Houston has the potential to be a great place for startups, but it might need some fine tuning. Photo by Scott Halleran/Getty Images

I often think about why Houston's entrepreneurship ecosystem hasn't taken off as much as it should, given the talent pool and the industrial gravity that's concentrated here.

I joined Station Houston as one of the very early members in January of 2016 and since then been watching all the moving parts in the Houston innovation ecosystem as an entrepreneur. I wanted to share four practical ideas on how Houston can emerge as a startup hub.

1. Houston entrepreneurship needs to focus on deep tech and multidisciplinary endeavors
I believe a lot of breakthrough innovations will come from the interaction between different scientific disciplines or industries. We can target startups built on multidisciplinary sciences and provide a support system for them to thrive in Houston. We have the absolute best engineers, rocket scientists, and doctors in Houston, yet they aren't talking to each other as much as they should. Programs like Pipes and Pumps are great, but we need a modernized initiative that goes beyond holding a one-day event per year. A methodical and continuous program that brings professionals from energy, space, and medicine together to address the challenges these industries face. This may sound crazy, but it works. For example, my last startup commercialized DNA Sequencing in the oil and gas industry. Another startup is using microfluidics to simulate the reservoir, and there are startups using satellite data to identify methane emissions. Now, imagine if we were systematically identifying these opportunities and incubating these startups in Houston. We would be unstoppable and, more importantly, we would be ourselves. Let's help our entrepreneurial doctors, scientists, and engineers launch deep technology startups instead of trying to make apps.

2. Houston needs a structured startup program
Let's be honest, coworking space and 30-minute sessions with mentors isn't going to cut it. First-time entrepreneurs need a lot of help to gain experience and kick start their business model. What's missing is a structured program that can take a talented entrepreneur from the idea stage to raising their seed round (better or at least similar to Creative Destruction Lab or Breakout Lab).

3. Focus on helping the entrepreneurs, and the ecosystem will flourish
Any initiative around entrepreneurship that doesn't boil down to helping entrepreneurs is effectively useless. We need to pass all activities through the "entrepreneur benefit" filter. The current suite of entrepreneurship activities in Houston are skewed towards self-celebratory warm and fuzzy feeling for the ecosystem; we need to shift the attention and resources to entrepreneurs who are in the trenches trying to make it to the next level. Once we have good entrepreneurs, we will have good exits which makes investors happy and incentivize them to invest more. Those entrepreneurs then start building other companies or turn investor and this cycle gradually builds the ecosystem. What's happening now is quite the opposite; all the attention is on building the ecosystem and hoping that it's going to make everything else happen/

4. Houston could be the home for moonshots
Moonshots come from the application of deep technology, and I can't think of a better place to be the home for moonshot startups than Houston. From cure for cancer to rockets to Mars, to reversing climate change via CO2 capture and utilization. That said ideating and incubating moonshots requires vision and the appetite for risk-taking. The good news is that this model really works. As proof look at the OS Fund amazing and astronomically successful portfolio of the companies. According to Bryan Johnson, "OS Fund is investing in deep tech companies that marry hard science and technology to solve big problems and make money." We need a new breed of investment firms such as OS Fund in Houston.

Imagine if we had a portfolio of multidisciplinary deep technology startups in Houston, going through a rigorous program and had the support of the Houston industrial magnets and investors to take off. Now that's what Houston deserves.

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Moji Karimi is co-founder and CEO of Houston-based Cemvita Factory Inc.

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Houston biopharma company launches equity crowdfunding campaign

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A clinical-stage company headquartered in Houston has opened an online funding campaign.

FibroBiologics, which is developing fibroblast cell-based therapeutics for chronic diseases, launched a campaign with equity crowdfunding platform StartEngine. The platform lets anyone — regardless of their net worth or income level — to invest in securities issued by startups.

The funding, according to a press release, will be used to support ongoing operations of Fibrobiologics and advance its clinical programs in multiple sclerosis, degenerative disc disease, wound care, extension of life, and cancer.

"We're excited to partner with StartEngine on this campaign. StartEngine has over 600,000 investors as part of their community and has raised over half a billion dollars for its clients," says FibroBiologics' Founder and CEO Pete O'Heeron, in the release.

"This is an exciting time at FibroBiologics as we continue progressing our clinical pipeline and developing innovative therapies to treat chronic diseases," he continues. "This new funding will fuel our growth in the lab and bring us one step closer to commercialization."

The campaign, launched this week, already has over 100 investors, at the time of publication, and has raised nearly $2 million, according to the page. The minimum investment is set at around $500, and the company's indicated valuation is $252.57 million.

In 2021, FibroBiologics announced its intention of going public. Last year, O'Heeron told InnovationMap on the Houston Innovators Podcast of the company's growth plans as well as the specifics of the technology.

Only two types of cells — stem cells and fibroblasts — can be used in cell therapy for a regenerative treatment, which is when specialists take healthy cells from a patient and inject them into a part of the body that needs it the most. As O'Heeron explains in the podcast, fibroblasts can do it more effectively and cheaper than stem cells.

"(Fibroblasts) can essentially do everything a stem cell can do, only they can do it better," says O'Heeron. "We've done tests in the lab and we've seen them outperform stem cells by a low of 50 percent to a high of about 220 percent on different disease paths."


Texas ranks as a top state for female entrepreneurs

women in business

Texas dropped three spots in Merchant Maverick’s annual ranking of the top 10 states for women-led startups.

The Lone Star State landed at No. 5 thanks in part to its robust venture capital environment for women entrepreneurs. Last year, Texas ranked second, up from its No. 6 showing in 2021.

Merchant Maverick, a product comparison site for small businesses, says Texas “boasts the strongest venture capital scene” for women entrepreneurs outside California and the Northeast. The state ranked fourth in that category, with $6.5 billion invested in the past five years.

Other factors favoring Texas include:

  • Women solely lead 22 percent of all employees working for a business in Texas (No. 4).
  • Texas lacks a state income tax (tied for No. 1).

However, Texas didn’t fare well in terms of the unemployment rate (No. 36) and the rate of business ownership by women (No. 29). Other Texas data includes:

  • Average income for women business owners, $52,059 (No. 19).
  • Early startup survival rate, 81.9 percent (No. 18).

Appearing ahead of Texas in the 2023 ranking are No. 1 Colorado, No. 2 Washington, No. 3 California, and No. 4 Arizona.

Another recent ranking, this one from NorthOne, an online bank catering to small businesses, puts Texas at No. 7 among the 10 best states for women entrepreneurs.

NorthOne says Texas provides “a ton of opportunities” for woman entrepreneurs. For instance, it notches one of the highest numbers of women-owned businesses in the country at 1.4 million, 2.1 percent of which have at least 500 employees.

In this study, Texas is preceded by Colorado at No. 1, Nevada at No. 2, Virginia at No. 3, Maryland at No. 4, Florida at No. 5, and New Mexico at No. 6. The rankings are based on eight metrics, including the percentage of woman-owned businesses and the percentage of women-owned businesses with at least 500 employees.