At the recent Global Corporate Venture conference, two corporate venture execs peeled back the curtain on what they look for from startups. Getty Images

One of the challenges for Houston energy startups is not knowing what potential big corporate partners want from them. At the recent Global Corporate Venture, two corporate venture execs shared what all they're looking for and the challenges they are facing.

Diana Grauer, director of external technology engagement and venture capital at Technip FMC, and Bradley Andrews, president of digital at Worley joined a panel with moderator Wade Bitaraf, founder of Plug and Play Energy & Sustainability. The panel, entitled "How globalization and diversification can boost a local innovation ecosystem," explored what each exec looks for in potential partnerships with startups.

At TechnipFMC, which has a newer corporate investment group, Grauer says her team looks for startup technologies within four key categories, industry 4.0, digitization, materials and processes, and energy transition. Within those categories, she says they aren't looking for startups that will provide a big return on investment, rather technologies that will advance the company's capabilities.

"We're focused on strategic returns, not necessarily your conventional financial returns," she says.

Andrews echoed this point, admitting that while a big exit for a portfolio company is never bad, but Worley would rather have technologies that benefit their business platform.

"As long as [a technology is] under core strategy and driving internal strategy, we're kind of in," he says. "Anything around data science, automation, new energy, sustainability, those are all kind of sweet spots for us."

A big challenge, Andrews says, is communicating companywide the importance of looking outward for innovative opportunities, rather than relying on the company's staff.

"The idea of corporate tech startups coming to fruition within our industry is kind of new. We used to build from within," Andrews says. "We're still as an industry trying to figure out how to do this."

Grauer says that, similarily, her biggest challenge is getting pushback from within TechnipFMC of people who just think their company should fund its current workforce to find solutions. But Grauer responds to them explaining that the company needs to move faster than that and the way to do that is through working with startups. That's why the company has created an Open Innovation Program. According to Grauer, the organization expects to make its first investment by the end of the year.

For Andrews, the state of Houston's innovation ecosystem is exciting, and he notes that he looks at emerging technologies across industries. A technical solution in medicine might have an application in energy, for example. And, considering the state of the energy industry, now is the time to be more collaborative within Houston as more and more global challenges emerge.

"I think Houston has everything it needs to make a stake in this," Andrews says. "We're not competing with each other in this industry. We're competing against what the world is going to demand from us. It's time for us in corporate land and set our egos aside."

Grauer says she's seen the city's innovation resources grow over the years, noting the emergence of The Cannon, Rice Alliance, and Plug and Play.

"I really think that the energy industry in Houston is really starting to catch up and blossom," she says.

From enlightening talks and conventions to networking opportunities, here's where you need to be in November. Getty Images

10+ can't-miss Houston business and innovation events for November

Where to be

Looking for some help navigating an innovation-filled month in Houston? Look no further.

November is jam packed with Houston business and innovation events — from huge conventions like SpaceCom and Global Corporate Venture taking over downtown on the same days to the Digital Fight Club battling it out in Houston for the first time and The Houston Innovation Summit planning a week of programming.

If you know of innovation-focused events for this month or next, email me at natalie@innovationmap.com with the details andsubscribe to our daily newsletterthat sends fresh stories straight to your inboxes every morning.

November 5 — Female Founder Luncheon with MassChallenge and HX

Houston is full of entrepreneurial women and this event aims to bring women together and give access to top female entrepreneurs and passionate women in local businesses. They will share their 'why,' their stories, challenges, successes, tips, and answer your burning questions about local entrepreneurship. Join us for a panel and lunch in a closed setting where we discuss what it takes to be a successful female entrepreneur.

Details: The event is from 11 am to 1 pm on Tuesday, November 5, at Houston Exponential (410 Pierce St.). Learn more.

November 6 — Texas Life Science Forum

Rice Alliance's Texas Life Science Forum brings together members from industry, emerging life science companies, academic, and investors. This is the "must attend" event for anyone in the life science industry in Texas or affiliated with innovation at the life science academic institutions.

Details: The event is from 8:30 am to 5 pm on Wednesday, November 6, at BioScience Research Collaborative (6500 Main St.). Learn more.

November 6 — Baker Tilly - Six Figure #Fail

Details: The event is from 11:30 am to 1 pm on Wednesday, November 6, at The Cannon (1336 Brittmoore Road). Learn more.

November 6 — Science First: Changing the Trajectory of Lung Cancer

In honor of Lung Cancer Awareness Month, JLABS sitting down with experts at The Lung Cancer Initiative at Johnson & Johnson and MD Anderson Lung Cancer Moon Shots as well as innovators in the field to present on and create dialogue around the core challenges faced by innovators in the field, new discoveries, emerging technologies, and potential solutions.

Details: The event is from 11 am to 1:30 pm on Wednesday, November 6, at JLabs @ TMC (2450 Holcombe Blvd.). Learn more.

November 7 — TMCx Demo Day: Medical Device 2019

TMCx's annual medical device cohort celebrates the end of another program as the participating entrepreneurs take to the main stage to pitch their solutions. During the event, 16 medical device startups will showcase the progress they have made on their solutions, and what they have planned for the future.

Details: The event is from 1:30 to 8 pm on Thursday, November 7, at TMC Innovation Institute (2450 Holcombe Blvd.). Learn more.

November 8-10 — Second Annual Health Equity Hackathon

CareSet presents the second annual Health Equity Hackathon using newly available data that will help address innovations for the underserved community in the U.S.

Details: The event is from November 8 through 10, at United Way of Greater Houston (50 Waugh Dr.). Learn more.

November 12 — Houston Forum for Equitable Development without Displacement

Rice University is planning to develop 16 acres around Houston's Wheeler Station to create a neighborhood centered around technology, innovation, and entrepreneurship. To demand that the developers sign a Community Benefits Agreement, we are establishing the Houston Coalition for Equitable Development without Displacement (HCEDD). All individuals, community groups, advocacy organizations, and supporting businesses/organizations who are interested in supporting this initiative are invited to attend.

Details: The event is from 6 to 8 pm on Tuesday, November 12, at Wesley AME Church (2209 Emancipation Ave). Learn more.

November 13 — Upstream Venturing + Technology Showcase

In collaboration and partnership with Equinor Technology Ventures, BP Ventures, Shell Ventures, Saudi Aramco Energy Ventures, and Cannon Ventures, hear the latest trends in upstream technology implementation.

Details: The event is from 5 to 8 pm on Wednesday, November 13, at The Cannon (1336 Brittmoore Road). Learn more.

November 14 — TopCoder Innovation Summit

The Topcoder Innovation Summit is the premier innovation event for industry leaders. At the Innovation Summit, you'll have the opportunity to speak with industry leaders, attend panels on innovation and emerging technologies, and meet with the Wipro and Topcoder executive teams.

Details: The event is from 8 am to 4:45 pm on Thursday, November 14, at InterContinental Hotel (6750 Main St.). Learn more.

November 14 — JLABS x UH: Startup Pains: From Academia to Startup (Therapeutics)

JLABS and the University of Houston Technology Bridge present a special installment of Startup Pains, a monthly talk given by entrepreneurs who share their journey of launching a company and overcoming unanticipated obstacles in order to find success in their industry. This month's focus is to arm those contemplating entrepreneurship with a road map for navigating the startup waters, specifically focused on therapeutics.

Details: The event is from 5:30 to 7 pm on Thursday, November 14, at JLabs @ TMC (2450 Holcombe Blvd.). Learn more.

November 15 — Tilting the Grid: How Electricity Companies Will Disrupt

Tilting the Grid is the conference where you can eavesdrop on what the most daring companies in the REP space are doing and discuss what the next "big" thing might be. Ready to learn what big data can reveal about customer behavior? Prepared for a deep dive into the latest customer acquisition trends?

Details: The event is from noon to 5 pm on Friday, November 15, at Whitehall Hotel Houston (1700 Smith St). Learn more.

November 18-24 — The Houston Innovation Summit

For the third year, Houston's innovation ecosystem is taking over the city for a week of events and programming coordinated by Impact Hub Houston. To check out the panels, meetups, and all other programming, click here. Note: Some of the specific events will also appear in this curated list of Houston events.

November 20 — Houston Digital Fight Club

Entrepreneurs and experts are taking the stage — or in this case ring — to battle out their ideas on tech and innovation in Houston. The high energy debate will take place across five fights and networking opportunities. Secure your tickets — it's expected to sell out.

Details: The event is from 6 to 10 pm on Wednesday, November 20, at White Oak Music Hall (2915 N Main St.). Learn more.

November 20 — Inside Billy's Brain: Surgeon, Inventor, Innovator

Join JLABS @ TMC and explore the mind and motivations of Dr. Billy Cohn, the renowned surgeon, inventor and innovator.

Details: The event is from 11:30 am to 1:30 pm on Wednesday, November 20, at JLabs @ TMC (2450 Holcombe Blvd.). Learn more.

November 20-21 — SpaceCom

SpaceCom, America's Commercial Space Conference and Exposition, addresses the strategic issues impacting the commercial space industry that will enable your business to set a clear course to gain a competitive advantage in the coming trillion-dollar space economy. SpaceCom is operating under a Space Act Agreement with NASA. In 2019, the Department of Commerce's Office of Space Commerce and the Department of Energy's Office of Technology Transitions join NASA and the commercial space industry in collaborating on the development of the show.

Details: The event is from Wednesday, November 20, to Thursday, November 21, at the George R. Brown Convention Center (1001 Avenida De Las Americas). Learn more.

November 20-21 — Global Corporate Venture 

Never has the energy industry been more vulnerable to disruption, but as open to change. The world's leading energy and transportation companies are using venture capital to invest in, and help deploy, new technologies and business models that will fundamentally change the way we generate, distribute and use energy.

Details: The event is from Wednesday, November 20, to Thursday, November 21, and takes place at various locations throughout the two-day conference. Learn more.

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.