Houston scores lofty ranking in new study of America’s best cities

h-town proud

Houston ranks at No. 11 in the best cities in America — and No. 1 in Texas. Getty Images

Buoyed by diversity, fine food, and Fortune 500 companies, Houston ranks as the 11th best city in the country and the top city in Texas, according to a consulting firm's annual study.

"Smart, skilled, and soulful, Houston is the American city of the future," says the study, published by Vancouver, Canada-based Resonance Consultancy Ltd., which specializes in marketing, strategy, and research for the real estate, tourism, and economic development sectors.

In last year's study, Houston also held the No. 11 ranking.

The 2020 study praises Houston for its:

  • Ethnic diversity, with more than 145 languages spoken in Houston-area homes.
  • Highly regarded restaurants, rated fourth behind Los Angeles, New York City, and Chicago.
  • Healthy concentration of Fortune 500 companies, representing the country's biggest businesses. Twenty-two companies based in the Houston area are listed on this year's Fortune 500.
  • Airport connectivity (No. 7 ranking).

The study further lauds the city for development of the Houston Spaceport, a hub for the region's space industry. However, the study notes that Houston ranks 47th for prosperity, 74th for employment, and 99th (next to last) for income equality.

"From medicine to space to energy, we are at the forefront of innovation. We are resilient problem-solvers who work together to find common solutions, no matter if we're facing Hurricane Harvey or a global pandemic," real estate developer David Mincberg, chairman of Houston First Corp., says in an August 6 release. "Houston continues to grow and get better, so we invite those who live here to rediscover our city and visitors to come as soon as it is safe and enjoy all that Houston has to offer."

Houston First promotes the city as a destination for leisure and business travelers.

Resonance Consultancy ranks large U.S. cities by relying on a mix of 26 performance and quality measures. This year, New York City tops the list, followed by Los Angeles; San Francisco; Chicago; Washington, D.C.; San Diego; Las Vegas; San Jose, California; Miami; and Boston.

Three spots behind Houston is Dallas, at No. 14. Austin comes in at No. 17 and San Antonio at No. 28. Fort Worth isn't included in the ranking.

Highlights for Dallas include:

  • No. 1 ranking for airport connectivity, thanks largely to the presence of Dallas/Fort Worth International Airport.
  • Country's highest concentration of corporate headquarters (more than 10,000).
  • Country's third largest grouping of Fortune 500 companies (24 in Dallas-Fort Worth).
  • Sixth largest LGBTQ community in the U.S.
  • Dallas Arts District, the country's largest contiguous urban arts district.

"Dallas inspires big ideas. This big and bold approach has resulted in world-class arts, culture, architecture, dining, business, and more, which are changing the face of the city," VisitDallas, the city's convention and tourism arm, says on its website.

Sitting at No. 17, Austin boasts No. 8 rankings for educational attainment and nightlife, the study says, along with a vibrant cultural scene anchored by events such as SXSW and a flourishing tech landscape dotted by the likes of Apple, Dell, Facebook, Google, and Oracle.

Austin's showing in the Resonance Consultancy study comes on the heels of the city being hailed by U.S. News & World Report as the No. 1 place to live in the country, with particularly high marks for desirability, jobs, and quality of life.

"With a strong, continually growing tech-talent labor force and an overall lower cost of living and doing business, I think Austin could end up being a beneficiary market in the recovery of the pandemic as many tech users look to move out of more densely populated areas like New York City or San Francisco," Erin Morales, senior vice president of commercial real estate services company CBRE, said in a July news release.

At No. 28, San Antonio earns kudos from Resonance Consultancy for its plethora of attractions, including the River Walk, five colonial missions, San Antonio Zoo, San Antonio Museum of Art, and Texas Golf Hall of Fame. Alamo City shows up at No. 7 in the study's attractions category.

In addition, the study highlights San Antonio's popular mixed-use Pearl district, whose assets include a campus of the Culinary Institute of America. "Around the esteemed school, a host of grads and chefs have clustered, creating a smorgasbord of choices from Italian to 'cue to bakery to vegetarian cuisine," according to the study.

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This article originally ran on CultureMap.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

New accelerator joins the Ion and more Houston innovation news to know

Trending News

Editor's note: The Houston innovation scene is buzzing with big news this month, from a new accelerator joining the fold at the Ion to pre-IPO funding and national expansion plans. Below are the five most-read InnovationMap stories from Feb. 1-15, 2026:

New accelerator for AI startups to launch at Houston's Ion this spring

The new AI Native Dual-Use Sports, Health & Wellness Accelerator is expected to launch in March. Photo courtesy of the Ion

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform. The AI Native Dual-Use Sports, Health & Wellness Accelerator is scheduled to formally launch in March. Continue reading.

10+ can't-miss Houston business and innovation events in February

From recurring monthly favorites to the return of annual celebrations and summits, here's what not to miss in February. Photo courtesy the Ion.

February may be a short month, but its event calendar isn’t. From recurring monthly favorites to the return of annual celebrations and summits, here are the Houston business and innovation events not to miss — and how to register. Continue reading.

Houston lab-test startup seeks $1M for nationwide expansion

Jim Gebhart, founder and CEO of TheLabCafe.com. Courtesy photo.

Health care industry veteran Jim Gebhart knew there had to be a better way for patients to access lab services, especially those with high health insurance deductibles or no insurance at all. Continue reading.

Houston wearable biosensing company closes $13M pre-IPO round

Wellysis is known for its continuous ECG/EKG monitor with AI reporting, known as the S-Patch. Photo via wellysis.com.

Wellysis, a Seoul, South Korea-headquartered wearable biosensing company with its U.S. subsidiary based in Houston, has closed a $13.5 million pre-IPO funding round and plans to expand its Texas operations. Continue reading. Continue reading.

Texas booms as No. 3 best state to start a business right now

Texas is rebounding in a report of the best states to start a business. Photo via Getty Images

High employment growth and advantageous entrepreneurship rates have led Texas into a triumphant No. 3 spot in WalletHub's ranking of "Best and Worst States to Start a Business" for 2026. Continue reading.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

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