New Houston accelerator leader dives into first cohort

HOUSTON INNOVATORS PODCAST EPISODE 83

Kate Evinger joins the Houston Innovators Podcast to discuss the latest from gBETA Houston. Photo courtesy of gBETA

Everything's bigger in Texas, but Kate Evinger is focused on zeroing in on a small group of startups to help them in a Texas-sized way.

As director of gBETA Houston, Evinger says the program, which expanded to Houston in 2019, is geared toward supporting companies as they navigate the initial challenges of starting a company.

"We look at early-stage companies, so those that are pre-seed or seed-stage that are looking for mentorship or support," Evinger says on this week's episode of the Houston Innovators Podcast, "and we help get to that next step whether that's to raise an upcoming round or if they are looking to get into an equity-based accelerator program."

The program runs two 7-week cohorts a year — and only five companies join each round. This tight-knit group is to the cohort's advantage, Evinger says.

"It's a very small group that we bring in, and we do this very purposefully, because we like to use a concierge approach, meaning that we tailor the experience to each of the five company's personal goals," she explains.

This week, gBETA Houston announced the latest cohort's member companies, which includes five Houston-based companies: Veza, Upbrainery, FareUpThere, Custodian Corp., and Clyr.

The program, which is a part of Wisconsin-based gener8tor, began May 6 and concludes July 7 with a pitch day. The local operation is housed out of the Downtown Launchpad alongside Impact Hub Houston and MassChallenge Texas.

"The Downtown Launchpad is a phenomenal space," Evinger says. "It's a really amazing collaborative ecosystem for our companies to be able to leverage."

Evinger shares more about the new cohort growth and gener8tor's other opportunities on the episode. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


gBETA Houston, which is based out of Downtown Launchpad, has announced its latest cohort. Photo courtesy of the Downtown Launchpad

Global accelerator announces 5 startups to its Houston cohort

early-stage support

Five Houston companies have been tapped to participate in a Houston-based, early-stage startup accelerator with a national presence.

The accelerator, gBETA, selected the five Houston companies out of over 85 applicants. The cohort represents industries like education, travel, and fintech. The summer program launched on May 6 and will take place over seven weeks before concluding on July 7 at the gBETA Houston Pitch Night.

Here are the five startups selected from Houston:

  • Clyr, led by CEO and Co-founder Jeff Jensen, makes pools smarter and more sustainable through its eco-friendly approach. Clyr connects users with their pools through the first ever solar-powered WiFi-connected Smart Skimmer device and automates pool care using renewable resources. Since launching in 2020, Clyr is located in hundreds of pools across the US and has analyzed over 2 million pool chemistry data points and given over 100,000 recommendations for fixes.
  • Custodian Corp's software-as-a-service platform solves the data management and valuation pain points of venture capital and private equity managers faster and at a fairer price than competitors. Led by CEO Federico Jost, Custodian's main product is the CPMTOOL, a cloud-based solution to collect, aggregate, organize and analyze portfolio company data for monitoring and reporting purposes. Custodian launched in January of 2021, has six pilots to date and has tripled revenue since February of 2021.
  • FareUpThere's travel platform takes the mystery out of booking the perfect flight. Led by CEO and Co-Founder Malcolm Woods, FareUpThere's restaurant-style menu of flight amenities allows passengers to easily customize their perfect flight ranging from exact inches of legroom to whether the flight has Netflix. FareUpThere successfully launched a private beta in December of 2020.
  • UpBrainery, led by CEO and Founder Ghazal Qureshi, created a marketplace provides an AI-driven software platform and research-based, results-driven curriculum to students, parents, teachers and organizations. UpBrainery's journey mapping tool aligns a students educational interests and learning styles with their goals to visualize the steps needed to achieve them. Since launching in March of 2020, UpBrainery has provided over 5,000 students with opportunities for digital learning and customers include Whataburger, Girl Scouts and The Houston Rockets.
  • Veza, Launched in December, connects the world's influencer marketing experts through its professional social network. Veza's network supports both sides of the influencer marketing industry; the businesses searching for talent and the influencers looking for opportunities. Led by CEO Efrain Batista, Veza offers businesses access to the world's first free influencer search and discovery platform.

The program, which has been operating online due to the pandemic, has its local office in the Downtown Launchpad.

"Downtown Launchpad starts at the edge of technology and entrepreneurship, where cutting-edge ideas can quickly be explored, and future technology can become high-impact businesses. It was developed around a framework of resources to help entrepreneurs as they seamlessly navigate through the stages of startup production," says Robert Pieroni, director of Economic Development of Central Houston, in the release.

The free accelerator is a part of Madison, Wisconsin-based gener8tor's suite of accelerators, and announced its plan to launch in Houston in September 2019. The program's inaugural cohort premiered in May and conducted the first program this summer completely virtually. The second cohort took place last fall.

"In order to harness the impact of entrepreneurs and innovators of new technologies, an ecosystem involving many parts is needed," continues Pieroni. "That is why we recruited the nationally acclaimed startup accelerator, gener8tor, to our city. We're thrilled that gener8tor is one of Downtown Launchpad's resident partners and are helping us continue our mission to inspire innovation in the Houston community. I look forward to the impact created by the startups in this year's cohort."

Kate Evinger leads the local program as director. She recently assumed this role, and this will be her first cohort to direct.

"Houston is at a pivotal moment in time with the exciting innovations taking place in the ecosystem," says Evinger in the release. "I'm thrilled to be a part of the Houston community supporting the work of these incredible founders in the gBETA Houston Summer 2021 program."

Stream a recent episode of the Houston Innovators Podcast where Evinger shares what she's excited about for this cohort:

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

New accelerator joins the Ion and more Houston innovation news to know

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

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