Camilo Mejia, CEO and founder of Houston-based Enovate Upstream, has big plans for increasing efficiency across the oil and gas sector. Photo courtesy of Enovate

A Houston energy tech company announced a new artificial intelligence platform that aims to digitize the oil and gas sector to provide the best efficiency and return on investment at every stage of the supply chain cycle — from drilling and production to completion.

Enovate Upstream's exponential growth, says Camilo Mejia, CEO and founder of the company, has already led to two new strategic partnerships in the works with European and Latin American companies.

"We see a better future in the oil and gas industry," Mejia shares in an interview with InnovationMap. "Our team worked in various roles in O&G, and we don't think the industry will end up as some people may think. The future will be different and digitized, we are just here to facilitate that transition to give back to the industry that gave us a lot."

The company's proprietary cloud-based ADA AI digital ecosystem is challenging the assumptions of the industry by using new technology powered artificial intelligence to provide historical data with AI to give real-time production forecasting. Thanks to the cloud, users can access the information anywhere in the world.

The new platform combines three models — digital drilling, digital completions, and digital production — that provide precise data that can be customized to the client's needs, integrating into an existing platform easily for a real-time view of their return on investment and carbon emission output.

Mejia shares more about his company's growth and what goals Enovate Upstream is setting to continue the course of digitization in the oil and gas industry in the Q&A with InnovationMap.

InnovationMap: What inspired Enovate Upstream’s focus on artificial intelligence technology for the upstream value chain?

Camilo Mejia: For the past five or six years, there's been talk of digitalization, and the value of data. The next level is not the value of the data, it's about the automation, how you can improve operations, and how you can help customers to make better decisions. Every single technology that we are developing here is about the return of investment.

Our AI concept is about the physics behind the data. We are accelerating digital adoption by properly showing the tangible value of the technology by speaking the same language and showing the value from the oil and gas perspective, which was one of the challenges other AI technology faced to break into the industry before. Our artificial intelligence component upgrades this technology to optimize the industry while integrating it with this digital ecosystem all in one place. The digital ecosystem we're building covers the entire value chain.

One of the challenges the industry faces is around capital allocation — how we can help customers to properly allocate capital into projects, which is a fundamental way we forecast new projects. Another challenge is the size of the organization that ranges from corporations to small businesses. They have many opportunities to improve cost but that varies across companies.

We are overcoming that challenge in order to develop a technology that can show the inefficiencies between the sizes. The third challenge is the adoption of digital technology. There are two different ways of deploying artificial intelligence. One is data-driven analysis, data-driven models, or data trading — this is the foundation.

IM: What fundamental changes do you think your cloud-based ADA technology can provide across every stage of the value chain?

CM: The biggest change we have in the platform is revising the workflow based on the production size. We use the data the customers already have, to develop a model that changes the way we forecast production in the industry. Before you deploy the capital and execute the project, you are going to have a better idea of the maximum potential profitability, so you can make better decisions at any stage from that point.

One of the inspirations for this was Tesla. The automotive industry was failing to provide a self-driving vehicle because it was using mathematical approaches, but Tesla overcame that challenge using data of millions of drivers to drive and park the cars efficiently, optimizing the process.

We are doing exactly the same, which is applying mathematical equations only for drilling forecasts, production forecasts, and using the data from the wells to see how the projects are behaving. We also integrate the modules so every single module is communicating with each other at every stage to correlate back to a production forecast to set your targets or operation based on that expected return of investment.

Our concept is about the return of investment, in order to develop the ROI concept, you got to plan the events right and the varying size production, that becomes the second component. The third component is about optimization of operations, which is about automation to improve operations and therefore decision-making. We are developing technology that has a very modern interface to automate operations in a more intuitive way so customers can be independent in the process and make the best decisions.

IM: At the moment, there is a need for virtual connections. How does your technology allow certain hands-on tasks to be handled remotely?

CM: In many ways, we have a big project in the Gulf of Mexico. We place technologies that we are using in today's market and deploy a platform that customers can use independently. We can also automate operations to the cloud by just deploying, trimming the data out of the field straight to the cloud so that people in the field can actually use the AI component to optimize operations. We don't require face to face interaction using the cloud environment.

Since the coronavirus these digital components have been on demand, we have grown about 500 percent from the end of Q1 and into the middle of Q2. We are experiencing an acceleration in the adoption of digital technology, but the ability to deploy the technology through the cloud has been instrumental in gaining more traction in the market. As a matter of fact, just as an indicator, we have been hiring people since the start of the coronavirus.

IM: Enovate Upstream started a year ago since then you’ve experienced exponential growth. What are a couple of goals that the company will achieve by the end of the year?

CM: Our strategy is focused on the next level for the company, which is securing funding round with investors in London. We are also aiming to facilitate the deployment of our technology globally. We are focusing on the United States and Latin America, but we hope to expand our funding round to Europe and the Middle East.

Our other goal lies with our partnerships, we are working through a distribution channel, through larger service companies that are facilitating the commercialization of the technology. The focus is on enabling these companies to properly support the customers by doing more technology integration and increasing the value creation.

The next goal is obviously to sustain the company, even though we have been growing, there is a lot of uncertainty in the market, and we are focusing on building the culture of the company, which is challenging in a virtual space.

IM: How has Enovate Upstream navigated an unstable market amid your rapid growth?

CM: That's a good question. I think the lesson is that you can always end up in a different direction. Coronavirus is having a big impact on many businesses, often negatively, but for us, it was instrumental to realize the full potential of the technology we were developing.

We saw that the activity was going from operations to the financial sector with companies selling assets to sustain their business. There were a lot of customers trying to decide what kind of wells they need to continue producing, so that was a market that we didn't capture before.

We grew the technology in that direction by starting a second company called Energy Partners. We created a joint venture with some producers in South Texas to make better decisions in asset acquisition. It was instrumental for us to realize the full potential on the finance side, as opposed to operations where the initial focus was.

We have assets in South Texas now and from a technology standpoint, it's the ideal way to test our analytic technology. We use our technology to properly evaluate the return of investment to make decisions about acquiring assets to optimize the operations and increase production. We have the opportunity to prove the technology with our investments, so we can actually build trust with customers. We are 100 percent sure that the technology works the way we say it works.

IM: There’s a huge emphasis on sustainability in the energy industry. How does your technology reduce carbon emissions?

CM: There are two kinds of components here. The first one is about optimizing operations — personnel transportation at the field level. We have studied calculations of what carbon dioxide output looks like to reduce it in terms of optimizing transportation, technology, and contributing to innovative ideas. We are currently initiating a feasibility study on a carbon capture technology, and working with customers to provide value in the technology in various aspects.

IM: I see several partnerships have already begun. Are you looking for more and what role do these partnerships play for your business?

CM: We have two partnerships about to close. One is with Telefonica, a Spanish telecommunications company, and another with Pluspetrol, an Argentinian production company. Telefonica provides cybersecurity services to oil and gas companies, we actually work with them to deploy our technology in Latin America and Europe. They provide the cloud and cybersecurity component while we provide the AI component.

In terms of our technology development, Pluspetrol has been one of our partners from the very beginning and we continue developing more technologies with this particular customer. They provide us with access to real data and real operational conditions that facilitate technological innovation.

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This conversation has been edited for brevity and clarity.

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Houston hardtech accelerator names 8 founders to 2026 cohort

hardtech fellows

Hardtech-focused organization Activate has named 50 new members to its 2026 cohort of scientists, which includes eight startups joining Activate Houston.

Activate aims to support scientists at "the outset of their entrepreneurial journey." It partners with U.S.-based funders and research institutions to support its fellows in developing high-impact technology. Its fellows receive a living stipend, research and development funding, connections from Activate's robust network of mentors and access to a curriculum specific to the program for two years.

This year's fellows represent 41 companies from 22 U.S. cities and 11 states.

“This cohort clearly demonstrates that the next industry-defining companies won't choose between modern technology and deep science; they'll be built by combining both,” Cyrus Wadia, CEO of Activate, said in the announcement. “These are the scientists and engineers turning our most urgent global challenges into the companies that will deliver a more sustainable future.”

The Houston fellows are working across the energy, space, AI infrastructure and agriculture sectors. They include:

  • Sophie Clare Broun, founder of Anning Corporation, which is producing clean hydrogen by stimulating naturally occurring geologic deposits
  • Kathy Andersen, founder of Brint Tech, which builds optical sensing systems that quantify hydrogen for infrastructure operators
  • Dorsa Talebi, founder of Kinetiq Drive, which builds rare-earth-free, contact-free electric motors with wireless rotors for small appliances and heavy industry alike
  • Neethu Pottackal, founder of Nivera, which is developing natural, edible coatings made from agricultural byproducts to reduce food waste and extend the shelf life of fresh food
  • Jonathan Huffman, founder of Orbital Arc, which is shrinking spacecraft propulsion to a microchip powerful enough for deep space
  • Tim Lee, founder of Renesin, which develops advanced materials for faster, more efficient AI hardware
  • Joshua Livingston, founder of Selerra Separations, which is developing high-performance membranes that cut the cost and energy consumption of water treatment
  • Wenli Jiang, founder of SwieNitro Recovery, which is developing technology that converts nitrogen-rich waste streams into valuable fertilizer

"Home to the largest concentration of engineers in the United States and a dense ecosystem of Fortune 100 and Fortune 500 companies, Houston is uniquely positioned for scientists tackling large-scale industrial challenges. Activate Houston fellows are connected to the city's deep networks in energy, chemicals, and materials," Activate said in the announcement.

Activate named its inaugural Houston cohort in 2024. It has other hubs in Boston, New York, and Berkley, California—where Activate is headquartered. The organization also offers a virtual and remote cohort, known as Activate Anywhere. Nationally, it has supported 346 fellows and 276 companies since 2015.

Activate Houston is led by managing director Jeremy Pitts, who co-founded Greentown Labs in Boston. It is based out of the Ion. The latest cohort is Activate Houston's third. Read more about the last year's cohort here.

Rice, Houston Methodist award $90K for cancer research projects

seed grants

Rice University’s Synthesis X Center, in partnership with the Houston Methodist Neal Cancer Center, announced earlier this month the organizations would award $90,000 in seed grant funding to two projects that could help fight cancer. One would ease the pain of chemotherapy, while the other could change the way the progression of leukemia is tracked.

“We’re excited to be collaborating with the Neal Cancer Center to support collaborative, novel and interdisciplinary proposals to improve cancer care and outcomes,” Han Xiao, Rice professor of chemistry and the director of the SynthX Center, said in a news release. “Together, we can achieve translational excellence.”

The projects

Chemotherapy is one of the most effective cancer treatments, but it can be hard on the body. The human body doesn’t like being injected with radioactive material, especially the skin around the injection point, which can become extremely irritated. For patients in long-term treatment, the skin irritation can be more than just a bother; it can lead to infections that are dangerous to a compromised immune system.

Angel A Marti, a professor of chemistry at Rice University, and Biana Godin, an associate professor of nanoscience at Houston Methodist Research Institute, are experimenting with metal nanoclusters as a way to block radiation at the injection site. The nanocluster could be applied in a cream or a gel on the skin, serving as a type of shield against the harsh radioactive material.

Meanwhile, Yuan Ma, an assistant professor of chemistry at Rice, and Shu-Hsia Chen, a professor of immunology at Houston Methodist Research Institute, are working with m6A. Discovered in the 1970s, m6A is the most prevalent chemical modifier found in mRNA in mammals. It is prevalent in many cancers, including leukemia.

Ma and Chen are working on measuring the amount of m6A in leukemia to see if it can determine the most effective cancer treatments. The team is also experimenting with ways to shut off m6A to see if it makes current leukemia treatments more effective.

Progress from SynthX

SynthX was first launched in April 2024 to turn research from Rice and Houston Methodist into real-world cancer treatments. Within a year, the center had secured $1.5 million in grant money to work on crossing the blood-brain barrier in brain cancer treatments. These latest awards show that SynthX Center continues to bridge the worlds of research and clinical practice.

“This collaboration reflects a shared commitment to team science in cancer research,” Daniela Matei, the director of the Houston Methodist Neal Cancer Center, added in the release. “These are the types of translational and pioneering projects that lead to transformation in patient care.”'

The SynthX Center awarded $90,000 in seed grants to three teams in 2025 and $80,000 to three teams in 2024.

Tesla self-driving mode wasn't to blame in Houston-area crash, report suggests

Tesla news

Federal safety investigators looking into a runaway Tesla that killed a grandmother in her home say the driver had pressed the accelerator to full speed, suggesting the vehicle's self-driving software was not to blame.

The driver had told police that he had the self-driving software turned on, but a report from the National Transportation Safety Board concluded that he had actually overridden that feature when he pushed hard on the pedal. Moments later the Tesla Model 3 raced down a residential street in Katy, Texas, at highway speeds, slammed into a brick home and killed a 76-year-old woman standing in the front room.

The crash last month drew national attention because Tesla CEO Elon Musk is seeking to reassure the public its self-driving feature is safe as he prepares to turn hundreds of thousands of Teslas already on the road into fully automatic vehicles and begin selling two-seated Cybercabs missing steering wheels and pedals.

The crash came two months after officials at a separate federal agency, the National Highway Traffic Safety Administration, announced it was elevating a 2024 investigation of the self-driving feature to new “engineering analysis” level, raising the possibility of a recall of 3.2 million Tesla vehicles.

That NHTSA probe was triggered by crashes where the self-driving feature failed to alert drivers to take control in fog and other poor visibility conditions.

The agency opened an investigation last year into 58 incidents in which Teslas reportedly violated traffic safety laws while using self-driving technology, leading to more than a dozen crashes and fires and nearly two dozen injuries.

Separate from the National Transportation Safety Board, NHTSA is also looking into the Tesla house crash in Texas, one of 46 “special crash” investigations of Tesla's self-driving or driver-assistance technology in the past decade, according to the agency’s records. In more than a dozen of those crashes, at least one person — a driver, passenger or pedestrian — was killed.

Tesla had originally called its driver assistance software Full Self-Driving, or FSD, but auto experts and regulators complained it was misleading because drivers must always keep their eyes on the road and be ready to take over at any time.

The company has since changed the name to Full Self-Driving (Supervised).

Video of the Katy, Texas, accident shows the Tesla traveling at more than 70 mph (112.65 kilometers per hour), jumping a curb then tearing across a lawn before crushing through a brick wall of a home. A woman standing feet away, Martha Avila, was found amid piles of crumbling plaster, split beams and bits of furniture and rushed to a hospital but died.

Sales of Tesla cars still haven't recovered fully from boycotts last year over Musk's political stands, but the stock is rising anyway as he has successfully shifted attention away from the sales figures. He says they matter less now that the company is on the cusp of major technological advances, such as turning Teslas into hands-free vehicles and having its Optimus robots take over for humans for tasks at home and work.

Tesla stock has risen 22% in the past year and is currently trading at 170 times expected annual earnings compared to 20 for the S&P 500.

For its second-quarter financial results, financial analysts surveyed by FactSet expect earnings per share will barely budge — 32 cents versus 33 cents a year earlier — continuing a sixth quarter streak of flat or falling profits.