Digital Fight Club is making its triumphant Houston return next week. Have you gotten your virtual tickets? Photo by Emily Jaschke/InnovationMap

In 2019, Houston innovators went head to head for the first Houston Digital Fight Club. While COVID-19 postponed a repeat match-up, the organizers have teamed up to put on a virtual event like none other.

Dallas-based Digital Fight Club, which first premiered in 2016, was founded by Michael Pratt who wanted the event structure to be intentionally different from your run-of-the-mill tech networking events. In Digital Fight Club, two innovation specialists "fight" against one another, with a referee steering the conversation, and the audience is involved and votes in real time for the winner.

The event came to Houston two years ago, presented by Accenture, and the two organizations wanted to be able to replicate the high-energy event online for 2021. (Note: InnovationMap is on the steering committee for the event.)

"We as Accenture are stoked to bring back Digital Fight club to our amazing city where provocative Houston topics will be debated by some of H-Town's most brilliant minds," says Accenture Houston Innovation Hub's Jessica Guerrero, who serves as the associate hub director.

The previous Houston event covered innovative topics, such as artificial intelligence, the future of primary care, and technology's hold on humans. Check out overheard moments and photos from the last event.

"Houston's well deserved reputation as an innovation city is the perfect ingredient for Digital Fight Club," Pratt tells InnovationMap. "What better forum to see the best minds debate the most pressing issues in business and technology."

Through the work of the two teams, Digital Fight Club will return to Houston on Tuesday, October 26, at 7 pm, virtually. Tickets are $20 per person and can be purchased online. This year's topics and fighters includes:

  • Energy Transition: What technology is king to get us there? Fighters: Moji Karimi, CEO of Cemvita Factory, vs Trevor Best, CEO of Syzygy Plasmonics
  • Space Race: Who will lead space commercialization? Fighters: Trent Martin, vice president of aerospace at Intuitive Machines, vs Steve Gonzalez, partner at Seldor Capital (retired NASA)
  • Digital Divide: The greatest barrier to bridging the divide? Fighters: Ashley DeWalt, managing director of DivInc, vs Jesse Martinez, co-founder of LatinX Startup Alliance
  • Sweet Teams are Made of This: The post-pandemic employee experience. Fighters: Brad Deutser, CEO of Deutser, vs Joe Alapat, CEO of Liongard
  • Innovation in a Virtual World: Impossible? Fighters: Lawson Gow, founder of The Cannon, vs Robert Pieroni, director of economic development at Central Houston Inc.

Each fighter will open with 45 seconds each, followed by two 30 seconds rebuttals each. Referees will have a chance to ask a follow up, then each fighter will respond for 15 seconds. Referees include:

  • Mary Beth Gracy, managing director of Accenture's Houston office
  • Scott Gale, executive director of Halliburton Labs
  • Sam Gunderson, director of partnership development at NASA
  • Elizabeth Haines McGee, director of innovation and engagement at Intel
  • Steve Rader, deputy director of collaborative innovation at NASA

Clearly, you shouldn't expect your average business event call. The platform that's hosting the event allows for attendees to join "rooms" with friends, coworkers, and more. Within the rooms, you can chat about the fighter's argument and even respond with emojis. You can even throw a tomato at a fighter you disagree with.

"As an attendee get ready to move beyond the traditional Zoom call and be immersed in an interactive environment where you can cheer on your favorite fights or even show your disagreement with digital tomatoes, all from your own virtual pink couch," Guerrero says. "So grab your favorite humans, come attend this entertaining experience and witness the throw down."

The virtual edition of Digital Fight Club first took place in Dallas. Now the interactive event is coming to Houston. Photo courtesy of Accenture

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.