A Houston expert weighs in on the importance of breaking down barriers for innovation. Photo via Getty Images

Innovation has always been the driving force behind progress and development in every industry. It is the engine that propels growth, fosters competition, and improves people’s lives. The importance of innovation in every sector has grown exponentially in recent years with new ideas and technologies emerging faster than ever before. This explosion has led to innovation silos, where each industry is developing its own innovations and making progress in isolation from the others.

Houston has embraced the rise of innovation with gusto and is a prime city to break down industry specific silos. We proudly host the largest medical center and the energy capital of the world as well as the headquarters for the space race. The mayor’s office has shown a strong commitment to support rapid innovation growth, providing incentives and infrastructure for technology companies and talent to reside in Houston. Our city’s emerging innovation district has already shown huge promise with the Ion building and Greentown Labs providing a strong foundation to expand. Organizations uniting innovators across all industries like Pumps & Pipes could only exist in a city as diverse and accessible as Houston. Nonetheless, our community needs to band together to ensure innovation growth is inclusive of all industries to create an equitable approach to technology that will continue to benefit generations to come.

While innovation silos may have some benefits, such as competition and differentiation, they also have some significant drawbacks, including inefficiencies, redundancies, and missed opportunities. Industries can become so focused on their own innovations that they fail to see the potential for cross-industry collaboration. Many examples exist today where certain technologies or practices were once reserved for specific use cases and now have become mainstream. For instance, the use of the common GPS network for location and navigation services was originally pioneered by NASA, and hospital safety and quality checklists were derived from the airline industry. By soliciting more opportunities for innovation sharing, we can achieve faster growth, implement stronger and safer processes, and reduce repetitive and costly pilot testing in every industry from energy, health care, finance, social impact, and more.

I am putting out a call to action to the Houston community to open your doors to cross-industry partnerships.

Engage in more open dialogue and information sharing outside your industry.

Attend events that bring together professionals from all industries for knowledge sharing and idea exchange. Many conferences, workshops, and meet-ups already exist to unite and recognize cross-industry communities within specific interest groups. In addition, startup accelerators, incubator programs, and collaborative workspaces provide unique environments that encourage spontaneous conversations and positive idea exchange.

Incentivize businesses, start-ups, and individuals who are willing to collaborate and share their ideas with others.

Knowledge sharing should be rewarded through recognition programs, awards, special partnership opportunities, and more. Professional organizations and leadership networks are a great place to turn to for connecting with like-minded individuals and identifying recognition opportunities that can promote the great work of experience sharing.

Commit investments in cross-industry research and development.

We need to create more incentives for researchers to work across different industries and apply their expertise to various fields. Examples like the Ion Prototyping Lab, a one-of-a-kind makerspace for all, and events at the upcoming Ion Activation Festival, including “Back to the Future of Innovation”, unite researchers with industry to encourage collaborative collisions.

In the end, breaking down innovation barriers is essential if we want to continue on this upward, fast-growth trend to improve our community and to make an impact in people’s lives across the world. We need to take action now to promote a more seamless cross-industry approach to knowledge sharing, collaboration, and research and development to create a better future for all.

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Arielle Rogg is the principal and founder of Rogg Enterprises LLC, a Houston-based company providing digital marketing for health care innovators.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.