New Houston accelerator leader dives into first cohort

HOUSTON INNOVATORS PODCAST EPISODE 83

Kate Evinger joins the Houston Innovators Podcast to discuss the latest from gBETA Houston. Photo courtesy of gBETA

Everything's bigger in Texas, but Kate Evinger is focused on zeroing in on a small group of startups to help them in a Texas-sized way.

As director of gBETA Houston, Evinger says the program, which expanded to Houston in 2019, is geared toward supporting companies as they navigate the initial challenges of starting a company.

"We look at early-stage companies, so those that are pre-seed or seed-stage that are looking for mentorship or support," Evinger says on this week's episode of the Houston Innovators Podcast, "and we help get to that next step whether that's to raise an upcoming round or if they are looking to get into an equity-based accelerator program."

The program runs two 7-week cohorts a year — and only five companies join each round. This tight-knit group is to the cohort's advantage, Evinger says.

"It's a very small group that we bring in, and we do this very purposefully, because we like to use a concierge approach, meaning that we tailor the experience to each of the five company's personal goals," she explains.

This week, gBETA Houston announced the latest cohort's member companies, which includes five Houston-based companies: Veza, Upbrainery, FareUpThere, Custodian Corp., and Clyr.

The program, which is a part of Wisconsin-based gener8tor, began May 6 and concludes July 7 with a pitch day. The local operation is housed out of the Downtown Launchpad alongside Impact Hub Houston and MassChallenge Texas.

"The Downtown Launchpad is a phenomenal space," Evinger says. "It's a really amazing collaborative ecosystem for our companies to be able to leverage."

Evinger shares more about the new cohort growth and gener8tor's other opportunities on the episode. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


gBETA Houston, which is based out of Downtown Launchpad, has announced its latest cohort. Photo courtesy of the Downtown Launchpad

Global accelerator announces 5 startups to its Houston cohort

early-stage support

Five Houston companies have been tapped to participate in a Houston-based, early-stage startup accelerator with a national presence.

The accelerator, gBETA, selected the five Houston companies out of over 85 applicants. The cohort represents industries like education, travel, and fintech. The summer program launched on May 6 and will take place over seven weeks before concluding on July 7 at the gBETA Houston Pitch Night.

Here are the five startups selected from Houston:

  • Clyr, led by CEO and Co-founder Jeff Jensen, makes pools smarter and more sustainable through its eco-friendly approach. Clyr connects users with their pools through the first ever solar-powered WiFi-connected Smart Skimmer device and automates pool care using renewable resources. Since launching in 2020, Clyr is located in hundreds of pools across the US and has analyzed over 2 million pool chemistry data points and given over 100,000 recommendations for fixes.
  • Custodian Corp's software-as-a-service platform solves the data management and valuation pain points of venture capital and private equity managers faster and at a fairer price than competitors. Led by CEO Federico Jost, Custodian's main product is the CPMTOOL, a cloud-based solution to collect, aggregate, organize and analyze portfolio company data for monitoring and reporting purposes. Custodian launched in January of 2021, has six pilots to date and has tripled revenue since February of 2021.
  • FareUpThere's travel platform takes the mystery out of booking the perfect flight. Led by CEO and Co-Founder Malcolm Woods, FareUpThere's restaurant-style menu of flight amenities allows passengers to easily customize their perfect flight ranging from exact inches of legroom to whether the flight has Netflix. FareUpThere successfully launched a private beta in December of 2020.
  • UpBrainery, led by CEO and Founder Ghazal Qureshi, created a marketplace provides an AI-driven software platform and research-based, results-driven curriculum to students, parents, teachers and organizations. UpBrainery's journey mapping tool aligns a students educational interests and learning styles with their goals to visualize the steps needed to achieve them. Since launching in March of 2020, UpBrainery has provided over 5,000 students with opportunities for digital learning and customers include Whataburger, Girl Scouts and The Houston Rockets.
  • Veza, Launched in December, connects the world's influencer marketing experts through its professional social network. Veza's network supports both sides of the influencer marketing industry; the businesses searching for talent and the influencers looking for opportunities. Led by CEO Efrain Batista, Veza offers businesses access to the world's first free influencer search and discovery platform.

The program, which has been operating online due to the pandemic, has its local office in the Downtown Launchpad.

"Downtown Launchpad starts at the edge of technology and entrepreneurship, where cutting-edge ideas can quickly be explored, and future technology can become high-impact businesses. It was developed around a framework of resources to help entrepreneurs as they seamlessly navigate through the stages of startup production," says Robert Pieroni, director of Economic Development of Central Houston, in the release.

The free accelerator is a part of Madison, Wisconsin-based gener8tor's suite of accelerators, and announced its plan to launch in Houston in September 2019. The program's inaugural cohort premiered in May and conducted the first program this summer completely virtually. The second cohort took place last fall.

"In order to harness the impact of entrepreneurs and innovators of new technologies, an ecosystem involving many parts is needed," continues Pieroni. "That is why we recruited the nationally acclaimed startup accelerator, gener8tor, to our city. We're thrilled that gener8tor is one of Downtown Launchpad's resident partners and are helping us continue our mission to inspire innovation in the Houston community. I look forward to the impact created by the startups in this year's cohort."

Kate Evinger leads the local program as director. She recently assumed this role, and this will be her first cohort to direct.

"Houston is at a pivotal moment in time with the exciting innovations taking place in the ecosystem," says Evinger in the release. "I'm thrilled to be a part of the Houston community supporting the work of these incredible founders in the gBETA Houston Summer 2021 program."

Stream a recent episode of the Houston Innovators Podcast where Evinger shares what she's excited about for this cohort:

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New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

Microsoft partners with Rice University's OpenStax on AI teaching tool

group project

Rice University’s OpenStax and Microsoft are partnering to integrate the nonprofit’s content with the tech giant’s AI innovation, known as Learning Zone.

“At OpenStax, our mission is to make an amazing education accessible to all,” Richard G. Baraniuk, founder and director of OpenStax, said in a news release. “That’s why we’re excited to integrate our trustworthy, peer-reviewed content with Microsoft’s AI technology through the Microsoft Learning Zone. Together, we aim to help more instructors and their students access engaging, effective learning experiences in new and dynamic ways. We also share a strong commitment to the thoughtful and responsible application of AI to better ensure all learners can succeed.”

OpenStax is a provider of affordable instructional technologies and is also one of the world’s largest publishers of open educational resources (OER).

Microsoft Learning Zone promises to provide educators and students with “responsible AI technology and peer-reviewed educational content to support learning” on Microsoft Copilot+ PCs. Microsoft Learning Zone works by utilizing on-device AI to generate interactive lessons for students, and its integration with OpenStax content means educators can rely on OpenStax’s digital library of 80 openly licensed titles.

The goal is for educators to create effective and engaging learning experiences safely, thereby bypassing the need to source and vet content independently. Included is a library of ready-to-use lessons, opportunity for immediate feedback and differentiated learning. Educators will maintain control of instructional content and pedagogical strategies and will be able to update or edit lessons or activities prior to sharing them with students.

Other tools included in the Microsoft Learning Zone are additional languages, reading coaching, public speaking help, math and reading progress, and a partnership with the online quiz platform Kahoot!

OpenStax resources have been reported as used across 153 countries, and this current collaboration combines the power and potential of responsible AI usage in education with content that has been utilized by 13,569 K-12 schools and 71 percent of U.S. colleges and universities, according to Rice.

“Through our partnership with OpenStax, we’re combining the power of on-device AI in Copilot+ PCs with OpenStax’s trusted and diverse peer-reviewed content to help educators quickly create high-quality, personalized, engaging lessons,” Deirdre Quarnstrom, vice president of Microsoft Education, added in the news release. “We’re excited about how this collaboration will empower classrooms globally.”

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