Nesh's digital assistant technology wants to make industry information more easily accessible for energy professionals. Photo courtesy of Thomas Miller/Breitling Energy

When Sidd Gupta's friend lost his job and struggled to find a new position after the major oil downturn in 2014, Gupta noticed a systemic problem within the industry.

"A company rejected him because he was unfamiliar with the software they used in their operations," Gupta explains. "In our industry, companies will judge a potential hire's technical capabilities based on which software they know how to use rather than how good they would be at the job."

While software requirements for oilfield jobs are common, it made Gupta consider how we can make complex data and knowledge more accessible.

Gupta saw something else brewing in the energy industry that also piqued his interest.

"There was entrepreneurship in the oil and gas space and an interest in data science during the oil downturn. We saw startups created in Austin then Houston. There was an infectious entrepreneurial energy at that time," he says.

Last year, he took the entrepreneurial leap, quit his job and founded Nesh, a smart assistant like Alexa or Siri, but specifically for oil and gas companies. Nesh sources information from public data, vendor sources, technical papers, journal articles, news feeds and more to give answers to complex, technical questions related to energy.

Nesh explained
Because this tool is meant for businesses and not personal use, the software must be trustworthy, Gupta says, and he asked himself what he needs to do to make an engineer or a CEO of an energy company believe Nesh's response.

The answer: transparency. With Nesh, users can see how the smart assistant came to its answer. The software shows the data and workflow behind the answer as part of the user interface.

And Nesh learns from its users too. If an unfamiliar question is posed to Nesh, users can add new training phrases to teach Nesh what to do next time the question is posed.

"We created Nesh as something super-simple to use," Gupta says. "There's no learning curve, no technical knowledge required, you just need to speak plain English."

Gupta, who was raised in India, came to the United States to pursue his master's degree in petroleum engineering at the University of Texas at Austin. After working in oil and gas for over a decade, he started Nesh last year with co-founder and CTO Seth Anderson.

Gearing up for the future
This year, Nesh is in the process of fundraising, and, with the new funds, he plans to expand his workforce, which is currently five employees (including Gupta himself) based in Houston. Due to its size, Nesh currently can run only one pilot program at a time. With more employees, Nesh will be able to scale up its pilot programs and run multiple pilots in parallel. The larger user pool for these pilots will give Gupta and his team better insights into Nesh and allow them to continue refining the tool.

Right now, Gupta wants to commercialize in those operations where Nesh is already running pilot programs. He says he hopes for Nesh to have both internal and external growth, with the next surge of hiring and an expanded user pool for the product.

He plans to make Nesh available as a commercial product in fall of this year with a target market of small to mid-sized oil and gas companies.

Gupta says Nesh is different from anything in the market.

"With enterprise software in general, it can be very hard to get a demo version of software without talking to a sales representative—something that people dislike," he says. "I want to bring the B2C aspect of trying a software to the B2B world."

The business model goal for Nesh is for potential clients to be able to test the software themselves, Gupta says, and then contact the company if they're interested.

"I want transparent pricing to be visible on our website," he says. "I want potential customers to be able to experience the demo just by giving their information."

As Gupta sees it, one of the main advantages to being in Houston is the important support networks as well as the potential customer base. He's grateful to local organizations such as Station Houston and Capital Factory for connecting him with many resources.

"I'm seeing a lot of innovation here in Houston," Gupta says. "There's a lot of oil and gas companies, so as we begin looking for potential customers, that's a very important advantage of being here."

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Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”

10+ Houston innovation leaders in the spotlight at SXSW 2026

where to be

Houston's innovation scene will be well represented at South by Southwest (SXSW) this month.

The week-long, Austin-based conference and festival will spotlight some of the Bayou City's leaders in health care, energy, space and more. The event kicks off today, March 12, and runs through March 18. The SXSW Innovation Conference will feature keynotes, workshops, mentoring sessions and more throughout various venues in the city.

Here's who to see and when and where to find them:

March 12

Aileen Allen, venture partner at Mercury Fund

Mentor Session from 4-5:15 p.m. at Hilton Austin Downtown

Allen will host a mentoring session focused on funding, marketing, advertising, PR and the future of work.

March 13

Heath Butler, partner at Mercury Fund

SXSW Pitch-Smart Cities, Transportation, Manufacturing & Logistics from 2:30-3:30 p.m. at the J.W. Marriott

Butler will judge five innovative startups as they pitch their solutions to advance smart cities, enhance transportation systems, modernize manufacturing, transform logistics, and strengthen government infrastructure and civic operations.

Jonathan Cirtain, CEO and president of Axiom Space

The Clock is Ticking for Space - Replacing the ISS from 4-5 p.m. at the J.W. Marriott

Cirtain will discuss Axiom's pursuit of building the world’s first commercial space station.

March 14

Jesse Martinez, founder and CEO of LSA Global

SXSW Pitch-Intelligent Systems, Robotics, & Multisensory Technology from 10-11 a.m. at the J.W. Marriott

Martinez will judge five innovative startups as they pitch their technologies that aim to enhance the way people connect, communicate and share unique life experiences with those around them in a digital ecosystem.

Jennifer Schmitt, head of operations at Rhythm Energy

Powering Texas with Reliable Integrated High-Demand Energy from 10-11 a.m. at Marlow

Schmitt will join a panel to discuss how EirGrid, the state-owned electric power transmission operator in Ireland, is pioneering solutions as the country works toward 80 percent renewable integration by 2030.

Saki Sasagawa, director of business development for JETRO Houston

Now is Japan's Time: Leading the Future with Deep Tech from 10-11 a.m. at the J.W. Marriott

Sasagawa joins a panel that will share real-time insights from diverse perspectives on the forefront of Japan’s deep tech and IP businesses.

March 15

Bosco Lai, CEO and co-founder of Little Place Labs

SXSW Pitch Alumni: Where Are They Now? from 10-11 a.m. at the J.W. Marriott

Lai joins a panel of four former SXSW Pitch winners to share how they leveraged the platform to take their startups to the next level.

Tara Karimi, cofounder and chief science and sustainability officer at Cemvita

South by South America: The Rise of Southern Brazil Tech from 2:30-3:30. p.m. at The Line

Karimi will participate in a panel to discuss how Rio Grande do Sul, Brazil's southernmost state, is attracting elite talent and AI infrastructure and share insights on navigating the next wave of South American tech growth.

March 16

Dr. Pavitra P. Krishnamani, emergency medicine physician at The University of Texas MD Anderson Cancer Center

Viva La Revolution: How the Digital Age is Transforming Wellness from 11:30 a.m.-12:30 p.m. at Hilton Austin Downtown

Krishnamani will discuss the latest advancements and policies that can accelerate the digital age of health care, such as wearables, telehealth and artificial intelligence.

March 18

Charlie Childs, co-founder and CEO of Intero Biosystems

Spinning Out: What It Takes to Build a University Startup from 2:30-3:30 p.m. at The Line

Childs will join founders who spun their companies out of the University of Michigan to share the real story of navigating IP, early capital, team building, market validation and the “valley of death.”

Dr. James Allison, regental chair of immunology and director of The Allison Institute at The University of Texas MD Anderson Cancer Center

Dr. Padmanee Sharma, professor in the Department of Genitourinary Medical Oncology, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center

Beyond Checkpoints: Immunotherapy’s Next Act from 2:30-3:30 p.m. at the J.W. Marriott

Allison and Sharma will sit down with 21-year-old, Stage 4 cancer survivor Sharon Belvin and Time Magazine journalist Alice Park will discuss the future of immunotherapy and what challenges remain.

Last year, Houston startups Little Places Labs and Helix Earth won top prizes in their respective categories at the prestigious SXSW Pitch event, held this year from March 13-14. No Houston startups were named finalists to compete in this year's event.