From the fourth annual Tejano Tech Summit to the first-ever Ion Family Tech Festival, here's what not to miss this month. Image courtesy the Ion

Editor's note: Houston's October calendar is packed with informative and impactful events—plus a few fun ones, too. From the fourth annual Tejano Tech Summit to the first-ever Ion Family Tech Festival, here's what not to miss and how to register. Please note: this article may be updated to include additional event listings.

Oct. 3 — Houston Methodist Joy in Medicine Initiative Symposium

The Houston Methodist Joy in Medicine Initiative Symposium will explore the power of connection in enhancing professional fulfillment for clinicians and healthcare teams, this year under the theme “The Power of We.” Hear from Dr. Shlomit Schall, Houston Methodist Physician Organization president and CEO and chief physician executive, and Dr. J. Bryan Sexton, director of the Duke Center for Advancement and Well-being Science. Stick around for a networking happy hour.

This event is Friday, Oct. 3, from 8:30 a.m.-4:30 p.m. at the InterContinental Houston. Find more information here.

Oct. 6-10 — Surgical Technology & Robotic Surgery Summit (STaRS)

Surgeons, engineers, researchers and innovators can explore the latest advancements in surgical robotics, imaging and AI-integrated technologies at this year’s Surgical Technology & Robotic Surgery Summit. They can also take in the inaugural Surgical Technology & Robotic Surgery Innovator Competition. The summit will feature live demonstrations, interactive panels and cutting-edge research.

This event begins Monday, Oct. 6, at MITIE at The Bookout Center. Find more information here.

Oct. 7 — SUPERGirlsInSTEM Summit: The Intersection of AI & Workforce

The SUPERGirls SHINE Foundation presents its SUPERGirlsInSTEM Summit, where attendees can take part in open discussions, networking and workshops while learning about AI skills that can advance college studies and entry into the workforce.

This event is Tuesday, Oct. 7, from 9 a.m.-1 p.m. at the Ion. Find more information here.

Oct. 7 — Future of Health Care: Thought Leader Series

Hear from Rice University President Reginald DesRoches, and Kristen Doyle, CEO of the Cancer Prevention and Research Institute of Texas, at the Greater Houston Partnership’s Future of Health Care: Thought Leader Series. The expert panel will discuss key topics, including the proposed Dementia Prevention and Research Institute of Texas (DPRIT), Rice's Momentous strategic plan and "critical role of public health systems and cross-sector partnerships in advancing access, equity, and workforce readiness."

This event is Tuesday, Oct. 7, from 9-10:15 a.m. at The Partnership Tower. Find more information here.

Oct 7-9 — Tejano Tech Summit Week

LSA Global will present its fourth annual Tejano Tech Summit Week. The week will feature happy hours, networking opportunities and a founders dinner, along with talks from Mariela Salas, co-founder and partner of Alma Fund; Latina in Tech Houston, Blue People, The Magnolia Fund and others.

This event starts on Tuesday, Oct. 7, with most events taking place at the Ion. Find more information here.

Oct. 8 — Digital Health Institute Launch event

Celebrate the launch of the Houston Methodist-Rice Digital Health Institute, which aims to translate “innovative ideas into scalable solutions” with a focus on engineering, digital health and artificial intelligence. The event will feature presentations from Houston Methodist clinical researchers and Rice University faculty, a startup and industry panel and a venture capital investment panel.

This event is Wednesday, Oct. 8, from 8 a.m.-6:30 p.m. at Rice University's Duncan Hall - McMurtry Hall. Find more information here.

Oct. 8 — Founders Live Houston

Founders Live Houston returns this month with its happy hour pitch event. The global competition will select five Texas founders to present 99-second pitches and participate in a four-minute audience Q&A. Voters decide the winner.

This event is Thursday, Oct. 8, from 6-8 p.m. at the Ion. Find more information here.

Oct. 14 — NASA Stories at the Ion

Dina Contella, deputy manager of NASA’s International Space Station Program, will speak at this month's NASA Stories event. Contella will share insights from her career overseeing International Space Station operations, shaping Artemis missions and guiding real-time decisions in Mission Control.

This event is Tuesday, Oct. 14, from 8:30-10:30 a.m. at the Ion. Find more information here.

Oct. 16 — Impact Hub Houston Celebrates 7 Years in Community + Open Project Night

Celebrate seven years of Impact Hub Houston with a hands-on learning experience focused on hosting. The organization will share the tools, practices and hosting frameworks that have helped it build community and support local changemakers since it launched in 2018. Afterward, participate in Impact Hub's signature Open Project Night, where developers can come together to work on solutions for some of Houston’s most pressing issues.

These events are on Thursday, Oct. 16, at the Ion. The anniversary party is from 2-5 p.m. and Open Project Night begins at 5:30 p.m. Find more information here and here.

Oct. 16 — Future of Global Energy presented by Shell

Industry leaders, academia, and government will "explore the forces shaping the future of energy" at the Greater Houston Partnership's fifth annual Future of Global Energy Conference. Andy Karsner, chief strategist for energy and innovation at X, Alphabet’s Moonshot Factory, and a former U.S. Assistant Secretary of Energy, will present the keynote address. Speakers from companies Fervo Energy, S&P Global, Bechtel and others will also be featured on panels and in fireside chats. The event will culminate in Houston's first National Labs Day, where attendees can engage with leaders and technology specialists from Argonne National Laboratory, Brookhaven National Laboratory and other institutions.

This event is Thursday, Oct. 16, from 9 a.m.-3:30 p.m. Find more information here.

Oct. 23 — NASA Tech Talks

Every fourth Thursday of the month, NASA experts, including longtime engineer Montgomery Goforth, present on technology development challenges NASA’s Johnson Space Center and the larger aerospace community are facing and how they can be leveraged by Houston’s innovation community. Stick around after for drinks and networking at Second Draught.

This event is Thursday, Oct. 23, from 6-7 p.m. at the Ion. Find more information here.

Oct. 25 — Ion Family Tech Festival

The Ion and partners will present the first-ever Ion Family Tech Fest this month, where families can participate in hands-on STEAM experiences.

This event is Saturday, Oct. 25, from 10 a.m.-1 p.m. at the Ion. Find more information here.

The new Rice Nexus announced its latest partnership–this time with a global venture capital firm, More Than Capital. Image via Rice University.

VC firm partners with Rice Nexus to open first global office

strategic partnership

Luxembourg-based venture capital and advisory firm MoreThan Capital (MTC) has established its first global office at the new Rice Nexus in Houston’s Ion District as part of a strategic partnership aimed at fostering entrepreneurship and growing Houston as an innovation hub.

MTC has committed to offering its “time, mentorship, industry expertise and global connections” to Rice Nexus. The state-of-the-art Rice Nexus, which opened earlier this year, aims to support and provide resources for ventures that are looking to scale and have "artificial intelligence (AI) as a central pillar of its innovation strategy," according to a statement from Rice.

“The Rice Nexus is a launchpad for world-changing ideas, and this partnership with MoreThan Capital is a key step in realizing that vision,” Sanjoy Paul, executive director of the Rice Nexus, said in a news release. “By combining Rice’s research and entrepreneurial talent with MTC’s global network and mentorship, we are creating an unparalleled engine for innovation that starts in Houston and reaches the world.”

MoreThan Capital has over 100 limited partners, including senior executives and professional investors, based in more than 35 countries.

“Establishing our first global office at the Rice Nexus within the Ion District is a significant milestone for MoreThan Capital,” Guillermo Ruiz, general partner of MoreThan Capital, said in a news release. “We are dedicated to partnering with top-tier academic institutions like Rice University and aligning with organizations that share our core values of trust, engagement and impact.”

The announcement comes just a few weeks after Rice Nexus announced its partnership with Google Public Sector to launch the new Rice AI Venture Accelerator, or RAVA.

Oxy, Fathom Fund, and Activate have new offices inside the Ion. Photo courtesy of the Ion

Energy, investment groups take up leases in Houston innovation hub

moving in

The Ion in Midtown has some new tenants taking up residence in its 90 percent-leased building.

Occidental Petroleum Corporation, Fathom Fund, and Activate are the latest additions to the Ion, according to a news release from Rice University and the Rice Real Estate Company, which own and operate the 16-acre Ion District where the Ion is located. With the additions, the building has just 10 percent left up for grabs.

“As the Ion continues to attract leading companies and organizations across industries, it’s clear that our vision of creating a dynamic and collaborative environment for innovation is resonating,” Ken Jett, president of the Rice Real Estate Company and vice president of facilities and capital planning at Rice, says in the release. “We are proud to set the standard for how the workplace can evolve to foster the commercialization and growth of transformative technologies that enhance quality of life in our community and beyond.”

Oxy, which was named a corporate partner of the Ion last year, now has nearly 6,500 square feet on the fourth floor. The build out process is slated to be completed by early 2025.

While Oxy represents the corporate side of innovation, the other two additions have their own roles in the innovation arena. Houston-based Fathom Fund, which launched its $100 million fund earlier this year, is targeting deep-tech venture opportunities and is led by Managing Partners Paul Sheng and Eric Bielke.

Founded in Berkeley, California, Activate, which announced its expansion into Houston in 2023, has officially named its local office in the Ion. The hardtech-focused incubator program recently named its inaugural cohort and opened applications for the 2025 program.

Other recent joiners to the Ion includes Kongsberg Digital, Artemis Energy Partners, CES Renewables, and Eleox.

“The partnerships we’ve forged are vital to shaping the Ion into a vibrant ecosystem for startups, where collaborative innovation is not only driving local economic growth but also positioning Houston as a global leader in the energy transition,” Paul Cherukuri, chief innovation officer at Rice University, says. “With our team leading the programming and activation across the Ion district, we are creating companies that harness cutting-edge technology for the benefit of society—advancing solutions that contribute to social good while addressing the most pressing challenges of our time. This powerful network is redefining Houston’s role in the future of energy, technology, and social impact.”

Here are over 10 can't-miss events for Houston innovators in June. Photo courtesy of Rice University

10+ can't-miss Houston business and innovation events for June

WHERE TO BE

From networking meetups to expert speaker summits, June is filled with opportunities for Houston innovators.

Here's a roundup of events you won't want to miss out on so mark your calendars and register accordingly.

Note: This post may be updated to add more events.


June 6 — Ion Block Party and Chef Showcase

On the first Thursday of each month, Block Party brings together startups, tech enthusiasts, and business visionaries in a dynamic and festive environment.

June’s special edition of Block Party will be a Chef Showcase! The District’s robust food and drink offerings showcase hyper-local concepts that reflect Houston’s reputation for having a culturally diverse restaurant industry.

This event is Thursday, June 6, from 4 to 7 pm at the Ion. Click here to register.

June 6 — Houston Blockchain Alliance Monthly Meetup

This in-person event is a great opportunity to connect with fellow blockchain enthusiasts in the Houston area. Whether you're a beginner or an expert, come and engage in lively discussions, share insights, and network with like-minded individuals. Discover the latest trends and advancements in blockchain technology while enjoying a friendly and casual atmosphere.

June's guest speaker, Alex Guerra of SYS Labs, will talk about DeFi today v. DeFi tomorrow. Alex is a business developer at SYS Labs and co-founder of Pachira Finance.

This event is Thursday, June 6, from 5:30 to 7:30 pm at The Cannon. Click here to register.

June 8 — Celebration of Entrepreneurship

Head to IAG Technology for an exciting evening dedicated to all things entrepreneurship. Whether you're a seasoned business owner or just starting out, this event has networking, learning, and celebrating the entrepreneurial spirit.

Come celebrate entrepreneurship and the launch of Earn On Purpose, a business mentoring and coaching company. At Earn on Purpose, entrepreneurship is simplified through solid fundamentals and practical strategies for success.

This event is Saturday, June 8, from 5 to 10 pm at IAG Technology. Click here to register.

June 10 — 2024 Energy Drone & Robotics Summit

Connect with 1500+ global energy & industrial robotics, drone & data leaders at a time of rapid growth in the robotics sector. Hear from expert speakers on the latest ideas, use cases, best practices, tech, and trends as innovators, regulators, the most energy asset owners & service firms and more break these topics down.

This event begins Monday, June 10, from 4 to 6:30 pm at The Woodlands Waterway Marriott. Click here to register.

June 11 — Software Day at the Ion: From Seed to Success

Software Day at the Ion is a program series hosted by the Ion and Mercury, where software founders can connect with mentorship at Houston’s HQ for innovation.

This monthly series provides support, inspiration, and connections needed to help startups on their path to rapid, sustainable growth. Each month, Software Day will include office hours (by application), a keynote session, and networking.

This event is Tuesday, June 11, from 3:30 to 7 pm at the Ion. Click here to register.

June 13 — 2024 Speaker Series: Dynamic Innovations in Energy Efficiency

Co-hosted by the TEPRI, in partnership with the Bullard Center for Environmental and Climate Justice, this event will spotlight just and effective strategies to boost energy efficiency, ensuring equitable access to sustainable energy solutions for all Texans. Keynote addresses by Dr. Robert D. Bullard, renowned environmental justice advocate and recipient of the 2024 Time Magazine Earth Award, and Donnel Baird, founder of BlocPower and inaugural recipient of TIME’s 2022 “Dreamer of the Year.”

The event is Thursday, June 13, from 2 to 4 pm at Melcher Hall. Click here to register.

June 13 — Out In Tech Monthly Mixer

Out in Tech Houston is the local chapter for Out in Tech, the world’s largest non-profit community of LGBTQ+ tech leaders. Check out their relaxed social-mixer event, hosted on the second Thursday of every month.

This event is Thursday, June 13, from 7 to 8:30 pm at Second Draught. Click here to register.

June 18 — Juneteenth Journey: Bridging Past and Present Through Technology

This special presentation will offer insights into the historical significance of Juneteenth, and illuminate the evolution of technology from the 1860s through World War II to modern Artificial Intelligence (AI) and the technology of today. Experts from the Buffalo Soldiers National Museum and Emancipation Park Conservancy will illustrate how technology has evolved as well as the parallels between the innovative spirit of the Buffalo Soldiers and today’s technological advancements, emphasizing the role of diversity and inclusion in driving innovation.

This event is Tuesday, June 18, from 10:30 am to 12:30 pm a the Ion. Click here to register.

June 20 — Visionary Voices: Leading Authentically with Woodside CEO Meg O’Neill

Celebrate Pride Month with a special edition of Ion’s “Visionary Voices” speaker series, featuring a powerful conversation between two leaders who’ve paved the way for LGBTQ+ representation in their respective fields – Woodside Energy CEO Meg O’Neill and former Houston Mayor Annise Parker. Attendees will gain insights into the unique experiences and milestones that have shaped both Meg and Annise’s careers, as well as the importance of visibility and representation in corporate leadership and public service.

This event is Thursday, June 20, from 3:30 to 6 pm at the Ion. Click here to register.

June 25 — State of AI: Generating Real Business Value with AI

This comprehensive one-day free event organized by the Houston-based CODE Group is designed to equip decision-makers, C-level executives, and software developers with strategies to harness AI effectively. The event kicks off with a keynote from Markus Egger, Microsoft Regional Director, on “Harnessing AI for Tangible Business Outcomes,” setting the stage by demonstrating how AI can integrate seamlessly into business applications to enhance productivity and innovation.

This event is Tuesday, June 25, from 9 am to 5 pm at the Ion. Click here to register.

June 28 — Young Professional Climate & Career Mixer

Climate Connect is a community resilience education and engagement program launching in Houston, Texas and powered by the Coalition of Community Organizations and Verizon. This meetup is for those interested in networking, learning, and exploring career opportunities in the field of climate change. The event will take place at 6500 Rookin Street, Houston, TX 77074 (Building E), where you can connect with like-minded individuals, meet industry professionals, and discover new, green career paths.

This event is Friday, June 28, from 5:30 to 7 pm at 6500 Rookin St. Click here to register.

Houston-based energy tech investor Neal Dikeman writes his observations on Houston's venture capital and startup community's growth — in stark comparison of Silicon Valley's recent evolution. Photo courtesy of the Ion

VC investor: Houston's energy tech ecosystem grows as Bay Area activity seemingly slows

guest column

There's stretch of sleek low rise office buildings in Palo Alto — referred to as Sandhill Road — that has long been the center of Silicon Valley (and the world’s) venture capital sector. An investor friend of mine told me recently that Sandhill Road is a ghost town these days, with the key partners at many of the Silicon Valley venture funds largely working from home or at their second homes.

That’s disappointing if true, but not surprising. Commuting sucks, and this business is a lot more far flung and global than it used to be. The venture capital business is always a wild and fun ride, focused on founders and the next big thing, with constant movement and alliances and partnerships.

I’ve been in these waves since I began investing during the dotcom boom in 2000, making the jump from private equity to venture capital in San Francisco at a fund behind Yellowpages.com and a few others, before co-leading a prior firm I founded in San Francisco doing seed investing and advising funds and investment arms of Macquarie Bank, ConocoPhillips, and Shell. We got in on the ground floor of cleantech and did well. This is my third major VC downcycle – there is always opportunity on both sides, and the more things change, the more they stay the same in venture capital. Hubs matter, because the business is heavily a critical mass of talent and capital business, with a power curve of outcomes. Cutthroat as venture capital and startups are, it is not private equity. You do need partners.

Houston has long lacked a center of gravity at all, let alone in tech. You might try rereading the 2001 Economist headline article “The Blob that Ate East Texas” for some humorous color on that score. But in tech, that’s changing.

Rice University’s Ion Houston innovation district project came out of some of the Greater Houston Partnership work a few years ago on how to get a serious tech hub going (I briefly served on the GHP affiliated Houston Technology Center board for Royal Dutch Shell during that revamp). After a slow start, Ion has begun to fill up with tech startups and bona fide check writing investors to go with the constant barrage of startup programming on its Ion Activation Floor and adjacent Greentown Labs incubation building.

Chevron Technology Ventures opened a guest office on day one on the third floor and Houston private equity and sometime crossover VC investor Ara Partners took early space with its headquarters in the building across the hall from them. Local fund of funds HX Venture Fund, which was created out of that GHP/HTC revamp and also puts on the Venture Houston Conference, moved in on the second floor.

Our fund, Energy Transition Ventures, was the first venture capital fund to move into the Ion when we launched in 2021, is located two doors down from HXVF. My partners and I made the call to make Houston our headquarters over Austin where my partner, Craig Lawrence, is located. He’s a former energy tech and solar executive who learned venture investing leading the successful cleantech effort at Accel Partners in Palo Alto. We are both Texas educated, Bay Area venture capital alums who are doing venture capital in Texas because it’s our home. Our third partner, Q Song, moved from Korea to the US, picking Houston over Austin and our Bay Area office to join us.

Houston was not the obvious choice – it still isn’t – I got nostalgia when driving through Austin and San Francisco in the last week seeing the sheer mass of tech and venture capital names to do business with, but doing things our own way is kind of our brand. We chose the Ion, because well, venture capital and startup life is a participation not a spectator sport, and if Houston was ever going to have a shot at being an investment hub, it needed an actual hub, and founders needed a place to go meet venture capitalists, and that won’t work if venture capitalists all work out of their homes or alone in some energy corridor or downtown high rise.

In our hallway of the Ion, you pass HX Venture Fund, Decarbonization Partners, Energy Transition Ventures, and WaterLens, a water testing startup which spun out of UT many years ago, all next door to each other at one end. And at the other end BP Ventures — with a newly added ExxonMobil venture capital team guest suite adjacent — next to water and energy pipeline corrosion detection software and hardware startup INGU, a Chevron Technology Ventures-backed startup, which is adjacent to one of Houston’s largest venture-backed SaaS companies, Liongard. That’s a half a dozen tech startup founders and a dozen investors across all stages in 125 feet.

I can count approximately 20 other startups in the building now, still heavily skewed to energy. Across the floor, Artemis Energy Partners and Veriten, run respectively by Houston energy fixtures Bobby Tudor and Maynard Holt two of the three Tudor Pickering Holt founders, have their offices, with Schlumberger and hydrogen software startup Velostics which just announced its seed round sandwiched in between. The co-founder of Tierra Climate, a Rice spinout that also just announced its seed round works out of the coworking, and Eigen Controls is building GHG detection equipment around the corner a few feet from an Edtech and medtech startup, and renewable energy services startup Clean Energy Services is headquartered a few feet from the entrance.

Since we moved in, GOOSE Capital, a Houston investment group launched out of Rice at the Rice Alliance Business Competition two decades ago, put its offices in the Ion Activation Floor, and you can quietly find their Managing Director Andrew Nicholson trooping up and down the stairs. BP Ventures then pulled the trigger in 2022 – and moved its US venture capital investing team HQ to the Ion — right down the hallway from us. Chad Bown who manages the US team is sitting in a phone booth 100 feet from me and Chris Spears is listening on pitches as I type this. And this month Decarbonization Partners, the climate growth fund of BlackRock and Temasek, opened its office next door to mine in between us and HX, with three investment professionals, led by David Hayes, formerly with BP Ventures. Aramco Ventures, now led by the former Energy Ventures US head Jim Sledzik, began weekly Friday morning office hours. Jim can often be grabbed for a casual chat on his way between meetings on a regular basis, as can Luis Alcoser or Kemal Anbarci who pop in and out of the Chevron Technology Ventures visiting offices on third floor, with Veriten, which just announced an investment fund, and now Artemis joining recently.

The Houston pool of high quality founders and startups has definitely improved as well – though we still don’t have the quantity or quality of teams needed for a healthy startup market. Blair Garrou from Mercury Fund was part of a recent panel for the Texas Venture Crawl at the Ion along with BP Ventures’ Ion based Grace Chan talking about why Houston, and he remarked that in their earlier funds, Mercury was 5 to 10 percent Houston startups, having to go far afield to fill up even one fund - but his recent fund is closer to 25 percent Houston based, as local team quality has improved.

Houston venture capital is two orders of magnitude smaller than the Bay Area – it’s about like writing an article asking whether Silicon Valley is the emerging Energy Corridor. But it’s nice to have coffee and beers with next door neighbors who are actually investing in, and founders who are actually running, venture backed businesses. Founders are learning that Houston’s venture investment and tech scene has an actual home these days, and is open for business.

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Neal Dikeman is a venture capitalist and seven-time startup co-founder investing out of Energy Transition Ventures.

Michelle Stansbury, vice president of innovation and IT applications at Houston Methodist, joins the Houston Innovators Podcast. Photo courtesy of Houston Methodist

Houston innovator powers health care innovation by collaboration — inside and outside of the hospital setting

HOUSTON INNOVATORS PODCAST EPISODE 202

It might surprise most to know that Houston Methodist doesn't have an innovation department within their hospital system — at least not one set up as you'd imagine, with a team specifically dedicated to innovation. Instead, Houston Methodist's Digital Innovation Obsessed People, or DIOP, consists of leaders across departments.

Michelle Stansbury is one of those leaders. As vice president of innovation and IT applications at Houston Methodist, she oversees the system's IT department and serves as a leader within its innovation efforts. This includes the Center for Innovation Technology Hub — which opened in 2020 in the Texas Medical Center location and opened its Ion outpost last week.

Stansbury explains on the Houston Innovators Podcast how effective this distribution of innovation responsibilities has been for Houston Methodist. With everyone having a seat at the table — operations knows the biggest problems that need solutions, IT knows how to deploy technology, etc. — implementation of new innovations has been sped up.

"If we partner together, we should be able to succeed fast or fail fast," she says on the show. "We've been able to find a solution, pilot it, and, if it works well, roll it out at a speed that most other organizations have not been able to do. It's been highly successful for us."

The newest way Houston Methodist is mixing up how it brings in innovative solutions to its team and patients is by taking its team outside of the Texas Medical Center and its hospitals in general. Now, Houston Methodist has a permanent tech hub in the Ion, owned and operated by Rice Management Company, on the lower level of the building, completely open to any of the Ion's visitors.

"We've always had a great partnership with Rice. This almost felt like an extension with Houston Methodist and our Rice collaboration with the Ion," Stansbury says. "Our main goals have been how can we utilize the talent that's housed out of that facility."

She explains that the new hub is an extension of the original hub in the TMC hospital, and that innovators who are interested in collaborating with Houston Methodist — especially those with solutions applicable to health care — can visit the Ion hub as an entry point.

Both hub locations showcase pilot technology Houston Methodist is working on, and that technology will then get deployed out into its hospital locations — and especially its Cypress hospital, which is being billed as being the "smart hospital of the future." The construction is underway and expected to deliver in 2025.

Stansbury shares more about this ninth location for Houston Methodist as well as more details on the new tech hub on the podcast. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

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Rice, Houston Methodist developing soft 'sleep cap' for brain health research

Researchers and scientists at Rice University and Houston Methodist are developing a “sleep cap” that aims to protect the brain against dementia and other similar diseases by measuring and improving deep sleep.

The project is a collaboration between Rice University engineering professors Daniel Preston, Vanessa Sanchez and Behnaam Aazhang; and Houston Methodist neurologist Dr. Timea Hodics and Dr. Gavin Britz, director of the Houston Methodist Neurological Institute and chairman of the Department of Neurosurgery.

According to Rice, deep sleep is essential for clearing waste products from the brain and nightly “cleaning cycles” help remove toxic proteins. These toxic proteins, like amyloids, can accumulate during the day and are linked to Alzheimer’s disease and other neurological issues.

Aazhang, director of the Rice Neuroengineering Initiative, and his team are building a system that not only tracks the brain’s clearing process but can also stimulate it, improving natural mechanisms that protect against neurodegeneration.

Earlier proof-of-concept versions of the caps successfully demonstrated the promise of this approach; however, they were rigid and uncomfortable for sleep.

Preston and Sanchez will work to transform the design of the cap into a soft, lightweight, textile-based version to make sleep easier, while also allowing the caps to be customizable and tailored for each patient.

“One of the areas of expertise we have here at Rice is designing wearable devices from soft and flexible materials,” Preston, an assistant professor of mechanical engineering, said in a news release. “We’ve already shown this concept works in rigid device prototypes. Now we’re building a soft, breathable cap that people can comfortably wear while they sleep.”

Additionally, the research team is pursuing ways to adapt their technology to measure neuroinflammation and stimulate the brain’s natural plasticity. Neuroinflammation, or swelling in the brain, can be caused by injury, stroke, disease or lifestyle factors and is increasingly recognized as a driver of neurodegeneration, according to Rice.

“Our brain has an incredible ability to rewire itself,” Aazhang added in the release. “If we can harness that through technology, we can open new doors for treating not just dementia but also traumatic brain injury, stroke, Parkinson’s disease and more.”

The project represents Rice’s broader commitment to brain health research and its support for the Dementia Prevention Research Institute of Texas (DPRIT), which passed voter approval last week. The university also recently launched its Rice Brain Institute.

As part of the project, Houston Methodist will provide access to clinicians and patients for early trials, which include studies on patients who have suffered traumatic brain injury and stroke.

“We have entered an era in neuroscience that will result in transformational cures in diseases of the brain and spinal cord,” Britz said in the release. “DPRIT could make Texas the hub of these discoveries.”

Autonomous truck company with Houston routes goes public

on a roll

Kodiak Robotics, a provider of AI-powered autonomous vehicle technology, has gone public through a SPAC merger and has rebranded as Kodiak AI. The company operates trucking routes to and from Houston, which has served as a launchpad for the business.

Privately held Kodiak, founded in 2018, merged with a special purpose acquisition company — publicly held Ares Acquisition Corp. II — to form Kodiak AI, whose stock now trades on the Nasdaq market.

In September, Mountain View, California-based Kodiak and New York City-based Ares disclosed a $145 million PIPE (private investment in public equity) investment from institutional investors to support the business combo. Since announcing the SPAC deal, more than $220 million has been raised for the new Kodiak.

“We believe these additional investments underscore our investors’ confidence in the value proposition of Kodiak’s safe and commercially deployed autonomous technology,” Don Burnette, founder and CEO of Kodiak, said in a news release.

“We look forward to leading the advancement of the commercial trucking and public sector industries,” he added, “and delivering on the exciting value creation opportunities ahead to the benefit of customers and shareholders.”

Last December, Kodiak debuted a facility near George Bush Intercontinental/Houston Airport for loading and loading driverless trucks. Transportation and logistics company Ryder operates the “truckport” for Ryder.

The facility serves freight routes to and from Houston, Dallas and Oklahoma City. Kodiak’s trucks currently operate with or without drivers. Kodiak’s inaugural route launched in 2024 between Houston and Dallas.

One of the companies using Kodiak’s technology is Austin-based Atlas Energy Solutions, which owns and operates four driverless trucks equipped with Kodiak’s driver-as-a-service technology. The trucks pick up fracking sand from Atlas’ Dune Express, a 42-mile conveyor system that carries sand from Atlas’ mine to sites near customers’ oil wells in the Permian Basin.

Altogether, Atlas has ordered 100 trucks that will run on Kodiak’s autonomous technology in an effort to automate Atlas’ supply chain.

Rice University scientists invent new algorithm to fight Alzheimer's

A Seismic Breakthrough

A new breakthrough from researchers at Rice University could unlock the genetic components that determine several human diseases such as Parkinson's and Alzheimer's.

Alzheimer's disease affected 57 million people worldwide in 2021, and cases in the United States are expected to double in the next couple of decades. Despite its prevalence and widespread attention of the condition, the full mechanisms are still poorly understood. One hurdle has been identifying which brain cells are linked to the disease.

For years, it was thought that the cells most linked with Alzheimer's pathology via DNA evidence were microglia, infection-fighting cells in the brain. However, this did not match with actual studies of Alzheimer's patients' brains. It's the memory-making cells in the human brain that are implicated in the pathology.

To prove this link, researchers at Rice, alongside Boston University, developed a computational algorithm called “Single-cell Expression Integration System for Mapping Genetically Implicated Cell Types," or SEISMIC. It allows researchers to zero in on specific neurons linked to Alzheimer's, the first of its kind. Qiliang Lai, a Rice doctoral student and the lead author of a paper on the discovery published in Nature Communications, believes that this is an important step in the fight against Alzheimer's.

“As we age, some brain cells naturally slow down, but in dementia — a memory-loss disease — specific brain cells actually die and can’t be replaced,” said Lai. “The fact that it is memory-making brain cells dying and not infection-fighting brain cells raises this confusing puzzle where DNA evidence and brain evidence don’t match up.”

Studying Alzheimer's has been hampered by the limitations of computational analysis. Genome-wide association studies (GWAS) and single-cell RNA sequencing (scRNA-seq) map small differences in the DNA of Alzheimer's patients. The genetic signal in these studies would often over-emphasize the presence of infection fighting cells, essentially making the activity of those cells too "loud" statistically to identify other factors. Combined with greater specificity in brain regional activity, SEISMIC reduces the data chatter to grant a clearer picture of the genetic component of Alzheimer's.

“We built our SEISMIC algorithm to analyze genetic information and match it precisely to specific types of brain cells,” Lai said. “This enables us to create a more detailed picture of which cell types are affected by which genetic programs.”

Though the algorithm is not in and of itself likely to lead to a cure or treatment for Alzheimer's any time soon, the researchers say that SEISMIC is already performing significantly better than existing tools at identifying important disease-relevant cellular signals more clearly.

“We think this work could help reconcile some contradicting patterns in the data pertaining to Alzheimer’s research,” said Vicky Yao, assistant professor of computer science and a member of the Ken Kennedy Institute at Rice. “Beyond that, the method will likely be broadly valuable to help us better understand which cell types are relevant in different complex diseases.”

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This article originally appeared on CultureMap.com.