These Houston startups and companies clock in as the top employers in the U.S.

best of the rest

MD Anderson Cancer Center is a top place to work in the U.S. and Texas. Photo by F. Carter Smith/courtesy of MD Anderson

Whose boss is doing something right in Houston? Forbes set out to find out.

New rankings from Forbes identified the top employers in Houston and beyond, and that included both bigger companies and the country’s best startup employers. In Houston, the startups ranked as top employers are:

No. 120 — Imbuit
No. 310 — Code Ninjas (Pearland)
No. 353 — Axiom Space
No. 462 — Liongard

When it comes to more traditional businesses, Dr. Pete Pisters, CEO of MD Anderson Cancer Center, continues his reign. He was named a top boss in 2021. Now, the cancer treatment facility/research center he leads has been named one of the best employers in a new report.

MD Anderson Cancer Center ranked No. 10 among the country’s best large employers in the country. Staffing some 22,000 employees, the world-renowned cancer center also landed at No. 25 in Forbes list of America's Best Employers in 2021.

Other Houston-area companies on the list include: Houston Methodist (No. 37), Waste Management (No. 245), Sysco (No. 314), Shell Oil (no. 361), Halliburton (No. 389), Schlumberger (No. 403), ExxonMobil (No. 440), and BP (No. 487).

Other Texas employers ranked among the best large employers in the U.S. are:

  • No. 10 — MD Anderson Cancer Center, Houston
  • No. 37 — Houston Methodist, Houston
  • No. 38 — H-E-B, San Antonio
  • No. 135 — USAA, San Antonio
  • No. 140 — Keller Williams Realty, Austin
  • No. 143 — Dell Technologies, Round Rock
  • No. 214 — Texas Tech University, Lubbock
  • No. 245 — Waste Management, Houston
  • No. 279 — University of Texas at Austin
  • No. 314 — Sysco, Houston
  • No. 318 — Daikin Industries, Waller (North American operations hub for manufacturing, marketing, research, R&D, and customer support)
  • No. 324 — Whole Foods Market, Austin
  • No. 361 — Shell Oil, Houston
  • No. 389 — Halliburton, Houston
  • No. 403 — Schlumberger, Houston
  • No. 440 — ExxonMobil, Houston
  • No. 487 — BP, Houston (North American headquarters)

Elsewhere in Texas, Dallas reigns as the capital of Texas when it comes to the best big and small employers, according to Forbes, which put University of Texas Southwestern Medical Center in Dallas at No. 9 among the country’s best large employers in the country and Dallas-based life insurance platform Bestow at No. 16 among the country’s best startup employers.

UT Southwestern isn’t the only Dallas-Fort Worth employer to pop up on the Forbes list of the best large employers. Richardson-based software company RealPage sits at No. 49; Dallas-based Southwest Airlines, No. 56; Plano-based Toyota North America, No. 253; Plano-based Cinemark, No. 370; Dallas-based Jacobs, No. 375; Dallas-based Topgolf, No. 394; Dallas-based Primoris Services, No. 399; Irving-based Fluor, No. 422; Dallas-based CBRE, No. 423; Irving-based McKesson, No. 429; Fort Worth-based American Airlines, No. 446; and Plano-based Keurig Dr Pepper, No. 483.

Dallas-based software company Slync.io, holding the No. 290 spot for best startups.

What follows are the other Texas employers ranked among the best startup employers in the country.

Austin

No. 104 — Apty
No. 121 — Homeward
No. 169 — SparkCognition
No. 186 — Outdoor Voices
No. 255 — Outdoorsy
No. 323 — ICON
No. 324 — The Zebra
No. 330 — TrustRadius
No. 335 — Innovetive Petcare (Cedar Park)
No. 387 — AlertMedia
No. 400 — Iris Telehealth
No. 410 — Wheel
No. 455 — Billd
No. 460 — Aceable
No. 470 — Shipwell

Forbes teamed up with data and research company Statista to develop the rankings of the best large employers and best startup employers.

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Rice University launches new venture fund for university-affiliated startups

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Rice University has launched its new One Giant Leap Ventures Fund I, which will invest in the university’s spinouts and alumni-founded startups.

The early-stage institutional venture fund will function with a hybrid structure that allows for participation from traditional equity investors and philanthropic investors. According to the university, the fund will invest up to $500,000 per Rice-affiliated company.

To be considered eligible for funds, companies must use intellectual property licensed by the university or be led or founded by alumni.

One Giant Leap will draw on support and mentorship from Rice’s pool of 60,000 alumni and aims to create educational opportunities within the investment phases, work with graduate and undergraduate venture students, explore the scaling and commercialization of their ideas, and help investigate all the facets of venture capital.

“Rice alumni bring an extraordinary depth of experience as entrepreneurs, investors and industry leaders, and One Giant Leap creates new ways to put that expertise to work for the next generation of Rice innovators,” Stephen Bayer, vice president for development and alumni relations, said in a news release. “It strengthens the connection between our alumni and the university while giving them meaningful opportunities to mentor, advise and support Rice-affiliated companies as they grow.”

The fund held its first close in August and made its first investment into Rice brain health spinout Motif Neurotech. Led by Rice faculty member Jacob Robinson, Motif is working to commercialize a minimally invasive neurostimulator that targets treatment-resistant depression. In May, the FDA approved the company to move forward with its first clinical trial.

“Research produces breakthrough technologies and our academic environment forms outstanding entrepreneurs,” said Adrian Trömel, the fund’s managing director, a Rice alumnus and a startup founder who also serves as Rice’s interim chief innovation officer.

One Giant Leap joins the already long list of Rice-led programs that foster innovation, including the Liu Idea Labs for Innovation and Entrepreneurship’s Innovation Fellows and Summer Venture Studio, the Rice Alliance’s Business Plan Competition, the Ion District, Woodside Rice Decarbonization Accelerator, Rice Nexus, the Biotech Launchpad and RBL Ventures and its upcoming 200,000 square-foot research lab the Arc.

“With One Giant Leap, I am excited that we are creating a unique structure that brings together traditional investment and philanthropic participation to invest in and help catalyze our startups, engage the deep expertise within the Rice ecosystem and transform those strengths into real-world impact,” Trömel added in the release.

New statewide plan aims to eliminate cervical cancer in Texas by 2032

fighting cancer

MD Anderson, on behalf of a coalition of health systems, has announced a new plan to eliminate cervical cancer in Texas.

The five-year Texas Lone Star Cervical Cancer Elimination Plan was launched during the Cancer Prevention and Research Institute of Texas (CPRIT) 2026 Innovations Conference in Galveston this month.

The plan focuses on three major pillars with goals to be achieved by 2032:

  • HPV vaccination: Increase the percentage of Texas boys and girls up to date on human papillomavirus (HPV) vaccination by age 15 from 50.5 percent to 80 percent
  • Cervical cancer screening: Raise the share of Texas women up to date on cervical cancer screening from 64 percent to 80 percent
  • Timely follow-up, diagnosis and treatment: Ensure 80 percent of women receive diagnostic follow-up and treatment when needed through community outreach, patient navigation, provider training and survivorship support

Overall, the coalition wants to see fewer than four new cases of cervical cancer annually per 100,000 Texas women by 2032, according to a news release from MD Anderson. Currently, Texas has an incidence rate of 9.5 women per 100,000 diagnosed with cervical cancer, compared with 7.5 women per 100,000 nationally.

“Texas has the tools to prevent nearly every case of cervical cancer, but tools can save lives only when people can utilize them,” Dr. Ernest Hawk, vice president and division head of Cancer Prevention and Population Sciences at MD Anderson, said in the release. “The Lone Star Cervical Cancer Elimination Plan gives us a shared roadmap to vaccinate more of our children, screen more of our women and make sure every abnormal result leads to care. With innovations like HPV self-collection and the commitment of partners across the state, elimination is within reach.”

About 40 other hospitals, health care organizations and companies join MD Anderson in the coalition that launched the Lonestar Plan. Those based in Houston include Houston Methodist, Rice University, UTHealth Houston, Texas Children's Hospital, Houston Health Department and others.

The CPRIT also announced its Texans Conquer Cancer Awards and its CPRIT Champion awards during the Innovations Conference this week. Several are based in Houston, including:

  • Zhiqiang An, co-founder of CrossBridge Bio, Director of the Texas Therapeutics Institute, and Vice President of Drug Discovery at the University of Texas Health Science Center at Houston
  • Dr. Abbey Berenson, Director of the UTMB Center for Interdisciplinary Research in Women's Health Care
  • Dr. Michael Taylor, Chair of Pediatric Neuro-Oncology at Texas Children's Cancer and Hematology Center and Director of Texas Children's Pediatric Brain Tumor Research Program

To date, the CPRIT has awarded more than $4.2 billion in grants to fight cancer in the state. Over the summer, it awarded four $2 million grants to institutions in Houston and Bryan for the creation or expansion of “core” cancer research facilities.

Texas Medical Center Innovation recently announced that its $2 million grant would renew its Accelerator for Cancer Therapeutics for five years. Read more from TMCi about the renewal here.

Announcing the 2026 Houston Innovation Awards finalists

Inspirational Innovators

InnovationMap is proud to reveal the finalists for the 2026 Houston Innovation Awards.

The sixth annual Houston Innovation Awards program returns in an all-digital format this fall to honor the best of Houston's innovation ecosystem, including startups, entrepreneurs, mentors, and more.

Finalists were determined by our esteemed panel of judges, comprised of past award winners and InnovationMap editorial leadership.

The panel reviewed applications across 10 prestigious categories to determine our finalists. They will select the winner for each category, except for Startup of the Year, which will be chosen by the public via online voting launching later this month.

We will announce the honoree of our annual Trailblazer Award in the coming weeks, then stay tuned as we unveil all of this year's winners on InnovationMap.com in mid-November.

Get to know our finalists in more detail through editorial spotlights leading up to the winner announcement. Without further ado, here are the 2026 Houston Innovation Awards finalists:

Minority-founded Business

Honoring an innovative startup founded or co-founded by BIPOC or LGBTQ+ representation:

  • AI Made Fun
  • Deep Anchor Solutions
  • HEXAspec
  • Prana Surgical
  • Torres Orbital Mining Inc.

Female-founded Business

Honoring an innovative startup founded or co-founded by a woman:

  • Adair
  • ARIX Technologies
  • Bairitone Health
  • FlowCellutions
  • ParaDocs Health

Energy Transition Business

Honoring an innovative startup providing a solution within renewables, climatetech, clean energy, alternative materials, circular economy and beyond:

  • Capwell Services
  • FlowCellutions
  • Hertha Metals
  • Mars Materials
  • Solidec

Health Tech Business

Honoring an innovative startup within the health and medical technology sectors:

  • Bairitone Health
  • InformAI Inc.
  • Prana Surgical
  • Skybound MedTech

Deep Tech Business

Honoring an innovative startup providing technology solutions based on substantial scientific or engineering challenges, including those in the AI, robotics and space sectors:

  • Casimir
  • Focis AI
  • Machine Saver Inc.
  • Square Robot
  • Venus Aerospace

Startup of the Year (People's Choice)

Honoring a startup celebrating a recent milestone or success. The winner will be selected by the community via an online voting experience:

  • Fluxworks
  • IronLattice
  • Lumino
  • Progress Report
  • Rosarium Health
  • Thread
  • TokenRoster

Scaleup of the Year

Honoring an innovative later-stage startup that's recently reached a significant milestone in company growth:

  • Erock
  • Hertha Metals
  • Venus Aerospace

Incubator/Accelerator of the Year

Honoring a local incubator or accelerator that is championing and fueling the growth of Houston startups:

  • Activate
  • Impact Hub Houston
  • MarMo Innovation

Mentor of the Year

Honoring an individual who dedicates their time and expertise to guide and support budding entrepreneurs:

  • Al Danto, Rice University
  • Eric Rubenstein, New Climate Ventures
  • Jeremy Pitts, Activate
  • Joe Alapat, Liongard
  • Kyle Judah, Rice University's Liu Idea Lab for Innovation & Entrepreneurship
  • Rachel Bickham, Bickham Services Unlimited LLC

Trailblazer Recipient

  • To be announced
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