3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Jon Lambert of The Cannon, Ken Cowan of Enchanted Rock, and Richard Wilson of the University of Houston. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a podcast with the CEO of a community-focused coworking space, a professor joining a major health care research project, and a guest columnist with advice on navigating the energy transition.

Jon Lambert, CEO of The Cannon

Jon Lambert, CEO of The Cannon, joins the Houston Innovators Podcast to discuss the growth of The Cannon, including its newest location. Photo courtesy of The Cannon

For the past five years as CEO, Jon Lambert has faced some challenges leading The Cannon — from navigating a global pandemic to the subsequent evolved real estate market. But now, the coworking and community building company is poised for even more growth — especially with its ninth location opening up this month — thanks to its community-driven mission.

The Cannon Memorial opens its doors on Monday, May 13, with a week of free coworking and events. And while the new space, developed in partnership with MetroNational, is open for leasing, Lambert says on the Houston Innovators Podcast the first and foremost, The Cannon is a community.

"The Cannon wasn't created as a real estate play — we got into coworking because as we started supporting the community and asking the question of, 'what can we do for you?,' one of the highlights was, 'hey, we need space to work,'" he says on the show. "For us, we were going to provide space because that's one of the key needs of this community.

"Our measurement of success is not the buildings we have or the occupancy even — it's what's the success of the companies that are part of the community," he continues. Click here to read more. 


Ken Cowan, senior vice president of Enchanted Rock

Ken Cowan writes a guest column for InnovationMap. Photo courtesy

As senior vice president of Enchanted Rock, a Houston-based provider of microgrid technology, Ken Cowan has seen how energy resilience has emerged as a key strategy for businesses across industries, as he writes in a guest column for InnovationMap.

"Executives must recognize the strategic imperative of investing in resilient energy infrastructure like microgrid systems, which can provide a competitive advantage against organizations that do not have similar measures in place," he writes. "In doing so, they can navigate uncertainty with confidence, set their business up for future success, and emerge stronger and more resilient than ever before."

In the piece, he explores the value proposition and other benefits to making these changes. Click here to read more.

Richard Willson, Huffington-Woestemeyer Professor of chemical and biomolecular engineering at the University of Houston

Richard Willson (center) and his team are working to develop a mix-and-read antibody measurement system that uses fluorescent materials to determine the amount of antibody present in a sample. Photo via UH.edu

An engineering project at the University of Houston has been selected to join a $10 million effort to bring biopharmaceutical manufacturing into the future. The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) chose the lab of Richard Willson, Huffington-Woestemeyer Professor of chemical and biomolecular engineering at UH, as one of eight development projects that it will fund.

Willson and his team are working to develop a mix-and-read antibody measurement system that uses fluorescent materials to determine the amount of antibody present in a sample. The funding for this project is $200,000. This is the first grant UH has received from NIIMBL.

“In the course of the manufacturing processes, it's important to know the concentration of antibody in your sample and this measurement needs to be made many times in a typical manufacturing process,” said Willson in a press release. In the realm of fluorescents, he is also working to pioneer the use of glow sticks to detect biothreats for the U.S. Navy. His discoveries include a fluorescent material that emits one color of light when excited with another color of light. Click here to read more. 

Here's why more and more companies — across industries — are making the switch to sustainable technology. Photo via Getty Images

Houston expert on why companies across industries are investing in sustainable energy

guest column

In a modern business landscape characterized by increasing uncertainty and volatility, energy resilience has emerged as a cornerstone of strategic decision-making.

Let's delve deeper into why executives should view energy resilience as one of the best risk management investments they can make.

Mitigating risks and enhancing stability

Investing in energy resilience isn't solely about averting risks; it's about mitigating the potential losses that could arise from energy-related disruptions. It is estimated that half of today’s businesses lack an effective resilience strategy, even though nearly 97 percent of companies have been impacted by a critical risk event.

Whether it's power outages from extreme weather events, grid emergencies from a changing resource mix that is more weather dependent or cyber-attacks, disruptions can inflict substantial financial and reputational damage on businesses. By implementing resilient energy infrastructure and practices, organizations can minimize the impact of such disruptions, ensuring consistent operations even in the face of adversity. As an added benefit, these investments can also contribute to enhancing the stability of our grid infrastructure, benefiting not just individual businesses but the local community and the entire economy.

Improving costs and operational efficiency

Energy resilience also isn't just a defensive strategy; it's also about optimizing costs and operational efficiency to create competitive advantage. By investing in resilient energy infrastructure, such as backup power systems and microgrids, businesses can reduce the downtime associated with energy disruptions, thus avoiding revenue losses and operational inefficiencies.

Additionally, resilient energy solutions often lead to long-term cost savings through increased energy efficiency and reduced reliance on costly backup systems. As circumstances become increasingly uncertain, businesses that prioritize energy resilience can gain a competitive edge by operating more efficiently and cost-effectively than their counterparts.

Ensuring consistent operations amidst uncertainty

In today's rapidly changing business environment, characterized by geopolitical tensions, climate change, and technological advancements, uncertainty has become the new normal. Amidst this uncertainty, ensuring consistent operations is paramount for business continuity and long-term success. Investing in energy resilience provides businesses with the assurance that they can maintain operations even in the face of unforeseen challenges.

Whether it's a sudden power outage from a storm or the grid is stressed and unable to deliver reliable power, resilient energy infrastructure enables organizations to adapt swiftly and continue delivering products and services to customers without interruption.

Enhancing sustainability efforts

In recent years, a growing emphasis on sustainability and environmental stewardship has led to organizations recognizing the importance of reducing their carbon footprint and transitioning towards cleaner, renewable energy sources. Investing in energy resilience provides an opportunity to align sustainability efforts with business objectives.

By integrating renewable energy technologies and energy-efficient practices into their resilience strategies, organizations can not only enhance their environmental performance but also achieve long-term cost savings, ensure regulatory compliance, and build stakeholder trust.

The value of energy resilience for businesses

It is not enough to successfully handle day-to-day operations anymore; organizations need to be prepared for unpredictable events with a reliable energy supply and backup plan. Recently, a hospital in Texas had to evacuate patients and experienced heavy financial losses due to the failure of their traditional diesel generators during an extended outage.

After reevaluating their resiliency strategy, they decided to implement full-facility backup power using Enchanted Rock’s dual-purpose managed microgrid solution, which kept their power on during the next outage and ensured both patient safety and full operational capabilities. Investing in an energy resilience strategy like a microgrid will mitigate these risks and ensure always-on power in times of uncertainty.

A responsible decision for the greater good

Beyond the immediate benefits to individual businesses, investing in energy resilience is also a responsible decision for the greater good. As businesses become increasingly reliant on the grid infrastructure, ensuring its resilience is essential for the stability and reliability of the entire energy ecosystem. By proactively investing in resilient energy solutions, for themselves, businesses also contribute to strengthening the grid infrastructure, reducing the risk of widespread outages, and promoting the overall resilience of the energy system.

Executives must recognize the strategic imperative of investing in resilient energy infrastructure like microgrid systems, which can provide a competitive advantage against organizations that do not have similar measures in place. In doing so, they can navigate uncertainty with confidence, set their business up for future success, and emerge stronger and more resilient than ever before.

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Ken Cowan is the senior vice president of Enchanted Rock, a Houston-based provider of microgrid technology.

This article originally ran on EnergyCapital.
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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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