Comicpalooza takes place Friday, May 9, to Sunday, May 12. Courtesy of Comicpalooza

People from around the world will be flocking to downtown Houston by the thousands, and not just for the Astros and the Rockets. The 11th annual Comicpalooza is taking over the George R. Brown Convention Center from Friday, May 10, to Sunday, May 12.

"This major super block in downtown will be absolutely electric this weekend," Michael Heckman, Comicpalooza president, tells InnovationMap.

Last year, the convention attracted over 50,000 people from 47 states and 17 countries, and it made an economic impact of over $20 million, Heckman says. This year, with the help of Game of Thrones stars and an inaugural ESPN event, Comicpalooza should surpass last year's accomplishments.

Here's what you can expect from this weekend.

A crowd at the panel that has two Game of Thrones actresses

Emilia Clarke (left) plays Daenerys in Game of Thrones, and Nathalie Emmanuel plays her adviser and friend, Missandei. Photos courtesy of Comicpalooza

A panel on Saturday morning at 11 am will have two Game of Thrones stars — Emilia Clarke (Daenerys) and Nathalie Emmanuel (Missandei). The panel is sure to attract the masses, and the two actresses are major gets by the organization.

"To be able to get Emilia Clarke in the middle of the final season of Game of Thrones, with only two episodes to go — the hype has been unbelievable," Heckman says. "To be able to have a pop culture phenomenon like that come here to Houston — and it will be her first fan event. She's done the San Diego Comic Con, but that was more of a media event."

Both actresses also have autograph visits available for purchase. Clarke's are sold out online, but some opportunities will be made available day of.

The first ever ESPN collegiate esports competition

ESPN's inaugural esports competition for college students is premiering at Comicpalooza. Jamie McInall/Pexels

For the first time ever, ESPN is having a collegiate esports championship and chose Houston to be the place for the finals.

"We've understood the value of [esports] for Comicpalooza for a number of years. ESPN is making a big investment — it's their first ever event of this nature, but it won't be their last," Heckman says.

Students from hundreds of schools have competed to make it to the semifinals and championship in Houston, and scholarships are on the line. The weekend will have 22 teams across five video games — Hearthstone, Heroes of the Storm, Overwatch, StarCraft II, and Street Fighter V — according to ESPN. To read more about the competition, click here.

Makers on display

Anyone can check out the Comicpalooza Maker's Space — there's even a place to fix any cosplay wardrobe malfunctions. Photo via comicpalooza.com

Calling all makers — professionals or wannabes. Comicpalooza's Maker's Space is open to cosplayers, artists, engineers, scientists and everyone in between who wants to create and build using old and new technology, from small electrical parts to towering 3D printers and Lego masterpieces.

"What a lot of people don't know is there are so many interesting aspects to Comicpalooza — from literature tracks to a film festival to a makerspace," Heckman says. "There are hundreds of exhibitors on the expo showfloor, but there's an area carved out for makers."

A party on the promenade

Free concert anyone? Photo via comicpalooza.com

From 6 to 10 pm on Saturday, Avenida Houston will be transformed into an after party put on by Saint Arnold's and headlined by Icona Pop. It's free to attend, and you can get more info here.

VIPs all around

It's not just the Game of Thrones people being featured. Photos via comicpalooza.com

Comicpalooza attendees can grab photos with or autographs from over 30 different actors across major franchises — like Star Trek, Walking Dead, and so much more.

The list of actors is as follows: Emilia Clarke, Nathalie Emmanuel, Grant Gustin, Wilmer Valderrama, Dan Fogler, Gates McFadden, Michael Dorn, John Wesley Shipp, Peter Serafinowicz, Griffin Newman, Yara Martinez, Brendan Hines, Scott Speiser, Jeremy Davies, Andrew Divoff, Mira Furlan, Erick Avari and more.

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”

Chevron enters the lithium market with major Texas land acquisition

to market

Chevron U.S.A., a subsidiary of Houston-based energy company Chevron, has taken its first big step toward establishing a commercial-scale lithium business.

Chevron acquired leaseholds totaling about 125,000 acres in Northeast Texas and southwest Arkansas from TerraVolta Resources and East Texas Natural Resources. The acreage contains a high amount of lithium, which Chevron plans to extract from brines produced from the subsurface.

Lithium-ion batteries are used in an array of technologies, such as smartwatches, e-bikes, pacemakers, and batteries for electric vehicles, according to Chevron. The International Energy Agency estimates lithium demand could grow more than 400 percent by 2040.

“This acquisition represents a strategic investment to support energy manufacturing and expand U.S.-based critical mineral supplies,” Jeff Gustavson, president of Chevron New Energies, said in a news release. “Establishing domestic and resilient lithium supply chains is essential not only to maintaining U.S. energy leadership but also to meeting the growing demand from customers.”

Rania Yacoub, corporate business development manager at Chevron New Energies, said that amid heightening demand, lithium is “one of the world’s most sought-after natural resources.”

“Chevron is looking to help meet that demand and drive U.S. energy competitiveness by sourcing lithium domestically,” Yacoub said.

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This article originally appeared on EnergyCapital.