The funds will go toward the Kinder Institute's civic data initiatives. Photo via news.rice.edu

The Houston Endowment has renewed its support of Rice University's Kinder Institute for Urban Research with a $2.25 million three-year grant to expand its services relating to urban data collection and use.

"We are immensely grateful to Houston Endowment for its continued support of Rice and the Kinder Institute," Rice President David Leebron says in a release. "This renewed funding will allow the institute to continue its critical data-driven work to better understand the challenges that Houston and other cities are facing and create lasting solutions. Contributing to our home city and others in this way is central to Rice's mission and its strategic plan, and we are extremely appreciative of this generous support."

In addition to supporting the Kinder Institute's data tools, the funding will contribute to the Houston Urban Data Project 2.0. The institute is involved in the project as is the Houston Community Data Connections, or HCDC. According to the release, the UDP will work to align and enhance urban and community data initiatives, develop training and research support for a larger user base, and raise awareness of the institute's research through outreach.

The HCDC, which was established in September of 2017, is already equipped to analyze 143 areas in Harris County with over 9,000 users, almost 16,000 site sessions, and over 45,000 page views, per the release. The program has seen 120 research and data requests since launch. Meanwhile, the UDP has 200 datasets in Houston and has 400 users who have accessed the site 6,000 times since it launched in the Spring of 2018

"The UDP and HCDC have laid the foundation for a shift in how data is used and decisions are made in the public, philanthropic and nonprofit sectors, and this funding will allow the Kinder Institute to build on this work," says Bill Fulton, director of the institute, in the release. "This project will help drive effective, data-driven decision-making for the region and will make the Kinder Institute the data hub for the entire region and a model for other cities around the world."

The purpose of the program will be two initiatives: Building Better Cities, which will focus on government efficiency and urban systems, and Building Better Lives, geared at quality of life and urban disparity among Houston residents.

"At Houston Endowment, our vision is a vibrant region where all have the opportunity to thrive," says Ann B. Stern, president and CEO of Houston Endowment, in the release. "We believe that making good data available to the public leads to better-informed decision-making on the part of our public officials and allows residents to more effectively advocate for their communities' needs. This is why the UDP and HCDC are so important for the future of our region."

The Kinder Institute, founded in 2010, is a research and advocate organization for urban development in Houston, and the Houston Endowment, established by Jesse H. and Mary Gibbs Jones in 1937, has assets of $1.8 billion and contributes around $70 million annually.

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.