EDP Renewables has launched its second iteration of its clean energy innovation program. Photo courtesy of EDP

EDP Renewables, whose North American division is based in Houston, has launched the second module of its Energy Starter 2022 program.

EDP Renewables launched the first module in May; it dealt with the future of energy distribution. Applications for startups seeking to join the second module are being accepted until September 30. The second module focuses on innovations in renewable energy and green hydrogen.

Next year, the third and final modules will focus on decarbonization.

Companies selected for the second module will attend a bootcamp in Houston where they, in partnership with EDP Renewables experts, will develop their ideas and work on pilot projects. After the current four-phase edition of the program ends, startups will be able to test their innovations in the U.S., Brazil, Portugal, or Spain.

During the six editions of Energy Starter, the more than 150 participating startups have sealed over 80 deals, including equity investments and pilot projects. The most recent edition of Energy Starter attracted over 700 applicants.

Earlier this year, EDP Ventures, the venture capital arm of EDP Renewables North America’s parent company, pledged to double its investments in startups pursuing energy transition technology and services.

EDP Ventures says its VC commitment is climbing from 45 million euros (about $45 million) already invested in the past decade to a total of 100 million euros by 2025. EDP Ventures plans to allocate as much as 10 million euros per startup.

“As the electricity sector moves at unprecedented speed, we want to work with the most promising startups, with a clear focus on projects that represent growth opportunities. The coming years will be challenging for the energy transition, and we want to face them with the best ideas on a global level,” says Ana Paula Marques, CEO of EDP Spain, a subsidiary of Lisbon, Portugal-based energy company EDP Group.

Houston-based EDP Renewables North America is part of Madrid, Spain-based EDP Renewables, the world’s fourth largest producer of renewable energy. It’s investing 1 billion euros in innovation efforts by 2025. EDP Group is the majority shareholder of EDP Renewables.

The Houston division builds, owns, and operates wind farms and solar parks throughout North America. EDP Renewables North America oversees 58 wind farms and nine solar parks.

Among the nine solar parks is the $280 million, 240-megawatt Cattlemen Solar Park in Milam County, between the Austin metro area and Bryan-College Station. The park is scheduled to start generating electricity next year. Meta, the parent company of Facebook, recently signed a long-term, 156-megawatt power deal with EDP Renewables North America.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.