Gensler is using a new software program to help optimize social distancing in the workplace for Houston companies returning to the office. Photo courtesy of Gensler

The COVID-19 pandemic has displaced many Houstonians from their office jobs to makeshift work-from-home setups. With coronavirus cases climbing in Houston, the obstacle of returning to work safely is undoubtedly on the minds of business owners across the city.

Thankfully, there's an algorithm for that. Gensler, a global architecture firm, has unveiled its ReRun program as a pandemic response tool to help offices create workspace layouts for safe social distancing.

ReRun allows Gensler to upload a floorplan into the program, which applies generative algorithms to determine safe separation between workplaces by creating circles ranging from six to eight-foot diameters. The tool can quickly generate scenarios and identify the most optimized capacity to meet social distancing demands, easing the role of operations and human resources.

"It's really just a tip of the spear in terms of occupancy planning, because once you know that information, then the next question is what do I do with that?" says Dean Strombom, strategy lead and principal at Gensler's Houston office.

"ReRun is the first tool we utilize to help [clients] determine how many people might be able to come back and still achieve the social distancing side. Then we work with them on how they should come back, whether it's a percentage of employees, staggered shift work or alternating days," Strombom says. Circulation patterns are also taken into account by the Gensler team, who analyze the traffic of hallways, meeting spaces and lounge areas.

Dean Strombom is the strategy lead and principal at Gensler's Houston office. Photo courtesy of Gensler

The international firm, with 50 offices around the world, has rolled out the ReRun tool to its database of clientele. The platform is also available to businesses outside of the firm's existing portfolio, who can use the tool by providing a simple CAD design of their workplace. ReRun is applied through the company's SaaS space management software, Wisp. Using occupancy planning, Wisp provides clients with color-coded floor plans to help visualize and communicate to their teams which seats are available or assigned for occupancy as employees phase back into the office.

The response has been positive among clientele. Strombom is currently applying Gensler's social distancing tool with a large financial services company with locations throughout the Houston area.

"We are loading the information from ReRun into the Wisp program, and then we'll be helping them determine how they will return to work, and specifically where people will sit," he shares. The company plans to come back with 20 percent of the workforce, increasing overtime with the help of Gensler's team. "Who comes back when and specifically where is what they're most excited about."

The company has determined four work modes employees exhibit: focus, collaboration, socialization, and learning. By categorizing the work modes, Gensler is looking ahead at how interior architecture can accommodate these phases.

"More recently, we've been talking about a need for regenerative spaces so that people can become more engaged in the workplace," says Strombom.

As described in a Gensler blog, isolation rooms were optioned as a way to contain an employee who begins to feel symptomatic but these rooms can also serve a different purpose for employees acclimating to a new normal.

"The isolation room is what we often call a wellness room in an office where people can get away from the general tensions that they may be feeling in a workplace where they can relax and reinvigorate themselves in a quiet space," says Strombom.

As the architecture industry adjusts to a post-pandemic world, Gensler is working with developer clients and building owners to share the near-term and long-term changes the company foresees. Strombom says clients have flexibility as a priority.

ReRun allows Gensler to upload a floorplan into the program, which applies generative algorithms to determine safe separation between workplaces by creating circles ranging from six to eight-foot diameters. Graphic courtesy of Gensler

"We have to think about the entire path or the entire entry sequence in office buildings that is true for residential as well. From the moment that you pull into the garage, what are all of those points along the way where you've got to be concerned about contact and cleanliness?" Strombom shares.

Strombom foresees new building systems coming to the forefront, for example air conditioners with a focus on keeping clean air circulation within the office building. He also predicts a need for flexible spaces that can change depending on the circumstances.

"You hear a lot about temperature readings and separations of people within building lobbies during pandemics. We need systems in place that you can rapidly deploy when something like this happens, but the majority of the time it can revert to a more normal circumstance," he says.

Tight spaces also require a new way of thinking.

"We've realized that the elevator cab is really one of the pinch points in office buildings if you're trying to maintain this social distancing," Strombom shares. "There's technology [out there] that can identify how many people are going to be entering a cab and restrict that occupancy. So that is something that's going to need to be done for the near term."

In a Gensler survey of its Houston office, 72 percent of respondents expect a maintained or increased level of virtual collaboration compared to these pre-COVID levels.

"As people have been semi-forced to work at home, they've realized that not only is it possible, but for some people it's the preferred way to work," says Strombom, who predicts virtual meetings will continue on.

While platforms like Zoom and Skype make meetings tenable, company employees are still anticipating a future in the office.

"Those of us that are now working from home, if you ask people the majority of respondents to the question of what they miss most, it's really the people," Strombom says.

From common space to desks and offices, ReRun can help enable social distancing in the workplace. Photo courtesy of Gensler

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”