Public universities can be negatively affected during a government shutdown — especially within its research department. Miguel Tovar/University of Houston

As the partial government shutdown loomed, academic institutions explored ways this might affect their research operations. Although we expect delays in processing proposals and award payouts, the impact on the institution may have been much less than expected. Consequently, most of the impact occurred at the individual principal investigator, or PI, level. That is where research that required federal resources came to a halt.

This is also the case for researchers at the Borders, Trade, and Immigration (BTI) Institute at the University of Houston. As a result of the shutdown, they were unable to start any new projects. Sadly, the government furloughed their program manager at the Department of Defense- Science and Technology Office of University Programs.

Education initiatives and multiple other research projects pending review were stuck along the "assembly line," as approvals did not happen during the month of January.

Consequently, BTI is a granted institution. Current projects were able to continue with slight delay due to the requirement to have meetings with the DHS representatives for their projects.

This scenario echoed across the research enterprise, as other researchers found themselves in similar situations.

Business as somewhat usual

Moreover, Nicholas Bond, climatologist and associate professor of atmospheric sciences at the University of Washington, felt the pinch of the shutdown and chronicled his experiences of how it impacted his research on climate and oceanography of the North Pacific.

Academic institutions across the country became burdened with the task of assuming unexpected financial responsibilities. In mid-January, the lapse in governmental funding forced The Ohio State University to temporarily cover the costs of unbilled expenditures to the tune of about $3 million. Harvard University continued to pay stipends for fellowships. They did this despite the fact that the shutdown included the federal funding agency.

Many faculty members, including our own, were able to continue working on their projects with the expectation of administrative delays. No new funding opportunities were issued, panel reviews were postponed and no new grants or no-cost extensions were awarded. For the most part, it was business as (somewhat) usual.

The big picture

It may be safe to say that the partial shutdown acted more as an inconvenience to the research enterprise than anything. Which is great news! Especially for the University of Houston, who has recently ignited the campus with the announcement of the 50-in-5 initiative. This ambitious program will increase the research and scholarly output by 50 percent over the next five years.

While this article focuses on the inconvenience of administrative delays, it's critical not to skim the surface. It may seem minute when compared to recipients of public assistance fearing not receiving benefits, but short-term implications are likely.

Keep in mind that most often, grants are not awarded by a single payment from the agency. Timelines are established between agencies and the institutions, and funds are released accordingly. Because of this, it's likely that research programs and educational initiatives across the academic research enterprise will not receive their funds on schedule.

What the future holds

Imagine, if you will, a conveyor belt. A system designed to allow items to move through a process with maximum efficiency. Because of the partial shutdown, research proposals that were in queue for review or funding experienced interruption along the conveyor belt.

Once disruptions to processes within federal agencies happen, it becomes inevitable that there will be delays further down the line.

Claudia Neuhauser, associate vice chancellor/vice president for Research and Technology Transfer for the UH System, warns of the "ripple effect" of the downstream delays and the potential impact on expenditures. We'll have to wait until the end of the year when annual reports are prepared for answers.

For now, it's a question of what the aftereffect will be.

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This article originally appeared on the University of Houston's The Big Idea.

Nitiya Spearman is the internal communications coordinator for the UH Division of Research.

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Greentown Labs names Lawson Gow as its new Houston leader

head of hou

Greentown Labs has named Lawson Gow as its Head of Houston.

Gow is the founder of The Cannon, a coworking space with seven locations in the Houston area, with additional partner spaces. He also recently served as managing partner at Houston-based investment and advisory firm Helium Capital. Gow is the son of David Gow, founder of Energy Capital's parent company, Gow Media.

According to Greentown, Gow will "enhance the founder experience, cultivate strategic partnerships, and accelerate climatetech solutions" in his new role.

“I couldn’t be more excited to join Greentown at this critical moment for the energy transition,” Gow said in a news release. “Greentown has a fantastic track record of supporting entrepreneurs in Houston, Boston, and beyond, and I am eager to keep advancing our mission in the energy transition capital of the world.”

Gow has also held analyst, strategy and advising roles since graduating from Rice University.

“We are thrilled to welcome Lawson to our leadership team,” Georgina Campbell Flatter, CEO of Greentown Labs, added in the release. “Lawson has spent his career building community and championing entrepreneurs, and we look forward to him deepening Greentown’s support of climate and energy startups as our Head of Houston.”

Gow is the latest addition to a series of new hires at Greentown Labs following a leadership shakeup.

Flatter was named as the organization's new CEO in February, replacing Kevin Dutt, Greentown’s interim CEO, who replaced Kevin Knobloch after he announced that he would step down in July 2024 after less than a year in the role.

Greentown also named Naheed Malik its new CFO in January.

Timmeko Moore Love was named the first Houston general manager and senior vice president of Greentown Labs. According to LinkedIn, she left the role in January.

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.