Flourishing Nexus recently won runner up in the innovation category of the city's Liftoff Houston competition. Photo courtesy of the City of Houston

Connecting medical professionals is about to get easier thanks to a new Houston company, Flourishing Nexus.

Next month, their digital platform, The Nexus, will debut to in a soft launch to a curated group of TMC employees.

“Think of it as a combination of existing platforms like LinkedIn, providing professional networking; Khan Academy, which provides excellent training and education; and a collaborative workspace like Google Workspace or Microsoft Teams, all enhanced by AI,” says Diane Nguyen.

Nguyen is a pharmacist by training, while her co-founder, Satid Thammasitboon, is an MD and master in health professions education.

The pair began working together in the health professions education space three years ago, but only established Flourishing Nexus in July of 2023. The company’s moniker refers to the concept of human flourishing.

“Our mission would be to promote human flourishing among health professionals,” says Thammasitboon.

The concept of human flourishing traces back at least to Aristotle, but The Nexus’ understanding of it is based on psychologist and educator Martin Seligman’s PERMA theory. The mnemonic stands for Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment.

“We endeavor to bring these concepts of PERMA and human flourishing into the health professions space,” says Nguyen.

“Often our healthcare organizations or industries, when they hear health professionals are having issues with burnout, the response or reaction would be to increase incentive, financial support, or professional development to enhance resilience,” adds Thammasitboon. “We search for meaning we want to make a difference in the life of another rather than ‘everything is all about money.’”

Both professionals have globe-spanning careers. Thailand native Thammasitboon says that his endeavors have taken him across Europe, Southeast Asia, and East Asia, while Nguyen’s work has focused her attention on South America, sub-Saharan Africa, and Eastern Europe.

“I realized that the key to providing better outcomes and health care for the patients was really dependent on the continuing education and training of the staff,” Nguyen says.

Those experiences proved to be the roots from which The Nexus grew.

But the team’s colleagues abroad won’t be among the first The Nexus users. That distinction will belong to Houston’s rich community of medical pros. And when the platform soft launches in January, it will be with two awards already under its belt.

The Liftoff Houston Startup Business Plan competition took place last month. Nine finalists, mostly entrepreneurs from underrepresented backgrounds, were selected from among 100 applicants to compete in Liftoff’s Pitch Day. Not only was The Nexus among those competitors, it raked in a runner-up prize, as well as fan favorite in the innovation category.

Nguyen, who did the pitching, says that Liftoff helped Flourishing Nexus tremendously with both its preparation workshops and feedback from the judges.

“Sometimes you think you have a great idea but it’s not until you critically think about your own plan, analyze your plan, and prepare to pitch it that you really learn about it. This preparation helped us and strengthened our mission. Our business plan is much better,” says Thammasitboon.

Next up? Launching and growing The Nexus’ community. Nguyen also says they plan to participate in more competitions, including possibly Houston Community College’s Business Plan Competition. It’s one more way of bringing the abstract concept of human flourishing to a flesh and blood audience.

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Austin company to bring AI-powered school to The Woodlands

AI education

Austin-based Alpha School, which operates AI-powered private schools, is opening its first Houston-area location in The Woodlands.

The 8,000-square-foot school, scheduled to be ready for the 2026-27 academic year, initially will serve students in kindergarten through eighth grade. Alpha says the school will offer “open workshop spaces and innovative classrooms that support personalized instruction, core academics, leadership development, and real-world life skills.”

Alpha sets aside two hours each school day for the AI-driven, self-paced study of core subjects like math, reading and science. The rest of each school day consists of life-skills workshops focusing on topics such as leadership and financial literacy.

Alpha’s school in The Woodlands has begun accepting applications for the 2026-27 school year. Annual tuition costs $40,000.

“The Woodlands is one of the most dynamic, forward-thinking communities in Texas, and Alpha is proud to bring

an innovative educational model that complements its strong academic foundation,” says Rachel Goodlad, head

of expansion for Alpha.

Founded in 2014, Alpha School combines adaptive technology-driven instruction with immersive life-skills workshops. Its model emphasizes mastery-based learning in core subjects alongside development of communication, critical thinking, financial literacy and leadership skills. It operates more than 15 schools across the country.

Elsewhere in Texas, Alpha operates schools in Austin, Brownsville, Fort Worth and Plano. Alpha also operates 12 Texas Sports Academy campuses in Texas, including locations in Houston, Pearland and Richmond, along with a NextGen Academy esports school in Austin, a school for gifted students in Georgetown, and lower-cost Nova Academy campuses in Austin and Bastrop.

Alpha has fans and critics. While supporters tout students’ high achievement rates, detractors complain about the high tuition and the AI-influenced depersonalization of education.

“Students and our country need to be in relationship with other human beings,” Randi Weingarten, president of the American Federation of Teachers, a teachers union, tells The New York Times. “When you have a school that is strictly AI, it is violating that core precept of the human endeavor and of education.”

Alpha co-founder MacKenzie Price, a podcaster and social media influencer, doesn’t share Weingarten’s views.

“Parents and teachers: We need to embrace this change,” Price wrote after President Trump signed an executive order promoting AI in schools.

The Times notes that Alpha doesn’t employ AI as a tutor or a supplement. Rather, the newspaper says, AI is “the school’s primary educational driver to move students through academic content.”

Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”