3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Taylor Anne Adams of Rice University, Kelly Adels Hess of CompuCycle, and Tatiana Fofanova of Koda Health. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a podcast with an innovation leader from Rice University, the CEO of a tech recycling company, and a startup founder with fresh funding.

Taylor Anne Adams, head of venture acceleration at Lilie

Taylor Anne Adams is working to support Rice University's most ambitious entrepreneurs. Photo courtesy of Lilie

Rice University can barely keep up with the interest of students in entrepreneurial classes and programming — even in the summer.

The university's Liu Idea Lab for Innovation and Entrepreneurship offers around 30 classes a year and over a dozen co-curricular programs — all focused on supporting student entrepreneurs.

"There is a huge desire for this across the campus," Taylor Anne Adams, head of venture acceleration at Lilie, says on the Houston Innovators Podcast. "Our class enrollment has just continued to skyrocket, and we've had to add on more classes and programs and that still seems to not be enough." Continue reading.

Kelly Hess, CEO of CompuCycle

Kelly Hess leads CompuCycle, a Houston-based company focused on electronics recycling. Courtesy of CompuCycle

An innovative Houston company focused on sustainable tech recycling has expanded.

CompuCycle describes its unique Plastics Recycling System as the first and only certified, single solution e-waste recycling business. The company's unique process can now break down discarded technology products into single polymers that can then be reused in the manufacturing process.

“Properly managing all components of electronics is a cornerstone of sustainability and environmental responsibility,” Kelly Adels Hess, CEO of CompuCycle, says in a news release. “Making single polymer plastics that original equipment manufacturers (OEMs) can reuse to produce new electronics or other products, while adhering to international recycling standards, is a gamechanger for domestic companies and those that need their plastics shipped globally.” Continue reading.

Tatiana Fofanova, co-founder and CEO of Koda Health

Tatiana Fofanova, co-founder and CEO of Koda, joined the Houston Innovators Podcast to discuss her company's growth. Image via LinkedIn

Koda Health achieved a successful oversubscription of additional seed round funding thanks to the participation of AARP, Memorial Hermann Health System, and the Texas Medical Center Venture Fund. The total amount raised was undisclosed, and the round was led by Austin-based Ecliptic Capital.

The tech platform improves planning for serious illness treatment and end-of-life care using a cloud-based advance care planning, or ACP, platform that pairs with in-house support. Essentially, it allows patients to do their planning ahead and make sure that their wishes are actually put into action. According to Koda Health, this results in an average of $9,500 saved per-patient, as well as improved health outcomes.

"If we’re looking at speed of market adoption, it’s clear that Koda Health is at the forefront of a crucial transformation in Advance Care Planning," says Tatiana Fofanova, PhD, CEO of Koda Health, in a press release. “In just a few years, we’ve built out a product that now serves well over 700,000 patients nationwide for industry giants like Cigna, Privia and Houston Methodist.” Continue reading.

Houston-based CompuCycle has acquired a new shredder that can automatically sort and dismantle electronics. Courtesy of CompuCycle

Houston small business introduces state-of-the-art technology for electronics recycling

E-cycling

Currently, there are more than 135 million cell phones, 23 million televisions, and 31 million computers in landfills in the United States that don't have to be.

"Eighty percent of electronics are still landfilled in the United States," says Kelly Hess, CEO of CompuCycle, citing Consumer Take Back Coalition and EPA 2014 data. "We really want to advocate to change that number, because it's not necessary."

CompuCycle — a Houston company that has been around for over 20 years — has taken a big step toward that goal by adding an electronics shredder to its services. The shredder can dismantle 40,000 pounds a day of electronic material down to just about the finest it can get. It's the only of its kind in Houston — and one of only a few in Texas.

"It's a game changer," Kelly says. "When it comes to electronics recycling, if there's anything that can be sexy about it, this is sexy. It's as good as you can get."

As a R2 certified company, CompuCycle works with large corporations — local and worldwide — to safely wipe data from old electronics, refurbish them, and recycle what can't be refurbished. While most of the company's business is this B2B model, Harris County residents can drop off electronics to be disposed of responsibly free of charge.

While CompuCycle has focused on responsible electronics disposal since Kelly's father-in-law, John Hess, founded the company in 1996, certain recent events have increased the need to recycle more efficiently.

"China is no longer accepting scrap, which is where a lot of materials would go after it was dismantled," Kelly says. "That's why we've created this solution to be able to responsibly handle it here in the U.S."

The new Chinese law shifts the responsibility of electronics recycling back to the U.S., resulting in a rising need for more education and legislation surrounding recycling, says Clive Hess, executive vice president at CompuCycle and husband to Kelly.

"Texas has pretty weak electronic recycling laws — they do have some laws, and something is better than nothing," Clive says. "But, in a perfect world they wouldn't allow the landfilling of electronics."

At the end of the day, CompuCycle's new shredder is moving the needle on electronics recycling, but there's much more to be done, especially since recyclers still bear the brunt of the costs associated with recycling.

"We need to educate the manufacturers, the retail outlets, and the recyclers," Clive says. "We need to work together to provide recycling programs for people to take advantage of. There's a lot more work that needs to take place in order for recycling to be more effective."


CompuCycle's new shredder can dismantle 40,000 pounds of electronics materials a day. Courtesy of CompuCycle

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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