Let's look at the pace of innovation in Houston over the past couple of years. Graphic by Miguel Tovar/University of Houston

When the world came to a halt in 2020 due to COVID-19, innovation moved forward as normal day to day operations went virtual. Small business incubators like the University of Houston Technology Bridge, The Cannon and The Rice Alliance for Technology and Entrepreneurship, have found that, even during a lockdown, new innovations and leading-edge technologies have become easier to create.

“Hardship always leads to innovation. People have to get scrappy and creative. There’s always a lot of good that comes from the bad, ” founder and president of The Cannon, Lawson Gow, said.

Incubators coping with lockdown

Small business incubators provide a wide variety of crucial resources that startups, entrepreneurs, investors and corporate innovators need to succeed.

What did these incubators do to continue to help push their communities toward success when the lockdown went into effect?

The very first thing The Cannon did was set up a 24-hour hotline that businesses could call if they needed help with anything.

“The Cannon Emergency Response Team emerged from these efforts and was on the front lines of doing whatever we could to help people survive and get back on track,” Gow said.

He also said that it was hard to see hundreds of businesses struggling at the beginning of the pandemic. Kerri Smith, the associate managing director of The Rice Alliance said, as an organization built on forging connections that accelerate startup success, The Rice Alliance knew that staying afloat and continuing to offer their programs were crucial aspects of their important work.

“Within a matter of weeks, we organized and hosted our first virtual pitch event for startups innovating in the energy sector. Originally slated to be held at the Offshore Technology Conference but then cancelled, The Rice Alliance Energy Tech Venture Day portion of the OTC event provided a great platform for our startups to get exposure,” Smith said.

The University of Houston Technology Bridge began to connect businesses to the Small Business Development Center, where they could get help with all their preliminary operational tasks. Also, the SBDC helped businesses access the COVID-related funding that the government was offering.

“That seemed to help some of them get through some of the challenging times early on in the pandemic, ” said Chris Taylor, executive director of the UH Office of Technology Transfer and Innovation.

Growing digitally

After the lockdown went into effect, just about everything went virtual. At this point social distancing wasn’t even an option unless you were going to the doctor’s office or the grocery store.

As organizations that were made to help and support small businesses, it was important that incubators remained connected to their communities and communicate with them even in a virtual world.

“We provided intentional and comprehensive updates on resources, events and community opportunities through email outreach and social media, and featured success stories of entrepreneurs who participated in our programs,” Smith said.

Through The Cannon’s CERT program, they stayed extremely connected to their community and even built an entire digital platform called Cannon Connect that served and continues to serve their virtual community.

“It’s our own internal LinkedIn for Cannon members inside and outside Cannon spaces. It has educational curriculum, a job board, an equity crowdfunding site, and much more,” Gow said.

Gow said Cannon Connect will be the “lasting legacy of the COVID era.”

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This article originally appeared on the University of Houston's The Big Idea. Cory Thaxton, the author of this piece, is the communications coordinator for The Division of Research.

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”