Houston software development firm Axon is planning its Texas expansion thanks to its recent acquisition. Photo courtesy of Axon

For Owen D. Goode, Houstonians have a propensity for never being satisfied — and that's been extremely advantageous for his business.

“There’s this feeling in Houston of not being finished yet that I love,” says Goode. “Nobody is every fully satisfied in the best possible way. Nobody is sitting back and saying, ‘This is the best we could have done.’”

Goode, formerly the CEO of Axon, comes from an aviation background that includes operating as both pilot and mechanic. He now uses those skillsets in a very different world—helping to lead a company that focuses on system transformation. Axon, which was founded in 2017 was a boutique software firm focused on cloud engineering and data engineering.

This January, a larger company, Zaelot, led by CEO Jeff Lombard, acquired Axon. Zaelot is a global, software firm with a presence in 14 countries, mostly focused in the United States, Uruguay, and Iceland.

“Together we have a strong suite of offerings across a wide variety of domains including full-stack development, cloud/data engineering, design, staff augmentation, project management, and software architecture. We also have experience in multiple domains, including health care, aviation, defense, finance, and startups,” says Goode.

To the layman, this sounds impressive—and complicated—but what does Zaelot, actually do? Asked to explain at a kindergarten level, Goode says, “We take old code and make it less bad.”

With the motto, “Solve Today, Build Tomorrow,” Goode has worked with companies such as a major international airline to clean up its back end. Using a real estate analogy, Goode says that he and his team transform brownfield development environments (“a half-finished building that’s messy and there’s sewage everywhere”) into greenfield ones. It’s essentially a fresh start for sites that have become muddled over years of neglect.

“Health care is notoriously bad for that,” Goode says, though he is unable to disclose specific past or present clients.

Thanks to the merger with Zaelot, Goode and his team are now poised for rapid growth. Becoming part of a 100-person multinational company has now unlocked capital that Axon had never seen before. Goode promises rapid expansion in Texas, beginning in Houston in the next six months to a year. The executive—now Zaelot’s executive vice president—is already a well-known face on the Houston scene, where he regularly attends Cup of Joey and other Houston community events, such as CodeLaunch.

That growth includes gaining office space and expanding his staff in Space City.

“Zaelot's claim to fame is an extreme focus on employee satisfaction, with a 94 percent retention rate,” he says.

It’s his goal to keep those numbers up by serving the people who work for and with the company and treating them as human beings with families, not interchangeable parts. Next on the horizon, Goode says he and his team will be hiring sales and technical account management positions.

Though Zaelot’s staff is distributed around the world, Goode says Houston will always be home base for him. “It’s a literal launchpad that we’re continuing to grow off of,” he says. “I’m a big believer in Texas in general. And I’m just excited to see what happens.”

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”