Looking back on the past few days of low temperatures, ice, snow, power and water outages, and more, it's time to focus on innovation for resilience. Photo courtesy of ABC13

Greater Houston and all of Texas have faced enough persistent challenges over the past seven years that communities and businesses are at a breaking point. Not just financially and economically, but at societal and emotional levels expected from repeated natural and man-made disasters.

Increasingly, the focus on "resilience" as a call to action has become a buzzword rather than measure of performance by public and private sector decision-makers. Simply, our version of resilience is defined as pre-disaster risk mitigation and investment, not recovery and rebuilding after the fact, which is precisely what is being debated across traditional and social media.

As families, small businesses, larger corporations, neighborhoods, and communities require stability, predictability, and frankly reliability, there is now disappointment and disillusion across party lines for our public agencies, programs, officials. When the last major freeze and snowfall hit Texas, the state's power grid ERCOT and the legislature were warned that unless immediate steps were taken to invest in our electrical grid, an expected collapse of the entire system would leave entire cities and potentially the state in darkness with life-threatening consequences. Review any of the published recommendations from previous disasters and each conclusion identifies necessary and urgent investment, re-engineering, and technological innovation. And yet many of those findings are but another can kicked down the road.

While finger-pointing, investigations, hearings, reports, studies can be the actions of our elected and appointed officials, we turn to entrepreneurs, inventors, innovators, and investors as the path forward. Want to add to your blood pressure? Read all the After-Action Reports and Lessons-Learned Analyses — from as far back as Hurricane Andrew to the most recent disasters, including snowstorms, derechos, wildfires, and now COVID-19. Very little changes in these documents regarding the failures of government and/or the significant gaps between alerts, warnings, preparation, response, recovery, rebuilding. More recently, analysis and assessments provided by Wharton at the University of Pennsylvania and the Insurance Information Institute suggest a 1:4+ return on investment for pre-disaster resilience.

Communities often are asked to rely upon hydrological engineering and science as the holy grails in response to our floods, storms, hurricanes. And yet, there is a new "class" of data scientists, analytic tools, curated information, and significant user interfaces that have changed how government, industry, civic, academia and philanthropy can allocate their resources in more efficient and effective ways to unleash innovative resilience. Emerging enterprises and organizations to watch that are driving the "new resilience data science" for entrepreneurs and innovators alike to develop the next generation of insight include Jupiter Intelligence, HazardHub, ResilientGrid, and EcoMetrics.

What is rarely captured in the post-incident studies and gatherings is the powerful impact of the "GSD" networks — "The Get Shit Done" relationships, partnerships, tools and resources mobilized by unleashing innovation! And the good news is that Greater Houston as well as across the nation, a number of companies, products, integrated data-equipment, digital platforms, and best practices have emerged from several innovation ecosystems that should be brought to the forefront of any next steps for community and civic leaders seeking to address a 21st century resilience agenda.

There are the data and platform folks — Umanity, FoodBot, GotSpot, Crowd Source Rescue (all based in Houston) along with Harbor, R3Water, and a host of other national firms — for example that have addressed the speed by which needs, resources, information and actionable intelligence can align to assist volunteers, neighborhoods, philanthropy, and small businesses. As previous senior leadership of FEMA have admitted, the public sector can no longer be the go-to resource during every disaster, incident, and threat.If we are to democratize resilience because no one entity can afford continued losses — such as the insurance and reinsurance sector — nor is there enough taxpayer dollars to fix our critical infrastructure, then we must spark private-philanthropic-public partnerships through innovation.

If COVID -19 taught us anything, it's that we continue to face inventory management supply-chain, and resilient inventory problems that have been identified during and after previous disasters. With blockchain, advanced sensors and monitors, robotics and remote screening, reopening Greater Houston and the US can be done with innovative health technologies such as San Antonio-based Xenex.

In regards to the challenge before us, we must recall that the demand and intersection for an energy, water and data "nexus" began to take off in response to the Texas and California droughts, rose again to the forefront during multiple hurricanes in the US, and are a now the latest critical infrastructure focus in the post snowstorms of 2021.

Why is having Elon Musk's GigaFactory in Texas so vital to resilience innovation? Because the research and product development of batteries to retain solar and wind produced power can directly impact the load-demands in advance of an oncoming weather or worse a cybersecurity threat to the grid. Sunnova — another Houston brand — has been proving the benefit of storage capacity from its work in Puerto Rico and now exhibits the unique performance for future off-grid resilience of homes, medical offices, and vital services.

Until and unless the public sector opens the doors for these and other innovators through immediate and permanent changes in procurement and contracting, strategic partnerships, incentives and credits — while frankly sharing the leadership function with entrepreneurs, inventors, and investors — we will all pay the price for the failure to act.

There is still work to be done from a legislative and governmental perspective, but more and more innovators — especially in Houston — are proving to be essential in creating a better future for the next historic disaster we will face. The Insurance Information Institute's National Resilience Accelerator Initiative and Resilience Innovation Hub Collaboratory (with its flagship in Houston) is working to unleash the best of Texas', the Nation's and the World's best ideas, resources, information and investments.

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Richard Seline is the co-founder of the Houston-based Resilience Innovation Hub.

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Houston researchers develop dissolvable implant for targeted cancer drug delivery

cancer research

Researchers at Houston Methodist have developed a biodegradable implant that can be used to safely and consistently deliver drug treatments to tumors and then dissolve without the need for further surgery.

The implant is only the size of a grain of rice, but its potential is staggering. The biodegradable nanofibrous drug-eluting seed (b-NDES) works as a reservoir parked inside a soft tumor, where it can slowly release immune-stimulating drugs over time. This overcomes a consistent problem with drugs such as immune checkpoint inhibitors. Normal systemic administration sees comparatively little of the drug making its way to the tumor, with most of it circulating throughout the body. The b-NDES is like deploying a small guerrilla fighting force embedded in enemy territory, doing maximum damage to the entrenched tumor.

"To improve cancer treatment, we're trying to start a fire inside the tumor itself," Corrine Chua, associate professor in the Center for BioNanoengineering at Houston Methodist Research Institute, said in a news release. "By activating immune cells directly within the tumor microenvironment, those cells can then travel throughout the body and seek out cancer wherever it exists. The b-NDES platform was developed to help keep therapeutic drugs concentrated inside tumors while minimizing exposure to healthy tissues.”

Chua co-led the study with Alessandro Grattoni, chair and director of the Center for BioNanoengineering at Houston Methodist Research Institute.

The study included support from the Nancy Owens Breast Cancer Foundation and the National Institutes of Health/National Cancer Institute.

Chau and Grattoni used preclinical models of triple-negative breast cancer, an aggressive form of cancer that is estrogen receptor-negative, progesterone receptor-negative and HER2-negative. Because of the receptor negativity, some popular treatments like tamoxifen and trastuzumab are ineffective. Chemotherapy has been shown to be the best course of action.

The b-NDES implant is deployed alongside radiation drugs. It keeps the drugs focused on the tumor, reducing the amount of harmful side effects typically seen when drugs are circulated more widely in the body. In 60 percent of the models, tumors were eliminated and did not cause side effects beyond the tumor site. Once the drugs have been deployed, the implant breaks down naturally.

While promising, more research will have to be done to expand use to other tumor types.

"Although the study focused on triple-negative breast cancer models, the approach could have broader applications for solid tumors," Grattoni added in the release. "It could potentially be used in cancers where there is a tumor lesion accessible for placement, including pancreatic or lung cancers."

New Houston platform Same Day Reels launches for on-demand content creation

In The Moment

If an event doesn't happen on Instagram, did it even really happen? In today's social media-driven age of branding and audience engagement, the answer increasingly is no.

Houston entrepreneur Karen De Amat is looking to fill the online content creation needs of companies with her new venture, Same Day Reels, which launched in early August. It will serve as a platform to connect companies and brands with talent that can help turn an event into a viral moment as it is happening.

"Events move quickly, and social media moves even faster,” said De Amat. “Same Day Reels was built to help brands capture the moment while it still matters. We are creating a more efficient way for businesses and creators to work together. Brands need content faster, and creators need more opportunities to turn their talent into real work. Same Day Reels brings those needs together.”

The company is focused on adding livestreams and concurrent short video content to "activations, launches, fundraisers, grand openings, conferences, hospitality experiences, and private celebrations." Such content can significantly increase the visibility of a product or brand according to digital marketing brands like Wyzowl, whose data found 63 percent of people in 2026 prefer to learn about new products via short video.

Packages offered by Same Day Reels will include filming, editing, and publishing content within hours of the targeted event.

De Amat says that her content creation platform will be a way to preserve the excitement of events and launches by enshrining them with immediate social media-driven memories.

“Event content is no longer just something you post after the fact,” De Amat said. “It is part of how people experience, remember and share the moment.”

Previously, De Amat is also the founder and CEO of Social Behavior, an influencer marketing company she launched from her home in 2014. It quickly garnered an array of clients and thrust De Amat into the spotlight, including numerous appearances on Fox 26's The Isiah Factor. Influencer Marketing Hub named her one of the top CEOs of influencer marketing companies in Houston in 2025.

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This article originally appeared on CultureMap.com.

Bristol Myers Squibb to build $2.3B Houston pharma manufacturing campus

coming soon

New Jersey-based pharmaceutical giant Bristol Myers Squibb Co. has officially named Houston as the home of its new state-of-the-art manufacturing site.

The 60,000-square-foot facility represents a $2.3 billion investment, according to a news release. It is expected to create 500 skilled jobs and will be located in Houston's Generation Park.

BMS first announced that it was considering Houston among 16 other cities for the facility in May. The new hub will manufacture small molecule, biologic and antibody-drug conjugates and is part of a $40 billion commitment to invest in the United States over five years. Construction is slated to begin next year, with the facility coming online in 2030.

"We're building the domestic manufacturing capabilities needed to deliver the next generation of medicines and support future scientific breakthroughs. Houston and the state of Texas offer the talent, infrastructure, and partnership needed to help bring that vision to life," Christopher Boerner, CEO and board chair of BMS, said in the release.

The new facility will feature a modular, multi-modal design, which will allow the company to reconfigure and add to its manufacturing capabilities over time. BMS says it expects the facility to "(grow) in scale and capability well beyond its opening configuration."

"Our decision to build this state-of-the-art manufacturing campus in Houston, Texas, reflects our confidence in the region’s ability to support a world-class, digitally advanced supply operation,” Karin Shanahan, EVP and chief supply chain and operations officer of BMS, added in the release. “This facility is designed to deliver the speed, quality, and reliability that patients depend on, combining flexible, modular manufacturing with advanced digital capabilities to ensure consistent supply across multiple modalities. It strengthens our ability to operate with resilience and positions us to reliably deliver medicines to patients today while adapting future demands.”

Texas Gov. Greg Abbott shared that the state has granted BMS a $4.89 million Texas Enterprise Fund (TEF) grant for the project. TEF grants, administered by the Texas Economic Development & Tourism Office, support business relocation or expansion projects that create "new, good-paying jobs in the community and attract significant new capital investment to the state." The development is also a qualified project under the Texas Jobs, Energy, Technology, and Innovation (JETI) program.

“Texas is a global hub for life sciences, where today’s innovations shape the future of healthcare,” Abbott said in a news release. “This $2.3 billion investment by Bristol Myers Squibb in the dynamic biotech ecosystem in Houston is a testament to the depth of our skilled workforce and the pipeline of talent coming through our nation-leading technical colleges and research universities. With lower operating costs and easy access to markets across the U.S. and the world, Texas drives affordability for consumers.”

"Bristol Myers Squibb’s announcement is a tremendous win for Texas and the Houston region, further reinforcing our position as a premier destination for life sciences and advanced manufacturing,” added Greater Houston Partnership President and CEO Steve Kean.

Last fall, Eli Lilly and Co. selected Generation Park, a 4,300-acre, master-planned commercial district near Lake Houston, for its $6.5 billion manufacturing plant. More than 300 locations in the U.S. competed for the factory. Read more here.