Houston organization names 10 most promising life sciences startups

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Here's which life science companies — in Houston and beyond — are ones to watch. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Last week, the Rice Alliance for Technology and Entrepreneurship gathered over 1,000 life science experts and attendees virtually for thought leadership as well as 40 company presentations.

The three-day 2020 Virtual Texas Life Science Forum was made possible through a partnership with BioHouston and support from Texas Medical Center and Insperity. At the close of the summit, several companies were recognized with awards.

Houston-based Starling Medical won the Michael E. DeBakey Memorial Life Science Award, established by BioHouston in honor of the groundbreaking Houston cardiovascular surgeon. The digital health device company is revolutionizing severe bladder dysfunction management with artificial intelligence.

Every year at the forum, the Rice Alliance names its 10 most promising companies working on developing innovative solutions in medical devices, digital health, diagnostics, pharmaceuticals, and therapeutics. This year, Brad Burke, managing director of the Rice Alliance, says they had more applications to present than ever before. Additionally, the presenting companies — about half of which are Houston-based — have already raised more than $275 million in funding.

The 2020 most-promising life science companies, which were chosen by investors and presented by the Greater Houston Partnership, were:

Droice Labs

Image via droicelabs.com

New York-based Droice Labs, is an artificial intelligence and big data company matches patients to therapies and delivers personalized medicine at scale while reducing costs.

"Our cutting-edge technology seamlessly integrates into clinical workflows, and we continue to evolve unique and powerful applications for our clients and the patients they serve," reads the company's website.

SFA Therapeutics

Image via sfatherapeutics.com

Based in Jenkintown, Pennsylvania, SFA Therapeutics is developing oral drugs for treating conditions of chronic inflammation that have the potential to change the practice of medicine. The company has treatments for Psoriasis, Liver Cancer (Hepatitis B, NASH and HCC), Ophthalmic Diseases, Cytokine Release Syndrome- a side effect in CAR-T, Prevention of Relapse/Recurrence in Leukemias, and other diseases.

Hummingbird Bioscience

Photo via jlabs.jnjinnovation.com

Hummingbird Bioscience, based in Houston's JLABS @ TMC, is tackling challenging targets that play a key role in disease yet have not been effectively drugged. The company has worked on 12 therapies in various stages of development, four of which have the potential to revolutionize their fields.

"At Hummingbird, we believe that modern approaches to systems biology and data science can overcome the challenges of classical methods of therapeutics discovery, and profoundly improve the way we deliver new transformative medicines," reads the company website.

CaseCTRL

Image via casectrl.com

Houston-based CaseCTRL is empowering surgeons with a management platform with software-as-a-service technology that uses AI and logistics to lower operational costs and simplify surgical planning.

"The surgical scheduling process is frustratingly stuck in the past: siloed, paper-based, and too dependent on single schedulers," reads the website. "Surgeons are stressed and overworked. They need a better way to communicate their complex surgical plans, timelines and resource needs."

Perimeter Medical

Image via perimetermed.com

Perimeter Medical, based in Dallas, is driven to transform cancer surgery with advanced, real-time, ultra high-resolution imaging tools including AI to address areas of unmet medical need.

"Perimeter is dedicated to providing solutions that drive better patient care and lower healthcare costs by providing critical information, during clinical procedures," reads the website.

Studio Bahria

Image via studiobahia.org

San Antonio-based Studio Bahia, is developing an accessible model for therapy in addressing mental health crises from the pandemic through virtual reality.

"We are in production of our first two therapies for release in the 4th quarter of 2020. Studio Bahia clients include corporate, retail, and institutional partners who purchase our headsets for $25 in providing mental health therapies and wellness tools to employees, executives, and patients," reads the company's website.

Tvardi Therapeutics

Photo via Getty Images

Tvardi Therapeutics, based in Houston, is a clinical-stage biopharmaceutical company focused on the development of a new class of breakthrough medicines for diverse cancers and chronic inflammatory and fibrotic diseases.

"Tvardi is focused on the development of orally delivered, small molecule inhibitors of STAT3, a key signaling molecule positioned at the intersection of many disease pathways," reads the website.

Koda Health

Image via kodahealthcare.com

Koda Health, Houston, uses AI to help guide difficult conversations in health care, starting with end-of-life care planning.

"You're entitled to protect the healthcare decisions that matter most to you and your family," the company's website promises. "Koda creates Care Plans to ensure that you get the medical care you want."

Immuno Genesis

Photo via Getty Images

Houston-based ImmunoGenesis is a clinical-stage biotechnology company developing therapeutics to catalyze effective immune responses in immunologically "cold" cancers such as prostate, colorectal, and pancreatic.

"Compared to existing immunotherapy drugs, we believe this antibody will both provide more consistent benefit for patients with immune-infiltrated tumors, and, for the first time, will also benefit patients with immune 'cold' cancers," says founder Dr. Michael A. Curran in a press release announcing the company's grant from the Cancer Prevention and Research Institute of Texas.

Ictero Medical

Image via Getty Images

Ictero Medical, based in Houston, is developing the first minimally invasive cryoablation solution to treat patients with gallstone disease. Ictero Medical has created a minimally invasive treatment, called The CholeSafe System, that uses cryoablation to defunctionize the gallbladder without having to remove it.

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Top Houston-based sustainability startups share their 4 biggest challenges

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Six Houston-area sustainability startups have been named finalists in the 2023 Houston Innovation Awards, but they didn't achieve this recognition — as well as see success for their businesses — without any obstacles.

The finalists were asked what their biggest challenges have been. From funding to market adoption, the sustainability companies have had to overcome major obstacles to continue to develop their businesses.

The awards program — hosted by InnovationMap, and Houston Exponential — will name its winners on November 8 at the Houston Innovation Awards. The program was established to honor the best and brightest companies and individuals from the city's innovation community. Eighteen energy startups were named as finalists across all categories, but the following responses come from the finalists in the sustainability category specifically.

    Click here to secure your tickets to see who wins.

    1. Securing a commercial pilot

    "As an early-stage clean energy developer, we struggled to convince key suppliers to work on our commercial pilot project. Suppliers were skeptical of our unproven technology and, given limited inventory from COVID, preferred to prioritize larger clients. We overcame this challenge by bringing on our top suppliers as strategic investors. With a long-term equity stake in Fervo, leading oilfield services companies were willing to provide Fervo with needed drilling rigs, frack crews, pumps, and other equipment." — Tim Latimer, founder and CEO of Fervo Energy

    2. Finding funding

    "Securing funding in Houston as a solo cleantech startup founder and an immigrant with no network. Overcome that by adopting a milestone-based fundraising approach and establishing credibility through accelerator/incubator programs." — Anas Al Kassas, CEO and founder of INOVUES

    "The biggest challenge has been finding funding. Most investors are looking towards software development companies as the capital costs are low in case of a risk. Geothermal costs are high, but it is physical technology that needs to be implemented to safety transition the energy grid to reliable, green power." — Cindy Taff, CEO of Sage Geosystems

    3. Market adoption

    "Market adoption by convincing partners and government about WHP as a solution, which is resource-intensive. Making strides by finding the correct contacts to educate." — Janice Tran, CEO and co-founder of Kanin Energy

    "We are creating a brand new financial instrument at the intersection of carbon markets and power markets, both of which are complicated and esoteric. Our biggest challenge has been the cold-start problem associated with launching a new product that has effectively no adoption. We tackled this problem by leading the Energy Storage Solutions Consortium (a group of corporates and battery developers looking for sustainability solutions in the power space), which has opened up access to customers on both sides of our marketplace. We have also leveraged our deep networks within corporate power procurement and energy storage development to talk to key decision-makers at innovative companies with aggressive climate goals to become early adopters of our products and services." — Emma Konet, CTO and co-founder of Tierra Climate

    4. Long scale timelines

    "Scaling and commercializing industrial technologies takes time. We realized this early on and designed the eXERO technology to be scalable from the onset. We developed the technology at the nexus of traditional electrolysis and conventional gas processing, taking the best of both worlds while avoiding their main pitfalls." — Claus Nussgruber, CEO of Utility Global

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    This article originally ran on EnergyCapital.

    Extended reality will have a big impact on business, this Houston expert says

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    What does your reality look like? Look around you. What do you see? It would be safe to say (almost guarantee) that you are looking at a screen right now, correct? We are consumers of information and use screens to access, view, and create information.

    But why are we spending so much of our time looking at screens?

    One poll stated that the average adult will spend 34 years of their lives looking at screens. It almost feels that screens (TV, laptop, or phone) have become so ubiquitous in everyday life that they have blended into our reality and are just ‘there’. Do you think the inventor of the TV, John Logie Baird, ever fully grasped how much the fabric of society would revolve around his invention? Time and time again, incredible disruptions have always come from breaking the ‘norm’ and given the vast level of integration of screens into our everyday reality, this ‘norm’ feels long overdue for innovation. This is where the world of augmented reality and spatial computing comes into play.

    The COVID-19 pandemic saw an unprecedented shift to even more screen time and interactions using remote video communication platforms. It was also around this time that wireless virtual reality headsets were, for the first time ever, economically accessible to the consumer due to the large push of one multinational corporation. Fast forward to 2023, there are even more companies beginning to enter the market with new extended reality (XR) headsets (i.e. virtual, mixed, and augmented reality) that offer spatial computing – the ability for computers to blend into the physical worlds (amongst other things).

    Some of our innovation engineering activities at the Houston Methodist Institute for Technology, Innovation, and Education (MITIE) have focused on specific use cases of XR in surgical education and training. One of our projects, the MITIEverse, is a VR-based platform focused on creating the first-ever metaverse for medical innovation. It is a fully immersive VR environment that allows the user to view 3D-rendered patient anatomies whilst watching the actual patient procedure, even offering the ability to meet the surgeon who performed the operation. It also affords the ability to give a ‘Grand Rounds’ style presentation to an audience of 50 participants.

    We have looked at using augmented reality to control robotic-assisted surgery platforms. In our proof-of-concept prototype, we successfully demonstrated the manipulation of guide wires and catheters using nothing more than an augmented reality headset, illustrating the possibility of surgeons performing surgery at a distance. Houston Methodist is dedicated to transforming healthcare using the latest innovative technology including XR. The question we now need to ask – is society ready and willing to replace screens with XR headsets?

    To learn more about our XR initiatives and other Houston’s cross-industry innovation collaborations, attend Pumps & Pipes Annual Event 2023, Problem Xchange: Where Solutions Converge next month at The Ion.

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    Stuart Corr is the director of Innovation Systems Engineering at Houston Methodist and executive director of Pumps & Pipes.

    Houston surprisingly plummets in prestigious list of best cities in the world

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    Economic investments and population growth are definitive highlights of Houston's success over the last year, but they weren't enough to keep it within the top 50 best cities in the world, according to a prestigious report by Canada-based real estate and tourism marketing advisors Resonance Consultancy.

    The annual "World's Best Cities" report quantifies the relative qualities of place, reputation, and competitive identity for the world's principal cities with metropolitan populations of 1 million or more.

    London topped the list again for 2024, followed by Paris (No. 2), New York (No. 3), Tokyo (No. 4), and Singapore (No. 5).

    Houston slipped from its position as No. 42 last year to a surprising No. 66 in 2024.

    However, the report primarily focuses on the city, its cultural diversity, and its astronomical prospects, rather than its ranking.

    "In the past year, immigration both domestic and international has swelled the metro population to above seven million and the city today is one of America’s most ethnically diverse metropolises," the report said.

    Houston's cultural footprint has always been significant, and has substantially developed throughout the years. According to the report (which cited the latest U.S. Census data), there are over 145 languages being spoken "at home" which is nearly as many as New York. And the city will soon have a new community center for those of all faiths and backgrounds: the nation's first Ismaili Center.

    But it's Houston's stellar ambitions as Space City that is a major highlight in its shining overview.

    "[The] Houston Spaceport is an FAA-licensed urban commercial spaceport offering unprecedented access to a thriving aerospace community," the report said. "The head start the city has in building a cluster of aerospace companies manufacturing locally is staggering, especially considering that the spaceport can eventually serve as the country’s takeoff point for passenger jets capable of flying at supersonic and hypersonic speeds."

    Austin and Dallas also earned spots on the World's Best Cities list for 2024, but only one took a weighty tumble from the previous year's rankings. Dallas fell from No. 47 in last year's report to its current rank as No. 66.

    Austin maintained its position as No. 43 for the second consecutive year, but the report suggests Houston is a much bigger player than what others have been led to believe about the Texas capital.

    "Austin may get the attention, but the promise of the Lone Star State drawing Californians and New Yorkers is quietly being fulfilled in Houston," the report said.

    The top 10 best cities in the world, according to Resonance Consultancy, are:

    • No. 1 – London, United Kingdom
    • No. 2 – Paris, France
    • No. 3 – New York, New York
    • No. 4 – Tokyo, Japan
    • No. 5 – Singapore
    • No. 6 – Dubai, United Arab Emirates
    • No. 7 – San Francisco, California
    • No. 8 – Barcelona, Spain
    • No. 9 – Amsterdam, Netherlands
    • No. 10 – Seoul, South Korea
    The full list of cities and the report's methodology can be found on worldsbestcities.com.

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    This article originally ran on CultureMap.

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