Houston's DataCon can help prepare business leaders for the digital revolution in AI and machine learning. Getty Images

Looming on the horizon is a data tsunami coming towards us at breakneck speed. Companies have worked hard to keep up, creating digital transformation, taking manual processes from desktops, clipboards, and the paper paradigm to the Cloud. We're now sitting on huge quantities of idle bits of information called dark data. It's over collected and unused data that has the potential power to create decision-making brilliance.

Business leaders are attempting to optimize siloed data – unrelated data collected in databases and spreadsheets or obsolete apps, to make critical decisions. We currently connect these siloes with other systems using a data processing step called ETL – Extract, Transform and Load. Take the data from one place, transform it so it can relate to another data resource and then load that data to another place for analysis. It's a big, time consuming, intermediary step we have figured out how to circumvent. "NoETL" technology is the next-generation magic wand of machine thinking and it's a game-changer.

As non-technical business leaders, we rely on our partners in IT to give us meaningful data that charts our course. They've been our faithful navigators. We've made the recommended investment in IT infrastructure and technology and counted on receiving analytics that will result in winning outcomes. It's now time to sit down at the table and have new conversations with IT leadership around AI.

A tectonic shift

We are now in a new place. AI has come upon us quickly and the promise of ROI is great. There are new technologies that give business leaders advantages never before realized. Data science is the new crystal ball to the future of business. Automation and machine learning are taking historical data to a look ahead using algorithms and mathematical modeling. It's a new predictive mindset. What business leader wouldn't want that crystal ball?

The real assets of your business exist not in better machines but in your current data stores which are like coal mines waiting for data science to turn those lumps of coal into data diamonds.

There are new vocabulary words associated with data analytics. Data science thought leaders are preparing the way for businesses to have learning opportunities and to know which resources to tap for direction in creating new competitive dynamics. Don't wait too long to be curious. The early adopters are already a step ahead and the competitive marketplace is changing in unexpected ways.

Leadership resources for the implementation of AI

Legacy businesses with data lakes are ripe for action. Who should lead the charge? It's up to the C-suite to have intentional conversations around data science. It's up to leadership to be ready to speak and understand new concepts and vocabulary combined with leaps of faith needed to join the new world order of information.

Learning resources 

Proactively look for learning opportunities. There are no excuses for not taking the initiative. No matter where you are in your career – this isn't something to linger about.

One upcoming seminar around AI and automation collaboration and education is DataCon Houston. It's an annual conference that brings important concepts around AI and Automation to business leaders. The target audience is not IT professionals, although there will be some in attendance; it's meant primarily to help the C-suite and non-technical leaders know where to begin and where to find that new vocabulary and translative resources. AI will affect every person in every business, and we must be ready for the cultural shifts that will come with the technological shifts.

Authors and thought leaders — George Danner, Dave McComb, and Gerald Kane will be speaking at DataCon October 10, 2019. In addition, Javier Fadul, director of innovation for HTX Labs will be speaking about XR and data visualization and its use in training employees and creating safer workplaces. Stefanos Damianakis will be teaching machine learning 101 and Juan Sequeda, principal scientist of data.world will present his UltraWrap NoETL patented technology.

Solving the unsolvable

The future of decision-making will render in blinks of an eye. Problems we thought unsolvable will suddenly have answers. Business leaders must get behind the leap of faith required for our own companies and push learning and understanding forward across the organization at all levels. AI and machine learning are the vortex of change. Are you ready for AI?

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Suzette Cotto is CEO of Innovate Social Media, a digital marketing agency specializing marketing for startups in the medical, technology, and energy industries. For more information on DataCon Houston 2019, please visit: https://incitelogix.com/datacon-houston-2019/

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.