Houston pipeline heirs strike it rich as wealthiest family in Texas

AMERICA'S WEALTHIEST FAMILIES

Randa Williams is the high-profile heir of the Duncan family. Photo courtesy of Texas Monthly

Missouri has the Busches. Nebraska has the Buffetts. New York has the Hearsts. These are among the best-known wealthy families in the U.S.

Lesser-known nationally but well-known in Texas is the Duncan family of Houston, identified by FamilyMinded.com as the richest family in Texas. The website, which rounded up a list of the richest family in each state, pegs the family's estimated net worth at $26 billion; Forbes puts it at $25.6 billion.

The Duncan family comprises the four children of the late pipeline mogul Dan Duncan.

The children — Dannine Avara, Scott Duncan, Milane Frantz, and Randa Williams — inherited a tax-free $10 billion share of their father's estate following his death in 2010, when the so-called "death tax" had temporarily been repealed, according to Forbes. Each of them has an estimated net worth of $6.4 billion, Forbes says.

Williams is perhaps the most visible of the four Duncan heirs.

Williams is the only Duncan sibling who's involved in running the family business. She is chairwoman of Houston-based Enterprise Products Partners LP, the pipeline company that her father founded in 1968. Last year, the company posted revenue of $36.5 billion. In June, Williams made a big splash with her purchase of Austin-based Texas Monthly magazine.

While the Duncans are worth close to $26 billion, their wealth doesn't come close to that of Alice Walton of Fort Worth, the richest person in Texas. Forbes estimates her net worth at $52.4 billion.

FamilyMinded.com lists Alice Walton and her fellow heirs to the Walmart fortune as the richest family in Arkansas (where Walmart is based), with an estimated net worth of $163 billion. They're also the richest family in the U.S.

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This article originally ran on CultureMap.

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Austin company to bring AI-powered school to The Woodlands

AI education

Austin-based Alpha School, which operates AI-powered private schools, is opening its first Houston-area location in The Woodlands.

The 8,000-square-foot school, scheduled to be ready for the 2026-27 academic year, initially will serve students in kindergarten through eighth grade. Alpha says the school will offer “open workshop spaces and innovative classrooms that support personalized instruction, core academics, leadership development, and real-world life skills.”

Alpha sets aside two hours each school day for the AI-driven, self-paced study of core subjects like math, reading and science. The rest of each school day consists of life-skills workshops focusing on topics such as leadership and financial literacy.

Alpha’s school in The Woodlands has begun accepting applications for the 2026-27 school year. Annual tuition costs $40,000.

“The Woodlands is one of the most dynamic, forward-thinking communities in Texas, and Alpha is proud to bring

an innovative educational model that complements its strong academic foundation,” says Rachel Goodlad, head

of expansion for Alpha.

Founded in 2014, Alpha School combines adaptive technology-driven instruction with immersive life-skills workshops. Its model emphasizes mastery-based learning in core subjects alongside development of communication, critical thinking, financial literacy and leadership skills. It operates more than 15 schools across the country.

Elsewhere in Texas, Alpha operates schools in Austin, Brownsville, Fort Worth and Plano. Alpha also operates 12 Texas Sports Academy campuses in Texas, including locations in Houston, Pearland and Richmond, along with a NextGen Academy esports school in Austin, a school for gifted students in Georgetown, and lower-cost Nova Academy campuses in Austin and Bastrop.

Alpha has fans and critics. While supporters tout students’ high achievement rates, detractors complain about the high tuition and the AI-influenced depersonalization of education.

“Students and our country need to be in relationship with other human beings,” Randi Weingarten, president of the American Federation of Teachers, a teachers union, tells The New York Times. “When you have a school that is strictly AI, it is violating that core precept of the human endeavor and of education.”

Alpha co-founder MacKenzie Price, a podcaster and social media influencer, doesn’t share Weingarten’s views.

“Parents and teachers: We need to embrace this change,” Price wrote after President Trump signed an executive order promoting AI in schools.

The Times notes that Alpha doesn’t employ AI as a tutor or a supplement. Rather, the newspaper says, AI is “the school’s primary educational driver to move students through academic content.”

Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”