Houston's top startup mentors of 2022 share go-to advice for founders

words of wisdom

The five finalists for Mentor of the Year in the Houston Innovation Awards sound off on their best advice. Photos courtesy

Houston is home to many great mentors — all hailing for completely different backgrounds.

At the Houston Innovation Awards Gala on November 9, InnovationMap and Houston Exponential are honoring five finalists selected by judges — and naming one winner — who have dedicated at least a portion of their lives to supporting others within the startup and tech scene in Houston.

Here are some words of wisdom from our awards honorees from the Mentor of the Year category for the 2022 Houston Innovation Awards.

"I always remind people to be open and ask for help. There is a common misconception that if you disclose your idea, someone else will quickly run with it and beat you to market! ... Don’t alienate yourself by overprotecting the idea and keeping it all to yourself. The more you open up about your idea the more feedback you’ll get, good and bad, both of which are vital in the success of the product long term."

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- Alfredo Arvide, Blue People and HOUnited. Arvide, who's been an advisor for over a decade, adds, that "most markets are big enough to allow competition to thrive, so keeping your idea behind close doors until you launch may hurt you as the market may not be ready for it. Having multiple players competing in the market will help you in the long run, as long as you have a great product and a sound marketing strategy."

"Understand the problem you are trying to solve. Build a team that works well together and has the intellect, drive, and willingness to develop and bring to market a solution for that problem. Leadership is not about giving orders and making all the decisions. It is about creating the environment for your team members individually and collectively to do their best work and be most fulfilled."

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- Barbara Burger, adviser and board member for several startups and organizations. With over 20 years of experience supporting startups, Burger says she is mostly focused on startups dedicated to decarbonizing the energy system.

"Don't have 'rocking chair regret.' What I mean is when you are old and in a rocking chair, you aren't going to regret the year (or less) you took away from a guaranteed salary to test if your idea worked. So, take the time and follow your dreams — you never know what could happen!"

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- Craig Ceccanti, T-Minus Solutions. Ceccanti, who also co-founded Pinot's Palette and Rivalry Technologies, has been mentoring for over a decade. "I love helping people and always have so helping others achieve their dreams is a natural progression for me, he says. "I've also had incredible mentors and I like to pay it forward every chance I get. I feel that mentoring is fun, therapeutic, and mutually beneficial as I feel I learn from the smart people I get to talk to daily!

"Bring great people on your journey with you — team members, advisors, investors, mentors, consultants, etc."

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- Emily Reiser, Texas Medical Center and Enventure. Reiser, who's mentored companies for several years, says it's her own mentors that inspired her. "I had excellent mentors who generously gave their time for me, especially Upendra Marathi, and it's just a given that I mentor others. It's a privilege to learn from the people I mentor and see them become successful."

"Be your own cheerleader. Stay true to yourself and don't give up."

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— Kara Branch, founder of Black Girls Do Engineer Corp. "I have always been the only black woman in all my roles. As a mother of three daughters, my oldest daughter inspired Black Girls Do Engineer Corp.," Branch says. "When she daughter was 9, she came to me and said she wanted to be a software engineer. ... If anyone can help her achieve her dreams is her mom and I wanted to create a space for girls who look like my daughter to come together and do the things they love and are passionate about."

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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