An expert from the U.S. Small Business Administration shares in an op-ed how critical women-owned businesses are to small business exports in Texas. Photo via Getty Images

Everything is bigger in Texas, including its small business ecosystem. There are over three million small businesses in the state, which represent 99.8 percent of all Texas businesses. However, according to the latest official U.S. Census Bureau data on small business exporters (2020), only 35,124 Texas-based companies exported goods abroad.

During my time in the Administration, I have had the opportunity to visit Texas on several occasions, including trips to Houston, San Antonio, and El Paso. Like most everything in Texas, the entrepreneurial ecosystem is sizable and a rich source of opportunity and ideas. But with over a thousand miles of shared border with Mexico, and considerable trade infrastructure like the Port of Houston, you can’t tell me that just 1 percent of Texas small businesses are exporting their products or services. This data, which mirrors the published trend for small business exporters nationwide, seemed severely undercounted. So, we endeavored to dig into what was going on.

As a result, the Office of International Trade (OIT) commissioned a study to determine the total addressable market (TAM) of small business exporters. The research dug deep into available public data and private surveys, which better accounted for smaller shipment values and growth in service exports. Among the key findings from the study is new data that places the actual number of exporting small businesses at 1.3 million – an almost fivefold increase over the estimates previously published by the Federal Government. Interestingly, minority, women-owned firms were found to over-index in selling abroad. The research also revealed a high concentration of certain tradeable sectors ranging from consumer, industrial, and other manufactured goods to services businesses in software, architectural, and engineering sectors. Ultimately, the study estimated the potential market size, or total addressable market, at over 2.6 million small businesses.

With the proliferation of digital commerce tools and with over 95 percent of the world’s consumers living outside the United States, international sales represent a rich growth opportunity for small businesses. Indeed, businesses that export are more resilient, expand faster, and create higher paying jobs for Americans.

My colleague, District Director Tim Jeffcoat agrees. With his finger on the local pulse of the Houston-area economic market, he knows that exporting can be both an enormous growth opportunity, but at the same time filled with a daunting set of challenges to navigate. In his

Houston area network alone, they have over 200 advisors, mentors, and counselors that can guide you to develop a robust exporting plan, connect you with capital to fund your overseas expansion, and can even help you pursue a competitive grant to kick-start international sales.

This is exactly the case for Pat Hartmann, founder of Hartmann’s Inc., an Abilene, TX-based woman-owned small business. As a manufacturer of high-quality parts from state-of-the-art metal fabrication and welding departments, Hartmann has leveraged international sales to grow her company over three generations. In her words: “exporting has allowed us to become competitive in multiple markets throughout the entire world. It has diversified our knowledge base allowing us to work in manufacturing situations that span multiple types of standards including European and Japanese. Exporting now makes up 20 percent of our sales.”

As a result, Regional Administrator Ted James and I are among the many Administration officials who are pleased to recognize Pat Hartmann of Hartmann’s Inc. as the 2023 South Central Regional Exporter of the Year. She has established herself as a personal and professional role model due to their expansion and contributions to the community. We are confident that small businesses like these, as well as those identified in our Total Addressable Market study, can start and continue to leverage SBA resources to scale their business and access international opportunities, just as Hartmann did.

Pat Hartmann is one of the more than 11 million female founders the SBA is recognizing during Women’s History Month this March. While the post-pandemic recovery has complicated the economic landscape, we continue to better understand the important role women-owned small businesses play in our entrepreneurial ecosystem. They continue to contribute substantially to the national economy, showcasing innovative solutions and trailblazing techniques to lead the way forward.

If you are a current or future entrepreneur looking for assistance in how to get started or grow internationally, contact the SBA’s Office of International Trade or our network of 68 district offices which offer access to counseling, access to contracts, and access to capital.

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Gabriel Esparza is the associate administrator for the Office of International Trade at the U.S. Small Business Administration.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”