3 Houston innovators to know this week

hou to know

This week's roundup of Houston innovators includes Brianna Brazle of CultureLancer, Sameer Soleja of Molecule, and Emerson Perin of Texas Heart Institute. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from health care to energy tech — recently making headlines in Houston innovation.

Brianna Brazle, founder of CultureLancer

Houston founder joins DivInc's newest accelerator that supports Web3 companies with a social impact. Photo courtesy

DivInc, aTexas-based accelerator focused on helping BIPOC and female founders on their entrepreneurial journeys, announced the inaugural class for its newest accelerator. DWeb for Social Impact Accelerator, a 12-week intensive hybrid program sponsored by Filecoin Foundation for the Decentralized Web, will mentor nine companies, all of whom integrate Web3 technologies into their impact entrepreneurship.

One Houston-based startup, CultureLancer, will be participating in the program. Founded by Brianna Brazle, the career-focused platform matches students from HBCU with companies looking to hire in the fields of business development, data analysis, marketing, and operations.

“That’s a problem that has been existing and then after doing more research I learned historically about 56%, year over year, of college graduates find themselves unemployed or underemployed,” Brazle explains. “My first solution to this problem was a hybrid marketplace.” Read more.

Sameer Soleja, founder and CEO of Molecule

Sameer Soleja has expanded his company's platform. Photo courtesy of Molecule Software

Houston startup Molecule Software hopes to get a big bang out of its new platform for the energy and commodities markets. The data-as-a-lake platform, Bigbang, is available as an add-on for current Molecule customers. It enables energy trading and risk management (ETRM) and commodities trading and risk management customers to automatically import trade data from Molecule, and then merge it with various sources to conduct queries and analysis.

Molecule sells Bigbang at a monthly rate through either a yearly or multiyear contract.

“We’re seeing a growing need in the energy and commodities trading space for a turnkey data lake, as indicated by our own customers. They need real-time and automated data streaming from key systems, the ability to query the data quickly and easily, and access to the data using the analytics tools they know well,” says Sameer Soleja, founder and CEO of Molecule. Read more.

Emerson Perin, medical director of The Texas Heart Institute

Emerson Perin of the Texas Heart Institute, recently published the largest clinical trial of cell therapy for patients with chronic heart failure to-date included 580 patients at 52 sites throughout North America. Photo via texasheart.org

Emerson Perin’s end goal isn’t to treat heart failure. The medical director of The Texas Heart Institute says that he has his sights set firmly on curing the malady altogether. And, with the power of innovation and a strong team, the Houston-based cardiologist has a good chance of meeting his objective.

Perin first came to THI for fellowship training in 1988, following his residency in Miami and medical school in his birthplace of Brazil.

“This is a very special place,” the physician and researcher, whose titles also include director for THI’s Center for Clinical Research and vice president for medical affairs, tells InnovationMap. “It has a worldwide-reaching reputation. I’ve always liked research and this is a great place in terms of innovation and practicing high-level cardiology.” Read more.

DivInc's newest accelerator based in Houston will support Web3 companies with a social impact. Photos courtesy of DivInc

Texas organization announces inaugural cohort of social enterprise startups with Web3 tech

Dedicated to DWeb

A Texas-based accelerator focused on helping BIPOC and female founders on their entrepreneurial journeys announced the inaugural class for its newest accelerator.

DivInc's DWeb for Social Impact Accelerator, a 12-week intensive hybrid program sponsored by Filecoin Foundation for the Decentralized Web, will mentor nine companies, all of whom integrate Web3 technologies into their impact entrepreneurship. Participating startups will have access to the Ion’s resources and receive a non-dilutive $10,000 grant to use during the course of the program.

Cherise Luter, marketing director at DivInc, says the Austin-based development program instead chose Houston to host this inaugural cohort because they have a secure partnership with the Ion and other premiere partners in the area, including Mercury, JP Morgan, and Bank of America.

“The team that we already have in place in Houston is so strong, we thought, this would be a great place to launch this concept and then from there determine if we want to launch it in Austin,” Luter says.

Amanda Moya, director of programs for DivInc, says this accelerator will truly be hybrid, enabling entrepreneurs from around the country to benefit from quality virtual mentorship and four weeks of in-person training.

“We want to really engulf them in the Houston innovation ecosystem, to let them know that this is also a landing pad if they are ever to move or travel around and come back to Houston,” Moya mentions.

One Houston-based startup, CultureLancer, will be participating in the program. A career-focused platform that matches students from HBCU with companies looking to hire in the fields of business development, data analysis, marketing, and operations, CultureLancer provides students with project-based learning opportunities.

Brianna Brazle, CultureLancer founder and therapist, says after discussing with friends and family members their struggles to get hired post-graduation she uncovered an underserved market of people in need of career guidance.

“That’s a problem that has been existing and then after doing more research I learned historically about 56%, year over year, of college graduates find themselves unemployed or underemployed,” Brazle explains. “My first solution to this problem was a hybrid marketplace.”

The rest of the inaugural cohort includes one to two entrepreneurs from the following companies:

  • Craftmerce, based in Dallas, is a B2B technology platform that brings African artisans and mainstream retail partners together through distributed production, enterprise management, and financing tools.
  • Instarails is working to simplify cross border payments through their API which provides the option to make instant global payments regardless of currency.
  • Looks for Lease, a Los Angeles based wardrobe rental company is combating the carbon emissions brought on by the fashion industry through their circular consumerism business model which operates on an AR platform.
  • Motherocity is an app that allows postpartum moms to track their mental and physical health through personal insights, experiential data, data science, and artificial intelligence, all the way through the first year after giving birth.
  • Salubata combines sustainable fashion and tech through their shoes made from old plastic bottles and integrating an NFT component that allows access to new shoe designs for customers.
  • Seed At The Table is a crowdfunding platform connecting marginalized founders with non-accredited investors, founded by a former Goldman Sachs investment manager.
  • Tribe is a mental health mobile app aiming to make mental healthcare affordable and accessible to black people through their directory of black therapists whose patients can directly book appointments within the app.
  • Subler, which was founded by a Los Angeles high school board member, is a digital marketplace that allows schools to rent out their unused spaces to local community groups.

The program will run from Sept. 18 until their demonstration day which is scheduled for Dec. 7 at the Ion.

DivInc, which runs several accelerators across Texas, originally partnered with the Ion in 2020. The organization introduced its new DWeb program earlier this year.

Last month, DivInc also introduced its inaugural cohort to another new diversity-focused accelerator. The 2023 Clean Energy Tech accelerator program sponsored by Chevron and Microsoft is currently ongoing.

The latest Houston cohort for gBETA has been announced. Photo courtesy of gBETA

Early-stage startup accelerator names latest Houston cohort

ready to grow

The sixth Houston cohort for global startup accelerator and investor gener8tor's gBETA program is underway, and five Houston early-stage companies have joined the program.

The no-equity program, which is based out of the Downtown Launchpad, kicked off in September and lasts seven weeks. In that time, the startups are connected to a national network of mentors, customers, corporate partners, and investors.

“This gener8tor Houston cohort is among our strongest yet,” says Robert Pieroni, director of Economic Development at Central Houston Inc., in the news release. “We are excited about the caliber of entrepreneurs the Downtown Launchpad is attracting and the entrepreneurial ecosystem being created.”

The program concludes at a public showcase event at 5 pm on November 17 at Amegy Bank Courtyard.

“I’m thrilled about this cohort,” says Muriel Foster, gBETA Houston director, in the release. “We’ve seen the incredible economic impact of the gBETA program in other parts of the country, and we’re excited to bring that same impact to Houston.”

Here are the members of gBETA Houston's latest cohort:

CultureLancer

CultureLancer's all-in-one career-focused platform connects students at HBCUs with opportunities to gain industry-specific education and experience. CultureLancer also provides companies with the ability to source qualified diverse talent to meet their needs. CultureLancer has onboarded 30 students with each completing certification in digital marketing, closing on two contracts, and currently onboarding companies for beta testing.

EYF

EYF gamifies financial literacy education and provides children with a fun alternative to educational programming. EYF aims to teach financial literacy and economics in a fun, interactive, and applicable way. EYF is set to go to market at the end of of the year.

Oodles

Oodles automates the sales process and 24/7 customer service for e-commerce retailers through a conversational AI chatbot. Leveraging AI and machine learning, Oodles chatbot results in significant cost savings for retailers and improves customer retention and loyalty. Oodles has currently raised a seed round of $280,000, launched the product, and onboarded 10 customers.

SafetyKay

SafetyKay LLC promotes safety awareness to young children. SafetyKay focuses on decreasing fatality and accident rates among children ages 5-12 years by teaching them critical health and safety skills. SafetyKay's current safety awareness material has been viewed 81,359 times and it is currently in the process of transitioning into a mobile app platform.

Stobridge Education Inc.

Stobridge Education Inc. connects students with mentors and postsecondary education college, career and life resources for better outcomes. Through its comprehensive and fully integrated web and mobile platform, Stobridge Education is a safer alternative to LinkedIn for high school students. Stobridge Education has engaged with over 1,000 participants through their nonprofit partner, Adeiur and has implemented its module curriculum in two universities and four student-serving organizations.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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