Houston is home to a few of the highest-ranked high schools in the nation. Getty Images

Three Houston high schools are continuing their streak of top appearances on a prestigious annual list of the country's best public high schools.

The 2023 rankings from U.S. News & World Report, released August 29, put Houston ISD’s Carnegie Vanguard High School at No. 35 nationally (up from No. 40 last year) among the country’s best high schools. The school also ranks No. 248 nationally among the best STEM (science, technology, engineering, and math) high schools and No. 12 among the best magnet high schools.

Also in the top 100 are two other Houston ISD high schools.

DeBakey High School for Health Professions ranks No. 66 nationally among the best high schools (down from No. 50 last year) and No. 18 among best magnet high schools for the second consecutive year.

Young Women's College Prep Academy comes in No. 94 nationally among the best high schools (up from No. 148 last year), and No. 26 among best magnet high schools.

Topping the national list for 2023 is the Early College at Guilford in Greensboro, North Carolina.

Each year, U.S. News evaluates about 18,000 high schools on six factors: college readiness, reading and proficiency, reading and math performance, underserved student performance, college curriculum breadth, and graduation rates.

"Having access to a strong high school program is paramount for students as they face an ever-changing world," said U.S. News' managing editor of education Liana Loewus in a release. "Making data on our high schools available helps parents ensure their child is in the educational environment that best sets them up to thrive."

Elsewhere in Texas
Around the state, these Texas high schools also made it into the top 100 nationally:

  • Dallas ISD's The School for the Talented and Gifted, No. 6 (up from No. 8 last year and No. 13 in 2021). No. 8 nationally among the best STEM high schools for the second consecutive year and No. 2 among the best magnet high schools (up from No. 4 last year).
  • Dallas ISD's Irma Lerma Rangel Young Women's Leadership School, No. 18 (up from No. 20 last year) and No. 8 nationally among the best magnet high schools for the second consecutive year.
  • Dallas ISD's Science and Engineering Magnet School, No. 23 nationally among the best high schools (down from No. 22 last year), No. 24 nationally among the best STEM high schools (down from No. 7 last year), and No. 2 nationally among the best magnet high schools (up from No. 10 in 2022).
  • Austin ISD’s Liberal Arts and Science Academy, No. 32 (up from No. 34 last year and No. 41 in 2021). No. 34 nationally among the best STEM high schools (up from No. 70 in 2022).
  • BASIS San Antonio - Shavano Campus, No. 81 (down from No. 77 last year and No. 102 in 2021). No. 41 nationally among the best STEM high schools (down from No. 25 in 2022) and No. 17 nationally among the best charter high schools.
  • Dallas ISD's Trinidad Garza Early College at Mt. View, No. 91 (up from No. 118 last year).
  • Dallas ISD’s Judge Barefoot Sanders Law Magnet, No. 93 (down from No. 48 last year and No. 59 in 2021) . No. 25 nationally among the best magnet high schools (down from No. 17 in 2022).
  • Austin ISD's Richards School for Young Women Leaders, No. 95 (up from No. 128 last year).

When broken down just to Texas schools, Houston's Carnegie Vanguard High School (No. 5), DeBakey High School for Health Professions (No. 6), and Young Women's College Prep Academy (No. 10) are all in the top 10 best-rated public high schools in Texas this year, U.S. News says.

Other Houston-area schools that rank among Texas' 100 best are:

  • No. 12 – Kinder High School for Performing and Visual Arts, Houston ISD
  • No. 21 – Challenge Early College High School, Houston ISD
  • No. 24 – Kerr High School, Alief ISD, Houston
  • No. 29 – Eastwood Academy, Houston ISD
  • No. 37 – YES Prep - Southwest, Houston
  • No. 39 – Harmony School of Innovation - Katy, Katy
  • No. 40 – North Houston Early College High School, Houston ISD
  • No. 42 – Clear Horizons Early College High School, Clear Creek ISD, Houston
  • No. 46 – Seven Lakes High School, Katy ISD
  • No. 53 – Victory Early College High School, Aldine ISD, Houston
  • No. 54 – YES Prep - Southeast, Houston
  • No. 57 – East Early College High School, Houston ISD
  • No. 58 – Houston Academy for International Studies, Houston ISD
  • No. 64 – YES Prep - East End, Houston
  • No. 69 – Tomball Star Academy, Tomball ISD
  • No. 72 – Early College Academy at Southridge, Spring ISD, Houston
  • No. 73 – Tompkins High School, Katy ISD
  • No. 75 – Clements High School, Fort Bend ISD, Sugar Land
  • No. 82 – YES Prep - North Central, Houston
  • No. 83 – Sharpstown International School, Houston ISD
  • No. 93 – YES Prep - North Forest, Houston
  • No. 95 – YES Prep - West, Houston
  • No. 97 – High School for Law and Justice, Houston ISD

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This article originally ran on CultureMap.

DeBakey High School for Health Professions is at the top of the class. Photo by skynesher/Getty Images

Houston STEM high school declared top of the class by U.S. News & World Report

A-plus

Three Houston high schools deserve a tip of the cap (or mortarboard) after earning marks for excellence. On June 12, U.S. News & World Report released its annual Best U.S. High Schools by metro area, ranking the top public schools in each major city.

DeBakey High School for Health Professions is at the top of the class in the Bayou City. In addition to earning top marks for academics, the school is notably comprised of mostly minority students — 89 percent.

To determine the country's best schools, U.S. News ranked each school using six metrics, applying different weights to each category:

  • College readiness (30 percent)
  • Math and reading proficiency (20 percent)
  • Math and reading performance (20 percent)
  • Underserved service (10 percent)
  • College curriculum breadth (10 percent)
  • Graduation rate (10 percent)

Based on the above, the school has an overall score of 99.9 (or an A-plus in high school lingo), complete with 100 percent graduation and reading and mathematics proficiency rates. Also, 100 percent of students took and passed at least one AP exam.

Located on the prestigious Texas Medical Center Campus, DeBakey offers students unparalleled access to on-site research facilities, as well as future academic opportunities, U.S. News notes.

"Graduates are eligible for the Houston Premedical Academy, an undergraduate program at the University of Houston designed specifically for DeBakey High School students," the report says. "Those selected for the premedical academy receive provisional acceptance to the Baylor College of Medicine."

DeBakey ranks first in Houston and No. 17 nationally. The school is also rated No. 10 in the U.S. among magnet schools and No. 11 among STEM schools.

Carnegie Vanguard High School earned the No. 2 spot in Houston, 24th in the nation, followed by Eastwood Academy at No. 3 locally and 97th nationally.

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A version of this story, with information on Texas' other metros, originally was published on CultureMap.

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.