Houston has the potential to be a great place for startups, but it might need some fine tuning. Photo by Scott Halleran/Getty Images

I often think about why Houston's entrepreneurship ecosystem hasn't taken off as much as it should, given the talent pool and the industrial gravity that's concentrated here.

I joined Station Houston as one of the very early members in January of 2016 and since then been watching all the moving parts in the Houston innovation ecosystem as an entrepreneur. I wanted to share four practical ideas on how Houston can emerge as a startup hub.

1. Houston entrepreneurship needs to focus on deep tech and multidisciplinary endeavors
I believe a lot of breakthrough innovations will come from the interaction between different scientific disciplines or industries. We can target startups built on multidisciplinary sciences and provide a support system for them to thrive in Houston. We have the absolute best engineers, rocket scientists, and doctors in Houston, yet they aren't talking to each other as much as they should. Programs like Pipes and Pumps are great, but we need a modernized initiative that goes beyond holding a one-day event per year. A methodical and continuous program that brings professionals from energy, space, and medicine together to address the challenges these industries face. This may sound crazy, but it works. For example, my last startup commercialized DNA Sequencing in the oil and gas industry. Another startup is using microfluidics to simulate the reservoir, and there are startups using satellite data to identify methane emissions. Now, imagine if we were systematically identifying these opportunities and incubating these startups in Houston. We would be unstoppable and, more importantly, we would be ourselves. Let's help our entrepreneurial doctors, scientists, and engineers launch deep technology startups instead of trying to make apps.

2. Houston needs a structured startup program
Let's be honest, coworking space and 30-minute sessions with mentors isn't going to cut it. First-time entrepreneurs need a lot of help to gain experience and kick start their business model. What's missing is a structured program that can take a talented entrepreneur from the idea stage to raising their seed round (better or at least similar to Creative Destruction Lab or Breakout Lab).

3. Focus on helping the entrepreneurs, and the ecosystem will flourish
Any initiative around entrepreneurship that doesn't boil down to helping entrepreneurs is effectively useless. We need to pass all activities through the "entrepreneur benefit" filter. The current suite of entrepreneurship activities in Houston are skewed towards self-celebratory warm and fuzzy feeling for the ecosystem; we need to shift the attention and resources to entrepreneurs who are in the trenches trying to make it to the next level. Once we have good entrepreneurs, we will have good exits which makes investors happy and incentivize them to invest more. Those entrepreneurs then start building other companies or turn investor and this cycle gradually builds the ecosystem. What's happening now is quite the opposite; all the attention is on building the ecosystem and hoping that it's going to make everything else happen/

4. Houston could be the home for moonshots
Moonshots come from the application of deep technology, and I can't think of a better place to be the home for moonshot startups than Houston. From cure for cancer to rockets to Mars, to reversing climate change via CO2 capture and utilization. That said ideating and incubating moonshots requires vision and the appetite for risk-taking. The good news is that this model really works. As proof look at the OS Fund amazing and astronomically successful portfolio of the companies. According to Bryan Johnson, "OS Fund is investing in deep tech companies that marry hard science and technology to solve big problems and make money." We need a new breed of investment firms such as OS Fund in Houston.

Imagine if we had a portfolio of multidisciplinary deep technology startups in Houston, going through a rigorous program and had the support of the Houston industrial magnets and investors to take off. Now that's what Houston deserves.

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Moji Karimi is co-founder and CEO of Houston-based Cemvita Factory Inc.

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”