Houston-based oil field service company, Halliburton, has introduced its new startup incubator. Getty Images

Not intending to be left out of the energy transition, a Houston-based, multinational oil and gas services company has announced its new incubator for startups to advance cleaner, affordable energy.

Halliburton Company has introduced Halliburton Labs this week and named Houston-based Nanotech Inc., which uses nanotechnology for thermal insulation and fireproofing, as its first participant. Nanotech — along with future entrepreneurs and academics — will have access to the Halliburton facilities, the company's experts, and its network.

"Halliburton Labs reflects our commitment to the science and continued evolution of sustainable, reliable energy," says Jeff Miller, chairman, president, and CEO at Halliburton, in a news release. "We firmly believe that oil and gas will remain an affordable and reliable energy resource for decades to come. At the same time, we recognize the importance of developing alternative energy sources. We are excited to help advance solutions that have the potential for a long term, meaningful impact and that align well with our sustainability objectives."

The program will be based out of Halliburton's North Houston headquarters and will be led by executive director, Scott Gale. The primary focus of the incubator is to help advance and scale the participating startups, which includes developing and advancing products, securing financing and customers, and more.

Startups that will be considered for the program must be past the proof-of-concept phase, and a formal application process will roll out in September. According to the release, additional startup participants will be announced in the next few months. Meanwhile, Nanotech has already moved into the new lab at Halliburton.

"We also couldn't be more pleased to have Nanotech, Inc. as the first participant of Halliburton Labs," says Miller in the release. "Nanotech delivers technology that will change the way we think about energy conservation and fire safety across many sectors."

Nanotech's Nano Shield products can protect from fire damage as well as improve energy efficiency. Mike Francis, CEO and co-founder, launched Nanotech in 2019.

"We are incredibly excited to have been selected as an anchor for Halliburton Labs and help drive meaningful change and innovation in the energy sector," says Francis, in the release. "Access to Halliburton Labs' resources and world-class facilities will help accelerate our growth and deliver our transformative line of products. Through this collaboration, we intend to fundamentally shift the fireproofing and thermal insulation markets towards more effective and environmentally friendly solutions."

The Cannon hosted a B2B pitch night, and all three companies have a mission to change the world. Courtesy of The Cannon

3 Houston entrepreneurs changing the world with their B2B startups

On purpose

I think it's safe to say that most B2B startups don't have sustainability or a mission-driven purpose at the core of their business model. In fact, it's probably safe to say that about any for-profit company of any size.

Three Houston entrepreneurs pitched their companies at The Cannon's recent B2B pitch night, and they all have something in common: They're not normal B2B startups. Each company has a mission to change the way we're doing something — from hiring to construction — in a way that's better for the world.

Natalie Goodman, founder and CEO IncentiFind

Courtesy of IncentiFind

Natalie Goodman realized there was a disconnect between builders and green incentives the government provides.

"The government is strapped — they have all this money that they want to give away, but not the (marketing) money to get the word out," Goodman told InnovationMap last month. "That's where IncentiFind stepped in."

IncentiFind is a portal for green incentives and works in three steps. First, you do a search for green incentives in your area — this part is completely free to the commercial developer or home owner. Next, the user might opt to pay IncentiFind to find the exact incentives for the project and submits the applications for the project. The final step is a promise of a 10 times return on investment.

A million green projects are completed in the United States each year, and IncentiFind is getting in front of that by forming partnerships with lenders, commercial developers, architects, etc., Goodman says to the crowd. Read more about IncentiFind here.

Jeff Miller, CEO of Potentia

Courtesy of The Cannon

The facts and figures are pretty startling. One-in-40 school-age children are on the autism spectrum and one-in-five college-educated autistic individuals don't have a job when they graduate, Jeff Miller says during his pitch at The Cannon. Miller, who has a long career in staffing around the world, founded his company Potentia to help correct this growing employment problem.

"We're seeking to help employers build their 21st century workforce at the intersection of technology, leadership, and, most specifically, the autism spectrum," he says.

Potentia is a technology-focused recruitment firm with resources and opportunities for applicants on the Autism spectrum. For Miller, it's personal. His 16-year-old son has autism, and Miller wants a world where his son can have access to employment opportunities around the world.

"I think we're in a position to improve this model here in Houston, and take it to other cities," Miller says. "The reality is this is a challenge that exists in every major city."

Kim Raath, co-founder of Topl

Courtesy of Topl

Sure, blockchain is a major buzzword nowadays, but for Topl co-founder Kim Raath it means having the ability to track the sustainability of a purchase. Topl's technology is able to tell you if your diamond ring came from a war-torn country or if your coffee's farmer was paid fairly.

Raath says she's seen an increased need for sustainable and transparent businesses that can prove their impact, but it's expensive to do that.

"These businesses are spending so much money on trying to prove this impact," Raath says in her pitch at The Cannon. "We have customers spending close to 15 percent in operational expenses just to be able to trace their growth."

The company, founded by three Rice University students, is growing. In May, Raath says they have four new ventures being developed, and by 2020, they want to have 24 live ventures with a monthly revenue of over $30,000.

"At Topl, we are really going to change the world," Raath tells the crowd. "But I can prove it to you." Read more about Topl here.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”