRA1 genes, cause an estimated 10 percent of cases of ovarian cancer, says Medical News Today.

The Cancer Prevention and Research Institute of Texas (CPRIT) says the Eisbach Bio funding will bolster the company’s “transformative approach to HRD tumor therapy, positioning Texas as a hub for innovative cancer treatments while expanding clinical options for HRD patients.”

The cancer institute also handed out grants to recruit several researchers to Houston:

  • $2 million to recruit Norihiro Goto from the Massachusetts Institute of Technology to MD Anderson.
  • $2 million to recruit Xufeng Chen from New York University to MD Anderson.
  • $2 million to recruit Xiangdong Lv from MD Anderson to the University of Texas Health Science Center at Houston.

In addition, the institute awarded:

  • $9,513,569 to Houston-based Marker Therapeutics for a first-phase study to develop T cell-based immunotherapy for treatment of metastatic pancreatic cancer.
  • $2,499,990 to Lewis Foxhall of MD Anderson for a colorectal cancer screening program.
  • $1,499,997 to Abigail Zamorano of the University of Texas Health Science Center at Houston for a cervical cancer screening program.
  • $1,497,342 to Jennifer Minnix of MD Anderson for a lung cancer screening program in Northeast Texas.
  • $449,929 to Roger Zoorob of the Baylor College of Medicine for early prevention of lung cancer.

On November 20, the Cancer Prevention and Research Institute granted funding of $89 million to an array of people and organizations involved in cancer prevention and research.

West Coast innovation organization unveils new location in Houston suburb to boost Texas tech ecosystem

plugging in

Leading innovation platform Plug and Play announced the opening of its new flagship Houston-area location in Sugar Land, which is its fourth location in Texas.

Plug and Play has accelerated over 2,700 startups globally last year with corporate partners that include Dell Technologies, Daikin, Microsoft, LG Chem, Shell, and Mercedes. The company’s portfolio includes PayPal, Dropbox, LendingClub, and Course Hero, with 8 percent of the portfolio valued at over $100 million.

The deal, which facilitated by the Sugar Land Office of Economic Development and Tourism, will bring a new office for the organization to Sugar Land Town Square with leasing and hiring between December and January. The official launch is slated for the first quarter of 2025, and will feature 15 startups announced on Selection Day.

"By expanding to Sugar Land, we’re creating a space where startups can access resources, build partnerships, and scale rapidly,” VP Growth Strategy at Plug and Play Sherif Saadawi says in a news release. “This location will help fuel Texas' innovation ecosystem, providing entrepreneurs with the tools and networks they need to drive real-world impact and contribute to the state’s technological and economic growth."

Plug and Play plans to hire four full-time equivalent employees and accelerate two startup batches per year. The focus will be on “smart cities,” which include energy, health, transportation, and mobility sectors. One Sugar Land City representative will serve as a board member.

“We are excited to welcome Plug and Play to Sugar Land,” Mayor of Sugar Land Joe Zimmerma adds. “This investment will help us connect with corporate contacts and experts in startups and businesses that would take us many years to reach on our own. It allows us to create a presence, attract investments and jobs to the city, and hopefully become a base of operations for some of these high-growth companies.”

The organization originally entered the Houston market in 2019 and now has locations in Bryan/College Station, Frisco, and Cedar Park in Texas.