By prioritizing the deployment of smart, energy-efficient technologies, we can ensure that Houston remains at the forefront of the global energy landscape, setting the standard for other cities to follow. Photo via Getty Images

As Houston, the energy capital of the world, navigates the global energy transition, the city is uniquely positioned to lead by example. This transition isn’t just about shifting from fossil fuels to renewable energy; it’s about creating an ecosystem where corporations, research institutions, startups, and investors collaborate to develop and implement innovative technologies.

One of the most promising areas for reducing energy consumption and minimizing environmental impact is in heating, ventilation, and air conditioning, or HVAC, systems.

Houston’s intense weather patterns demand efficient and adaptable climate control solutions. Traditional HVAC systems, while effective in maintaining indoor comfort, often operate on fixed settings that don’t account for real-time changes in occupancy or weather. This results in energy waste and increased utility costs — issues that can be mitigated by integrating artificial intelligence into HVAC systems.

AI-driven HVAC systems offer a dynamic approach to heating and cooling, learning from user preferences and environmental conditions to optimize performance. These systems use advanced algorithms to continuously adjust their operation, ensuring that energy is used only when and where it’s needed. This results in up to 30 percent greater energy efficiency compared to conventional systems, translating into significant savings for consumers and a reduction in overall energy demand.

For a city like Houston, where energy consumption is a critical concern, the widespread adoption of AI-integrated HVAC systems could have a substantial impact. By optimizing energy use in homes, offices, and industrial spaces, these systems help reduce the strain on the electrical grid, particularly during peak usage times. Additionally, they contribute to lowering greenhouse gas emissions, aligning with Houston’s broader sustainability goals.

The potential of AI in HVAC systems extends beyond efficiency and environmental benefits. These systems enhance the user experience by offering precise control over indoor climates, adapting to individual preferences, and responding to external conditions in real-time. This level of customization not only improves comfort but also supports a smarter, more sustainable approach to energy management.

Houston’s energy transition requires the collective efforts of all sectors. While large corporations and government entities play a significant role, the contributions of startups, research institutions, and energy service companies are equally important. These entities are at the forefront of developing technologies that address both the economic and environmental challenges of our time. Investors are increasingly recognizing the value of funding solutions that offer long-term sustainability alongside financial returns, further driving the adoption of innovative energy technologies.

The integration of AI into HVAC systems represents a crucial step forward in this journey. As Houston continues to evolve as a leader in energy innovation, embracing advanced technologies like AI-driven HVAC systems will be key to achieving a more sustainable and resilient energy future. These systems are not just a technological advancement—they are a strategic tool in the broader effort to reduce energy consumption, lower emissions, and create a healthier environment for all.

At the heart of Houston’s energy transition is the commitment to building a future that balances growth with sustainability. By prioritizing the deployment of smart, energy-efficient technologies, we can ensure that Houston remains at the forefront of the global energy landscape, setting the standard for other cities to follow. As we move forward, the integration of AI into our energy infrastructure, particularly in HVAC systems, will be instrumental in shaping a sustainable and prosperous future for Houston and beyond.

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Trevor Schick is the president of KOVA, a Texas company creating sustainable solutions in building development.

This article originally ran on EnergyCapital.
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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.