This Houston innovator is using data to power industrial reliability and sustainability

HOUSTON INNOVATORS PODCAST EPISODE 92

Ryan Sitton joins the Houston Innovators Podcast to discuss his career in data and reliability. Photo courtesy of Ryan Sitton

Ryan Sitton has had a varied career so far. Formerly working in oil and gas, he started his own company in 2006 to help companies to better utilize their data. Now, still leading Houston-based Pinnacle as CEO, Sitton works with the world's largest companies to solve their problems with data. He also served as Texas Railroad Commissioner and has written two books about decision-making and leadership.

Sitton joined the Houston Innovators Podcast to discuss how, despite the multiple hats he wears, at the core of his passion is using data to drive better decision making to drive more sustainable and reliable operations.

"I was basically doing data analytics in the mid 2000s before it was sexy. I was pulling together data in chemical plants and refineries and trying to predict how these plants would behave with the data I had," Sitton says. "I realized early on how there was so much opportunity here — but we don't have the technologies or the methodology to do it."

But over the years, the technology has caught up and now Sitton is able to provide clients with even more data-driven solutions.

"We go into the biggest companies of the world that are trying to have more reliability at the same time as lowering cost," Sitton explains. "We build models that pull together literally millions of pieces of data and we do a combination of engineering analysis and data analysis and data science to give them better predictions — better ways to run their facilities so that they are more sustainable and more profitable."

Sitton's two books — Crucial Decisions, which is out now, and the Myth of Status, which is coming later this year — also center around decision making and leadership.

He shares more about his time at the Texas Railroad Commision and shares how COVID-19 affected business — as well as shares his advice for startups tapping into data-driven solutions — on the episode. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


"Texas is an energy leader and no one wants to see that change." Photo via Getty Images

Expert: Texas leaders need to expedite long-term energy solutions

Guest column

Soaring temperatures have arrived, and while Texans should be enjoying the return to normalcy, instead they're facing another energy crisis.

Many saw February's winter storm and severe power outages as a once-in-a-century problem, but these unusual events are becoming all too commonplace, despite the governor's directive to improve grid reliability. Last month, Texans were again being asked to conserve energy while lawmakers considered a slew of new regulations, some of which would cripple investments in renewable energy.

For three months following the storm, the Texas legislature debated how to prevent another energy crisis. We applaud our elected officials for resisting political pressure to wrongly blame and punish renewable energy, and we want to encourage them to continue with this forward-thinking strategy.

Texas is an energy leader and no one wants to see that change. We urge our representatives in Austin to take a comprehensive view of what went wrong during the winter storm and ensure that any new rules and regulations work in support of, and not against, the energy market as a whole.

Texas needs a long term, comprehensive plan – not just for preventing blackouts, but for a more sustainable state.

Hot weather in Texas is a given, but we're anticipating temperatures will continue to rise. A climatologist at Texas A&M University recently predicted that the state will see the number of 100-degree days double by 2036. Rather than take a step back, we need to move forward and prioritize renewable energy as well as other investments in sustainability to future-proof our state and our planet.

Prioritizing green energy will have a ripple effect on Texas' economy. As the country's leader in wind-generated electricity, Texas has already reaped the benefit of creating thousands of new jobs for the state. In 2019, it was reported that Texas had over 230,000 clean energy jobs. If our state leaders are committed to job creation, we want to see how they're supporting clean energy, as well as continuing to work on maintaining the grid in an effective, efficient way.

The energy market is complex and dynamic, but it’s a key player in our road to a sustainable future. 

Continuing to invest in renewable energy is one simple step our lawmakers can make to ensure our energy market is addressing the climate crisis — and that Texans aren't dependent on generators and gas-fired power plants which let the state down during Winter Storm Uri. This should be a priority. In a recent survey of 1,000 adults by OnePoll in May 2021 commissioned by Bulb, 74 percent of respondents stated Texas should continue to develop and invest in renewable energy and over half of respondents expressed that investing in more green, clean renewable energy is the most important environmental issue that needs to be addressed.

As we come out of the pandemic, we have a chance to do better, together.

Texas has had over $60 billion in renewable energy investment to provide low-cost electricity generation. And with the growing technology sector across the state, there'll be more opportunities for renewables in the future. Continuing to promote policies that pushed Texas to its leadership position will unleash even more investments and innovation, which is good for Texas, good for Texans and good for the planet.

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Vinnie Campo is the general manager for Bulb U.S., a new type of energy company that aims to make energy simpler, cheaper, and greener by providing renewable electricity to its members from Texas wind and solar. He is based in Texas.

What winter storm Uri ultimately demonstrated was the multitude of technology solutions that needs to scale up to provide us with the best energy reliability and availability. Photo by Lynn in Midtown via CultureMap

Houston expert: Winter storm Uri's devastation should be a reminder to prioritize innovative energy solutions

guest column

Texas has landed itself in the middle of a fierce debate following what's been considered one of the worst winter storm in recent history for the state.

Uri wreaked havoc as it rolled through regions that were wholly unprepared for the sudden temperature drops, single digit wind chills, and unusual precipitation (e.g. thundersnow in Galveston). Rolling power outages and water shortages affected more than 4.5 million Texans. Businesses like grocery stores and restaurants — unable to wash food or sanitize equipment or even turn on the lights, —closed throughout the ordeal, leaving many families without food, water, or power.

For most, this was an unprecedented experience. The majority of catastrophes in Texas are in the form of warm weather events like floods, hurricanes, or tornadoes, which means that even if power is lost, freezing is rarely an issue. Uri turned this upside down. ERCOT's failure to provide reliable energy for days on end led to families sleeping in devastatingly cold temperatures, further water shortage due to municipal water facilities failing, carbon monoxide deaths, disruption in vaccine rollouts, hospitals overrun with people needing to charge essential medical equipment, and much more. Uri highlighted in harrowing detail the domino effect that energy (and lack thereof) has on everything around it.

A single source of ERCOT's failure is hard to pinpoint. The cold led to production shut-ins, exacerbating the existing natural gas supply shortage and resulted in the RRC prioritizing "direct-to-consumer" natural gas delivery (i.e. to residences, hospitals, schools, etc.) over natural gas for the grid. Iced-over gas lines disrupted this flow even further. Freezing temperatures shut off some wind turbines and solar panels (if they were not already covered in snow). Coal and nuclear plants in Texas also shut down due to frozen instruments and equipment.

Thrown into sharp relief was the importance of consumer access to natural gas and other fossil fuels like propane. Most homes that had completely electrified (including my own) were ill-prepared to heat their homes without access to the grid or backup generators. Residential and community solar did little to alleviate this problem in many cases as lower technology configurations either froze, were not able to capture enough energy from a low-light environment, or were covered in snow. Having access to gas for heating or a propane stove was a lifeline for most folks.

But it's oversimplifying to say that the only solution to preventing another situation like this is continued or increased reliance on the oil and gas industry.

What last week ultimately demonstrated was the multitude of technology solutions that needs to scale up to provide us with the best energy reliability and availability.

It wasn't enough for our grid to have five potential generation sources – they all failed in different ways. But what if we incorporated more geothermal, which is more cold-weather resistant? What if we upgraded our solar panels to all have trackers or heating elements to prevent snow accumulation? What if our grid had access to larger scale energy storage? What if consumers had more access to off-grid distributed energy systems like generators, residential solar, geothermal pumps, or even just really large home batteries? What if we had predictive solutions that were able to detect when the non-winterized equipment would fail, days before they did? What if we could generate power from fossil fuels without dangerous emissions like carbon monoxide?

All of these technologies and more are being created and developed in our energy innovation ecosystem today, and many in Houston. What we're building towards is diversity of our energy system — but not just diversity of source — which is often the focus – but diversity of energy transportation, energy delivery, and energy consumption. Energy choice is about being able to, as a consumer, have a variety of options available to you such that in extenuating circumstances like winter storms or other catastrophes, there is no need to depend on any single configuration.

In a state like Texas, which is not only the largest oil and gas producer but also the largest wind energy producer and soon to be home to the largest solar project in the US, innovation should and will happen across all energy types and systems. Uri can teach us about the importance of the word all and how critical it is to encourage startups and technology development to develop stronger energy choice. Texas is the perfect home for all of this — and our state's rather embarrassing failure around Uri should be exactly the kind of reminder we need to keep encouraging this paradigm.

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Deeana Zhang is the director of energy technology at Houston-based Tudor, Pickering, Holt & Co.

According to Houston-based ENGlobal, the company "has more promising opportunities for significant new business than at any time in [the] company's history." Photo via Getty Images

Houston company focused on renewables sees high growth potential amid 'energy revolution'

seeing green

For Houston-based ENGlobal Corp., a provider of engineering and automation services geared toward the energy industry, renewable fuel facilities are a business pipeline gushing with opportunity.

ENGlobal's potential contracts for renewable fuels projects currently exceed $320 million, says Bill Coskey, the company's founder, president, and CEO. That's about six times the amount of ENGlobal's revenue through the first nine months of this year — $52.9 million.

During the company's third-quarter earnings call November 5, Coskey said publicly traded ENGlobal "has more promising opportunities for significant new business than at any time in our company's history."

Many of those opportunities stem from ENGlobal's shift a couple of years ago to a sharp focus on the renewable energy sector. This includes building utility-scale systems to store wind and solar power, and supplying modular engineered process plants for forms of energy like hydrogen and renewable diesel. Modular process plants consist of separately engineered and automated modules that are made off-site and assembled on-site.

"Manufacturing plants based on modular equipment are emerging as a viable and beneficial alternative to conventional stick-built processing plants. Modular equipment offers several benefits, including flexibility in plant siting, fewer safety concerns during construction, and ease of equipment modification," according to the American Institute of Chemical Engineers.

ENGlobal is engineering and fabricating a modular hydrogen plant for a renewal diesel facility scheduled for completion in May. Incorporating proprietary technology from Denmark-based Haldor Topsoe (which has two offices and one plant in the Houston area), this hydrogen plant will consume about 20 percent less feed and fuel than conventional hydrogen plants, leading to lower operating costs and a smaller carbon footprint. It's the first facility of its kind in the U.S. This $25 million project falls into a bucket of modular process plants — valued at $10 million to $200 million each — that ENGlobal typically pursues.

ENGlobal's emphasis on renewable energy is paying off, especially now. That's because this sector is less susceptible to economic harm caused by the coronavirus pandemic and to the downturn in the oil and gas industry, according to Coskey.

"To the contrary, the green and renewable energy sector is driven by a different set of project economics — the majority of which play directly to our core strengths and capabilities," Coskey said during the November 5 earnings call.

ENGlobal comprises two business units that are capitalizing on those core strengths and capabilities:

  • Engineering, procurement, and construction management
  • Automation

Through September 26, the automation segment of the business accounted for 63 percent of the company's revenue this year, with engineering, procurement, and construction at 37 percent. In the third quarter, the balance was roughly 50-50.

For the nine-month period ended September 26, ENGlobal posted a 33 percent increase in revenue compared with the same period a year earlier. Revenue for the period rose 37 percent in the automation segment of the business and 27 percent in the engineering, procurement, and construction management segment.

Looking ahead, Coskey says plants like the one employing the Haldor Topsoe technology are "a big area of growth for us."

"We've built a business which is really vertically integrated. We can engineer and design, we can mechanically fabricate the processing modules, we can automate them, we can go onto the site and start them up. So we have full-service capabilities," Coskey says in an interview.

Those capabilities are helping ENGlobal, which Coskey started in 1985, capitalize on what he dubs the "energy revolution" in the U.S.

"Oil and gas has a long runway and is sometimes not given enough credit," he says. "But I can tell you that the capital spending for traditional oil and gas projects pretty much dried up during the course of this year. And we had to look for other sources of work for our people, so we were fortunate to have these renewable energy projects to work on."

Evercore ESI predicts capital spending on energy exploration and production in the U.S. will fall 43 percent this year compared with 2019. Meanwhile, S&P Global Market Intelligence forecasts $14.26 billion in capital spending this year on renewable energy by major U.S. utilities, up more than 20 percent from an earlier projection for 2020. The share of U.S. electricity generation from renewable energy is expected to increase from 18 percent in 2019 to 20 percent this year and 21 percent in 2021, the U.S. Energy Information Administration says.

"There's a lot of money that used to flow into oil and gas projects that now seems to be flowing into renewable energy projects," Coskey says. "We were lucky to identify that early and be positioned to capture some of that."

The 2020 election results will take the energy industry one of two paths — toward the energy transition or continuing the status quo. In this guest column, an energy investor assesses the situation ahead of election day. Photo via Getty Images

Energy and the election: What the 2020 outcome means for the future of oil and gas

guest column

The United States Presidential election is at our doorstep. The fossil fuel industry is under significant pressure and the outcome of the election could impact the speed at which exploration and production is impacted. This pressure is financial in nature, but also is operational, technological and all wrapped in physics. A mere 12 to 18 months ago, environmental, social and governance influences and overlays on E&P began and are only accelerating.

My company, Riverbend Oil and Gas, is beginning to see the industry rebound from a significant downturn in revenues, activity, and confidence in 2020 due to the impacts of COVID-19 and the OPEC price war earlier this year. The industry is battling with headwinds, including, lack of access to debt/equity capital, transaction valuations, commodity prices, shale well spacing, and other issues, all impairing market conditions.

At present, there is little to no lubrication in the system. With most talking about an oil and gas market cycle that is driven by supply and demand fundamentals over previous decades, now there is more discussion of a contrarian view of those confident of a demand recovery for oil and gas.

Since the start of energy private equity, funds were raised by general partners to support the small cap E&P space, in the late '80s, private equity became a significant participant in the oil and gas upstream space. Private equity firms became great in number as institutions desired exposure to a growing segment of the market outside of merely investing in the oil and gas public equities. This role, 30 to 35 years later, remains essential, but is currently stifled with thoughts of a declining fossil fuel world and with energy representing only about 2 percent of the S&P 500.

Hydrocarbon outlook

Looming headwinds in the fossil fuel industry include The Green New Deal, an accelerating consciousness of the carbon footprint, the Paris Climate Accord, ESG importance, and the growth of renewables. Additionally, the advent of electric vehicles presents a significant new entrant that is causing a substantial threat to oil's monopoly on the transportation sector. A collision of possible futures exists. Currently, around 1 billion vehicles today are using around 30 percent of the world's oil supply with an estimate of 4 million electric vehicles on the roads globally. Some forecasters predict around 400 million electric vehicles in 2040, decreasing oil supply demand by an estimated 6 percent.

These forecasts of human mobility are driven by the nature of human ambition and worldwide population growth. Africa, China, and India are expected to grow significantly through 2100. Moreover, all persons worldwide strive for a better life for themselves and their families — energy drives these ambitions.

Meanwhile, the capital markets for public fossil fuel companies has declined by over 90 percent from 2016 to 2019 with a continued dismal outcome year-to-date in 2020. The lack of cash flow and capital markets will likely drive less U.S. and non-nationalized produced oil and gas volumes and fewer sustainable companies. Many confident analysts predict a looming oil supply shortage in 2021 driven by these factors along with a federal lands development ban and the possible slowdown of fracking. However, others predict that peak oil demand is now and the need for fossil fuels has already reached a peak.

Assessing the candidates

The results of the election are anticipated to have significantly differing implications (should campaigning be a real signal) for the oil and gas industry. While a Donald Trump win would largely represent a status quo for the environment, a Joe Biden triumph could drive towards changes. Implications are wide ranging across the equity, credit and commodities market energy value chain.

It is important to evaluate who will have control of the House and Senate to pass said legislation. The House is expected to remain with the Democrats, comfortably winning at least 224 of the 435 seats. Recent polls have pointed toward a competitive Senate election cycle. The Republicans currently have a 53-47 Senate majority, but a Democrat favored majority of 51-49 is currently predicted.

The next question is whether the filibuster would be eliminated to push legislation through without a super majority needed; meaning Democrats could drive approvals with a 50-50 tie and Kamala Harris's vote. Although polls are pointing toward a "blue wave" for the Democrats, certain moderate democrats in oil and gas states such as Colorado, New Mexico and Pennsylvania may be swayed against major regulatory or legislative threats to oil and gas exploration and production. Additionally, elected authorities in anticipated Republican states such as Texas, Oklahoma, North Dakota, Utah, and Ohio who are home to industry trade groups and fossil fuel companies will play a significant role.

The Biden Administration has discussed several energy-related policies. These include support for climate-friendly legislation, a ban on federal lands and water permits that represented 21 percent of U.S. oil output in 2019, and an increased investment of $2 trillion over four years in clean energy technologies. To put this investment into perspective, total global energy investment from 2017 to 2019 averaged $2 trillion, and Biden's plan would add $500 billion per year. Biden would target roughly two thirds of U.S. carbon emissions focusing on transportation (40 percent) and electricity production (31 percent).

Broadly, the goal is a nationwide carbon reduction to achieve net-zero emission no later than 2050 and transition to a carbon pollution-free power sector by 2035. In order to achieve the 2050 net zero emissions goal, the world requires 2020 COVID-19 sized reductions (8 percent) every other year for the next 25 years. Throughout this energy transition, energy prices are likely to increase, and as a result, the pace of the energy transition will likely reflect the balance of societal demand to reduce fossil fuel usage and the costs (economic, convenience, speed, satisfaction) of doing so.

Renewables and hydrocarbons

In 2019, the U.S. accounted for 15 percent of global CO2 emissions (5,130 MM metric tons of CO2), down 873 MM metric tons since the U.S. peaked in 2007. The large decrease can be attributed to coal-to-gas switching, while wind generation and solar power installations also aided the decline. From 2018 to 2019 alone, coal-to-gas switching decreased U.S. emissions by 140 MM metric tons, driving the largest decrease for the year. While shifting from one end of the carbon-emitting energy spectrum to another, it is imperative to balance costs, plausibility and expectations.

Hydrocarbons can be stored for less than $1 per barrel of oil equivalent, or BOE, while renewables cost $200 per BOE. Total U.S. renewable storage capabilities can provide two hours of national electricity demand which is stored in the utility-scale batteries on the grid and in the about 1 million electric vehicles on U.S. roads. Storage, physics and costs are major drivers for a hydrocarbon partnership as the U.S. transitions to a less carbon-heavy source of fuel. While costs of wind and solar have been driven down by around 70 percent and 89 percent, respectively since 2009, the Betz Limit and Shockley-Queisser Limit do have a governor on further improvements of the current technology and materials. Similarly, subsurface oil and gas reservoirs have similar boundary conditions of physics involving ultimate recovery of resources through natural production, fracking and/or enhanced recovery techniques.

The goal of providing low cost, reliable energy to consumers, enhancing lives and providing better futures can be reached through utilizing hydrocarbon technologies in tandem with renewable sources. A vast amount of investment, research and development is still required in the renewable world, including battery storage, solar/wind efficiency, electric grid expansion and electric vehicle technology/charging stations.

According to the 2020 IEA Energy Outlook, oil and gas represented 55 percent of global energy demand in 2019 and the agency predicts that oil and gas will comprise 46 percent to 54 percent of the energy stack in 2040. This is a relatively flat market share. Coal, on the other hand, cedes market share to renewables and nuclear power, decreasing from 30 percent to 10 percent. While renewables are vital to reaching the U.S. goals of net-zero emissions, hydrocarbons are essential in backstopping U.S. energy needs and ambitions throughout this energy transition. Additionally, on a global scale, cheaply sourced and stored hydrocarbons are essential for emerging economies to advance through existing carbon-emitting infrastructure, eventually leading to renewable alternatives and global carbon reduction.

We remain encouraged for the next decade of growth and performance as we look to identify unique opportunities in the space. In a dynamic oil and gas market, Riverbend has a high degree of confidence to sustain and thrive due to our culture, performance-based team and systems. Riverbend is anchored by vigorous technical subsurface reserve assessments as well as land, accounting and commercial diligence. Additionally, Riverbend, as an energy company, is investing in the alternatives segment, concentrating on materials and services in the wind, solar and battery portions of the value chain. In a world full of human ambition, we see a need for all energy to support undeveloped nations and economies to access the opportunity of the American Dream, pursuing elimination of a "have" and "have not" world.

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Randy Newcomer is president and CEO of Houston-based Riverbend Oil and Gas, a private equity investment group specializing in the energy industry.

"Superteams," or workforces optimized by artificial intelligence, may shape the energy sector. Getty Images

AI-optimized teams are a game changer for energy companies, this Houston expert says

guest column

The speed and scale of change in the business world had been on a fast track, with technology enabling bigger and bolder advances within shorter time frames.

Enter 2020: a global pandemic struck, and here in the Gulf Coast region, we were also hit by an energy industry downturn. The effects of both these crises have touched nearly every sector and revealed the factors that are essential to effectively managing through economic recovery. In a time of extreme challenges, two areas — human talent and technology — are now more important and intertwined than ever.

Earlier this year, Deloitte released its 2020 Global Human Capital Trends report, "The social enterprise at work: Paradox as a path forward," which addresses the intricacies of this issue. The survey was conducted before the pandemic took hold only to see its findings on the future of work play out in real time as companies respond to COVID-19 and the economic toll it's taking.

The rise of the superteam

Despite some dramatic predictions about machines replacing humans, many organizations, including oil and gas companies, are looking to integrate artificial intelligence into teams of people. These "superteams" of human talent and AI may enable organizations to reinvent themselves to create new value and meaning. For organizations that still view AI mainly as an automation tool to reduce costs, connecting AI initiatives with efforts to craft more effective teams is a first step toward enabling humans and machines to work together in new, more productive ways.

In the report, 60 percent of respondents said their organizations are currently using AI to assist, rather than to replace, workers. An additional 58 percent explained that they are using it to improve consistency and quality because superteams can allow organizations to both transform the nature of their output and create worker capacity. Furthermore, 66 percent of respondents believed that the number of jobs would either stay the same or increase as a result of AI's use in the next three years.

Drilling down on the energy sector

As the oil and gas industry reels from the dual effects of a global health crisis and oil price shocks, most organizations are focused on recovery, but forward-looking companies are devising strategies for better integrating technology into their operations.

The value of superteams is clear: they offer the promise of enabling organizations to reinvent themselves while giving employees the potential to further their careers by learning sought-after skills. It's no surprise, then, that many oil and gas companies are rethinking how the future of work may play out within their operations. For example, as outlined in Deloitte's Tech Trends 2020 report, a growing cohort of AI-powered solutions is increasing the need for technology that understands and responds to humans. This might take shape via a field worker being equipped with digital tools to provide real-time support for maintenance and upgrades. Augmented reality applications could offer the employee context-based instructions and the ability to connect with remote workers for live support.

This is just one example of how superteams can transform the sector; there are many other ways that humans and technology can work together to drive organizational value.

Working together to shape the new normal

As the future of work rapidly evolves amidst the world's "new normal," business leaders are wrestling with an increasing range of challenges. These challenges are especially pronounced at the intersection between humans and technology, where new questions have risen about the impact of emerging technologies on workers and society. Organizations that tackle these issues head-on – changing their perspectives to consider not only "could we" but also "how should we" – will be well-positioned to make the bold choices that drive organizational value.


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Amy Chronis is the Houston managing partner at Deloitte.

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Rice researchers score $45M from NIH for cancer-fighting tech

freshly funded

A research funding agency has deployed capital into a team at Rice University that's working to develop a technology that could cut cancer-related deaths in half.

Rice researchers received $45 million from the National Institutes of Health's Advanced Research Projects Agency for Health, or ARPA-H, to scale up development of a sense-and-respond implant technology. Rice bioengineer Omid Veiseh leads the team developing the technology as principal investigator.

“Instead of tethering patients to hospital beds, IV bags and external monitors, we’ll use a minimally invasive procedure to implant a small device that continuously monitors their cancer and adjusts their immunotherapy dose in real time,” he says in a news release. “This kind of ‘closed-loop therapy’ has been used for managing diabetes, where you have a glucose monitor that continuously talks to an insulin pump. But for cancer immunotherapy, it’s revolutionary.”

Joining Veiseh on the 19-person research project named THOR, which stands for “targeted hybrid oncotherapeutic regulation,” is Amir Jazaeri, co-PI and professor of gynecologic oncology at the University of Texas MD Anderson Cancer Center. The device they are developing is called HAMMR, or hybrid advanced molecular manufacturing regulator.

“Cancer cells are continually evolving and adapting to therapy. However, currently available diagnostic tools, including radiologic tests, blood assays and biopsies, provide very infrequent and limited snapshots of this dynamic process," Jazaeri adds. "As a result, today’s therapies treat cancer as if it were a static disease. We believe THOR could transform the status quo by providing real-time data from the tumor environment that can in turn guide more effective and tumor-informed novel therapies.”

With a national team of engineers, physicians, and experts across synthetic biology, materials science, immunology, oncology, and more, the team will receive its funding through the Rice Biotech Launch Pad, a newly launched initiative led by Veiseh that exists to help life-saving medical innovation scale quickly.

"Rice is proud to be the recipient of the second major funding award from the ARPA-H, a new funding agency established last year to support research that catalyzes health breakthroughs," Rice President Reginald DesRoches says. "The research Rice bioengineer Omid Veiseh is doing in leading this team is truly groundbreaking and could potentially save hundreds of thousands of lives each year. This is the type of research that makes a significant impact on the world.”

The initial focus of the technology will be on ovarian cancer, and this funding agreement includes a first-phase clinical trial of HAMMR for the treatment of recurrent ovarian cancer that's expected to take place in the fourth year of THOR’s multi-year project.

“The technology is broadly applicable for peritoneal cancers that affect the pancreas, liver, lungs and other organs,” Veiseh says. “The first clinical trial will focus on refractory recurrent ovarian cancer, and the benefit of that is that we have an ongoing trial for ovarian cancer with our encapsulated cytokine ‘drug factory’ technology. We'll be able to build on that experience. We have already demonstrated a unique model to go from concept to clinical trial within five years, and HAMMR is the next iteration of that approach.”

TMC again expands global impact with new Netherlands partnership

breaking news

The Texas Medical Center may be based in Houston, but the organization has again grown its global impact.

Since 2016, TMC’s BioBridges have worked with 88 startup companies. Those include strategic alliances with four other countries. Australia, the United Kingdom, Denmark and Ireland are all among TMC’s BioBridges partners. As of today, add the Netherlands to that list.

On September 27, TMC president and CEO, William F. McKeon, and Carmen van Vilsteren, chair of Health~Holland, Top Sector Life Sciences & Health (LSH), signed an agreement in Rotterdam. The TMC Netherlands BioBridge Memorandum of Understanding codifies the innovative goals of the partnership. Essentially, the BioBridge program provides a means for entrepreneurs, researchers, clinicians and industry partners from other countries to access the US market, as well as TMC experts.

“The TMC Netherlands BioBridge represents an unparalleled opportunity for collaboration and growth,” Ashley McPhail, chief external affairs & administration officer at Texas Medical Center said in a press release. “The Netherlands has solidified its position as a global leader in the field of life sciences and health, with a thriving ecosystem of research institutions, innovative companies, and highly skilled professionals. This strategic partnership will bring positive benefits to patients, clinicians and industry partners on a global scale.”

This lifeline for international healthcare companies makes expansion into the United States far smoother. The Global Innovators Launch Pad allows for startup founders to take part in a 10-week residency at the TMC Innovation Factory that will teach them about foundational infrastructure, clinical evidence and funding in the US.

“Since Texas is an important hub for innovation in the MedTech and digital health sectors, the collaboration with Texas Medical Center creates opportunities for Dutch companies looking to expand their international reach. Vice versa, it gives companies in Texas access to the vibrant Dutch Life Sciences & Health sector,” said van Vilsteren.

That exchange includes members of the TMC gaining the opportunity to participate in the Health~Holland Visitors Programme (HVP), “Shaping the Healthcare of the Future.”

The annual event invites high-level representatives from the private sector, NGOs, knowledge institutions, healthcare providers and different tiers of government to share their expertise.

It's the fifth partnership of its kind for TMC, with the last one being with Ireland, announced last year. TMC's other global initiatives include accelerators with Denmark and the United Kingdom, both announced earlier this year.

Houston startup founders prepare to scale globally following Shark Tank success

HOUSTON INNOVATORS PODCAST EPISODE 205

While Milkify's founders — husband and wife team Pedro Silva and Berkley Luck — secured partners on a popular business pitch and investment show, the entire experience almost didn't happen.

Silva and Luck, who got her PhD in molecular and biomedical s at Baylor College of Medicine, founded the company to provide breast milk freeze drying as a service to Houston-area families. Now, Milkify has customers across the country, but the duo didn't know if going through the process would be worth the investment and publicity, or if it would just be a distraction.

"The competitor in me wanted to be the first breast milk company to go on the show and to tell our story to the world — to show the world what my wife came up with that we thought was so great," Silva says on the Houston Innovators Podcast. "It was probably the scariest 45 minutes of my life."

But the sharks bit. Milkify's episode aired in April, and two investors — Gwyneth Paltrow and Lori Greiner — agreed to a $400,000 convertible note for 20 percent equity in the company. Paltrow even said on the show that she would have used the service when she was breastfeeding.

"It was empowering," Luck says of getting to wear her white coat on TV and share the story of how she came up with the idea of Milkify. "It was important to me when we went on the show to express that this had a scientific basis, that we didn't start this lightly, and that we've made huge strides in doing this in the absolute safest way possible."

Silva says they can't talk about some of the details of the show or the deal, but since then, Milkify has reached new customers, received additional investment interest, grown its team, and built out its plan to scale, the founders shared on the podcast. The team also shares its big-picture scale plans, which include tapping international partners to potentially take Milkify's tech global.

"Our vision is for every family to have access to breast milk formula, but instead of re-creating breast milk in a lab, we're doing it with mom's own milk," Silva says, mentioning a partnership with a breast milk bank that will convert its operation from freezing to freeze drying donated milk. "We're also working with groups in the UK and Australia to launch similar services using our patented technology."

"By the end of the year, we hope to see some announcements with those partnerships across the globe."

From the beginning, the importance of Milkify's team has been on supporting working parents to give them the best way to care for their families, Silva says. And for Luck — who says she's proud of the integrity Milkify has at its core despite competitors offering lower-quality and, in some cases, dangerous alternatives — she sees a lot of research benefits for the company.

"It's amazing to be at this leading edge, not just of innovation but of research, and to be able to still put out meaningful advances as an industry partner, not just as an academic," Luck says, adding that she hopes to be able to continue to contribute to the ongoing research into breast milk.

Luck and Silva share more about their Shark Tank experience, their co-founder strengths, and the future of Milkify on the podcast. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

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