Houston nonprofit wins coworking space in Shark Tank-inspired pitch competition

winner, winner

At a startup pitch competition, a local nonprofit won free coworking space for a year to continue their impactful work with individuals with special needs. Photo courtesy of Macy's Miracles

Macy's Miracles, a local nonprofit that helps people with special needs, had a special need of its own: a place to call home. Now, thanks to coworking operator WorkLodge LLC, it has one.

On February 27, representatives of Macy's Miracles and Houston-based WorkLodge held a ribbon-cutting ceremony for the nonprofit's first-ever office. The organization (not affiliated with the Macy's department store chain) won the second annual Shark Tank-inspired Ignite by WorkLodge pitch contest, which awards a one-year WorkLodge lease to a local nonprofit. Macy's Miracle now occupies space at WorkLodge's site in The Woodlands.

Previously, leaders of the nonprofit had carried out business at various public places like coffee shops. Today, the nonprofit enjoys a startup-style setting — including access to meeting rooms and common areas — that enables it to operate more like a business and less like an organization on a shoestring budget.

Haley Ahart-Keiffer, founder and president of Macy's Miracles, says the free one-year lease of a four-person office at WorkLodge (valued at $24,000) is "priceless."

For one thing, being located at WorkLodge opens up fundraising opportunities. In the past, Macy's Miracles ran into roadblocks when prospective corporate sponsors inquired about meeting at the nonprofit's office, Ahart-Keiffer says. But the nonprofit had no formal address to give them.

Now that Macy's Miracles is housed at WorkLodge, folks associated with the nonprofit can more professionally host potential corporate donors and can network with Houston businesses, Ahart-Keiffer says.

As a matter of fact, that networking paid off at the ribbon-cutting ceremony, according to Ahart-Keiffer. For instance, it exposed WorkLodge tenants to potential employees — people attending the ceremony who benefit from services delivered by Macy's Miracles. In addition, the event paved the way for meetings with three businesses interested in assisting Macy's Miracles.

Aside from fostering opportunities for networking, the WorkLodge space lets Macy's Miracles more easily conduct mentorship programs and put on events, according to Ahart-Keiffer.

Being based at WorkLodge "has allowed us to really take it to the next level by being able to seek out even larger corporate sponsors and donors to be a part of the mission," she says.

That mission, carried out since the formation of Macy's Miracles in 2018, centers on elevating the education, networking skills, and employability of people with special needs. Aside from boosting the ability to raise more money for that mission, the WorkLodge space introduces high-functioning people with special needs to a work environment, Ahart-Keiffer says.

In a short amount of time, setting up shop at WorkLodge "has changed the trajectory of where we see that we can go now," she says.

Part of the nonprofit's new trajectory is its soon-to-launch Adaptive Center of Excellence, featuring a vocational/trade initiative and an adaptive sports program.

Ahart-Keiffer didn't envision the current scenario when she established Macy's Miracles two years ago. She established the nonprofit as a "grassroots movement" after her daughter Macy Savoy, who is part of the special needs community, faced a less-than-ideal future in the workforce after graduating from high school. Savoy is CEO of the volunteer-run nonprofit.

Mike Thakur, founder and CEO of WorkLodge, says Ignite by WorkLodge is designed to offer free high-quality space so that nonprofits like Macy's Miracles "take their game up a notch and attract some more support." The contest is geared toward smaller nonprofits making a "hands-on, roll-up-your-sleeves" difference in the community, he says.

In addition to Macy's Miracles securing space at WorkLodge's location in The Woodlands, Ignite by WorkLodge recently granted space to a Dallas nonprofit that's now a tenant at the coworking company's location in the Dallas Design District.

WorkLodge currently operates five coworking spaces: two in the Houston area, two in Dallas-Fort Worth, and one in Tampa-St. Petersburg, Florida.

Thakur says one of the reasons Macy's Miracles received the free space at WorkLodge is that it serves both children and adults.

"But I think the main thing was just the fact that they were delivering help in a way that could then create self-sustainability," says Thakur, whose company runs its own nonprofit foundation. "That's a really big deal for us."

It's also, of course, a big deal for Macy's Miracles. The nonprofit's free one-year lease expires around the end of the year, but Ahart-Keiffer says the Macy's Miracles plans to carve out money in its budget to pay for space at WorkLodge. In conjunction with that, Macy's Miracles will teach some of the members of its mentorship program about fundraising and budgeting.

"I don't think it's a place that we'll ever want to leave," Ahart-Keiffer says. "WorkLodge is definitely the perfect spot for us and what we do."

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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