Houston researchers advance unique nasal vaccine that prevents COVID transmission

cutting spread at the source

The University of Houston's Navin Varadarajan explains that while COVID vaccines prevent advanced disease, they don’t prevent transmission. But he has a solution. Photo via Getty Images

Since the force of COVID-19 hit globally in 2020, scientists have made efficient progress in the fight against it. As Dr. Navin Varadarajan puts it, vaccines have “allowed us to become a society again.”

And he should know, the M.D. Anderson Professor of William A. Brookshire Chemical and Biomolecular Engineering at University of Houston just published back-to-back studies for nasal sprays that combat viruses. One, the NanoSTING therapeutic, has proven effective in treating strains of SARS-CoV-2 and the flu virus. The other, NanoSTING-NS Pan-coronavirus Vaccine is targeted at preventing the transmission of multiple COVID variants altogether.

Why a nasal vaccine? Varadarajan explains that while COVID vaccines prevent advanced disease, they don’t prevent transmission.

“Intramuscular vaccines do not facilitate a component of peer immunity called mucosal immunity, which takes care of these points of entries, these wet surfaces, which can be of the nose and the wet surfaces of the nose, and so they don't prevent transmission,” he tells InnovationMap. “So I can be vaccinated, I pick up a small infection that's confined largely to my nostrils, and I can still pass it on to vulnerable people, the aged, the immunocompromised people who have all the drugs they're taking to fight other things, like cancer patients. And so for them, the vaccines tend to be less efficacious, and if I transfer it to them, unfortunately they can end up in a hospital, right? And so preventing transmission is the way to end this cycle.”

Dr. Navin Varadarajan is the M.D. Anderson Professor of William A. Brookshire Chemical and Biomolecular Engineering at University of Houston. Photo via UH.edu

The NanoSTING-NS is also notable for its potential ability to end what Varadarajan calls “the endless cycle of boosting.” The way to do that, he explains, is to prevent the infection at its root. And theoretically, his lab’s invention could do that. But he cautions readers not to get too excited just yet.

The vaccine is currently in the phase of animal testing, though Varadarajan is hopeful that it could move to human samples in about a year.

The therapeutic can treat multiple respiratory viruses by using fat droplets to deliver the immune booster cGAMP.

“The ability to activate the innate immune system presents an attractive route to armoring humans against multiple respiratory viruses, viral variants and also minimizing transmission to vulnerable people,” says postdoctoral associate Ankita Leekha, first author on the paper that shares NanoSTING’s findings. “The advantage of NanoSTING is that only one dose is required, unlike the antivirals like Tamiflu that require 10 doses.”

Ankita Leekha is the first author on the paper that shares NanoSTING’s findings. Photo via UH.edu

Varadarajan puts it even more simply: “Just like we have Tylenol, just like you take aspirin, you feel like you have some symptoms, and you take it afterwards.”

Currently, he says that the partners with whom the lab is working towards commercialization are prioritizing the therapeutic over the vaccine. The reasons are clear. Varadarajan explains that, while we’ve now long had antibiotics to broadly combat infections, there hasn’t been anything like that to battle viruses. With its ability to target multiple viruses, NanoSTING could be that innovation.

“We activate the innate immune system. So our drug is not virus-specific. Our drug works by activating your own immune system, and that will then fight off different kinds of viruses,” he says.

A single product that treats everything from the common cold to COVID-19 by capitalizing on the patient’s own immune system could be closer than we realize.

The researchers hope to get the vaccine into human trials soon. Photo via UH.edu

From Your Site Articles
Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

Diversity-focused sports tech accelerator opens applications to Houston innovators for the first time

apply now

A global organization has announced it's opening applications to its equity-focused sports tech accelerator to Houston founders for the first time.

Thanks to a collaboration with Impact Hub and Black Ambition, the adidas Community Lab has expanded its footprint and is now accepting applicants from new markets, including Houston, Toronto, Los Angeles, Atlanta, and New York, for its 2024-2025 cohort.

The initiative, which has been running for three years, has a goal of supporting Black and Latino/a/e founders with mentorship, pitch training, event programming, and networking. The eight-month program also has $75,000 in grant funding to dole out to participants as well.

“As Community Lab enters its third year, we are thrilled to cultivate a larger cohort of social entrepreneurs who share our vision of removing barriers to accessing sport for the communities we collectively serve,” Ayesha Martin, senior director of adidas Purpose, says in a news release.

Both the global organization of Impact Hub and the local group, Impact Hub Houston, are involved in the collaboration.

“Impact Hub is thrilled to partner and support this third iteration of adidas Community Lab, empowering visionary leaders who are advancing SDG3 —Good Health and Wellbeing — and SDG10 — Reduced Inequalities," Michelle Avalos, co-founder of Impact Hub Houston, adds. Together, we’re helping entrepreneurs create equitable access to sports and foster healthier, more inclusive communities for all."

Applications are open online now until September 23.

Founded by Pharrell Williams, Black Ambition will also collaborate with the program this year on key programing sessions. The organization invests funding and resources into Black and Hispanic entrepreneur-founded startups.

"Black Ambition was founded to create the space, bespoke opportunities and relationships needed for underrepresented founders to excel, uninterrupted. We are excited to partner with adidas Purpose to extend elements of our renowned, global founder support model to social impact entrepreneurs positively transforming their communities through sports and wellness," says Jermeen Sherman, managing director at Black Ambition.

City of Houston grants $100,000 to 10 innovative arts organizations

civic support

Ten Houston individuals and nonprofits are beneficiaries of grants totaling $100,000 for efforts to furthers cultural tourism and resilience throughout the City of Houston.

The Mayor’s Office of Cultural Affairs (MOCA) awarded the funds through the Initiative, a competitive grant program administered by Houston Arts Alliance (HAA) and funded by a portion of the city’s Hotel Occupancy Tax.

The application period is open three times annually and grant funding falls into three categories: Art + Neighborhood Cultural Destinations, Art + Disaster Resilience Awareness, and Art + Conference Tourism.

Here is a look at the winners and the projects that will be created with these grants.

Art + Conference Tourism

Contemporary Arts Museum Houston
This week, from September 16-19, the museum, in partnership with Houston Freedmen’s Town Conservancy (HFTC) and artist Theaster Gates, hosts Houston’s edition of the renowned Black Artists Retreat (B.A.R). The initiative explores the concept of “Black Land Ownership and Space: Black Stabilization and Determination." The four-day event brings together speakers, panelists, and experts from Houston and across the country to elevate and inspire the brain trust in local Black and BIPOC artists, creatives, and intellectuals. Programming occurs in Houston Freedmen’s Town, POST Houston, and CAMH.

One Sample Cultural Foundation
The organization will use its grant to produce the Ethnography of Afro-Venezuelan Music, a multidisciplinary educational conference that includes videos, music, and dance that exploring the syncretism of African culture and European religious practices in Venezuela through music. This free event will take place twice — at the Institute of Hispanic Culture of Houston on October 10 and at Teatro Bilingüe de Houston on April 13, 2025. The project aims to strengthen ties between the African American and Venezuelan communities and promote a dynamic cultural exchange.

SoulSista Art Foundation
The organization hosts a conference highlighting Houston’s contributions to the new music business at Houston Warehouse Studio on November 11. Free and open to the general public, it will include performances from selected poets and Afrobeats artists who have been recognized over the years in Houston, along with a DJ and food trucks. Donations will be accepted.

Art + Neighborhood Cultural Destinations

DaCamera
The music organization will use its grant for a series of jazz concerts at the historic El Dorado Ballroom in Third Ward. DaCamera at The Eldorado: Rising Jazz Stars features up-and-coming jazz artists from around the country, providing a new opportunity for Houstonians to experience the next generation of outstanding jazz talent. Concerts begin in October and run through May 2025. All performances will be pay-what-you-can.

Dance Afrikana
A curated exhibition, digital dance archive, and a book are planned as part of the organization's Black Dance in Texas multidisciplinary project. Documenting the rich history of Black dance in the state, this project is an extension of the research project by Dance Afrikana’s founder and Scholar-in-Residence for Rice University’s CERCL Program at the African American History Research Center Gregory Campus.

Norma Jo Thomas
The composer's original musical, Carol of the Bells, will have its world premiere on December 14 at the C. Lee Turner Performing Arts Center on the campus of Lone Star College. The holiday offering is part of Thomas' ongoing tradition to bring cultural programming to the community, and is part of an Acres Homes community collaboration.

The Pilot Dance Project

Celebrated Houston-based choreographer Cynthia Garcia presents Loteria, which brings to life the characters of the traditional Mexican board game. In an urban landscape of constant gentrification, often cultural signifiers, customs, and traditions are left behind to show the legacies of cultural communities. The work will be performed at two major cultural events in gentrified neighborhoods that have histories as Mexican and Mexican American neighborhoods, MECA’s Day of the Dead Festival in October and the MD Anderson YMCA’s annual posada in Near Northside in December.

University of Houston Foundation
Seven-time Grammy Award-winner Terence Blanchard will engage communities from Third Ward and downtown Houston in a series of events. In addition to performing a concert, the jazz legend will collaborate with University of Houston and University of Houston-Downtown students. Performance will take place November 7, 8, and 10 at the Wortham Theater Center or at the University of Houston Moores School of Music. A fireside chat and workshop are also part of the visit.

Art + Resilience Awareness

Group Acorde
The organization's Batimento Cardiaco is a new work that depicts Houstonians' mental health before, during, and after a natural disaster occurs. It will premiere at the MATCH October 3 and 4, and feature musicians, two contemporary dance choreographers, and a visual artist who've collaborated on this important work. Sets and costumes are made of recyclable materials. A discussion will follow the performance. Rehearsals streamed on Group Acorde's social media will give audiences a look at the work as it develops.

Lance Flowers
The artists solo exhibit, Take Me As I Am, takes place simultaneously at the Hogan Brown Gallery in Third Ward and Yale University’s Institute for Sacred Music. It's a collection of new 2D works, videography, music, and photography pieces highlighting Third Ward and its community, and all the materials used will be gathered from the Third Ward. It's curated by gallery director Robert Hodge. The Yale portion of this show has received its own funding.

------

This article originally ran on CultureMap.

How to prepare your business for severe weather, according to this Houston expert

guest column

Unprecedented severe weather events are becoming more frequent and intense. Proactive business planning is critical to navigating what Mother Nature has in store for us.

In Houston, severe weather can impact operations any time of year, not just hurricane season, so now is the time to incorporate any fresh lessons learned during Hurricane Beryl into your plans. Employers are responsible for safeguarding their employees and assets during these emergencies, which requires establishing an emergency action plan as a foundation of preparedness.

Develop an Emergency Action Plan

If your business does not have an emergency action plan (EAP), today is the perfect time to start it so you are prepared with a response strategy. This clearly written plan is a blueprint for how your business will react and protect employees when severe weather strikes. The more detailed the EAP, the better you and your employees will respond in a time of crisis. Within the EAP, it is important to outline specific protocols, designate key roles and responsibilities and establish communication channels for employees and clients. As power can be an issue during severe weather events, outlining various communication channels is helpful.

Identify Key Employees

During an emergency, you need to know who has the authority to make the decisions that impact your employees and your business. The designated person needs to assess the situation, determine whether employees should work remotely or shelter in place, and communicate these decisions clearly and quickly. This person is usually on the leadership team and can be trusted to make clear decisions, act promptly and communicate effectively to mitigate undue risks.

Implement Regular Emergency Training

Practice makes perfect. A plan on paper is the first step, but it must be practiced and drilled so everyone knows what to do, asks questions and makes any needed adjustments, all when the stakes are not as high. Familiarity with emergency procedures through periodic training and drills allows employees to practice evacuation routes, assembly points and safety protocols.Incorporating local emergency responders in safety drills familiarizes employees with the roles and responsibilities of each group. Through this emergency training, your teams will become confidently prepared to calmly respond to emergencies.

Provide a Swift and Orderly Response

Proactively thinking through and planning for location-specific emergency situations allows business owners to mitigate risks associated with severe weather events and quickly respond when a crisis strikes. When your business is prepared, there is less downtime and disruption to business operations, it protects physical assets, and most importantly, it prioritizes the safety and well-being of employees.

Houston experiences a wild mix of severe weather situations, which makes proactive business planning and preparedness even more critical. Prioritizing EAP development and implementation, designating responsible decision-makers, conducting regular training and drills, and ensuring clear communication channels sets the stage for a resilient organization in severe weather. Additionally, establishing a clear EAP helps foster a culture of safety and readiness that can significantly protect lives and livelihoods during times of crisis.

———

Ray Brock is a director of safety services with Insperity, a leading provider of human resources offering the most comprehensive suite of scalable HR solutions available in the marketplace.

This article originally ran on EnergyCapital.

View All Listings