Here's what you should think about before rolling this hot new technology into your business. Photo via Getty Images

The world has been captivated by ChatGPT, an artificial intelligence program that can understand and respond to questions and statements using natural language, just like humans. It has been trained on a large amount of text data and uses this knowledge to generate helpful and informative responses to users.

As great and resourceful as this can be, there are some major aspects about it that can be harmful in a business setting, such as the inability to make personal connections. A sales manager using AI to write sales scripts cannot incorporate the emotional intelligence needed to form a connection. With the switch to AI and loss of this personal touch, the company’s close rate drops significantly, and the sales manager’s effort to find solution may just be to run more numbers in terms of contacts and sales attempts, which usually exacerbates the problem.

Another example of how ChatGPT can hurt your business is by relying on it to generate website and social media content. A business owner that believes ChatGPT will do the “heavy lifting” and grow his or her business is overlooking the importance of creating real and experiential marketing experiences for customers. Business owners can inadvertently spend entire budgets on AI driven social media ands and not have the sales numbers to cover these costs due to their low returns on investments for many industries and keep the business in operation.

The overarching theme, or danger behind ChatGPT, is that people are relying heavily on it to produce their work. After all, relying on technology is part of our human nature. When great technology is introduced, such as email, teleconferencing, AI assisted searching, etc., we rarely ask ‘how can this technology assist me?’ versus ‘how can this technology do things for me?’ The greater the technology, the greater likelihood humans will take the easiest path.

ChatGPT not only affects businesses, but it also applies to education. Teachers are already seeing a drop in math skills as kids carry around calculators. Just wait until next semester when educators are reading thousands of essays written by ChatGPT.

Just as we would hate to see our children deprive themselves of actual skills, the same can be said for our business people. Some of the main issues that arise from the use of ChatGPT are:

Diminishing Rates of Return

When we embrace technology to the point that we no longer put forth effort from a practiced skill set, we can expect to see declining engagement rates, click-through rates and customer loyalty. As of 2023, the online engagement rate has fallen from 5% to 0.06%. Click-through rates are not faring much better with a measly 6.3%. As these numbers continue to fall (which they have every year for the past couple decades now), we continue to just brush it off as this is how business is done.

Aversion in the Marketplace

People are becoming so displeased with technology driven processes (as opposed to technology assisted processes) that they have a strong aversion to companies using it. How many social media ads have prompted you to make a purchase? How many times do you provide a bogus email to a website form? When doing a search, how many times do you scroll to the bottom without looking and hit page two because you know you are not getting any real results on the first page anymore?

Yes, ChatGPT is cool and yes, there are some amazing uses you can implement into your business; however, do not look at it as the answer to any and all business problems. Embrace your craft as a leader and avoid subbing the work out to tech - doing so could cost you everything.

As a business owner myself, I am not opposed to technology. I am all in favor of what technology can do. However, there is no denying that the more we look to technology to do the work for us instead of with us, the more we see a drastic decline in the overall skill set of business people without an increase in business success rates.

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Josh Tolley is the founder of Kingsbridge LLC and is based in Houston.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.