The new Rice Nexus announced its latest partnership–this time with a global venture capital firm, More Than Capital. Image via Rice University.

Luxembourg-based venture capital and advisory firm MoreThan Capital (MTC) has established its first global office at the new Rice Nexus in Houston’s Ion District as part of a strategic partnership aimed at fostering entrepreneurship and growing Houston as an innovation hub.

MTC has committed to offering its “time, mentorship, industry expertise and global connections” to Rice Nexus. The state-of-the-art Rice Nexus, which opened earlier this year, aims to support and provide resources for ventures that are looking to scale and have "artificial intelligence (AI) as a central pillar of its innovation strategy," according to a statement from Rice.

“The Rice Nexus is a launchpad for world-changing ideas, and this partnership with MoreThan Capital is a key step in realizing that vision,” Sanjoy Paul, executive director of the Rice Nexus, said in a news release. “By combining Rice’s research and entrepreneurial talent with MTC’s global network and mentorship, we are creating an unparalleled engine for innovation that starts in Houston and reaches the world.”

MoreThan Capital has over 100 limited partners, including senior executives and professional investors, based in more than 35 countries.

“Establishing our first global office at the Rice Nexus within the Ion District is a significant milestone for MoreThan Capital,” Guillermo Ruiz, general partner of MoreThan Capital, said in a news release. “We are dedicated to partnering with top-tier academic institutions like Rice University and aligning with organizations that share our core values of trust, engagement and impact.”

The announcement comes just a few weeks after Rice Nexus announced its partnership with Google Public Sector to launch the new Rice AI Venture Accelerator, or RAVA.

Oxy, Fathom Fund, and Activate have new offices inside the Ion. Photo courtesy of the Ion

Energy, investment groups take up leases in Houston innovation hub

moving in

The Ion in Midtown has some new tenants taking up residence in its 90 percent-leased building.

Occidental Petroleum Corporation, Fathom Fund, and Activate are the latest additions to the Ion, according to a news release from Rice University and the Rice Real Estate Company, which own and operate the 16-acre Ion District where the Ion is located. With the additions, the building has just 10 percent left up for grabs.

“As the Ion continues to attract leading companies and organizations across industries, it’s clear that our vision of creating a dynamic and collaborative environment for innovation is resonating,” Ken Jett, president of the Rice Real Estate Company and vice president of facilities and capital planning at Rice, says in the release. “We are proud to set the standard for how the workplace can evolve to foster the commercialization and growth of transformative technologies that enhance quality of life in our community and beyond.”

Oxy, which was named a corporate partner of the Ion last year, now has nearly 6,500 square feet on the fourth floor. The build out process is slated to be completed by early 2025.

While Oxy represents the corporate side of innovation, the other two additions have their own roles in the innovation arena. Houston-based Fathom Fund, which launched its $100 million fund earlier this year, is targeting deep-tech venture opportunities and is led by Managing Partners Paul Sheng and Eric Bielke.

Founded in Berkeley, California, Activate, which announced its expansion into Houston in 2023, has officially named its local office in the Ion. The hardtech-focused incubator program recently named its inaugural cohort and opened applications for the 2025 program.

Other recent joiners to the Ion includes Kongsberg Digital, Artemis Energy Partners, CES Renewables, and Eleox.

“The partnerships we’ve forged are vital to shaping the Ion into a vibrant ecosystem for startups, where collaborative innovation is not only driving local economic growth but also positioning Houston as a global leader in the energy transition,” Paul Cherukuri, chief innovation officer at Rice University, says. “With our team leading the programming and activation across the Ion district, we are creating companies that harness cutting-edge technology for the benefit of society—advancing solutions that contribute to social good while addressing the most pressing challenges of our time. This powerful network is redefining Houston’s role in the future of energy, technology, and social impact.”

Here are over 10 can't-miss events for Houston innovators in June. Photo courtesy of Rice University

10+ can't-miss Houston business and innovation events for June

WHERE TO BE

From networking meetups to expert speaker summits, June is filled with opportunities for Houston innovators.

Here's a roundup of events you won't want to miss out on so mark your calendars and register accordingly.

Note: This post may be updated to add more events.


June 6 — Ion Block Party and Chef Showcase

On the first Thursday of each month, Block Party brings together startups, tech enthusiasts, and business visionaries in a dynamic and festive environment.

June’s special edition of Block Party will be a Chef Showcase! The District’s robust food and drink offerings showcase hyper-local concepts that reflect Houston’s reputation for having a culturally diverse restaurant industry.

This event is Thursday, June 6, from 4 to 7 pm at the Ion. Click here to register.

June 6 — Houston Blockchain Alliance Monthly Meetup

This in-person event is a great opportunity to connect with fellow blockchain enthusiasts in the Houston area. Whether you're a beginner or an expert, come and engage in lively discussions, share insights, and network with like-minded individuals. Discover the latest trends and advancements in blockchain technology while enjoying a friendly and casual atmosphere.

June's guest speaker, Alex Guerra of SYS Labs, will talk about DeFi today v. DeFi tomorrow. Alex is a business developer at SYS Labs and co-founder of Pachira Finance.

This event is Thursday, June 6, from 5:30 to 7:30 pm at The Cannon. Click here to register.

June 8 — Celebration of Entrepreneurship

Head to IAG Technology for an exciting evening dedicated to all things entrepreneurship. Whether you're a seasoned business owner or just starting out, this event has networking, learning, and celebrating the entrepreneurial spirit.

Come celebrate entrepreneurship and the launch of Earn On Purpose, a business mentoring and coaching company. At Earn on Purpose, entrepreneurship is simplified through solid fundamentals and practical strategies for success.

This event is Saturday, June 8, from 5 to 10 pm at IAG Technology. Click here to register.

June 10 — 2024 Energy Drone & Robotics Summit

Connect with 1500+ global energy & industrial robotics, drone & data leaders at a time of rapid growth in the robotics sector. Hear from expert speakers on the latest ideas, use cases, best practices, tech, and trends as innovators, regulators, the most energy asset owners & service firms and more break these topics down.

This event begins Monday, June 10, from 4 to 6:30 pm at The Woodlands Waterway Marriott. Click here to register.

June 11 — Software Day at the Ion: From Seed to Success

Software Day at the Ion is a program series hosted by the Ion and Mercury, where software founders can connect with mentorship at Houston’s HQ for innovation.

This monthly series provides support, inspiration, and connections needed to help startups on their path to rapid, sustainable growth. Each month, Software Day will include office hours (by application), a keynote session, and networking.

This event is Tuesday, June 11, from 3:30 to 7 pm at the Ion. Click here to register.

June 13 — 2024 Speaker Series: Dynamic Innovations in Energy Efficiency

Co-hosted by the TEPRI, in partnership with the Bullard Center for Environmental and Climate Justice, this event will spotlight just and effective strategies to boost energy efficiency, ensuring equitable access to sustainable energy solutions for all Texans. Keynote addresses by Dr. Robert D. Bullard, renowned environmental justice advocate and recipient of the 2024 Time Magazine Earth Award, and Donnel Baird, founder of BlocPower and inaugural recipient of TIME’s 2022 “Dreamer of the Year.”

The event is Thursday, June 13, from 2 to 4 pm at Melcher Hall. Click here to register.

June 13 — Out In Tech Monthly Mixer

Out in Tech Houston is the local chapter for Out in Tech, the world’s largest non-profit community of LGBTQ+ tech leaders. Check out their relaxed social-mixer event, hosted on the second Thursday of every month.

This event is Thursday, June 13, from 7 to 8:30 pm at Second Draught. Click here to register.

June 18 — Juneteenth Journey: Bridging Past and Present Through Technology

This special presentation will offer insights into the historical significance of Juneteenth, and illuminate the evolution of technology from the 1860s through World War II to modern Artificial Intelligence (AI) and the technology of today. Experts from the Buffalo Soldiers National Museum and Emancipation Park Conservancy will illustrate how technology has evolved as well as the parallels between the innovative spirit of the Buffalo Soldiers and today’s technological advancements, emphasizing the role of diversity and inclusion in driving innovation.

This event is Tuesday, June 18, from 10:30 am to 12:30 pm a the Ion. Click here to register.

June 20 — Visionary Voices: Leading Authentically with Woodside CEO Meg O’Neill

Celebrate Pride Month with a special edition of Ion’s “Visionary Voices” speaker series, featuring a powerful conversation between two leaders who’ve paved the way for LGBTQ+ representation in their respective fields – Woodside Energy CEO Meg O’Neill and former Houston Mayor Annise Parker. Attendees will gain insights into the unique experiences and milestones that have shaped both Meg and Annise’s careers, as well as the importance of visibility and representation in corporate leadership and public service.

This event is Thursday, June 20, from 3:30 to 6 pm at the Ion. Click here to register.

June 25 — State of AI: Generating Real Business Value with AI

This comprehensive one-day free event organized by the Houston-based CODE Group is designed to equip decision-makers, C-level executives, and software developers with strategies to harness AI effectively. The event kicks off with a keynote from Markus Egger, Microsoft Regional Director, on “Harnessing AI for Tangible Business Outcomes,” setting the stage by demonstrating how AI can integrate seamlessly into business applications to enhance productivity and innovation.

This event is Tuesday, June 25, from 9 am to 5 pm at the Ion. Click here to register.

June 28 — Young Professional Climate & Career Mixer

Climate Connect is a community resilience education and engagement program launching in Houston, Texas and powered by the Coalition of Community Organizations and Verizon. This meetup is for those interested in networking, learning, and exploring career opportunities in the field of climate change. The event will take place at 6500 Rookin Street, Houston, TX 77074 (Building E), where you can connect with like-minded individuals, meet industry professionals, and discover new, green career paths.

This event is Friday, June 28, from 5:30 to 7 pm at 6500 Rookin St. Click here to register.

Houston-based energy tech investor Neal Dikeman writes his observations on Houston's venture capital and startup community's growth — in stark comparison of Silicon Valley's recent evolution. Photo courtesy of the Ion

VC investor: Houston's energy tech ecosystem grows as Bay Area activity seemingly slows

guest column

There's stretch of sleek low rise office buildings in Palo Alto — referred to as Sandhill Road — that has long been the center of Silicon Valley (and the world’s) venture capital sector. An investor friend of mine told me recently that Sandhill Road is a ghost town these days, with the key partners at many of the Silicon Valley venture funds largely working from home or at their second homes.

That’s disappointing if true, but not surprising. Commuting sucks, and this business is a lot more far flung and global than it used to be. The venture capital business is always a wild and fun ride, focused on founders and the next big thing, with constant movement and alliances and partnerships.

I’ve been in these waves since I began investing during the dotcom boom in 2000, making the jump from private equity to venture capital in San Francisco at a fund behind Yellowpages.com and a few others, before co-leading a prior firm I founded in San Francisco doing seed investing and advising funds and investment arms of Macquarie Bank, ConocoPhillips, and Shell. We got in on the ground floor of cleantech and did well. This is my third major VC downcycle – there is always opportunity on both sides, and the more things change, the more they stay the same in venture capital. Hubs matter, because the business is heavily a critical mass of talent and capital business, with a power curve of outcomes. Cutthroat as venture capital and startups are, it is not private equity. You do need partners.

Houston has long lacked a center of gravity at all, let alone in tech. You might try rereading the 2001 Economist headline article “The Blob that Ate East Texas” for some humorous color on that score. But in tech, that’s changing.

Rice University’s Ion Houston innovation district project came out of some of the Greater Houston Partnership work a few years ago on how to get a serious tech hub going (I briefly served on the GHP affiliated Houston Technology Center board for Royal Dutch Shell during that revamp). After a slow start, Ion has begun to fill up with tech startups and bona fide check writing investors to go with the constant barrage of startup programming on its Ion Activation Floor and adjacent Greentown Labs incubation building.

Chevron Technology Ventures opened a guest office on day one on the third floor and Houston private equity and sometime crossover VC investor Ara Partners took early space with its headquarters in the building across the hall from them. Local fund of funds HX Venture Fund, which was created out of that GHP/HTC revamp and also puts on the Venture Houston Conference, moved in on the second floor.

Our fund, Energy Transition Ventures, was the first venture capital fund to move into the Ion when we launched in 2021, is located two doors down from HXVF. My partners and I made the call to make Houston our headquarters over Austin where my partner, Craig Lawrence, is located. He’s a former energy tech and solar executive who learned venture investing leading the successful cleantech effort at Accel Partners in Palo Alto. We are both Texas educated, Bay Area venture capital alums who are doing venture capital in Texas because it’s our home. Our third partner, Q Song, moved from Korea to the US, picking Houston over Austin and our Bay Area office to join us.

Houston was not the obvious choice – it still isn’t – I got nostalgia when driving through Austin and San Francisco in the last week seeing the sheer mass of tech and venture capital names to do business with, but doing things our own way is kind of our brand. We chose the Ion, because well, venture capital and startup life is a participation not a spectator sport, and if Houston was ever going to have a shot at being an investment hub, it needed an actual hub, and founders needed a place to go meet venture capitalists, and that won’t work if venture capitalists all work out of their homes or alone in some energy corridor or downtown high rise.

In our hallway of the Ion, you pass HX Venture Fund, Decarbonization Partners, Energy Transition Ventures, and WaterLens, a water testing startup which spun out of UT many years ago, all next door to each other at one end. And at the other end BP Ventures — with a newly added ExxonMobil venture capital team guest suite adjacent — next to water and energy pipeline corrosion detection software and hardware startup INGU, a Chevron Technology Ventures-backed startup, which is adjacent to one of Houston’s largest venture-backed SaaS companies, Liongard. That’s a half a dozen tech startup founders and a dozen investors across all stages in 125 feet.

I can count approximately 20 other startups in the building now, still heavily skewed to energy. Across the floor, Artemis Energy Partners and Veriten, run respectively by Houston energy fixtures Bobby Tudor and Maynard Holt two of the three Tudor Pickering Holt founders, have their offices, with Schlumberger and hydrogen software startup Velostics which just announced its seed round sandwiched in between. The co-founder of Tierra Climate, a Rice spinout that also just announced its seed round works out of the coworking, and Eigen Controls is building GHG detection equipment around the corner a few feet from an Edtech and medtech startup, and renewable energy services startup Clean Energy Services is headquartered a few feet from the entrance.

Since we moved in, GOOSE Capital, a Houston investment group launched out of Rice at the Rice Alliance Business Competition two decades ago, put its offices in the Ion Activation Floor, and you can quietly find their Managing Director Andrew Nicholson trooping up and down the stairs. BP Ventures then pulled the trigger in 2022 – and moved its US venture capital investing team HQ to the Ion — right down the hallway from us. Chad Bown who manages the US team is sitting in a phone booth 100 feet from me and Chris Spears is listening on pitches as I type this. And this month Decarbonization Partners, the climate growth fund of BlackRock and Temasek, opened its office next door to mine in between us and HX, with three investment professionals, led by David Hayes, formerly with BP Ventures. Aramco Ventures, now led by the former Energy Ventures US head Jim Sledzik, began weekly Friday morning office hours. Jim can often be grabbed for a casual chat on his way between meetings on a regular basis, as can Luis Alcoser or Kemal Anbarci who pop in and out of the Chevron Technology Ventures visiting offices on third floor, with Veriten, which just announced an investment fund, and now Artemis joining recently.

The Houston pool of high quality founders and startups has definitely improved as well – though we still don’t have the quantity or quality of teams needed for a healthy startup market. Blair Garrou from Mercury Fund was part of a recent panel for the Texas Venture Crawl at the Ion along with BP Ventures’ Ion based Grace Chan talking about why Houston, and he remarked that in their earlier funds, Mercury was 5 to 10 percent Houston startups, having to go far afield to fill up even one fund - but his recent fund is closer to 25 percent Houston based, as local team quality has improved.

Houston venture capital is two orders of magnitude smaller than the Bay Area – it’s about like writing an article asking whether Silicon Valley is the emerging Energy Corridor. But it’s nice to have coffee and beers with next door neighbors who are actually investing in, and founders who are actually running, venture backed businesses. Founders are learning that Houston’s venture investment and tech scene has an actual home these days, and is open for business.

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Neal Dikeman is a venture capitalist and seven-time startup co-founder investing out of Energy Transition Ventures.

Michelle Stansbury, vice president of innovation and IT applications at Houston Methodist, joins the Houston Innovators Podcast. Photo courtesy of Houston Methodist

Houston innovator powers health care innovation by collaboration — inside and outside of the hospital setting

HOUSTON INNOVATORS PODCAST EPISODE 202

It might surprise most to know that Houston Methodist doesn't have an innovation department within their hospital system — at least not one set up as you'd imagine, with a team specifically dedicated to innovation. Instead, Houston Methodist's Digital Innovation Obsessed People, or DIOP, consists of leaders across departments.

Michelle Stansbury is one of those leaders. As vice president of innovation and IT applications at Houston Methodist, she oversees the system's IT department and serves as a leader within its innovation efforts. This includes the Center for Innovation Technology Hub — which opened in 2020 in the Texas Medical Center location and opened its Ion outpost last week.

Stansbury explains on the Houston Innovators Podcast how effective this distribution of innovation responsibilities has been for Houston Methodist. With everyone having a seat at the table — operations knows the biggest problems that need solutions, IT knows how to deploy technology, etc. — implementation of new innovations has been sped up.

"If we partner together, we should be able to succeed fast or fail fast," she says on the show. "We've been able to find a solution, pilot it, and, if it works well, roll it out at a speed that most other organizations have not been able to do. It's been highly successful for us."

The newest way Houston Methodist is mixing up how it brings in innovative solutions to its team and patients is by taking its team outside of the Texas Medical Center and its hospitals in general. Now, Houston Methodist has a permanent tech hub in the Ion, owned and operated by Rice Management Company, on the lower level of the building, completely open to any of the Ion's visitors.

"We've always had a great partnership with Rice. This almost felt like an extension with Houston Methodist and our Rice collaboration with the Ion," Stansbury says. "Our main goals have been how can we utilize the talent that's housed out of that facility."

She explains that the new hub is an extension of the original hub in the TMC hospital, and that innovators who are interested in collaborating with Houston Methodist — especially those with solutions applicable to health care — can visit the Ion hub as an entry point.

Both hub locations showcase pilot technology Houston Methodist is working on, and that technology will then get deployed out into its hospital locations — and especially its Cypress hospital, which is being billed as being the "smart hospital of the future." The construction is underway and expected to deliver in 2025.

Stansbury shares more about this ninth location for Houston Methodist as well as more details on the new tech hub on the podcast. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

Houston Methodist opened a new tech hub in the Ion this week. Photo by Shannon O’Hara/Ion

Photos: Houston hospital opens tech hub in the Ion

innovation outpost

A Houston hospital has opened an innovation outpost in the Ion this week in order to showcase health tech innovation and connect with Houston innovators.

The Houston Methodist Tech Hub at Ion hub has officially opened. The 1,200-square-foot space was created in addition to the Center for Innovation Technology Hub that's in Houston Methodist’s flagship location in the Texas Medical Center, which opened in February 2020.

The new space, located on the lower level of the Ion, exists to serve as a common ground for innovators across industries to promote collisions and innovation, as well as interaction with Houston Methodist team members

“Our new Tech Hub at Ion supports not only our commitment to the Houston innovation community but also to the rapidly shifting healthcare industry,” Michelle Stansbury, vice president of innovation and IT applications at Houston Methodist, says in a statement. “We know we can’t solve the healthcare challenges of the future if we confine ourselves within our hospital walls or even within our own industry.

"We look forward to the collaborative space our new Tech Hub will provide and the future programming opportunities we can create together to inspire, challenge, and foster a spirit of innovation in our city.”

The new hub, according to the news release, also will host educational events, reverse pitch sessions, and more. Visitors can schedule a time to view the space or connect with the Houston Methodist innovation team by filling out a form online.

The hub, which was originally announced last year, is the latest partner to open within the Ion's space. Earlier this year, the organization announced other new tenants.

“Houston Methodist’s space at the Ion opens up even more opportunities for our start-up and entrepreneur community to embed and gain exposure to the latest innovations in health care, health technology, and digital health,” Jan E. Odegard, executive director of Ion, says. “This partnership and opportunity provided by Houston Methodist, a leading healthcare organization in the country, is a testament to the ecosystem we’re building and the talent within our building. Furthermore, Houston Methodist’s approach and appetite for cross-industry innovation and collaboration meshes seamlessly with the Ion’s ongoing plans to support Houston’s growing innovation community in industries and fields that will change the world.”

Both of Houston Methodist's tech hubs will showcase its latest technologies its implementing in its hospital system, including the "hospital of the future" it's building out in Cypress.

Collaborative effort

Photo by Shannon O’Hara/Ion

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Greentown Labs names Lawson Gow as its new Houston leader

head of hou

Greentown Labs has named Lawson Gow as its Head of Houston.

Gow is the founder of The Cannon, a coworking space with seven locations in the Houston area, with additional partner spaces. He also recently served as managing partner at Houston-based investment and advisory firm Helium Capital. Gow is the son of David Gow, founder of Energy Capital's parent company, Gow Media.

According to Greentown, Gow will "enhance the founder experience, cultivate strategic partnerships, and accelerate climatetech solutions" in his new role.

“I couldn’t be more excited to join Greentown at this critical moment for the energy transition,” Gow said in a news release. “Greentown has a fantastic track record of supporting entrepreneurs in Houston, Boston, and beyond, and I am eager to keep advancing our mission in the energy transition capital of the world.”

Gow has also held analyst, strategy and advising roles since graduating from Rice University.

“We are thrilled to welcome Lawson to our leadership team,” Georgina Campbell Flatter, CEO of Greentown Labs, added in the release. “Lawson has spent his career building community and championing entrepreneurs, and we look forward to him deepening Greentown’s support of climate and energy startups as our Head of Houston.”

Gow is the latest addition to a series of new hires at Greentown Labs following a leadership shakeup.

Flatter was named as the organization's new CEO in February, replacing Kevin Dutt, Greentown’s interim CEO, who replaced Kevin Knobloch after he announced that he would step down in July 2024 after less than a year in the role.

Greentown also named Naheed Malik its new CFO in January.

Timmeko Moore Love was named the first Houston general manager and senior vice president of Greentown Labs. According to LinkedIn, she left the role in January.

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.