Houston-based subscription box startup plans expansion and new subscriber features

Hostess with the Mostess

Lindsey Rose King created a seasonal home goods box that shows consumers how to enjoy each item. Courtesy of Mostess

A few years ago, Lindsey Rose King offered to host her friend's engagement party, and she realized she had no clue where to start. There weren't any real resources out there for her to seek out.

King created Mostess, a seasonally curated home goods subscription box aiming to make it easier to host friends and family into their homes. The company was founded in January of 2017.

"I came up with the idea out of a need," says King, founder and lead curator, "it's hard to casually invite people into your house."

Almost two years later, King has managed to accomplish a lot of her goals, and Mostess has a great retention rate of subscribers with about a 30 percent growth each quarter, King says.

"We have a 5 percent churn rate, so 95 percent of customers have been customers since their first purchase," says King.

Mostess moves to disrupt the retail space by changing how consumers shop for home goods, accessories, and tabletop items. The box presents products in a different setting than consumers are used to seeing in a brick-and-mortar store by combining products from different brands and lines that may not be typically paired.

"Consumers are getting a product because we are referring it and picking it for them," King says. "We're choosing for the consumer, rather than them choosing themselves."

Growing business
In need of more space, the growing company recently moved into a warehouse in the Houston-area in a partnership with Alpha Graphics West Houston to launch its first local fulfillment center.

Currently, Mostess ships to 48 states, and next year, King says she wants to be able to ship to Alaska and Hawaii by July. Since the box has already got some buzz around it in Canada, King says she hope to be able to start her first international shipping there by 2020.

Mostess is in the wrapping up its busiest season; the company just released its winter box, which, along with the autumn box, King says subscribers usually purchase additional boxes for friends and family.

Looking forward to 2019, she's got exciting advancements for her subscribers.

In 2019, Mostess will begin offering slight customizations to each seasonal box and a special evergreen box. Customers will be able to purchase add-on items beginning with the spring box, such as extra candles or accessories in addition to what is offered. The Mostess evergreen boxes will have neutral and classic home accessories and hosting pieces. King says she wants these boxes to be a go-to gift idea or party-hosting asset for everything from a housewarming to an engagement party.

Starting from scratch
King first had the idea for Mostess toward the end of her 10-year stint living in Washington, D.C. Anticipating a move to Houston, King began to research local bloggers and small businesses to build a support system and platform for Mostess prior to the launch.

"In the small business world in Houston, there is the blogging community and there are actual small businesses," says King. "Both are very active and both very open to chatting about how to make business work between both of you."

King tells InnovationMap that Houston is an ideal city for an entrepreneur, offering a collaborative community of friendly, laid back, and hard-working small business owners.

King shares that she launched Mostess without any outside investment, using only her personal funds to get the product off the ground and relied on her friends and family as a test market. From there, she sought feedback from every single customer and potential customer, collected data, and tweaked details leading up to the launch.

"There was not a home goods subscription box on the market," says King, "I didn't have something to model after."

Elegant items shipped to your door

Paige Baker/Mostess

Mostess memberships begin at $120 per seasonal box.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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