These 3 Houston researchers are revolutionizing health science innovation

research roundup

From biomolecular research to oral cancer immunotherapy, here are three research projects to watch out for in Houston. Photo via Getty Images

Research, perhaps now more than ever, is crucial to expanding and growing innovation in Houston — and it's happening across the city right under our noses.

In InnovationMap's latest roundup of research news, a couple local scientists are honored by awards while another duo of specialists tackle a new project.

University of Houston professor recognized with award

Mehmet Orman of UH has been selected to receive an award for his research on persister cells. Photo via UH.edu

Mehmet Orman, assistant professor of chemical and biomolecular engineering at the University of Houston Cullen College of Engineering has been honored with a Faculty Early Career Development Award from the National Science Foundation. The award comes with a $500,000 grant to study persister cells — cells that go dormant and then become tolerant to extraordinary levels of antibiotics.

"Nearly all bacterial cultures contain a small population of persister cells," says Orman in a news release. "Persisters are thought to be responsible for recurring chronic infections such as those of the urinary tract and for creating drug-resistant mutants."

Previously, Orman developed the first methods to directly measure the metabolism of persister cells. He also developed cell sorting strategies to segregate persisters from highly heterogeneous bacterial cell populations, and, according to the release, he will be using his methods in the NSF research project.

Houston researchers collaborate on oral cancer innovation

Dr. Simon Young of UTHealth and Jeffrey Hartgerink of Rice University are working on a new use for an innovative gel they developed. Photo via Rice.edu

Two Houston researchers — chemist and bioengineer Jeffrey Hartgerink at Rice University and Dr. Simon Young at the University of Texas Health Science Center at Houston — have again teamed up to advance their previous development of a sophisticated hydrogel called STINGel. This time, they are using it to destroy oral cancer tumors.

SynerGel combines a pair of antitumor agents into a gel that can be injected directly into tumors. Once there, the gel controls the release of its cargo to not only trigger cells' immune response but also to remove other suppressive immune cells from the tumor's microenvironment. The duo reported on the technology in the American Chemical Society journal ACS Biomaterials Science & Engineering.

SynerGel, combines a pair of antitumor agents into a gel that can be injected directly into tumors, where they not only control the release of the drugs but also remove suppressive immune cells from the tumor's microenvironment.

"We are really excited about this new material," Hartgerink says in a news release. "SynerGel is formulated from a specially synthesized peptide which itself acts as an enzyme inhibitor, but it also assembles into a nanofibrous gel that can entrap and release other drugs in a controlled fashion.

In 2018, the pair published research on the use of a multidomain peptide gel — the original STINGel — to deliver ADU-S100, an immunotherapy drug from a class of "stimulator of interferon gene (STING) agonists."

The research is supported by the Oral and Maxillofacial Surgery Foundation, the National Institutes of Health, the Welch Foundation, the National Science Foundation and the Mexican National Council for Science and Technology.

Texas Heart Institute researcher honored by national organization

Dr. James Martin of Texas Heart Institute has been named a senior member of the National Academy of Inventors. Photo courtesy of THI

The National Academy of Inventors have named Houston-based Texas Heart Institute's Dr. James Martin, director of the Cardiomyocyte Renewal Lab, a senior member.

Martin is an internationally recognized developmental and regenerative biologist and his research is focused on understanding how signaling pathways are related to development and tissue regeneration.

"Dr. Martin has long been a steward of scientific advancement and has proven to be a tremendous asset to the Texas Heart Institute and to its Cardiomyocyte Renewal Lab through his efforts to translate fundamental biological discoveries in cardiac development and disease into novel treatment strategies for cardiac regeneration," says Dr. Darren Woodside, vice president for research at THI, in a news release. "Everyone at the Texas Heart Institute is thrilled for Dr. Martin, whose induction into the NAI as a Senior Member is well-deserved."

Martin has authored over 170 peer-reviewed papers in top journals he holds nine U.S. patents and applications, including one provisional application, all of which have been licensed to Yap Therapeutics, a company he co-founded.

The full list of incoming NAI Senior Members, which includes three professionals from the University of Houston, is available on the NAI website.

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Hardtech startup adviser on mentorship, Houston's past and future as an innovation hub

HOUSTON INNOVATORS PODCAST EPISODE 211

To Wogbe Ofori, the definition of entrepreneurship is simple: "To be more opportunity centric than risk averse." And Houston, as he says, has be entrepreneurial for a very long time — despite it being considered the specialty of a certain coastal region.

"Silicon Valley has hijacked the concept of innovation and entrepreneurship, and this city has been filled with entrepreneurs long before the concept of 'tech entrepreneurs,'" Ofori says on this week's episode of the Houston Innovators Podcast.

Ofori, the founder and chief strategist of WRX Companies, has developed a keen eye for entrepreneurship and innovation activity in Houston and shares his observations on the show. An adviser to Nauticus Robotics and strategist to Intuitive Machines and Jacobs, he's also served as a mentor across the local innovation community.

In fact, on the episode, he explains what makes a good mentor for founders in tech. Ofori says he specializes in helping entrepreneurs see around corners and think things through, make wise decisions, and get things done.

"It starts with an ability to listen," Ofori says of advisers and mentors. "One of the keys to my advisory practice is to not only listen but reframe and ask a lot of questions."

"What differentiates this from therapy — and sometimes the line can be fine," he continues, "is that as a mentor or adviser in the context of commerce, is you're always thinking about it toward a transaction in the marketplace."

As he's spent a lot of time working with hardtech founders, Ofori has observed a momentum within energy transition innovation — specifically Houston's role in it.

"It's difficult for an incumbent to disrupt itself. We’ve been positioning ourselves as moving from the energy capital of the world to the energy transition capital," he says. "Now we are just at the place where we're really going to start to see the difference between those who were caught up in the excitement of the energy transition, and those who really have the faith to see this thing through."

Houston universities rack up rankings in reports on top schools for entrepreneurship

5 years running

Rice University and the University of Houston have once again scooped up accolades for their entrepreneurship programs.

For the fifth consecutive year, Rice’s Jones Graduate School of Business has been ranked the No. 1 graduate entrepreneurship program by The Princeton Review, a provider of education services, and Entrepreneur magazine.

“Our close ties to Houston as well as national startup ecosystems give our students unique opportunities to pitch to and connect with angel investors, venture capitalists and corporations,” Brad Burke, managing director of the Rice Alliance, says in a news release. “These connections allow for mentorship, as well as launch points for new ideas, not only for our students but also for the city and surrounding communities.”

The list identifies 50 undergraduate and 50 graduate programs that boast the best entrepreneurship offerings based on factors such as coursework, experiential learning opportunities, and career outcomes. The ranking measures more than 40 data points about the schools’ entrepreneurship programs, faculties, students, and alumni.

Also for the fifth consecutive year, the University of Houston’s Cyvia and Melvyn Wolff Center for Entrepreneurship in the C.T. Bauer College of Business has been named the No. 1 undergraduate entrepreneurship program by The Princeton Review and Entrepreneur magazine.

“We believe in entrepreneurship, we believe in free enterprise, and we’re in the number one city for entrepreneurship,” Dave Cook, executive director of the Wolff Center, says in a news release.

“When we put students into this entrepreneurial mix,” he adds, “and we introduce and reinforce free enterprise values, our intent is to change students’ lives and to create the next generation of business leaders with the highest integrity who are going to go out and create their own cultures, their own companies and their own futures.”

The University of Texas at Austin is the only other school in the state to make the top 10 of either the graduate ranking or undergraduate ranking. UT captures the No. 6 spot on the graduate list and No. 2 spot on the undergraduate list.

Aside from The Princeton Review and Entrepreneur honor, Rice climbed four spots in Poets&Quants’ annual ranking of the world’s best MBA programs for entrepreneurship.

Last year, Rice’s graduate school for business landed at No. 7 on the list. This year, it rose to No. 3, behind the first-ranked Olin School of Business at Washington University in St. Louis and second-ranked ESTM Berlin.

This is the fifth annual ranking of MBA programs for entrepreneurship from Poets&Quants, a website that focuses on graduate-level business education.

“MBA programs are increasingly sought after in today’s environment, and our focus on entrepreneurship sets us apart,” Peter Rodriguez, business dean at Rice, says in a news release. “The entrepreneurship classes emphasize a combination of mindset and skill set and focus on multiple stages of the entrepreneurial process, preparing our students for any industry and climate.”

Poets&Quants relies on 16 data points collected through an annual survey to come up with its ranking. Among those data points are:

  • Average percentage of MBA students launching businesses during their program or within three months of graduation between 2018 and 2022.
  • Percentage of MBA elective courses with all of the curriculum focused on entrepreneurship or innovation during the 2022-23 academic year.
  • Percentage of MBA students active in the business school’s main student-run entrepreneurship club during the 2022-23 academic year.
  • Square footage of incubator or accelerator space available to MBA students during the 2022-23 academic year.

America's labor shortage crisis: Local Houston company’s solution for a thriving future

A Brighter Future

The labor shortage crisis gripping America is not isolated to a particular region; it's a challenge that reverberates from coast to coast.

CNN Business projects that this issue could cost the nation a staggering $1 trillion, while the Manufacturing Institute predicts that 2.1 million jobs will go unfilled. To address this pressing concern, a local Houston company called Innovapptive and its connected workforce platform stands as a beacon of hope to improve productivity and capacity, while also upskilling the digital native worker.

Innovapptive is a provider of a “mobile first '' AI-connected workforce SaaS solution to help companies manage labor shortage by empowering front-line workers with digital tools to boost productivity.

The platform’s integrated suite of apps for both the front-line workers and back-office staff closes the loop between people and assets to eliminate inefficiencies. By connecting the front-line workers and back-office with critical information in real time, and harnessing the potential of generative AI and cutting-edge AI/ML technology trends, Innovapptive is enhancing productivity and upskilling workers for some of the world’s largest brands.

Solving the labor shortage by focusing on productivity

The labor shortage crisis has left industries scrambling for solutions. Rather than simply trying to fill the void with more labor, the focus should be on optimizing the existing workforce.

By enhancing the productivity of front-line workers, companies can not only meet the demands of the market but also reduce the need for additional labor. A connected workforce platform can improve the productivity of the front-line workers by 10% to 20% to help companies do more with less.

Empowering front-line workers with real-time connectivity

Innovapptive's connected workforce platform brings front-line workers, back-office, and assets together by providing them with the right information at the right time.

Operators can simply execute their inspections, rounds, and raise issues. These issues automatically convert into an ERP notification and get pushed to a maintenance technician to close out the open compliance issue, while keeping the operator in the loop in real-time. At the same time, the warehouse is alerted in real-time on the work order priorities and criticality to ensure spare part kits are ready for the technician’s pick up.

This effective communication and collaboration between operators, maintenance, and warehouses is a game-changer for asset intensive companies nationwide. Workers can access essential data and insights instantly, leading to smarter decision-making, quicker problem-solving, and improved operational efficiency.

Recently, Sabert, a sustainable packaging company, launched Innovapptive’s solution and is seeing dramatic improvement in productivity. Click here to watch the video.

Harnessing generative AI and cutting-edge AI/ML technology trends to upskill workers

To achieve dramatic productivity improvements upwards of 20%, companies need to leverage the power of generative AI and AI/ML technology trends.

Innovapptive's platform has launched a beta version of its generative AI capabilities, automating the creation of paper-based inspections, SOPs, and work instructions. Furthermore, the company recently launched a computer vision-based AI/ML inspection solution in partnership with Deloitte.

The solution allows an operator or an inspector to simply take an inspection image and the image is instantly analyzed to predict the condition of the equipment, criticality, and use generative AI to describe the problem to their maintenance teams. By converging technology trends such as cloud, mobile, generative AI, and AI/ML, Innovapptive is streamlining processes and eliminating bottlenecks, resulting in substantial productivity gains.

Furthermore, Innovapptive is expected to launch a video AI/ML technology in FY-24 to rapidly upskill workers. This trend allows employees to access on-demand training materials and instructional videos, reducing the learning curve and increasing proficiency. By facilitating continuous learning and development, companies can adapt to changing demands more effectively.

A brighter future for asset-intensive industries

The labor shortage is a nationwide concern that requires a unified approach. Rather than relying solely on more labor, companies can take advantage of Innovapptive's connected workforce platform to empower front-line workers, connect them in real time, capture critical information efficiently, and harness the power of generative AI and cutting-edge AI/ML technology trends.

This holistic approach not only dramatically improves productivity by 10% to 20% but also reduces the need for additional labor. By embracing video AI/ML technology, businesses can rapidly upskill their workers, ensuring they remain agile and adaptable in the face of evolving challenges. Together, we can build a brighter future for American industries and address the labor shortage crisis more effectively.

Some of the world's largest brands rely on Innovapptive's technology, platforms and software, including:

  • Shell Oil
  • Hess
  • Chevron Phillips Chemical
  • Dominion Energy
  • Jemena
  • Loudoun Water
  • Newmont Mining
  • AkzoNobel
  • Pluspetrol
  • EDF Renewables
  • Sabert
  • LiftOne
  • Par Pacific

Innovapptive is headquartered in Houston with offices across the globe in India, Europe, and Asia-Pacific. To learn more and see what Innovapptive can do for your company, visit here.

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