At a startup pitch competition, a local nonprofit won free coworking space for a year to continue their impactful work with individuals with special needs. Photo courtesy of Macy's Miracles

Macy's Miracles, a local nonprofit that helps people with special needs, had a special need of its own: a place to call home. Now, thanks to coworking operator WorkLodge LLC, it has one.

On February 27, representatives of Macy's Miracles and Houston-based WorkLodge held a ribbon-cutting ceremony for the nonprofit's first-ever office. The organization (not affiliated with the Macy's department store chain) won the second annual Shark Tank-inspired Ignite by WorkLodge pitch contest, which awards a one-year WorkLodge lease to a local nonprofit. Macy's Miracle now occupies space at WorkLodge's site in The Woodlands.

Previously, leaders of the nonprofit had carried out business at various public places like coffee shops. Today, the nonprofit enjoys a startup-style setting — including access to meeting rooms and common areas — that enables it to operate more like a business and less like an organization on a shoestring budget.

Haley Ahart-Keiffer, founder and president of Macy's Miracles, says the free one-year lease of a four-person office at WorkLodge (valued at $24,000) is "priceless."

For one thing, being located at WorkLodge opens up fundraising opportunities. In the past, Macy's Miracles ran into roadblocks when prospective corporate sponsors inquired about meeting at the nonprofit's office, Ahart-Keiffer says. But the nonprofit had no formal address to give them.

Now that Macy's Miracles is housed at WorkLodge, folks associated with the nonprofit can more professionally host potential corporate donors and can network with Houston businesses, Ahart-Keiffer says.

As a matter of fact, that networking paid off at the ribbon-cutting ceremony, according to Ahart-Keiffer. For instance, it exposed WorkLodge tenants to potential employees — people attending the ceremony who benefit from services delivered by Macy's Miracles. In addition, the event paved the way for meetings with three businesses interested in assisting Macy's Miracles.

Aside from fostering opportunities for networking, the WorkLodge space lets Macy's Miracles more easily conduct mentorship programs and put on events, according to Ahart-Keiffer.

Being based at WorkLodge "has allowed us to really take it to the next level by being able to seek out even larger corporate sponsors and donors to be a part of the mission," she says.

That mission, carried out since the formation of Macy's Miracles in 2018, centers on elevating the education, networking skills, and employability of people with special needs. Aside from boosting the ability to raise more money for that mission, the WorkLodge space introduces high-functioning people with special needs to a work environment, Ahart-Keiffer says.

In a short amount of time, setting up shop at WorkLodge "has changed the trajectory of where we see that we can go now," she says.

Part of the nonprofit's new trajectory is its soon-to-launch Adaptive Center of Excellence, featuring a vocational/trade initiative and an adaptive sports program.

Ahart-Keiffer didn't envision the current scenario when she established Macy's Miracles two years ago. She established the nonprofit as a "grassroots movement" after her daughter Macy Savoy, who is part of the special needs community, faced a less-than-ideal future in the workforce after graduating from high school. Savoy is CEO of the volunteer-run nonprofit.

Mike Thakur, founder and CEO of WorkLodge, says Ignite by WorkLodge is designed to offer free high-quality space so that nonprofits like Macy's Miracles "take their game up a notch and attract some more support." The contest is geared toward smaller nonprofits making a "hands-on, roll-up-your-sleeves" difference in the community, he says.

In addition to Macy's Miracles securing space at WorkLodge's location in The Woodlands, Ignite by WorkLodge recently granted space to a Dallas nonprofit that's now a tenant at the coworking company's location in the Dallas Design District.

WorkLodge currently operates five coworking spaces: two in the Houston area, two in Dallas-Fort Worth, and one in Tampa-St. Petersburg, Florida.

Thakur says one of the reasons Macy's Miracles received the free space at WorkLodge is that it serves both children and adults.

"But I think the main thing was just the fact that they were delivering help in a way that could then create self-sustainability," says Thakur, whose company runs its own nonprofit foundation. "That's a really big deal for us."

It's also, of course, a big deal for Macy's Miracles. The nonprofit's free one-year lease expires around the end of the year, but Ahart-Keiffer says the Macy's Miracles plans to carve out money in its budget to pay for space at WorkLodge. In conjunction with that, Macy's Miracles will teach some of the members of its mentorship program about fundraising and budgeting.

"I don't think it's a place that we'll ever want to leave," Ahart-Keiffer says. "WorkLodge is definitely the perfect spot for us and what we do."

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Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”

Houston startup raises $6M to scale home-based healthcare platform

fresh funding

As healthcare systems race to expand care beyond hospitals and into the home, investors are placing bigger bets on the infrastructure needed to make that shift possible.

This month, Rosarium Health announced it has raised $6 million in seed funding led by Kalos Ventures, with participation from ResilienceVC, Rock Health Capital, Symphonic Capital, Black Tech Nations Ventures and others.

The investment will help the Houston-based startup continue to build its platform, which features a national network of 800-plus clinicians and 3,000-plus contractors to coordinate home accessibility upgrades and modifications for seniors and people living with disabilities.

For founder and CEO Cameron Carter, the company’s mission grew out of firsthand caregiving experiences.

“From my own personal caregiving experiences, I realized that the benefits exist on paper, but not in reality,” Carter said in a news release. “Families are being left to figure out the paperwork and installations all on their own, which shouldn’t be how this works.”

While Medicare Advantage and Medicaid plans have expanded coverage for home-based services and accessibility modifications, the logistics behind delivering those services often remain fragmented.

Rosarium’s platform coordinates the entire process, from clinical assessments and referrals to contractor management, documentation, reimbursement and installation.

“A clinician can document that a home isn’t safe and a plan can approve a benefit, but there’s no one that’s responsible for making sure the work actually gets done,” Carter says. “We built the missing piece.”

The company was founded in 2021 as Rose Health and was a 2023 participant in the Texas Medical Center’s Accelerator for HealthTech program. It has scaled quickly, building a network of more than 800 clinicians and 3,000 contractors across 34 states.

Rosarium is currently in-network for 1.2 million Medicare and Medicaid lives, with projected coverage expected to reach nearly 4 million by the end of the year, according to the release.

“We’re excited to back Cameron because he and the team at Rosarium are building the infrastructure healthcare needs right now to make the home a safe and comfortable place of care,” Kate Ballinger, investor at Kalos Ventures, added in the release.

As part of the recent investment, Ballinger will join Rosarium’s board of directors.

With eyes on the future, Rosarium plans to grow its partnerships with Medicaid and Medicare Advantage plans, including CalViva and Community Health Plan of Imperial Valley, strengthening its presence in California while expanding access to underserved communities.

Additionally, Carter predicts that home-based healthcare will be part of a broader transformation happening across the industry.

“There’s a growing recognition that health outcomes are shaped by what happens in the home,” he said in the release. “The future of healthcare isn’t just treating people after something goes wrong. It’s creating environments that help prevent those problems in the first place.”