Fresh funds: 2 Houston organizations dole grants to advance research

research roundup

Here's what researchers raked in the cash to support their research. Photo via Getty Images

Funding fuels the research that supports the innovations of tomorrow. Two Houston-based scientific organizations announced funding recipients that are working on advancing research in space health and chemistry.

4 research teams receive funds to advance space health work

The Translational Research Institute for Space Health, known as TRISH, at Baylor College of Medicine has announced almost $4 million in grants to four research teams. As more and more plans to launch humans into space continue to develop, TRISH is working to support research addressing human health in space.

TRISH's Biomedical Research Advances for Space Health initiative looked for new ways to reduce potential damage from the environment through manipulation of human metabolism and the normal state-of-being at the cellular or whole organism level, according to a press release.

"These outstanding awardees brought cutting-edge proposals to the table. Each project provides a unique opportunity to advance human health research on the bleeding edge of science fiction," says TRISH Executive Director, Dorit Donoviel, in the release. "This creative research has the potential to protect all humans through advancing tissue transplantation or helping patients that have medical conditions such as heart or brain damage that could be aided by reducing cellular activity."

The awardees, who will begin their TRISH-funded research in April 2022, for BRASH 2101 included:

Clifton Callaway, M.D., Ph.D., University of Pittsburgh, Pennsylvania
- Cold-Sleep for Long Duration Spaceflight
Tammy Chang, M.D., Ph.D., University of California, San Francisco
- The Effect of Isochoric Supercooling on Human Liver Metabolic Function
Allyson Hindle, Ph.D., University of Nevada, Las Vegas
- Can Humans Hibernate at Warm Temperatures?
Christopher Porada, Ph.D., Wake Forest University, Winston-Salem, North Carolina
- Using Human Organoids and Fossilized Remains from Extinct Hominins to Unlock the Secrets of Torpor/Hibernation

Houston organization names 2021 award recipient

The Welch Foundation has named professor Chi-Huey Wong as the 2021 recipient of the Robert A. Welch Award in Chemistry. Wong is a leader in synthetic chemistry and chemical biology. Specifically, the award recognizes Wong for his development of new methods for the synthesis of complex carbohydrates and glycoproteins and the elucidation of carbohydrate-mediated biological recognition associated with disease progression, according to a press release.

"The mission of The Welch Foundation is to improve the lives of others through the advancement of chemical research, and Dr. Wong has been working towards that goal for decades," says Carin Barth, chair and director of The Welch Foundation Board of Directors. "Not only has he made revolutionary advances in chemistry and biology, but his methodologies will facilitate new drug and vaccine developments for years to come."

Wong is the Scripps Family Chair Professor in the Department of Chemistry at The Scripps Research Institute. He will receive $500,000 to advance his research. Houston-based Welch Foundation has contributed more than $1.1 billion to the advancement of chemistry since 1954.

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

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