Here's how these Houston health care institutions ranked compared to the rest of the country. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

It’s a three-peat for Houston Methodist Hospital.

For the third in a row, Healthgrades has named Houston Methodist the best hospital in Texas and one of the 50 best hospitals in the country. It’s the only Texas hospital in the top 50. Houston Methodist, a 907-bed facility at the Texas Medical Center, earned the same recognition in 2020 and 2021.

Four other hospitals in the Houston area made Healthgrades’ list of the top 250 hospitals in the U.S.:

  • Baylor St. Luke’s Medical Center
  • Houston Methodist Baytown Hospital
  • Houston Methodist Willowbrook Hospital
  • Memorial Hermann – Texas Medical Center

Four Houston hospitals also excelled in several of Healthgrades’ specialty categories:

  • Memorial Hermann Memorial City Medical Center, No. 3 in the state for heart surgery.
  • Memorial Hermann – Texas Medical Center, No. 1 in the state for stroke care and No. 2 for coronary intervention.
  • Houston Methodist Hospital, No. 2 in the state for critical care and No. 2 for pulmonary care.
  • Texas Orthopedic Hospital, No. 1 in the state for joint replacement.

Healthgrades, an online platform for finding physicians, hospitals, and other health care providers, rates hospitals based on clinical outcomes such as rates for patient deaths and treatment complications. For this year’s list, Healthgrades evaluated clinical performance at nearly 4,500 hospitals.

“For almost 25 years, our mission has been to provide consumers with clear and accessible information to make more informed health care decisions,” Dr. Brad Bowman, chief medical officer and head of data science at Healthgrades, says in a news release.

The Healthgrades rankings “provide consumers with increased transparency regarding the care in their areas, and empowers them to make more confident care decisions for themselves and their families,” Bowman adds.

For Houston Methodist, kudos like those from Healthgrades are common. For instance, the hospital last year landed at No. 16 on U.S. News & World Report’s national honor roll for the best hospitals, up from No. 20 the previous year. It was the top-rated Texas hospital on the list.

“These national accolades are something to be proud of, but most important, our patients are benefiting from all of our hard work. Ultimately, they are the reason we need to be one of the best hospital systems in the country,” Dr. Marc Boom, president and CEO of Houston Methodist, said last year in a news release about the U.S. News award.

The Healthgrades honor is one of several pieces of good news for Houston Methodist this year.

The hospital recently unveiled plans for the 26-story Centennial Tower. Scheduled to open in 2027, the $1.4 billion tower will include a larger emergency department and hundreds of patient beds, among other features. The new tower will replace the Houston Main building and West Pavilion.

Shortly after that announcement, the Houston Methodist system said it had received an anonymous $50 million gift. It’s the second largest donation in the system’s 102-year history.

Joining Houston Methodist Hospital in Healthgrades’ national top 250 this year are:

  • Baylor Scott & White Medical Center – McKinney
  • Baylor Scott & White Medical Center – Temple
  • Doctors Hospital at Renaissance in Edinburg
  • Hendrick Medical Center in Abilene
  • Medical City Arlington
  • Medical City McKinney
  • Methodist Hospital in San Antonio
  • St. David’s Medical Center in Austin
  • St. David’s South Austin Medical Center
  • William P. Clements Jr. University Hospital in Dallas
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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.