Despite the effect COVID-19 has had on Houston venture capital, this Kansas City, Missouri-based VC is looking to continue to connect with the local tech scene remotely. Getty Images

A Kansas City, Missouri-based venture capital firm has had its eyes on Houston since fall of last year, and it's not letting the pandemic slow down its immersion into the local startup ecosystem.

Flyover Capital focuses on tech startups based in the middle of the country — from Denver to Atlanta, and the Twin Cities down to Houston. Usually funding seed to series A rounds, Flyover's thesis is geared at "creating the next generation of tech success stories outside traditional tech hubs," says Dan Kerr, principal at the firm.

This region, which Crunchbase dubbed "The Mighty Middle" in a recent report, has seen a growth in venture capital invested over the past decade. Annual investment grew from $5.8 billion invested in 2010 to $20.2 billion in 2019 alone, according to the report, and Texas is leading the pack. The Lone Star State accounted for $24 billion of the region's $92.6 billion venture capital invested in the past decade, per the report.

Flyover Capital, which was founded in 2014, has connected a couple dozen Houston startups in the past six months, Kerr says, and the firm is keeping up with several of those to this day. He predicts the firm will "dive in deeper" into some of those companies in the next six months.

Houston is "one of the cities among those that fall in our region where we plan to spend a significant amount of time," Kerr tells InnovationMap. "We cover a lot of ground, but there are certain cities were we try to get there quarterly. Houston is definitely one of those places."

Kerr says his first impression of Houston was its strength as a B2B — especially as that pertains to its entrepreneurs.

"There are a lot of people who are experienced in their career, maybe with a technical background, and are looking to build a business going after some problem that they see," Kerr says.

In a similar vein, Houston's corporate involvement with its startup ecosystem has been a big indicator of opportunity.

"One of the things we've identified as a strength in a lot of the middle America ecosystems is if they get the corporations involved, then that is a good marker for success, especially if you have some of the other ingredients involved," Kerr says.

Houston Exponential, which Kerr says has been helpful in allowing Flyover to tap into the ecosystem — especially in times like these — has also demonstrated Houston's strength as a B2B community with deep corporate connections.

And Flyover isn't the only VC firm that HX has seen interest from recently. This month, HX has planned more immersion days — where it connects VCs to startup development organizations and startups across town — than it's ever had in a single month, says Harvin Moore, president of HX. The immersion days will be happening completely online.

"It's clear from the indication that we get from VCs and angel networks that people are saying, 'Okay, we need to be looking for new deals,'" Moore says.

For Flyover Capital, Kerr describes the VC as "active, but of course cautious" when it comes to investing in new deals in the current economic environment.

"We're not alone in saying we're actively investing," Kerr says. "I think I've seen some surveys that 60 or so percent of investors are saying they're staying the course."

In fact, finding a positive spin, Kerr says the pandemic has had a "moderating effect" to the investment environment. "Rounds were happening in some cases in a crazy manner," he says of pre-COVID conditions.

Plus, while he hasn't seen a huge change to valuations, the economic conditions caused by COVID-19 could correct some of the over-valuations on the coasts.

"As unfortunate as these times are for lots of people, this is where many companies ultimately find their footing and success," Kerr says.

From entrepreneur networking opportunities to thought-provoking panels, here's where you need to be in December. Getty Images

10+ can't-miss Houston business and innovation events for December

Where to be

Before everyone checks out of 2019, Houston has a couple more weeks filled with exciting entrepreneurial networking opportunities. Scroll through the curated list of innovation events you can't miss.

For a full calendar of Houston innovation events, head to Houston Exponential's page.

If you know of innovation-focused events for this month or next, email me at natalie@innovationmap.com with the details and subscribe to our daily newsletter that sends fresh stories straight to your inboxes every morning.

December 3 — Intro to the Houston Startup Scene & Ask Me Anything with Omair Tariq and Dr. Brittany Barreto

Are you new to the Houston tech startup community? Thinking about moving here? Trying to figure out how to plug in? Come hear a comprehensive overview from local community leaders and get a chance to introduce yourself and ask questions at the Intro to the Houston Startup Scene & Ask Me Anything. Tickets are $10.

Details: The event is from 4 to 7 pm on Tuesday, December 3, at The Cannon (1334 Brittmoore Road). Learn more.

December 3 — Houston Coalition for Equitable Development without Displacement community forum

The Houston Coalition for Equitable Development without Displacement is gathering for a second time to discuss securing a Community Benefits Agreement with Rice Management Company as they develop the 16-acre Innovation District around the old Sears building and Fiesta at the edge of Third Ward.

Details: The event is from 6 to 8 pm on Tuesday, December 3, at Wesley Chapel AME Church (2209 Emancipation Ave.). Learn more.

December 3-4 — InvestH2O 2019 Forum: Investing in Resiliency

With nearly $1 trillion in losses over the past 5-7 years for FEMA and other federal agencies, states-counties-cities, private insurance and reinsurance companies, industry and business operations from water- and weather-related incidents, the need for alternative investment and resource allocation could not be more obvious. The event's programming will be focused on innovating solutions.

InnovationMap readers can attend for free through this link.

Details: The event is from Tuesday, December 3, to Wednesday, December 4, at various locations. Learn more.

December 4 — The Cannon & EPIcenter - Jumpstart your innovation Happy Hour

In partnership with The Cannon, EPIcenter's Incubator and Accelerator will be hosting a six-week seminar using the Wendy Kennedy curriculum, "So what? Who cares? Why you?" for innovators in any industry. Director of the EPIcenter Energy Incubator and Accelerator and certified Business Coach Andi Littlejohn will lead participants through a proven methodology to discover, define and describe the commercial opportunities of innovations.

Details: The event is from 4 to 6 pm on Wednesday, December 4, at The Cannon (1334 Brittmoore Road). Learn more.

December 4 — The Ion Smart Cities Accelerator Demo Day

The Ion Smart Cities Accelerator will present its inaugural cohort of companies that are addressing the needs of Houston's people by deploying technology into the infrastructure and civic fabric that makes Houston so strong.

Details: The event is from 5 to 8 pm on Wednesday, December 4, at ion Accelerator and Prototyping Lab (1301 Fannin Street, Suite 2100). Learn more.

December 5 — Houston Region Economic Outlook

The Greater Houston Partnership's Annual Houston Region Economic Outlook event will feature Partnership Senior Vice President of Research Patrick Jankowski who will deliver the 2020 employment forecast for the region. ConocoPhillips Chief Economist Helen Currie will follow with a presentation on the national economy.

Details: The event is from 9:30 am to 1:30 pm on Thursday, December 5, at the Royal Sonesta (2222 West Loop S.). Learn more.

December 5 — Evening of Pediatric Device Innovation

Please join JLABS @ TMC for the 5th Annual Evening of Pediatric Device Innovation as top experts from Houston and across the country will discuss the latest in pediatric medical device innovation and updates on bringing a pediatric medical device to market.

Details: The event is from 3 to 6:30 pm on Thursday, December 5, at the TMC Innovation Institute (2450 Holcombe Blvd). Learn more.

December 5 — Meet & Greet with Flyover Capital

Meet Flyover Capital's Dan Kerr on his last night in town and learn how they are working to creating the next generation of technology success stories outside the coastal tech hubs.

Details: The event is from 6 to 7:30 pm on Thursday, December 5, at WeWork (708 Main Street, 3rd Floor). Learn more.

December 11 — ENRICH/LEAP Information Session

ENRICH and LEAP are 6-8 week fellowship programs where you and a team of your peers will work directly with established companies on one of a wide scope of projects. These invaluable programs allow people the ability to gain skills and insights that only professional work can offer. Come hear Enventure leadership discuss these programs and learn how you can get involved.

Details: The event is from 5:30 to 8 pm on Wednesday, December 11, at the TMC Innovation Institute (2450 Holcombe Blvd). Learn more.

December 12 — WeWork Labs x NextSeed Launch Event

WeWork Labs, a global acceleration program with a location in downtown Houston, and NextSeed, a Houston-based online investment platform, have announced a partnership set to begin in December. Together, the two entities will build a support system for Houston-based food entrepreneurs to provide workshops, programming, events, and more.

Details: The event is from 6 to 8:30 pm on Thursday, December 12, at WeWork (708 Main Street). Learn more.

December 14 — Smart Infrastructure Hackathon

On Saturday, December 14, join Microsoft and The Cannon for a smart infrastructure hackathon. Bring your own ideas and team, or join a team when you arrive. Everyone is welcome, regardless of skill level.

Details: The event is from to 9 am to 7 pm on Saturday, December 14, at The Cannon (1334 Brittmoore Road). Learn more.

December 14 — TEDxHoustonWomen 2019 : BOLD + Brilliant!

Connect with a locally rooted, globally connected community of people interested in leading the change they wish to see in the world; and sow the seeds to collaborate with innovative thinkers who catalyze ideas toward action.

Details: The event is from 10:30 am to 4 pm on Saturday, December 14, at Unity of Houston (2929 Unity Dr). Learn more.

December 17 — The Future of Work: Closing the Skills Gap

GA gathers Houston industry leaders to share how they approach the challenge of upskilling the workforce. In this discussion, we'll cover how to bridge the gap between current team capabilities and the skills needed to stay competitive. Whether radically reskilling existing teams or onboarding new talent, the companies who adapt fastest will stand the test of time.

Details: The event is from 8:30 to 11 am on Tuesday, December 17, at Station Houston (1301 Fannin Street, 21st Floor). Learn more.

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European spacecraft developer expands to Houston with U.S. business, new lab

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European aerospace manufacturer The Exploration Company has established its first U.S. entity and named Space City as its headquarters.

The company announced earlier this month that it has launched TEC Federal to support U.S. government customers and agencies, and to scale The Exploration Company's engineering operations in the country.

Mark Kirasich serves as president of TEC Federal. Kirasich most recently served as the senior director of human spaceflight at Blue Origin after a nearly 40-year career at NASA.

The Exploration Company is developing the reusable Nyx space vehicle. Nyx is designed to take off from any heavy launcher in the world. It will then dock at space stations, retrieve up to 3,000 kilograms of cargo, splash down and return the cargo to Earth. The company aims to make Nyx fully reusable for up to 10 missions, making it a more affordable and sustainable option for aerospace missions.

The Exploration Company completed a successful drop test of the spacecraft in May in the Mojave Desert. The company says Nyx is slated to perform its first flight demonstration in 2028.

In addition to launching the Houston business, The Exploration Company also opened its new Rapid Innovation Lab near Houston's NASA Johnson Space Center on Space Park Drive.

The Exploration Company opened its Rapid Innovation Lab earlier this month. Photo via LinkedIn

The Rapid Innovation Lab features a full-scale mockup of the future Nyx crew capsule as well as ongoing development and testing of the Nyx cargo capsule, according to the company.

The Exploration Company says the new lab will allow its engineers, designers, and operators to prototype and test crew interfaces. It will also support partnerships with NASA personnel and astronauts.

“Houston gives us direct access to the people and expertise that have built and operated human spaceflight systems for decades. We’re excited to invest and expand around that— engineers, operators, and astronauts working together and moving quickly towards building a crew capsule.” Hélène Huby, founder and CEO of The Exploration Company, said in a blog post.

According to The Houston Chronicle, The Exploration Company has about 30 employees in the Houston area.

The company was founded in 2021 by Huby, a French rocket scientist, and has raised more than $350 million in venture capital. It operates out of Germany, France, Luxembourg, Spain and Italy, with offices in the U.S. and the United Arab Emirates. It is also developing a reusable, high-thrust rocket engine known as Storm.

UH lands $4M NIH grant to study early signs of autoimmune disease

NIH funding

The University of Houston recently received a $4 million National Institutes of Health grant to support a 10-year longitudinal study to identify the earliest biological markers of autoimmune disease.

Led by Chandra Mohan, the Hugh Roy and Lillie Cranz Cullen Endowed Professor of Biomedical Engineering, the study aims to examine what causes Systemic Autoimmune Rheumatic Diseases (SARDs) and to identify targets for future treatments. The study will be carried out in collaboration with Dr. Karen Costenbader at Harvard Medical School, Boston.

SARDs include conditions like rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s syndrome and systemic sclerosis—all are considered chronic diseases currently without a cure. Autoimmune diseases affect over 30 million people globally, according to UH.

SARDs occur when the body’s immune system attacks healthy, non-threatening tissues and organs. According to UH, in these diseases, the body often attacks nuclear antigens, creating anti-nuclear autoantibodies, which can be early detection signs for SARDs in more than 50 percent of patients, Mohan says.

Researchers will study blood samples and environmental exposure over the 10 years to better understand anti-nuclear autoantibodies.

“Collectively, these studies will help identify the genetic, environmental and cellular factors that are operative at the two steps of SARD development, namely the emergence of anti-nuclear autoantibodies and disease onset,” Mohan said in a news release. “ More importantly, these studies will highlight functional molecular pathways and mechanisms that may be operative at each step."

Mohan predicts that looking at SARDs’ shared characteristics, rather than each disease individually, could help identify more treatment methods.

“Individual SARDs have been examined in silos without an attempt to discern shared underlying features at the molecular level,” he added in the release. “Current understanding of the initial (and likely shared) origins of SARDs is only rudimentary but urgently needed to develop means for prevention and treatment.”

Earlier this year, UH also received an $11 million NIH grant to conduct a first-of-its-kind study of early language development in children ages 18 to 24 months. Read more here.